PL3190113T3 - Związki pirolopirymidynowe stosowane jako agonista TLR7 - Google Patents
Związki pirolopirymidynowe stosowane jako agonista TLR7Info
- Publication number
- PL3190113T3 PL3190113T3 PL15831451T PL15831451T PL3190113T3 PL 3190113 T3 PL3190113 T3 PL 3190113T3 PL 15831451 T PL15831451 T PL 15831451T PL 15831451 T PL15831451 T PL 15831451T PL 3190113 T3 PL3190113 T3 PL 3190113T3
- Authority
- PL
- Poland
- Prior art keywords
- compounds used
- tlr7 agonist
- pyrrolopyrimidine compounds
- pyrrolopyrimidine
- tlr7
- Prior art date
Links
- 229940124615 TLR 7 agonist Drugs 0.000 title 1
- 150000004944 pyrrolopyrimidines Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410405136.0A CN105367576A (zh) | 2014-08-15 | 2014-08-15 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| CN201510392499 | 2015-07-06 | ||
| EP15831451.8A EP3190113B1 (en) | 2014-08-15 | 2015-08-14 | Pyrrolopyrimidine compounds used as tlr7 agonist |
| PCT/CN2015/086909 WO2016023511A1 (zh) | 2014-08-15 | 2015-08-14 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3190113T3 true PL3190113T3 (pl) | 2021-10-25 |
Family
ID=55303885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15831451T PL3190113T3 (pl) | 2014-08-15 | 2015-08-14 | Związki pirolopirymidynowe stosowane jako agonista TLR7 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9962388B2 (pl) |
| EP (1) | EP3190113B1 (pl) |
| JP (2) | JP6328341B2 (pl) |
| KR (2) | KR102215609B1 (pl) |
| CN (4) | CN112898308A (pl) |
| AU (3) | AU2015303558B2 (pl) |
| BR (1) | BR112017002811B1 (pl) |
| CA (1) | CA2958097C (pl) |
| CL (1) | CL2017000379A1 (pl) |
| DK (1) | DK3190113T3 (pl) |
| EA (1) | EA032824B1 (pl) |
| ES (1) | ES2875313T3 (pl) |
| HR (1) | HRP20210927T1 (pl) |
| HU (1) | HUE054672T2 (pl) |
| IL (2) | IL250586B (pl) |
| LT (1) | LT3190113T (pl) |
| MX (1) | MX386981B (pl) |
| MY (1) | MY190026A (pl) |
| PH (2) | PH12017500281B1 (pl) |
| PL (1) | PL3190113T3 (pl) |
| PT (1) | PT3190113T (pl) |
| SG (2) | SG11201701169XA (pl) |
| SI (1) | SI3190113T1 (pl) |
| UA (1) | UA117634C2 (pl) |
| WO (1) | WO2016023511A1 (pl) |
| ZA (1) | ZA201803736B (pl) |
Families Citing this family (97)
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| DK3160513T3 (da) | 2014-06-30 | 2020-04-06 | Glykos Finland Oy | Saccharidderivat af en toksisk payload og antistofkonjugater deraf |
| SI3190113T1 (sl) * | 2014-08-15 | 2021-09-30 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pirolopirimidinske spojine, ki se uporabljajo kot agonist TLR7 |
| KR102690131B1 (ko) | 2015-05-08 | 2024-07-31 | 에프. 호프만-라 로슈 아게 | 바이러스 감염의 치료 및 예방을 위한 신규한 설폰이미도일푸린온 화합물 및 유도체 |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| UA121345C2 (uk) * | 2015-11-05 | 2020-05-12 | Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд. | 7-(тіазол-5-іл)піролопіримідин як агоніст рецептора tlr7 |
| CN107043378A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| CN107043377A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 |
| CN107043379A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的晶型a、其制备方法和医药用途 |
| CN107043380A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| CN109563144B (zh) | 2016-06-01 | 2023-03-28 | 雅斯娜 | 化合物 |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| PT3504210T (pt) | 2016-08-29 | 2021-04-19 | H Hoffnabb La Roche Ag | Compostos de sulfonimidoílpurinona 7-substituídos para o tratamento e profilaxia de infeção por vírus |
| NZ750781A (en) | 2016-09-09 | 2025-06-27 | Novartis Ag | Compounds and compositions as inhibitors of endosomal toll-like receptors |
| CN109715214B (zh) | 2016-09-13 | 2022-03-04 | 豪夫迈·罗氏有限公司 | Tlr7激动剂和hbv衣壳组装抑制剂的组合治疗 |
| BR112019007450A2 (pt) | 2016-10-14 | 2020-07-07 | Precision Biosciences, Inc. | meganucleases modificadas específicas para sequências de reconhecimento no genoma do vírus da hepatite b |
| WO2018078149A1 (en) * | 2016-10-31 | 2018-05-03 | F. Hoffmann-La Roche Ag | Novel cyclicsulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection |
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