PE20061484A1 - Compuestos triciclicos fusionados como inhibidores de la actividad de quinesina de ksp - Google Patents
Compuestos triciclicos fusionados como inhibidores de la actividad de quinesina de kspInfo
- Publication number
- PE20061484A1 PE20061484A1 PE2006000258A PE2006000258A PE20061484A1 PE 20061484 A1 PE20061484 A1 PE 20061484A1 PE 2006000258 A PE2006000258 A PE 2006000258A PE 2006000258 A PE2006000258 A PE 2006000258A PE 20061484 A1 PE20061484 A1 PE 20061484A1
- Authority
- PE
- Peru
- Prior art keywords
- halo
- alkyl
- ksp
- activity
- tetrahydrotien
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE Y ES UN ANILLO DE 5 A 7 MIEMBROS TAL COMO CICLOALQUILO, CICLOALQUENILO, HETEROCICLILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON R2 O R6, DONDE R2 ES H, HALO, ALQUILO(C1-C20), CICLOALQUILO(C3-C10), ENTRE OTROS; R6 ES H, ALQUILO(C1-C20), ARILO(C6-C14), ENTRE OTROS; W ES N O C(R12) DONDE R12 ES H, HALO, ALQUILO(C1-C20), ENTRE OTROS, OPCIONALMENTE SUSTITUIDO; X ES N O N-OXIDO; Z ES S, S(=O) O S(=O)2; R1 ES H, ALQUILO(C1-C20), HIDROXI, HALO, CN, ENTRE OTROS; R3 ES H, HALO, ALQUILO(C1-C20), CICLOALQUILO(C3-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-TER-BUTIL-5,6,7,8-TETRAHIDROTIEN[2,3-b]QUINOLIN-2-CARBONITRILO, AMIDA DEL ACIDO 6-TER-BUTIL-5,6,7,8-TETRAHIDROTIEN[2,3-b]QUINOLIN-2-CARBOXILICO, AMIDA DEL ACIDO 6-TER-BUTIL-5,6,7,8-TETRAHIDROTIEN[2,3-b]QUINOLIN-2-CARBOTIOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DE LA PROTEINA DE QUINESINA DEL HUSO ACROMATICO (KSP) SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS TALES COMO CANCER DE PULMON, CANCER DE PANCREAS, HIPERTROFIA CARDIACA, ARTRITIS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65988805P | 2005-03-09 | 2005-03-09 | |
US71227405P | 2005-08-29 | 2005-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20061484A1 true PE20061484A1 (es) | 2007-02-05 |
Family
ID=36660847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000258A PE20061484A1 (es) | 2005-03-09 | 2006-03-07 | Compuestos triciclicos fusionados como inhibidores de la actividad de quinesina de ksp |
Country Status (12)
Country | Link |
---|---|
US (1) | US20060247320A1 (es) |
EP (1) | EP1871776A2 (es) |
JP (1) | JP2008533018A (es) |
KR (1) | KR20070113267A (es) |
AR (1) | AR052682A1 (es) |
AU (1) | AU2006223461A1 (es) |
CA (1) | CA2599899A1 (es) |
IL (1) | IL185510A0 (es) |
MX (1) | MX2007010972A (es) |
PE (1) | PE20061484A1 (es) |
TW (1) | TW200700422A (es) |
WO (1) | WO2006098961A2 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007011647A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin ksp |
WO2007101225A2 (en) * | 2006-02-27 | 2007-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods to identify inhibitors of the unfolded protein response |
CN101687838A (zh) * | 2006-12-21 | 2010-03-31 | 先灵公司 | 抑制ksp驱动蛋白活性的吡咯并[3,2-a]吡啶衍生物 |
WO2008157753A1 (en) * | 2007-06-21 | 2008-12-24 | Sma Foundation | Methods of treatment for spinal muscular atrophy |
CA2702922C (en) | 2007-10-19 | 2018-01-16 | Schering Corporation | Spiro-condensed 1,3,4-thiadiazole derivatives for inhibiting ksp kinesin activity |
US8361959B2 (en) | 2008-10-03 | 2013-01-29 | Merck Sharp & Dohme Corp. | Spiro-imidazolone derivatives as glucagon receptor antagonists |
WO2011002887A1 (en) | 2009-07-02 | 2011-01-06 | Schering Corporation | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS |
EP2473041B1 (en) | 2009-09-04 | 2018-03-07 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
US20140045847A1 (en) | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
WO2013016164A1 (en) | 2011-07-26 | 2013-01-31 | Merck Sharp & Dohme Corp. | FUSED TRICYCLIC COMPOUNDS AS mTOR INHIBITORS |
WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113788A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
AR089884A1 (es) | 2012-02-03 | 2014-09-24 | Basf Se | Compuestos fungicidas de pirimidina |
EP2809659A1 (en) | 2012-02-03 | 2014-12-10 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013135672A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
JP2016506929A (ja) * | 2013-01-23 | 2016-03-07 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ヒト銅輸送タンパク質atox1およびccsを阻害するための方法および組成物 |
US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
WO2018145080A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
EP3972590A4 (en) * | 2019-05-22 | 2023-06-14 | Merck Sharp & Dohme LLC | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USED TO TREAT CARDIOMETABOLIC DISEASES, KIDNEY DISEASES AND DIABETES |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2638828A1 (de) * | 1976-08-28 | 1978-03-09 | Thomae Gmbh Dr K | Neue thieno-pyridine |
EP0127883B1 (en) * | 1983-06-02 | 1989-06-07 | American Cyanamid Company | (2-Imidazolin-2-yl)thieno and furo(2,3-b) and (3,2-b) pyridines and intermediates for the preparation thereof, and use of said compounds as herbicidal agents. |
JP4597519B2 (ja) * | 2001-12-06 | 2010-12-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 有糸分裂キネシン阻害薬 |
US7345046B2 (en) * | 2003-05-30 | 2008-03-18 | Chiron Corporation | Heteroaryl-fused pyrimidinyl compounds as anticancer agents |
-
2006
- 2006-03-07 JP JP2008500852A patent/JP2008533018A/ja active Pending
- 2006-03-07 KR KR1020077022387A patent/KR20070113267A/ko not_active Application Discontinuation
- 2006-03-07 AU AU2006223461A patent/AU2006223461A1/en not_active Abandoned
- 2006-03-07 CA CA002599899A patent/CA2599899A1/en not_active Abandoned
- 2006-03-07 PE PE2006000258A patent/PE20061484A1/es not_active Application Discontinuation
- 2006-03-07 AR ARP060100850A patent/AR052682A1/es not_active Application Discontinuation
- 2006-03-07 EP EP06748316A patent/EP1871776A2/en not_active Withdrawn
- 2006-03-07 US US11/369,643 patent/US20060247320A1/en not_active Abandoned
- 2006-03-07 MX MX2007010972A patent/MX2007010972A/es unknown
- 2006-03-07 WO PCT/US2006/008145 patent/WO2006098961A2/en active Application Filing
- 2006-03-08 TW TW095107817A patent/TW200700422A/zh unknown
-
2007
- 2007-08-23 IL IL185510A patent/IL185510A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2006098961A2 (en) | 2006-09-21 |
WO2006098961A3 (en) | 2007-03-22 |
KR20070113267A (ko) | 2007-11-28 |
EP1871776A2 (en) | 2008-01-02 |
CA2599899A1 (en) | 2006-09-21 |
TW200700422A (en) | 2007-01-01 |
AR052682A1 (es) | 2007-03-28 |
IL185510A0 (en) | 2008-01-06 |
JP2008533018A (ja) | 2008-08-21 |
US20060247320A1 (en) | 2006-11-02 |
MX2007010972A (es) | 2007-09-19 |
AU2006223461A1 (en) | 2006-09-21 |
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Legal Events
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FD | Application declared void or lapsed |