PE20080931A1 - Imidazopirazinas como inhibidores de proteina quinasa - Google Patents

Imidazopirazinas como inhibidores de proteina quinasa

Info

Publication number
PE20080931A1
PE20080931A1 PE2007001524A PE2007001524A PE20080931A1 PE 20080931 A1 PE20080931 A1 PE 20080931A1 PE 2007001524 A PE2007001524 A PE 2007001524A PE 2007001524 A PE2007001524 A PE 2007001524A PE 20080931 A1 PE20080931 A1 PE 20080931A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
imidazopyrazines
protein kinase
kinase inhibitors
Prior art date
Application number
PE2007001524A
Other languages
English (en)
Inventor
David B Belanger
M Arshad Siddiqui
Timothy J Guzi
Patrick J Curran
Praveen K Tadikonda
Blake Hamann
Panduranga Adulla P Reddy
Lianyun Zhao
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39276164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080931(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20080931A1 publication Critical patent/PE20080931A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZO[1,2-a]PIRAZINA DE FORMULA (I) DONDE L ES S, S(O) O S(O2); G ES ALQUILO(C1-C20), ALQUENILO(C2-C15), CICLOALQUILO(C3-C10), ENTRE OTROS; R1 ES H, HALO, ALQUILO(C1-C20), ARILO(C6-C14), ENTRE OTROS; R2 ES H, ALQUILO(C1-C20), ARILO(C6-C14), ALQUENILO(C2-C15), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON CF3, CN, OCF3, ENTRE OTROS SUSTITUYENTES; R3 ES H, ALQUILO(C1-C20), CICLOALQUILO(C3-C10), HETEROARILO DE 5 A 14 MIEMBROS, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON HALO, CF3, CN, OCF3, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE AURORA QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCER, ARTRITIS, ENFERMEDAD DE ALZHEIMER
PE2007001524A 2006-11-08 2007-11-06 Imidazopirazinas como inhibidores de proteina quinasa PE20080931A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85824406P 2006-11-08 2006-11-08

Publications (1)

Publication Number Publication Date
PE20080931A1 true PE20080931A1 (es) 2008-07-19

Family

ID=39276164

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001524A PE20080931A1 (es) 2006-11-08 2007-11-06 Imidazopirazinas como inhibidores de proteina quinasa

Country Status (11)

Country Link
US (1) US7511040B2 (es)
EP (1) EP2079746A2 (es)
JP (1) JP2010509328A (es)
CN (1) CN101589045A (es)
AR (1) AR063581A1 (es)
CA (1) CA2669465A1 (es)
CL (1) CL2007003212A1 (es)
MX (1) MX2009005011A (es)
PE (1) PE20080931A1 (es)
TW (1) TW200829588A (es)
WO (1) WO2008057512A2 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0716292D0 (en) 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
CN102105148B (zh) * 2008-07-24 2013-04-10 内尔维阿诺医学科学有限公司 包含aurora激酶抑制剂和抗肿瘤药的治疗组合
WO2010009967A1 (en) * 2008-07-24 2010-01-28 Nerviano Medical Sciences S.R.L. Therapeutic combination comprising an aurora kinase inhibitor and an antineoplastic agent
WO2010031816A1 (en) * 2008-09-19 2010-03-25 Nerviano Medical Sciences S.R.L. 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES
TW201107329A (en) * 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
WO2011028638A1 (en) 2009-09-04 2011-03-10 Schering Corporation Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
EP2493889B1 (en) 2009-10-30 2017-09-06 Janssen Pharmaceutica, N.V. IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
US9468642B2 (en) 2010-03-18 2016-10-18 Bayer Intellectual Property Gmbh Imidazopyrazines
US9199999B2 (en) * 2010-06-01 2015-12-01 Bayer Intellectual Property Gmbh Substituted imidazopyrazines
AU2011261375B2 (en) 2010-06-04 2016-09-22 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
ES2530802T3 (es) 2010-12-17 2015-03-06 Bayer Ip Gmbh Imidazopirazinas 6-tiosustituidas para uso como inhibidores de MPS-1 y TKK en el tratamiento de trastornos hiperproliferativos
US20140187548A1 (en) * 2010-12-17 2014-07-03 Bayer Intellectual Property Gmbh 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
JP2013545779A (ja) * 2010-12-17 2013-12-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過剰増殖性障害の治療におけるｍｐｓ−１およびｔｋｋ阻害剤として使用するための６置換イミダゾピラジン
US8673905B2 (en) * 2011-03-17 2014-03-18 Hoffmann-La Roche Inc. Imidazo pyrazines
AU2012277912B2 (en) 2011-06-27 2017-03-23 Janssen Pharmaceutica Nv 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
EP2863909B1 (en) 2012-06-26 2020-11-04 Janssen Pharmaceutica N.V. Combinations comprising 4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline compounds as pde 2 inhibitors and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
MX362197B (es) 2012-07-09 2019-01-08 Janssen Pharmaceutica Nv Derivados de imidazo[1,2-b]piridazina e imidazo[1,2-a]pirazina como inhibidores de la fosfodiesterasa 10; y el uso de los mismos en el tratamiento de trastornos neurológicos, psiquiátricos y metabólicos.
KR20170029580A (ko) * 2014-07-14 2017-03-15 길리애드 사이언시즈, 인코포레이티드 암을 치료하기 위한 조합물
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
CN107531710B (zh) * 2015-08-13 2020-02-14 北京韩美药品有限公司 Irak4抑制剂及其应用
CN107056789B (zh) * 2017-04-21 2019-03-29 陈剑 具有取代吡嗪并咪唑类衍生物,其制备及其在医药上的应用
WO2022061155A1 (en) * 2020-09-17 2022-03-24 The Translational Genomics Research Institute Imidazopyridazine and imidazopyrazine compounds as inhibitors of cdk7

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050081A1 (es) * 2002-09-23 2005-03-01 Schering Corp Nuevas imidazopirazinas como inhibidores de cinasas dependientes de ciclinas
US7186832B2 (en) * 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
WO2005085252A1 (en) * 2004-03-04 2005-09-15 Biofocus Discovery Limited Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases
US7713973B2 (en) * 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
CA2628534A1 (en) * 2005-11-10 2007-05-18 Schering Corporation Methods for inhibiting protein kinases
TW200804386A (en) * 2005-11-10 2008-01-16 Schering Corp Imidazopyrazines as protein kinase inhibitors

Also Published As

Publication number Publication date
MX2009005011A (es) 2009-05-20
JP2010509328A (ja) 2010-03-25
CA2669465A1 (en) 2008-05-15
CL2007003212A1 (es) 2008-06-27
EP2079746A2 (en) 2009-07-22
TW200829588A (en) 2008-07-16
AR063581A1 (es) 2009-02-04
WO2008057512A2 (en) 2008-05-15
US7511040B2 (en) 2009-03-31
WO2008057512A3 (en) 2008-06-26
CN101589045A (zh) 2009-11-25
US20080139571A1 (en) 2008-06-12

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