PE20070723A1 - Imidazopirazinas como inhibidores de quinasas dependientes de ciclina - Google Patents

Imidazopirazinas como inhibidores de quinasas dependientes de ciclina

Info

Publication number
PE20070723A1
PE20070723A1 PE2006001397A PE2006001397A PE20070723A1 PE 20070723 A1 PE20070723 A1 PE 20070723A1 PE 2006001397 A PE2006001397 A PE 2006001397A PE 2006001397 A PE2006001397 A PE 2006001397A PE 20070723 A1 PE20070723 A1 PE 20070723A1
Authority
PE
Peru
Prior art keywords
cycline
inhibitors
dependent kinases
imidazopyrazines
influencies
Prior art date
Application number
PE2006001397A
Other languages
English (en)
Inventor
Timothy J Guzi
Michael P Dwyer
Lianyun Zhao
Patrick J Curran
David B Belanger
Blake Hamann
Panduranga A Reddy
M Arshad Siddiqui
Kamil Paruch
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20070723A1 publication Critical patent/PE20070723A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE IMIDAZOPIRAZINA DE FORMULAS (a), (b), (c), (d), ENTRE OTRAS O UNA SAL, SOLVATO O ESTER DE LOS MISMOS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEINA QUINASA TALES COMO QUINASAS DEPENDIENTES DE CICLINA, PROTEINA QUINASA ACTIVADA POR MITOGENO, GLUCOGENO SINTASA QUINASA 3 Y SIMILARES, Y SON UTILES EN EL TRATAMIENTO DEL CANCER, INFLAMACION, ARTRITIS, ENFERMEDADES VIRALES, ENFERMEDADES NEURODEGENERATIVAS, CARIOVASCULARES Y FUNGICAS
PE2006001397A 2005-11-10 2006-11-08 Imidazopirazinas como inhibidores de quinasas dependientes de ciclina PE20070723A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/272,392 US7576085B2 (en) 2002-09-23 2005-11-10 Imidazopyrazines as cyclin dependent kinase inhibitors

Publications (1)

Publication Number Publication Date
PE20070723A1 true PE20070723A1 (es) 2007-08-10

Family

ID=38002043

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001397A PE20070723A1 (es) 2005-11-10 2006-11-08 Imidazopirazinas como inhibidores de quinasas dependientes de ciclina

Country Status (9)

Country Link
US (1) US7576085B2 (es)
EP (1) EP1945643A2 (es)
JP (1) JP5109109B2 (es)
CN (1) CN101331135A (es)
AR (1) AR058780A1 (es)
CA (1) CA2627965A1 (es)
PE (1) PE20070723A1 (es)
TW (1) TW200804387A (es)
WO (1) WO2007058873A2 (es)

Families Citing this family (33)

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US7576085B2 (en) * 2002-09-23 2009-08-18 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
JP2008542219A (ja) * 2005-05-25 2008-11-27 インゲニウム ファーマシューティカルズ ジーエムビーエイチ 疼痛処置法
TW200800213A (en) * 2005-09-02 2008-01-01 Abbott Lab Novel imidazo based heterocycles
AU2006315718B2 (en) * 2005-11-10 2012-10-04 Merck Sharp & Dohme Corp. Imidazopyrazines as protein kinase inhibitors
EP1945216A1 (en) 2005-11-10 2008-07-23 Schering Corporation Methods for inhibiting protein kinases
MX2008015747A (es) * 2006-06-06 2008-12-19 Schering Corp Imidazopirazinas como inhibidores de la proteina quinasa.
JP2010510222A (ja) * 2006-11-17 2010-04-02 シェーリング コーポレイション 増殖性障害に対する併用療法
EP2086540B8 (en) * 2006-12-01 2011-03-02 Galapagos N.V. Triazolopyridine compounds useful for the treatment of degenerative & inflammatory diseases
US20080249305A1 (en) * 2007-03-27 2008-10-09 Calderwood David J Novel imidazole based heterocycles
US8507498B2 (en) 2007-04-24 2013-08-13 Ingenium Pharmaceuticals Gmbh 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases
WO2008138842A1 (en) * 2007-05-10 2008-11-20 Galapagos N.V. Imidazopyrazines and triazolopyrazine for the treatment of joint degenerative and inflammatory diseases
US8133895B2 (en) * 2007-05-10 2012-03-13 Janssen Pharmaceutica N.V. Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
MX2009013729A (es) * 2007-06-14 2010-01-25 Schering Corp Imidazopirazinas como inhibidores de proteina quinasa.
DE102007032349A1 (de) 2007-07-11 2009-01-15 Bayer Healthcare Ag Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung
US20100249030A1 (en) * 2007-07-31 2010-09-30 Schering Corporation Anti-mitotic agent and aurora kinase inhibitor combination as anti-cancer treatment
GB0716292D0 (en) * 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
DE102008023801A1 (de) 2008-05-15 2009-11-19 Bayer Schering Pharma Aktiengesellschaft Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine
JP2012521354A (ja) * 2009-03-20 2012-09-13 アムジエン・インコーポレーテツド Ｐｉ３キナーゼの阻害薬
TW201107329A (en) * 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
US8993535B2 (en) 2009-09-04 2015-03-31 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
WO2011051342A1 (en) 2009-10-30 2011-05-05 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
AR080754A1 (es) * 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
ES2551407T3 (es) 2010-03-18 2015-11-18 Bayer Intellectual Property Gmbh Imidazopirazinas
ES2555261T3 (es) 2010-06-01 2015-12-30 Bayer Intellectual Property Gmbh Imidazopirazinas sustituidas
US20140135319A1 (en) * 2010-12-17 2014-05-15 Bayer Intellectual Property Gmbh 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
EA027418B1 (ru) 2011-06-27 2017-07-31 Янссен Фармацевтика Нв ПРОИЗВОДНЫЕ 1-АРИЛ-4-МЕТИЛ[1,2,4]ТРИАЗОЛО[4,3-a]ХИНОКСАЛИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, СПОСОБЫ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ ИХ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ
CN102659785B (zh) * 2012-05-11 2014-04-30 山东大学 一种2-氨基-6-氨甲基嘌呤类化合物及其制备方法和应用
WO2014001314A1 (en) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
BR112015000459B1 (pt) 2012-07-09 2022-02-08 Janssen Pharmaceutica N.V. Inibidores da enzima fosfodiesterase 10, seu uso, composição farmacêutica que os compreende, seus processo de preparação e produto
KR20180083902A (ko) 2015-11-18 2018-07-23 젠자임 코포레이션 다낭성 신장병의 바이오마커 및 그의 용도
WO2021249417A1 (zh) * 2020-06-09 2021-12-16 赛诺哈勃药业（成都）有限公司 杂环化合物及其衍生物
WO2022061155A1 (en) * 2020-09-17 2022-03-24 The Translational Genomics Research Institute Imidazopyridazine and imidazopyrazine compounds as inhibitors of cdk7
CN116715668A (zh) * 2022-03-07 2023-09-08 上海凌达生物医药有限公司 一类含氮杂环类细胞周期抑制剂化合物、制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026310A1 (en) * 2002-09-23 2004-04-01 Schering Corporation Novel imidazopyrazines as cyclin dependent kinase inhibitors
US7576085B2 (en) * 2002-09-23 2009-08-18 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
DE60317353T2 (de) * 2002-09-23 2008-08-28 Schering Corp. Imidazopyrazine als cdk-inhibitoren
MXPA05009885A (es) * 2003-03-14 2005-12-05 Astrazeneca Ab Nuevas triazolonas fusionadas y los usos de las mismas.
GB0405055D0 (en) * 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
AU2006315718B2 (en) * 2005-11-10 2012-10-04 Merck Sharp & Dohme Corp. Imidazopyrazines as protein kinase inhibitors

Also Published As

Publication number Publication date
JP5109109B2 (ja) 2012-12-26
AR058780A1 (es) 2008-02-20
CN101331135A (zh) 2008-12-24
CA2627965A1 (en) 2007-05-24
US20060106023A1 (en) 2006-05-18
WO2007058873A3 (en) 2007-07-19
JP2009515883A (ja) 2009-04-16
US7576085B2 (en) 2009-08-18
EP1945643A2 (en) 2008-07-23
TW200804387A (en) 2008-01-16
WO2007058873A2 (en) 2007-05-24

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