PE20110387A1 - Aminotriazolo-piridinas como inhibidores de cinasa - Google Patents
Aminotriazolo-piridinas como inhibidores de cinasaInfo
- Publication number
- PE20110387A1 PE20110387A1 PE2011000599A PE2011000599A PE20110387A1 PE 20110387 A1 PE20110387 A1 PE 20110387A1 PE 2011000599 A PE2011000599 A PE 2011000599A PE 2011000599 A PE2011000599 A PE 2011000599A PE 20110387 A1 PE20110387 A1 PE 20110387A1
- Authority
- PE
- Peru
- Prior art keywords
- pyran
- tetrahydro
- methyl
- triazolo
- pyridin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
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- Heart & Thoracic Surgery (AREA)
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Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE AMINOTRIAZOLOPIRIDINAS DE FORMULA (I) DONDE R1 ES ARILO(C6-C14) O HETEROCICLILO DE 3 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDOS; R2 ES ALQUILO(C1-C8), CICLOALQUILO(C3-C10), NR3R4, ENTRE OTROS, EN DONDE R3 Y R4 SON CADA UNO H, ALQUILO(C1-C8), ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-METIL-N3-(TETRAHIDRO-2H-PIRAN-4-IL)-N6-(5-((TETRAHIDRO-2H-PIRAN-4-IL)METIL)-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-2-IL)-1H-INDAZOL-3,6-DIAMINA; N3-(TETRAHIDRO-2H-PIRAN-4-IL)-N6-(5-((TETRAHIDRO-2H-PIRAN-4-IL)METIL)-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-2-IL)-1H-INDAZOL-3,6-DIAMINA; 1-METIL-N3-(PIPERIDIN-4-IL)-N6-(5-((TETRAHIDRO-2H-PIRAN-4-IL)-METIL)-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-2-IL)-1H-INDAZOL-3,6-DIAMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA Syk, FLT3, JAK1 O JAK2 SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, LUPUS, ESCLEROSIS MULTIPLE, CANCER
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US9521708P | 2008-09-08 | 2008-09-08 | |
US23047909P | 2009-07-31 | 2009-07-31 |
Publications (1)
Publication Number | Publication Date |
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PE20110387A1 true PE20110387A1 (es) | 2011-06-22 |
Family
ID=41228355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011000599A PE20110387A1 (es) | 2008-09-08 | 2009-09-08 | Aminotriazolo-piridinas como inhibidores de cinasa |
Country Status (22)
Country | Link |
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US (2) | US8299056B2 (es) |
EP (1) | EP2344494B1 (es) |
JP (1) | JP5689060B2 (es) |
KR (1) | KR20110053266A (es) |
CN (2) | CN102203093B (es) |
AU (1) | AU2009288618B2 (es) |
BR (1) | BRPI0918854A2 (es) |
CA (1) | CA2735806A1 (es) |
CL (1) | CL2011000480A1 (es) |
CO (1) | CO6531502A2 (es) |
CR (1) | CR20110132A (es) |
EC (1) | ECSP11010945A (es) |
ES (1) | ES2581565T3 (es) |
IL (1) | IL211549A (es) |
MX (1) | MX2011002536A (es) |
NI (1) | NI201100048A (es) |
NZ (1) | NZ591551A (es) |
PE (1) | PE20110387A1 (es) |
RU (1) | RU2552642C2 (es) |
TW (1) | TWI453207B (es) |
WO (1) | WO2010027500A1 (es) |
ZA (1) | ZA201101586B (es) |
Families Citing this family (143)
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JPS60100852A (ja) * | 1984-09-28 | 1985-06-04 | Hitachi Ltd | 情報伝送方法 |
KR101389246B1 (ko) | 2004-07-15 | 2014-04-24 | 브리스톨-마이어스스퀴브컴파니 | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
US20090221612A1 (en) | 2008-02-13 | 2009-09-03 | Mitchell Scott A | Certain substituted amides, method of making, and method of use thereof |
WO2009103652A1 (en) | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
WO2009155565A1 (en) * | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
WO2010068257A1 (en) | 2008-12-08 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Imidazopyrazine syk inhibitors |
GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
KR101324414B1 (ko) | 2008-10-09 | 2013-11-01 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타의 조절자 |
CA2743196A1 (en) | 2008-11-10 | 2010-05-14 | F.Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
KR101743784B1 (ko) | 2008-12-08 | 2017-06-05 | 질레드 코네티컷 인코포레이티드 | 이미다조피라진 syk 억제제 |
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2009
- 2009-09-07 TW TW098130164A patent/TWI453207B/zh not_active IP Right Cessation
- 2009-09-08 BR BRPI0918854-1A patent/BRPI0918854A2/pt not_active IP Right Cessation
- 2009-09-08 KR KR1020117007996A patent/KR20110053266A/ko active Search and Examination
- 2009-09-08 NZ NZ591551A patent/NZ591551A/en not_active IP Right Cessation
- 2009-09-08 CA CA2735806A patent/CA2735806A1/en not_active Abandoned
- 2009-09-08 JP JP2011526054A patent/JP5689060B2/ja not_active Expired - Fee Related
- 2009-09-08 AU AU2009288618A patent/AU2009288618B2/en not_active Ceased
- 2009-09-08 ES ES09789271.5T patent/ES2581565T3/es active Active
- 2009-09-08 CN CN200980144169.1A patent/CN102203093B/zh not_active Expired - Fee Related
- 2009-09-08 WO PCT/US2009/005020 patent/WO2010027500A1/en active Application Filing
- 2009-09-08 CN CN201510173699.6A patent/CN104910148B/zh not_active Expired - Fee Related
- 2009-09-08 EP EP09789271.5A patent/EP2344494B1/en active Active
- 2009-09-08 PE PE2011000599A patent/PE20110387A1/es not_active Application Discontinuation
- 2009-09-08 MX MX2011002536A patent/MX2011002536A/es active IP Right Grant
- 2009-09-08 RU RU2011113540/04A patent/RU2552642C2/ru not_active IP Right Cessation
- 2009-09-08 US US12/555,018 patent/US8299056B2/en active Active
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2011
- 2011-03-01 ZA ZA2011/01586A patent/ZA201101586B/en unknown
- 2011-03-03 IL IL211549A patent/IL211549A/en not_active IP Right Cessation
- 2011-03-07 NI NI201100048A patent/NI201100048A/es unknown
- 2011-03-07 CL CL2011000480A patent/CL2011000480A1/es unknown
- 2011-03-11 CR CR20110132A patent/CR20110132A/es unknown
- 2011-04-01 EC EC2011010945A patent/ECSP11010945A/es unknown
- 2011-04-05 CO CO11041595A patent/CO6531502A2/es not_active Application Discontinuation
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2012
- 2012-09-11 US US13/609,412 patent/US20130005707A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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EP2344494A1 (en) | 2011-07-20 |
CR20110132A (es) | 2011-06-20 |
BRPI0918854A2 (pt) | 2019-02-26 |
US8299056B2 (en) | 2012-10-30 |
CN104910148B (zh) | 2017-06-27 |
US20100093698A1 (en) | 2010-04-15 |
CN102203093A (zh) | 2011-09-28 |
TWI453207B (zh) | 2014-09-21 |
RU2552642C2 (ru) | 2015-06-10 |
CA2735806A1 (en) | 2010-03-11 |
AU2009288618A1 (en) | 2010-03-11 |
ECSP11010945A (es) | 2011-05-31 |
ES2581565T3 (es) | 2016-09-06 |
IL211549A0 (en) | 2011-05-31 |
CN104910148A (zh) | 2015-09-16 |
IL211549A (en) | 2017-04-30 |
CL2011000480A1 (es) | 2011-09-16 |
EP2344494B1 (en) | 2016-04-20 |
KR20110053266A (ko) | 2011-05-19 |
JP2012502029A (ja) | 2012-01-26 |
WO2010027500A1 (en) | 2010-03-11 |
CO6531502A2 (es) | 2012-09-28 |
AU2009288618B2 (en) | 2014-10-02 |
MX2011002536A (es) | 2011-04-04 |
US20130005707A1 (en) | 2013-01-03 |
JP5689060B2 (ja) | 2015-03-25 |
ZA201101586B (en) | 2012-05-30 |
NZ591551A (en) | 2011-10-28 |
CN102203093B (zh) | 2015-05-13 |
RU2011113540A (ru) | 2012-10-20 |
NI201100048A (es) | 2011-11-17 |
TW201024293A (en) | 2010-07-01 |
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