NI201100048A - Aminotriazolopiridinas y su uso como inhibidores de la cinasa. - Google Patents
Aminotriazolopiridinas y su uso como inhibidores de la cinasa.Info
- Publication number
- NI201100048A NI201100048A NI201100048A NI201100048A NI201100048A NI 201100048 A NI201100048 A NI 201100048A NI 201100048 A NI201100048 A NI 201100048A NI 201100048 A NI201100048 A NI 201100048A NI 201100048 A NI201100048 A NI 201100048A
- Authority
- NI
- Nicaragua
- Prior art keywords
- aminotriazolopyridines
- kinase inhibitors
- kinase
- effective amount
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
Abstract
Se proporcionan Compuestos de Heteroarilo de fórmula (I): en donde R1 y R2 son como se define en este documento, composiciones que comprenden un cantidad efectiva de un Compuesto de Heteroarilo y métodos para tratar o prevenir condiciones inflamatorias o cáncer, y condiciones tratables o evitables por la inhibición de una cinasa o via cinasa que comprende administrar una cantidad efectiva del Compuesto de Heteroarilo a un sujeto que lo necesite.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9521708P | 2008-09-08 | 2008-09-08 | |
US23047909P | 2009-07-31 | 2009-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201100048A true NI201100048A (es) | 2011-11-17 |
Family
ID=41228355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201100048A NI201100048A (es) | 2008-09-08 | 2011-03-07 | Aminotriazolopiridinas y su uso como inhibidores de la cinasa. |
Country Status (22)
Country | Link |
---|---|
US (2) | US8299056B2 (es) |
EP (1) | EP2344494B1 (es) |
JP (1) | JP5689060B2 (es) |
KR (1) | KR20110053266A (es) |
CN (2) | CN104910148B (es) |
AU (1) | AU2009288618B2 (es) |
BR (1) | BRPI0918854A2 (es) |
CA (1) | CA2735806A1 (es) |
CL (1) | CL2011000480A1 (es) |
CO (1) | CO6531502A2 (es) |
CR (1) | CR20110132A (es) |
EC (1) | ECSP11010945A (es) |
ES (1) | ES2581565T3 (es) |
IL (1) | IL211549A (es) |
MX (1) | MX2011002536A (es) |
NI (1) | NI201100048A (es) |
NZ (1) | NZ591551A (es) |
PE (1) | PE20110387A1 (es) |
RU (1) | RU2552642C2 (es) |
TW (1) | TWI453207B (es) |
WO (1) | WO2010027500A1 (es) |
ZA (1) | ZA201101586B (es) |
Families Citing this family (142)
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JPS60100852A (ja) * | 1984-09-28 | 1985-06-04 | Hitachi Ltd | 情報伝送方法 |
JP5007226B2 (ja) | 2004-07-15 | 2012-08-22 | エーエムアール テクノロジー インコーポレイテッド | アリールおよびヘテロアリール置換テトラヒドロイソキノリンならびにノルエピネフリン、ドーパミン、およびセロトニンの再取り込みを遮断するためのその利用方法 |
NZ587039A (en) | 2008-02-13 | 2013-01-25 | Gilead Connecticut Inc | 6-aryl-imidazo[1, 2-a]pyrazine derivatives, method of making, and method of use thereof |
EP2257541B1 (en) | 2008-02-22 | 2013-08-14 | F. Hoffmann-La Roche AG | Modulators for amyloid beta |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
CN102131390A (zh) * | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | 三唑并吡啶jak抑制剂化合物和方法 |
GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
BRPI0920651A2 (pt) | 2008-10-09 | 2016-01-12 | Hoffmann La Roche | moduladores para amiloide beta |
EP2355817A1 (en) | 2008-11-10 | 2011-08-17 | F. Hoffmann-La Roche AG | Heterocyclic gamma secretase modulators |
AU2009325133B2 (en) | 2008-12-08 | 2016-02-04 | Gilead Connecticut, Inc. | Imidazopyrazine Syk inhibitors |
US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
EP3123864A1 (en) | 2008-12-08 | 2017-02-01 | Gilead Connecticut, Inc. | Imidazopyrazine syk inhibitors |
AU2011211410B2 (en) * | 2009-02-13 | 2013-01-31 | Fovea Pharmaceuticals Sa | [1,2,4] triazolo [1,5-A] pyridines as kinase inhibitors |
SG173610A1 (en) * | 2009-02-13 | 2011-09-29 | Fovea Pharmaceuticals Sa | [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors |
CN102458123A (zh) | 2009-05-12 | 2012-05-16 | 阿尔巴尼分子研究公司 | 芳基、杂芳基和杂环取代的四氢异喹啉及其用途 |
KR101830447B1 (ko) | 2009-05-12 | 2018-02-20 | 알바니 몰레큘라 리써치, 인크. | 7-([1,2,4]트리아졸로[1,5-α]피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도 |
JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用 |
TWI546537B (zh) * | 2009-05-19 | 2016-08-21 | 維維亞生技公司 | 提供針對血液腫瘤之體外個人化藥物測試之方法 |
WO2010141796A2 (en) | 2009-06-05 | 2010-12-09 | Cephalon, Inc. | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES |
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CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
CA2577478A1 (en) | 2004-08-18 | 2006-02-23 | Pharmacia & Upjohn Company Llc | Triazolopyridine compounds |
US7524860B2 (en) | 2004-10-07 | 2009-04-28 | Pfizer Inc. | Antibacterial agents |
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WO2008025821A1 (en) * | 2006-08-30 | 2008-03-06 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
EP1894931A1 (en) * | 2006-08-30 | 2008-03-05 | Cellzome Ag | Triazole derivatives as kinase inhibitors |
GB0719803D0 (en) * | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
FR2928924B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
US7863291B2 (en) * | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
WO2009155551A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
CN102131390A (zh) * | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | 三唑并吡啶jak抑制剂化合物和方法 |
WO2010010189A1 (en) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
WO2010010188A1 (en) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
-
2009
- 2009-09-07 TW TW098130164A patent/TWI453207B/zh not_active IP Right Cessation
- 2009-09-08 ES ES09789271.5T patent/ES2581565T3/es active Active
- 2009-09-08 KR KR1020117007996A patent/KR20110053266A/ko active Search and Examination
- 2009-09-08 NZ NZ591551A patent/NZ591551A/en not_active IP Right Cessation
- 2009-09-08 US US12/555,018 patent/US8299056B2/en active Active
- 2009-09-08 WO PCT/US2009/005020 patent/WO2010027500A1/en active Application Filing
- 2009-09-08 PE PE2011000599A patent/PE20110387A1/es not_active Application Discontinuation
- 2009-09-08 CN CN201510173699.6A patent/CN104910148B/zh not_active Expired - Fee Related
- 2009-09-08 JP JP2011526054A patent/JP5689060B2/ja not_active Expired - Fee Related
- 2009-09-08 EP EP09789271.5A patent/EP2344494B1/en active Active
- 2009-09-08 MX MX2011002536A patent/MX2011002536A/es active IP Right Grant
- 2009-09-08 CA CA2735806A patent/CA2735806A1/en not_active Abandoned
- 2009-09-08 BR BRPI0918854-1A patent/BRPI0918854A2/pt not_active IP Right Cessation
- 2009-09-08 RU RU2011113540/04A patent/RU2552642C2/ru not_active IP Right Cessation
- 2009-09-08 AU AU2009288618A patent/AU2009288618B2/en not_active Ceased
- 2009-09-08 CN CN200980144169.1A patent/CN102203093B/zh not_active Expired - Fee Related
-
2011
- 2011-03-01 ZA ZA2011/01586A patent/ZA201101586B/en unknown
- 2011-03-03 IL IL211549A patent/IL211549A/en not_active IP Right Cessation
- 2011-03-07 NI NI201100048A patent/NI201100048A/es unknown
- 2011-03-07 CL CL2011000480A patent/CL2011000480A1/es unknown
- 2011-03-11 CR CR20110132A patent/CR20110132A/es unknown
- 2011-04-01 EC EC2011010945A patent/ECSP11010945A/es unknown
- 2011-04-05 CO CO11041595A patent/CO6531502A2/es not_active Application Discontinuation
-
2012
- 2012-09-11 US US13/609,412 patent/US20130005707A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW201024293A (en) | 2010-07-01 |
WO2010027500A1 (en) | 2010-03-11 |
IL211549A (en) | 2017-04-30 |
BRPI0918854A2 (pt) | 2019-02-26 |
ES2581565T3 (es) | 2016-09-06 |
US8299056B2 (en) | 2012-10-30 |
TWI453207B (zh) | 2014-09-21 |
CA2735806A1 (en) | 2010-03-11 |
NZ591551A (en) | 2011-10-28 |
CR20110132A (es) | 2011-06-20 |
JP2012502029A (ja) | 2012-01-26 |
EP2344494B1 (en) | 2016-04-20 |
CO6531502A2 (es) | 2012-09-28 |
CN102203093B (zh) | 2015-05-13 |
US20130005707A1 (en) | 2013-01-03 |
AU2009288618A1 (en) | 2010-03-11 |
RU2011113540A (ru) | 2012-10-20 |
PE20110387A1 (es) | 2011-06-22 |
CL2011000480A1 (es) | 2011-09-16 |
IL211549A0 (en) | 2011-05-31 |
US20100093698A1 (en) | 2010-04-15 |
KR20110053266A (ko) | 2011-05-19 |
ZA201101586B (en) | 2012-05-30 |
RU2552642C2 (ru) | 2015-06-10 |
CN104910148A (zh) | 2015-09-16 |
CN102203093A (zh) | 2011-09-28 |
AU2009288618B2 (en) | 2014-10-02 |
CN104910148B (zh) | 2017-06-27 |
JP5689060B2 (ja) | 2015-03-25 |
EP2344494A1 (en) | 2011-07-20 |
ECSP11010945A (es) | 2011-05-31 |
MX2011002536A (es) | 2011-04-04 |
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