MX2012007402A - Pirrolidinonas heteroaromaticas fusionadas como inhibidores de tirosina cinasa esplenica (syk). - Google Patents

Pirrolidinonas heteroaromaticas fusionadas como inhibidores de tirosina cinasa esplenica (syk).

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Publication number
MX2012007402A
MX2012007402A MX2012007402A MX2012007402A MX2012007402A MX 2012007402 A MX2012007402 A MX 2012007402A MX 2012007402 A MX2012007402 A MX 2012007402A MX 2012007402 A MX2012007402 A MX 2012007402A MX 2012007402 A MX2012007402 A MX 2012007402A
Authority
MX
Mexico
Prior art keywords
fused heteroaromatic
syk inhibitors
diseases
formula
syk
Prior art date
Application number
MX2012007402A
Other languages
English (en)
Inventor
Christopher Smith
Masashi Takahashi
Benjamin Jones
Victoria Feher
Betty Lam
Zhe Nie
Yasuyoshi Arikawa
Qing Dong
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43618073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012007402(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MX2012007402A publication Critical patent/MX2012007402A/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

Se describen los compuestos de fórmula 1, (fórmula), Y sus sales farmacéuticamente aceptables, donde G, L1, L2, R1, R2, R3, y R4 se definen en la descripción. La presente descripción además de referirse a materiales y métodos para preparar los compuestos de fórmula 1, las composiciones farmacéuticas que los contienen, y su uso para tratar trastornos, enfermedades, y afecciones que involucran el sistema inmune y la inflamación, que incluyen artritis reumatoide, malignidades hematológicas, canceres epiteliales (es decir, carcinomas), y otros trastornos, enfermedades, y afecciones para las cuales se indica la inhibición de la SYK.
MX2012007402A 2009-12-23 2010-12-17 Pirrolidinonas heteroaromaticas fusionadas como inhibidores de tirosina cinasa esplenica (syk). MX2012007402A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28996909P 2009-12-23 2009-12-23
US38696410P 2010-09-27 2010-09-27
PCT/US2010/061146 WO2011079051A1 (en) 2009-12-23 2010-12-17 Fused heteroaromatic pyrrolidinones as syk inhibitors

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Publication Number Publication Date
MX2012007402A true MX2012007402A (es) 2012-08-23

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MX2012007402A MX2012007402A (es) 2009-12-23 2010-12-17 Pirrolidinonas heteroaromaticas fusionadas como inhibidores de tirosina cinasa esplenica (syk).

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