PE20130188A1 - Pirrolidinonas heteroaromaticas fusionadas como inhibidores de syk - Google Patents

Pirrolidinonas heteroaromaticas fusionadas como inhibidores de syk

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Publication number
PE20130188A1
PE20130188A1 PE2012000885A PE2012000885A PE20130188A1 PE 20130188 A1 PE20130188 A1 PE 20130188A1 PE 2012000885 A PE2012000885 A PE 2012000885A PE 2012000885 A PE2012000885 A PE 2012000885A PE 20130188 A1 PE20130188 A1 PE 20130188A1
Authority
PE
Peru
Prior art keywords
cycloalkyl
fused
compounds
aminociclohexylamine
ona
Prior art date
Application number
PE2012000885A
Other languages
English (en)
Inventor
Yasuyoshi Arikawa
Benjamin Jones
Betty Lam
Zhe Nie
Christopher Smith
Masashi Takahashi
Qing Dong
Victoria Feher
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43618073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130188(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20130188A1 publication Critical patent/PE20130188A1/es

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Abstract

SE REFIERE A COMPUESTOS DE PIRROLIDINONA HETEROAROMATICOS FUSIONADOS DE FORMULA (I) DONDE: G ES N Y C(R5); L1 Y L2 SON INDEPENDIENTEMENTE NH Y UN ENLACE; R1 Y R2 SON INDEPENDIENTEMENTE H, HALO, ALQUILO C1-C3 Y HALOALQUILO C1-C3, O R1 Y R2 JUNTO AL ATOMO AL CUAL ESTAN UNIDOS FORMAN CICLOALQUILO C3-C6; R3 ES ALQUILO C2-C6, CICLOALQUILO C3-C8, HETEROARILO C1-C9, ENTRE OTROS; R4 ES CICLOALQUILO C3-C8, ARILO C6-C14, HETEROARILO C1-C9, ENTRE OTROS; R5 ES HALO, CN, H, ENTRE OTROS. SON COMPUESTO PREFERIDOS: 2-((1R,2S)-2-AMINOCICLOHEXILAMINO)-4-(m-TOLILAMINO)-6,7-DIHIDRO-5H-PIRROLO[3,4-d]PIRIMIDIN-5-ONA, 4-(1H-INDAZOL-6-ILAMINO)-2-((1R,2S)-2-AMINOCICLOHEXILAMINO)-6,7-DIHIDRO-5H-PIRROLO[3,4-d]PIRIMIDIN-5-ONA, ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA ESPLENICA (SYK) SIENDO UTILES PARA EL TRATAMIENTO DE ASMA ALERGICO, ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, SORIASIS
PE2012000885A 2009-12-23 2010-12-17 Pirrolidinonas heteroaromaticas fusionadas como inhibidores de syk PE20130188A1 (es)

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US28996909P 2009-12-23 2009-12-23
US38696410P 2010-09-27 2010-09-27

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PE20130188A1 true PE20130188A1 (es) 2013-02-21

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WO2015164330A1 (en) 2014-04-21 2015-10-29 Millennium Pharmaceuticals, Inc. Anti-psyk antibody molecules and use of same for syk-targeted therapy
MX2012007402A (es) * 2009-12-23 2012-08-23 Takeda Pharmaceutical Pirrolidinonas heteroaromaticas fusionadas como inhibidores de tirosina cinasa esplenica (syk).
JP6001048B2 (ja) * 2011-03-28 2016-10-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ チアゾロピリミジン化合物
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