MA33909B1 - Pyrrolidinones accoles en tant d'inhibiteurs de syk - Google Patents

Pyrrolidinones accoles en tant d'inhibiteurs de syk

Info

Publication number
MA33909B1
MA33909B1 MA35044A MA35044A MA33909B1 MA 33909 B1 MA33909 B1 MA 33909B1 MA 35044 A MA35044 A MA 35044A MA 35044 A MA35044 A MA 35044A MA 33909 B1 MA33909 B1 MA 33909B1
Authority
MA
Morocco
Prior art keywords
pyrolidine
adherent
disorders
diseases
compounds
Prior art date
Application number
MA35044A
Other languages
Arabic (ar)
English (en)
Inventor
Yasuyoshi Arikawa
Benjamin Jones
Betty Lam
Zhe Nie
Christopher Smith
Masashi Takahashi
Qing Dong
Victoria Feher
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43618073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33909(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA33909B1 publication Critical patent/MA33909B1/fr

Links

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    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Immunology (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Obesity (AREA)
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  • Emergency Medicine (AREA)
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  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
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Abstract

LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS DE FORMULE 1, ET DES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI, DANS LAQUELLE G, L1, L2, R1, R2, R3, ET R4 SONT TELS QUE DÉFINIS DANS LA DESCRIPTION. LA PRÉSENTE INVENTION CONCERNE ÉGALEMENT DES MATÉRIAUX ET DES PROCÉDÉS POUR LA PRÉPARATION DES COMPOSÉS DE FORMULE 1, DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, ET LEUR UTILISATION POUR LE TRAITEMENT DE TROUBLES, MALADIES, ET CONDITIONS IMPLIQUANT LE SYSTÈME IMMUNITAIRE ET L'INFLAMMATION, COMPRENANT LA POLYARTHRITE RHUMATOÏDE, LES MALIGNITÉS HÉMATOLOGIQUES, LES CANCERS ÉPITHÉLIAUX (OU CARCINOMES), ET D'AUTRES TROUBLES, MALADIES, ET CONDITIONS POUR LESQUELS L'INHIBITION DE SYK EST INDIQUÉE.
MA35044A 2009-12-23 2010-12-17 Pyrrolidinones accoles en tant d'inhibiteurs de syk MA33909B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28996909P 2009-12-23 2009-12-23
US38696410P 2010-09-27 2010-09-27
PCT/US2010/061146 WO2011079051A1 (fr) 2009-12-23 2010-12-17 Pyrrolidinones accolés en tant d'inhibiteurs de syk

Publications (1)

Publication Number Publication Date
MA33909B1 true MA33909B1 (fr) 2013-01-02

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ID=43618073

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35044A MA33909B1 (fr) 2009-12-23 2010-12-17 Pyrrolidinones accoles en tant d'inhibiteurs de syk

Country Status (42)

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US (7) US8440689B2 (fr)
EP (4) EP2902392B1 (fr)
JP (7) JP5658274B2 (fr)
KR (1) KR101790255B1 (fr)
CN (1) CN102753548B (fr)
AR (1) AR081797A1 (fr)
AU (1) AU2010333804B2 (fr)
BR (1) BR112012015651B1 (fr)
CA (1) CA2786950C (fr)
CL (1) CL2012001745A1 (fr)
CO (1) CO6592058A2 (fr)
CR (1) CR20120392A (fr)
CY (1) CY1116736T1 (fr)
DK (1) DK2516434T3 (fr)
DO (1) DOP2012000180A (fr)
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ES (1) ES2545616T3 (fr)
GE (1) GEP20156243B (fr)
HR (1) HRP20150878T1 (fr)
HU (1) HUE025177T2 (fr)
IL (1) IL220509A (fr)
JO (1) JO3108B1 (fr)
MA (1) MA33909B1 (fr)
ME (1) ME02186B (fr)
MX (1) MX2012007402A (fr)
MY (1) MY159257A (fr)
NZ (1) NZ601267A (fr)
PE (1) PE20130188A1 (fr)
PH (1) PH12012501311A1 (fr)
PL (1) PL2516434T3 (fr)
PT (1) PT2516434E (fr)
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SG (1) SG181857A1 (fr)
SI (1) SI2516434T1 (fr)
SM (1) SMT201500199B (fr)
TN (1) TN2012000316A1 (fr)
TW (1) TWI457339B (fr)
UA (1) UA107100C2 (fr)
UY (1) UY33151A (fr)
WO (1) WO2011079051A1 (fr)
ZA (1) ZA201205428B (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2516434T3 (pl) * 2009-12-23 2015-11-30 Takeda Pharmaceuticals Co Skondensowane heteroaromatyczne pirolidynony jako inhibitory SYK
US8921383B2 (en) * 2011-03-28 2014-12-30 Hoffmann-La Roche Inc. Thiazolopyrimidine compounds
US9056873B2 (en) 2011-06-22 2015-06-16 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
US9469654B2 (en) 2012-09-27 2016-10-18 Portola Pharmaceuticals, Inc. Bicyclic oxa-lactam kinase inhibitors
WO2014051653A1 (fr) 2012-09-27 2014-04-03 Portola Pharmaceuticals, Inc. Inhibiteurs de kinase à base de dihydropyridone bicyclique
LT2914296T (lt) 2012-11-01 2018-09-25 Infinity Pharmaceuticals, Inc. Vėžio gydymas, panaudojant p13 kinazės izoformos moduliatorius
US20160024051A1 (en) 2013-03-15 2016-01-28 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP3003309B1 (fr) 2013-05-30 2020-09-09 Infinity Pharmaceuticals, Inc. Traitement anticancer au moyen de modulateurs isoformes de la kinase p13
KR101750667B1 (ko) 2013-07-31 2017-07-04 길리애드 사이언시즈, 인코포레이티드 Syk 억제제
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015051244A1 (fr) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TWI662037B (zh) 2013-12-23 2019-06-11 美商基利科學股份有限公司 脾酪胺酸激酶抑制劑
US9340540B2 (en) 2014-02-28 2016-05-17 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof
EP3119397B1 (fr) 2014-03-19 2022-03-09 Infinity Pharmaceuticals, Inc. Composés hétérocycliques destinés à être utilisés dans le traitement de troubles médiés par pi3k-gamma
US10245262B2 (en) 2014-04-01 2019-04-02 The University Of Queensland Immunological reagents and uses therefor
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
JP2017518737A (ja) * 2014-04-21 2017-07-13 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＳＹＫ標的治療薬のための抗ｐＳＹＫ抗体分子及びその使用
WO2016054491A1 (fr) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
UA120065C2 (uk) * 2014-12-05 2019-09-25 Ерей Біофарма Інк. 4,6-ЗАМІЩЕНІ ПІРАЗОЛО[1,5-a]-ПІРАЗИНИ ЯК ІНГІБІТОРИ JAK-КІНАЗИ
EP3677582B1 (fr) 2014-12-18 2023-01-25 Calithera Biosciences Inc. Formes solides de pyrrolidinones hétéroaromatiques condensées
EP3262049B1 (fr) * 2015-02-27 2022-07-20 Nimbus Lakshmi, Inc. Inhibiteurs de tyk2 et leurs utilisations
WO2017040757A1 (fr) 2015-09-02 2017-03-09 Nimbus Lakshmi, Inc. Inhibiteurs de tyk2 et leurs utilisations
CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
GB201604970D0 (en) 2016-03-23 2016-05-04 Syngenta Participations Ag Improvements in or relating to organic compounds
WO2017205801A1 (fr) * 2016-05-27 2017-11-30 Takeda Pharmaceutical Company Limited Association d'agents d'immunothérapie et d'inhibiteurs de la tyrosine kinase de la rate
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MA45244A (fr) 2016-06-13 2019-04-17 Cancer Research Tech Ltd Pyridines substituées utilisées en tant qu'inhibiteurs de dnmt1
UA125216C2 (uk) 2016-06-24 2022-02-02 Інфініті Фармасьютікалз, Інк. Комбінована терапія
WO2018013239A1 (fr) * 2016-07-13 2018-01-18 Takeda Pharmaceutical Company Limited Combinaison d'inhibiteurs de la tyrosine kinase de la rate et d'autres agents thérapeutiques
TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
CA3036384A1 (fr) 2016-09-14 2018-03-22 Gilead Sciences, Inc. Inhibiteurs de syk
WO2018195471A1 (fr) 2017-04-21 2018-10-25 Gilead Sciences, Inc. Inhibiteurs de syk en association avec des agents d'hypométhylation
CA3065114A1 (fr) * 2017-06-14 2018-12-20 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Inhibiteur de syk et procede d'utilisation correspondant
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
WO2019062329A1 (fr) * 2017-09-28 2019-04-04 上海海雁医药科技有限公司 Dérivé 4,6,7-trisubstitué de 1,2-dihydropyrrol[3,4-c]pyridin/pyrimidin-3-one et son utilisation
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
KR20200073216A (ko) 2017-10-19 2020-06-23 바이엘 애니멀 헬스 게엠베하 동물에서의 질환의 치료 및 방지를 위한 융합된 헤테로방향족 피롤리돈의 용도
WO2019088039A1 (fr) 2017-10-30 2019-05-09 Takeda Pharmaceutical Company Limited Traitement de la leucémie myéloïde aiguë
CN111295384B (zh) * 2018-10-10 2022-08-12 江苏豪森药业集团有限公司 双环类衍生物抑制剂、其制备方法和应用
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
KR20210114001A (ko) 2019-01-11 2021-09-17 시오노기 앤드 컴파니, 리미티드 Mgat2 저해 활성을 갖는 다이하이드로피라졸로피라지논 유도체
CN113950479A (zh) * 2019-02-22 2022-01-18 克洛诺斯生物股份有限公司 作为syk抑制剂的缩合吡嗪的固体形式
JP2022505053A (ja) * 2019-03-18 2022-01-14 上海海雁医薬科技有限公司 Ｂｔｋ阻害剤、その薬学的に許容可能な塩と結晶多形体、及びその応用
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
WO2022048551A1 (fr) * 2020-09-01 2022-03-10 上海海雁医药科技有限公司 Polymorphe d'un inhibiteur de tyrosine kinase de bruton, son procédé de préparation et son utilisation
WO2022127753A1 (fr) * 2020-12-18 2022-06-23 山东轩竹医药科技有限公司 Inhibiteur de l'ahr à cycle condensé
WO2022165530A1 (fr) * 2021-02-01 2022-08-04 Janssen Biotech, Inc. Inhibiteurs à petites molécules de kinases inductibles par le sel
WO2022174253A1 (fr) 2021-02-12 2022-08-18 Nimbus Saturn, Inc. Antagonistes de hpk1 et leurs utilisations
EP4301756A4 (fr) 2021-03-05 2025-02-26 Nimbus Saturn, Inc. Antagonistes de hpk1 et leurs utilisations
US12071442B2 (en) 2021-03-29 2024-08-27 Nimbus Saturn, Inc. Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists
AU2022383577A1 (en) * 2021-11-04 2024-05-02 Redx Pharma Plc Ddr1 and ddr2 inhibitors for the treatement of cancer and fibrotic diseases
CN114907992B (zh) 2022-05-18 2023-06-16 塔里木大学 拮抗植物病原菌的菌株c11及其应用

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63107966A (ja) 1986-05-22 1988-05-12 Fujisawa Pharmaceut Co Ltd ピリミジン誘導体
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5272158A (en) 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
US5238950A (en) 1991-12-17 1993-08-24 Schering Corporation Inhibitors of platelet-derived growth factor
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO1999031073A1 (fr) * 1997-12-15 1999-06-24 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives de pyrimidine-5-carboxamide
AU2095099A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Phthalimide-piperidine, -pyrrolidine and -azepine derivatives, their preparationand their use as muscarinic receptor (ant-)agonists
EP1184376B1 (fr) 1999-06-09 2005-02-02 Yamanouchi Pharmaceutical Co. Ltd. Nouveaux derives carboxamide heterocycliques
FR2796946A1 (fr) 1999-07-30 2001-02-02 Aventis Pharma Sa Nouveaux derives 8-carbonyl chromanes, leur preparation et leur utilisation en therapeutique
GB9918035D0 (en) 1999-07-30 1999-09-29 Novartis Ag Organic compounds
BR0016415A (pt) 1999-12-16 2002-12-24 Alcon Inc Inibidores de adenosina cinase para o tratamento de dano retinal e de nervo ótico
CA2396276A1 (fr) 2000-01-07 2001-07-12 Universitaire Instelling Antwerpen Derives de purine, procede de preparation et utilisation de ces derniers
WO2001058489A1 (fr) 2000-02-14 2001-08-16 Japan Tobacco Inc. Agents prophylactiques/therapeutiques contre le stress postoperatoire
JP2001302667A (ja) 2000-04-28 2001-10-31 Bayer Ag イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
WO2002088079A2 (fr) 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Inhibiteurs doubles de pde 7 et pde 4
US7105667B2 (en) * 2001-05-01 2006-09-12 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US20040235867A1 (en) 2001-07-24 2004-11-25 Bilodeau Mark T. Tyrosine kinase inhibitors
US20030158195A1 (en) 2001-12-21 2003-08-21 Cywin Charles L. 1,6 naphthyridines useful as inhibitors of SYK kinase
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
GB0206215D0 (en) * 2002-03-15 2002-05-01 Novartis Ag Organic compounds
PL375447A1 (en) 2002-08-14 2005-11-28 Vertex Pharmaceuticals Incorporated Protein kinase inhibitors and uses thereof
AU2003286711A1 (en) 2002-10-25 2004-05-13 Vertex Pharmaceuticals Incorporated Indazolinone compositions useful as kinase inhibitors
CA2507406A1 (fr) 2002-11-05 2004-05-21 Vertex Pharmaceuticals Incorporated Composes utiles comme inhibiteurs de proteines jak et autres proteines kinase
EP1605946B1 (fr) 2003-03-25 2008-05-28 Vertex Pharmaceuticals Incorporated Thiazoles utiles en tant qu'inhibiteurs des proteines kinases
AU2004225965A1 (en) 2003-03-25 2004-10-14 Vertex Pharmaceuticals Incorporated Thiazoles useful as inhibitors of protein kinases
KR20050122220A (ko) 2003-03-25 2005-12-28 다케다 샌디에고, 인코포레이티드 디펩티딜 펩티다제 억제제
ES2421139T3 (es) 2003-07-30 2013-08-29 Rigel Pharmaceuticals, Inc. Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias
US7320992B2 (en) 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US20050182061A1 (en) 2003-10-02 2005-08-18 Jeremy Green Phthalimide compounds useful as protein kinase inhibitors
AU2004293436B2 (en) * 2003-11-19 2010-12-09 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
WO2005056524A2 (fr) 2003-12-09 2005-06-23 Euro-Celtique S.A. Agents therapeutiques pour traitement de la douleur
US8057815B2 (en) 2004-04-19 2011-11-15 Portola Pharmaceuticals, Inc. Methods of treatment with Syk inhibitors
JP2008511659A (ja) 2004-09-01 2008-04-17 ライジェル ファーマシューティカルズ， インコーポレイテッド ２，４−ピリミジンジアミン化合物の合成
WO2006068770A1 (fr) 2004-11-24 2006-06-29 Rigel Pharmaceuticals, Inc. Composes de spiro-2, 4-pyrimidinediamine et leurs utilisations
US20060128710A1 (en) 2004-12-09 2006-06-15 Chih-Hung Lee Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
BRPI0608934A2 (pt) 2005-04-06 2010-02-17 Irm Llc compostos e composições contendo diarilamina, e seu uso como moduladores de receptores nucleares de hormÈnios esteróides
CA2610446A1 (fr) * 2005-04-19 2006-10-26 Kyowa Hakko Kogyo Co., Ltd. Compose heterocyclique azote
WO2006129100A1 (fr) 2005-06-03 2006-12-07 Glaxo Group Limited Nouveaux composes
EP1901744A2 (fr) 2005-06-28 2008-03-26 Bausch & Lomb Incorporated Préparations contenant de l arylazine substituée par une portion carbonylique afin d augmenter l activité de la gélatinase a dans les cellules oculaires
AR056191A1 (es) 2005-08-23 2007-09-26 Idenix Phatmaceuticals Inc Anillo de nucleosidos de siete miembros como inhibidores de la replica viral, metodos para su sintesis, composiciones farmaceuticas que los contienen y su uso en el tratamiento de infecciones con virus de la familia flaviviridae
WO2007023382A2 (fr) 2005-08-25 2007-03-01 Pfizer Inc. Composes de pyrimidine amino pyrazole, puissants inhibiteurs de kinase
EP1948659A1 (fr) * 2005-10-13 2008-07-30 Glaxo Group Limited Dérivés de la pyrrolopyrimidine inhibiteurs de la syk
CA2627242A1 (fr) 2005-10-31 2007-05-10 Rigel Pharmaceuticals, Inc. Preparations et methodes pour le traitement de troubles inflammatoires
JP5400388B2 (ja) * 2005-12-15 2014-01-29 ライジェル ファーマシューティカルズ， インコーポレイテッド キナーゼインヒビターおよびその利用
NZ601687A (en) 2006-01-17 2014-03-28 Vertex Pharma Azaindoles useful as inhibitors of janus kinases
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
EP2108642A1 (fr) 2006-10-17 2009-10-14 Kyowa Hakko Kirin Co., Ltd. Inhibiteurs de jak
CN105693730A (zh) 2006-10-19 2016-06-22 西格诺药品有限公司 杂芳基化合物、其组合物以及它们作为蛋白激酶抑制剂的用途
WO2008057402A2 (fr) 2006-11-02 2008-05-15 Cytovia, Inc. N-aryl-isoxazolopyrimidin-4-amines et composés associés servant d'activateurs de caspases et d'inducteurs d'apoptose et leur utilisation
US8163902B2 (en) 2006-11-21 2012-04-24 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
US20100298557A1 (en) 2006-12-28 2010-11-25 Taisho Pharmaceutical Co., Ltd Pyrazolopyrimidine compound
WO2008100715A1 (fr) * 2007-02-09 2008-08-21 Astrazeneca Ab Aza-iso-indolones et leur utilisation comme potentiateurs du récepteur du glutamate métabotrope - 613
US20100104534A1 (en) 2007-03-23 2010-04-29 Srikanth Venkatraman Hydrazido-peptides as inhibitors of hcv ns3-protease
CA2689282A1 (fr) 2007-06-03 2008-12-11 Vanderbilt University Derives benzamides modulateurs allosteriques positifs recepteurs metabotropiques du glutamate 5 (mglur5) et leurs procedes de fabrication et d'utilisation
WO2009026107A1 (fr) 2007-08-17 2009-02-26 Portola Pharmaceuticals, Inc. Inhibiteurs de protéine kinases
JP2009067729A (ja) 2007-09-14 2009-04-02 Kyowa Hakko Kirin Co Ltd Ｈｓｐ９０ファミリー蛋白質阻害剤
CN101917999A (zh) 2007-11-07 2010-12-15 弗尔德里克斯制药股份有限公司 蛋白质运输的调节
CA2710118A1 (fr) 2007-12-20 2009-07-02 Cellzome Limited Sulfamides en tant qu'inhibiteurs de zap-70
TW200942537A (en) * 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
AU2009215191A1 (en) 2008-02-13 2009-08-20 Gilead Connecticut, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
AU2009215430B2 (en) 2008-02-22 2015-02-12 Rigel Pharmaceuticals, Inc. Use of 2,4-pyrimidinediamines for the treatment of atherosclerosis
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives
CN102066339B (zh) 2008-04-16 2014-09-24 波托拉医药品公司 作为syk或jak蛋白激酶抑制剂的2，6-二氨基-嘧啶-5-基甲酰胺类化合物
CA2960692C (fr) 2008-04-16 2019-09-24 Portola Pharmaceuticals, Inc. 2,6-diamino-pyrimidin-5-yl-carboxamides comme inhibiteurs d'activite de syk ou de jak kinase
JP2011522865A (ja) 2008-06-13 2011-08-04 ノバルティス アーゲー Ｉａ心不全および癌の治療に有用なプロテインキナーゼｄ阻害剤としての２，４’−ビピリジニル化合物
CA2731926A1 (fr) 2008-08-05 2010-02-11 Boehringer Ingelheim International Gmbh Naphtyridines a substitution 4-dimethylamino-phenyle, et leur utilisation en tant que medicaments
CA2732087A1 (fr) 2008-08-05 2010-02-11 Boehringer Ingelheim International Gmbh Naphtyridines substituees et leur utilisation en tant que medicaments
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
PE20120121A1 (es) 2008-12-08 2012-02-20 Gilead Connecticut Inc Derivados de imidazopirazina como inhibidores de syk
CA2763730A1 (fr) 2009-06-18 2010-12-23 Cellzome Limited Heterocyclylaminopyrimidines servant d'inhibiteurs de kinases
WO2011075560A1 (fr) 2009-12-17 2011-06-23 Merck Sharp & Dohme Corp. Aminopyrimidines en tant qu'inhibiteurs de la syk
US8551984B2 (en) 2009-12-17 2013-10-08 Merck Sharp & Dohme Corp. Aminopyrimidines as SYK inhibitors
PL2516434T3 (pl) * 2009-12-23 2015-11-30 Takeda Pharmaceuticals Co Skondensowane heteroaromatyczne pirolidynony jako inhibitory SYK
GB201007203D0 (en) 2010-04-29 2010-06-16 Glaxo Group Ltd Novel compounds
US9056873B2 (en) 2011-06-22 2015-06-16 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives

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DOP2012000180A (es) 2012-09-15
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