PE20150021A1 - 5-amino[1,4]tiazinas como inhibidores de bace1 - Google Patents
5-amino[1,4]tiazinas como inhibidores de bace1Info
- Publication number
- PE20150021A1 PE20150021A1 PE2014002013A PE2014002013A PE20150021A1 PE 20150021 A1 PE20150021 A1 PE 20150021A1 PE 2014002013 A PE2014002013 A PE 2014002013A PE 2014002013 A PE2014002013 A PE 2014002013A PE 20150021 A1 PE20150021 A1 PE 20150021A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- amino
- halogen
- thiazines
- thiazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA L, DONDE R1 ES ARILO, HETEROARILO, ENTRE OTROS; R2 ES H, ALQUILO C1-C6 Y HALOGENO; R3 ES ALQUILO C1-C6, HALOGENO-ALQUILO C1-C6; R4 ES ALQUILO C1-C6, HALOGENO-ALQUILO C1-C6, H; R5 ES ALQUILO C1-C6, HALOGENO-ALQUILO C1-C6, H; X ES 0, 2. SON COMPUESTOS PREFERIDOS [3-(( R)-5-AMINO-3-METIL-3,6-DIHIDRO-2H-[1,4]TIAZIN-3-IL)-4-FLUORO-FENIL]-AMIDA DEL ACIDO 5-CIANO-PIRIDIN-2-CARBOXILICO; [3-(( R)-5-AMINO-3-METIL-1,1-DIOXO-1,2,3,6-TETRAHIDRO-1?6-[1,4] TIAZIN-3-IL)-4-FLUORO-FENIL]-AMIDA DEL ACIDO 5-DIFLUOROMETOXI-PIRIDIN-2-CARBOXILICO. DICHO COMPUESTO TIENE ACTIVIDAD INHIBIDORA DE BACE1 Y ES UTIL EN EL TRATAMIENTO TERAPEUTICO Y/O PROFILACTICO DE LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12169353 | 2012-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20150021A1 true PE20150021A1 (es) | 2015-01-28 |
Family
ID=48534350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014002013A PE20150021A1 (es) | 2012-05-24 | 2013-05-21 | 5-amino[1,4]tiazinas como inhibidores de bace1 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9273042B2 (es) |
| EP (1) | EP2855469B1 (es) |
| JP (1) | JP6251249B2 (es) |
| KR (1) | KR20150014934A (es) |
| CN (1) | CN104334554B (es) |
| AU (1) | AU2013265376B2 (es) |
| BR (1) | BR112014028813A2 (es) |
| CA (1) | CA2872179A1 (es) |
| CL (1) | CL2014003123A1 (es) |
| CO (1) | CO7131369A2 (es) |
| CR (1) | CR20140495A (es) |
| EA (1) | EA026004B1 (es) |
| HK (1) | HK1201261A1 (es) |
| IL (1) | IL235681A (es) |
| MA (1) | MA37691B1 (es) |
| MX (1) | MX2014013839A (es) |
| NZ (1) | NZ702254A (es) |
| PE (1) | PE20150021A1 (es) |
| PH (1) | PH12014502541A1 (es) |
| SG (1) | SG11201407575PA (es) |
| UA (1) | UA113438C2 (es) |
| WO (1) | WO2013174781A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012298983A1 (en) * | 2011-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as BACE inhibitors, compositions and their use |
| WO2014059185A1 (en) | 2012-10-12 | 2014-04-17 | Amgen Inc. | Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use |
| US9096615B2 (en) | 2013-07-30 | 2015-08-04 | Amgen Inc. | Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof |
| US9725468B2 (en) | 2013-09-13 | 2017-08-08 | Merck Sharp & Dohme Corp. | C5-spiro iminothiazine dioxides as BACE inhibitors, compositions, and their use |
| EP3215514B1 (en) * | 2014-11-03 | 2018-11-21 | F. Hoffmann-La Roche AG | Bace1 inhibitors |
| PE20171349A1 (es) | 2015-03-20 | 2017-09-13 | Hoffmann La Roche | Inhibidores de bace1 |
| JP6895424B2 (ja) * | 2015-08-12 | 2021-06-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｂａｃｅ１阻害剤 |
| JP7353708B2 (ja) | 2018-04-27 | 2023-10-02 | 塩野義製薬株式会社 | 選択的ｂａｃｅ１阻害活性を有するテトラヒドロピラノオキサジン誘導体 |
| CN110467611B (zh) * | 2018-05-11 | 2022-09-27 | 广东东阳光药业有限公司 | 亚氨基噻二嗪二氧化物衍生物及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090221579A1 (en) * | 2004-10-15 | 2009-09-03 | Jeffrey Scott Albert | Substituted Amino-Compounds and Uses Thereof |
| US8461160B2 (en) * | 2009-05-08 | 2013-06-11 | Hoffmann-La Roche, Inc. | Dihydropyrimidinones |
| US8188079B2 (en) | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
| US20110065695A1 (en) * | 2009-09-11 | 2011-03-17 | Jeremy Beauchamp | Use of aminodihydrothiazines for the treatment or prevention of diabetes |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| MX2013011947A (es) * | 2011-04-13 | 2014-01-16 | Merck Sharp & Dohme | Iminotiazinas 5-sustituidas y sus monoxidos y dioxidos como inhibidores de la enzima que encinde la proteina precursora amiloide en el sitio beta, composiciones y su uso. |
| AU2012298983A1 (en) * | 2011-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as BACE inhibitors, compositions and their use |
-
2013
- 2013-05-21 KR KR1020147032555A patent/KR20150014934A/ko not_active Application Discontinuation
- 2013-05-21 UA UAA201413535A patent/UA113438C2/uk unknown
- 2013-05-21 NZ NZ702254A patent/NZ702254A/en not_active IP Right Cessation
- 2013-05-21 EA EA201492097A patent/EA026004B1/ru not_active IP Right Cessation
- 2013-05-21 PE PE2014002013A patent/PE20150021A1/es not_active Application Discontinuation
- 2013-05-21 JP JP2015513132A patent/JP6251249B2/ja not_active Expired - Fee Related
- 2013-05-21 CN CN201380026707.3A patent/CN104334554B/zh not_active Expired - Fee Related
- 2013-05-21 US US14/400,448 patent/US9273042B2/en not_active Expired - Fee Related
- 2013-05-21 SG SG11201407575PA patent/SG11201407575PA/en unknown
- 2013-05-21 CA CA2872179A patent/CA2872179A1/en not_active Abandoned
- 2013-05-21 WO PCT/EP2013/060352 patent/WO2013174781A1/en active Application Filing
- 2013-05-21 MX MX2014013839A patent/MX2014013839A/es unknown
- 2013-05-21 BR BR112014028813A patent/BR112014028813A2/pt not_active IP Right Cessation
- 2013-05-21 AU AU2013265376A patent/AU2013265376B2/en not_active Ceased
- 2013-05-21 EP EP13725321.7A patent/EP2855469B1/en active Active
-
2014
- 2014-10-27 CR CR20140495A patent/CR20140495A/es unknown
- 2014-11-11 CO CO14249385A patent/CO7131369A2/es unknown
- 2014-11-13 IL IL235681A patent/IL235681A/en not_active IP Right Cessation
- 2014-11-14 PH PH12014502541A patent/PH12014502541A1/en unknown
- 2014-11-18 CL CL2014003123A patent/CL2014003123A1/es unknown
- 2014-12-24 MA MA37691A patent/MA37691B1/fr unknown
-
2015
- 2015-02-17 HK HK15101737.9A patent/HK1201261A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ702254A (en) | 2016-08-26 |
| EP2855469B1 (en) | 2019-06-19 |
| US20150141413A1 (en) | 2015-05-21 |
| UA113438C2 (xx) | 2017-01-25 |
| PH12014502541B1 (en) | 2015-01-21 |
| IL235681A0 (en) | 2015-02-01 |
| CN104334554B (zh) | 2017-10-31 |
| EA026004B1 (ru) | 2017-02-28 |
| MA37691B1 (fr) | 2016-11-30 |
| CA2872179A1 (en) | 2013-11-28 |
| AU2013265376B2 (en) | 2017-07-20 |
| CL2014003123A1 (es) | 2015-02-27 |
| SG11201407575PA (en) | 2014-12-30 |
| BR112014028813A2 (pt) | 2017-06-27 |
| US9273042B2 (en) | 2016-03-01 |
| JP2015517548A (ja) | 2015-06-22 |
| EP2855469A1 (en) | 2015-04-08 |
| IL235681A (en) | 2017-10-31 |
| CN104334554A (zh) | 2015-02-04 |
| PH12014502541A1 (en) | 2015-01-21 |
| EA201492097A1 (ru) | 2015-04-30 |
| AU2013265376A1 (en) | 2014-11-13 |
| KR20150014934A (ko) | 2015-02-09 |
| HK1201261A1 (en) | 2015-08-28 |
| JP6251249B2 (ja) | 2017-12-20 |
| WO2013174781A1 (en) | 2013-11-28 |
| CR20140495A (es) | 2014-12-01 |
| CO7131369A2 (es) | 2014-12-01 |
| MX2014013839A (es) | 2015-02-04 |
| MA37691A1 (fr) | 2016-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |