CO7131369A2 - 5-amino[1,4]tiazinas como inhibidores de bace1 - Google Patents

5-amino[1,4]tiazinas como inhibidores de bace1

Info

Publication number
CO7131369A2
CO7131369A2 CO14249385A CO14249385A CO7131369A2 CO 7131369 A2 CO7131369 A2 CO 7131369A2 CO 14249385 A CO14249385 A CO 14249385A CO 14249385 A CO14249385 A CO 14249385A CO 7131369 A2 CO7131369 A2 CO 7131369A2
Authority
CO
Colombia
Prior art keywords
thiazines
amino
bace1 inhibitors
present
bace1
Prior art date
Application number
CO14249385A
Other languages
English (en)
Inventor
Hans Hilpert
Thomas Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO7131369A2 publication Critical patent/CO7131369A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

La presente invención proporciona un compuesto de fórmula I que tiene actividad inhibidora de BACE1, su fabricación, composiciones farmacéuticas que lo contienen y su uso como sustancias terapéuticamente activas. Los compuestos activos de la presente invención son útiles en el tratamiento terapéutico y/o profiláctico de, por ejemplo, la enfermedad de Alzheimer.
CO14249385A 2012-05-24 2014-11-11 5-amino[1,4]tiazinas como inhibidores de bace1 CO7131369A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12169353 2012-05-24

Publications (1)

Publication Number Publication Date
CO7131369A2 true CO7131369A2 (es) 2014-12-01

Family

ID=48534350

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14249385A CO7131369A2 (es) 2012-05-24 2014-11-11 5-amino[1,4]tiazinas como inhibidores de bace1

Country Status (22)

Country Link
US (1) US9273042B2 (es)
EP (1) EP2855469B1 (es)
JP (1) JP6251249B2 (es)
KR (1) KR20150014934A (es)
CN (1) CN104334554B (es)
AU (1) AU2013265376B2 (es)
BR (1) BR112014028813A2 (es)
CA (1) CA2872179A1 (es)
CL (1) CL2014003123A1 (es)
CO (1) CO7131369A2 (es)
CR (1) CR20140495A (es)
EA (1) EA026004B1 (es)
HK (1) HK1201261A1 (es)
IL (1) IL235681A (es)
MA (1) MA37691B1 (es)
MX (1) MX2014013839A (es)
NZ (1) NZ702254A (es)
PE (1) PE20150021A1 (es)
PH (1) PH12014502541B1 (es)
SG (1) SG11201407575PA (es)
UA (1) UA113438C2 (es)
WO (1) WO2013174781A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013028670A1 (en) * 2011-08-22 2013-02-28 Merck Sharp & Dohme Corp. 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
US9556135B2 (en) 2012-10-12 2017-01-31 Amgen, Inc. Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
WO2015017407A1 (en) 2013-07-30 2015-02-05 Amgen Inc. Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta- secretase
WO2015038446A1 (en) * 2013-09-13 2015-03-19 Merck Sharp & Dohme Corp. C5-spiro iminothiazine dioxides as bace inhibitors, compositions, and their use
JP6554547B2 (ja) * 2014-11-03 2019-07-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂａｃｅ１阻害剤
JP6674960B2 (ja) 2015-03-20 2020-04-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂａｃｅ１阻害剤
CN107683283B (zh) * 2015-08-12 2021-05-18 豪夫迈·罗氏有限公司 Bace1抑制剂
MX2020011382A (es) 2018-04-27 2020-11-24 Shionogi & Co Derivados de tetrahidropiranoxazina que tienen actividad inhibidora de beta-secretasa 1 (bace1) selectiva.
CN110467611B (zh) * 2018-05-11 2022-09-27 广东东阳光药业有限公司 亚氨基噻二嗪二氧化物衍生物及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101084199A (zh) * 2004-10-15 2007-12-05 阿斯利康(瑞典)有限公司 取代的氨基化合物及其用途
US8461160B2 (en) * 2009-05-08 2013-06-11 Hoffmann-La Roche, Inc. Dihydropyrimidinones
US8188079B2 (en) 2009-08-19 2012-05-29 Hoffman-La Roche Inc. 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
US20110065695A1 (en) 2009-09-11 2011-03-17 Jeremy Beauchamp Use of aminodihydrothiazines for the treatment or prevention of diabetes
UA103272C2 (uk) 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
EP2697210B1 (en) * 2011-04-13 2017-03-01 Merck Sharp & Dohme Corp. 5-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions, and their use
WO2013028670A1 (en) * 2011-08-22 2013-02-28 Merck Sharp & Dohme Corp. 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use

Also Published As

Publication number Publication date
PH12014502541A1 (en) 2015-01-21
JP2015517548A (ja) 2015-06-22
MA37691A1 (fr) 2016-03-31
UA113438C2 (xx) 2017-01-25
AU2013265376A1 (en) 2014-11-13
US20150141413A1 (en) 2015-05-21
HK1201261A1 (en) 2015-08-28
PE20150021A1 (es) 2015-01-28
CA2872179A1 (en) 2013-11-28
WO2013174781A1 (en) 2013-11-28
AU2013265376B2 (en) 2017-07-20
KR20150014934A (ko) 2015-02-09
CN104334554A (zh) 2015-02-04
EA026004B1 (ru) 2017-02-28
EP2855469B1 (en) 2019-06-19
IL235681A0 (en) 2015-02-01
PH12014502541B1 (en) 2015-01-21
CN104334554B (zh) 2017-10-31
EA201492097A1 (ru) 2015-04-30
CL2014003123A1 (es) 2015-02-27
CR20140495A (es) 2014-12-01
IL235681A (en) 2017-10-31
MX2014013839A (es) 2015-02-04
EP2855469A1 (en) 2015-04-08
SG11201407575PA (en) 2014-12-30
NZ702254A (en) 2016-08-26
BR112014028813A2 (pt) 2017-06-27
US9273042B2 (en) 2016-03-01
MA37691B1 (fr) 2016-11-30
JP6251249B2 (ja) 2017-12-20

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