MX2009005011A - Imidazopirazinas como inhibidores de proteina quinasa. - Google Patents
Imidazopirazinas como inhibidores de proteina quinasa.Info
- Publication number
- MX2009005011A MX2009005011A MX2009005011A MX2009005011A MX2009005011A MX 2009005011 A MX2009005011 A MX 2009005011A MX 2009005011 A MX2009005011 A MX 2009005011A MX 2009005011 A MX2009005011 A MX 2009005011A MX 2009005011 A MX2009005011 A MX 2009005011A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- methods
- imidazopyrazines
- protein kinase
- kinase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En sus muchas modalidades, la presente invención provee una nueva clase de compuestos de imidazopirazina de la siguiente fórmula (1) (ver fórmula) como inhibidores de proteínas y/o Aurora quinasas, métodos de preparación de dichos compuestos, composiciones farmacéuticas que incluyen uno o más de dichos compuestos, métodos de preparación de formulaciones farmacéuticas que incluyen uno o más de dichos compuestos, y métodos de tratamiento, prevención, inhibición, o mejoría de una o más enfermedades asociadas con las proteínas o Aurora quinasas que utilizan dichos compuestos o composiciones farmacéuticas, tales como cáncer y leucemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85824406P | 2006-11-08 | 2006-11-08 | |
PCT/US2007/023329 WO2008057512A2 (en) | 2006-11-08 | 2007-11-06 | Imidazopyrazines as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005011A true MX2009005011A (es) | 2009-05-20 |
Family
ID=39276164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005011A MX2009005011A (es) | 2006-11-08 | 2007-11-06 | Imidazopirazinas como inhibidores de proteina quinasa. |
Country Status (11)
Country | Link |
---|---|
US (1) | US7511040B2 (es) |
EP (1) | EP2079746A2 (es) |
JP (1) | JP2010509328A (es) |
CN (1) | CN101589045A (es) |
AR (1) | AR063581A1 (es) |
CA (1) | CA2669465A1 (es) |
CL (1) | CL2007003212A1 (es) |
MX (1) | MX2009005011A (es) |
PE (1) | PE20080931A1 (es) |
TW (1) | TW200829588A (es) |
WO (1) | WO2008057512A2 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0716292D0 (en) | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
WO2010009985A2 (en) * | 2008-07-24 | 2010-01-28 | Nerviano Medical Sciences S.R.L. | Therapeutic combination comprising an aurora kinase inhibitor and antiproliferative agents |
JP5518062B2 (ja) * | 2008-07-24 | 2014-06-11 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | オーロラキナーゼ阻害剤および抗悪性腫瘍剤を含む治療用組み合わせ |
US8394802B2 (en) * | 2008-09-19 | 2013-03-12 | Nerviano Medical Sciences S.R.L. | 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one derivatives for the modulation of the activity of protein kinases |
TW201107329A (en) * | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
US8993535B2 (en) | 2009-09-04 | 2015-03-31 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
NZ599597A (en) | 2009-10-30 | 2013-05-31 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
CA2793279A1 (en) * | 2010-03-18 | 2011-09-22 | Ulrich Klar | Imidazopyrazines |
EP2576560B1 (en) | 2010-06-01 | 2015-09-30 | Bayer Intellectual Property GmbH | Substituted imidazopyrazines |
WO2011153359A1 (en) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US20140187548A1 (en) * | 2010-12-17 | 2014-07-03 | Bayer Intellectual Property Gmbh | 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
ES2530802T3 (es) | 2010-12-17 | 2015-03-06 | Bayer Ip Gmbh | Imidazopirazinas 6-tiosustituidas para uso como inhibidores de MPS-1 y TKK en el tratamiento de trastornos hiperproliferativos |
CA2821819A1 (en) | 2010-12-17 | 2012-06-21 | Marcus Koppitz | 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
US8673905B2 (en) * | 2011-03-17 | 2014-03-18 | Hoffmann-La Roche Inc. | Imidazo pyrazines |
MX344600B (es) | 2011-06-27 | 2016-12-20 | Janssen Pharmaceutica Nv | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina. |
RU2657540C2 (ru) | 2012-06-26 | 2018-06-14 | Янссен Фармацевтика Нв | Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств |
RU2667058C2 (ru) | 2012-07-09 | 2018-09-14 | Янссен Фармацевтика Нв | Ингибиторы фермента фосфодиэстеразы 10 |
SG11201610551TA (en) | 2014-07-14 | 2017-01-27 | Gilead Sciences Inc | Combinations for treating cancers |
WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
US10562902B2 (en) | 2015-08-13 | 2020-02-18 | Beijing Hanmi Pharmaceutical Co., Ltd. | IRAK4 inhibitor and use thereof |
CN107056789B (zh) * | 2017-04-21 | 2019-03-29 | 陈剑 | 具有取代吡嗪并咪唑类衍生物,其制备及其在医药上的应用 |
WO2022061155A1 (en) * | 2020-09-17 | 2022-03-24 | The Translational Genomics Research Institute | Imidazopyridazine and imidazopyrazine compounds as inhibitors of cdk7 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004026877A1 (en) * | 2002-09-23 | 2004-04-01 | Schering Corporation | Imidazopyrazines as cyclin dependent kinase inhibitors |
US7186832B2 (en) * | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
WO2005085252A1 (en) * | 2004-03-04 | 2005-09-15 | Biofocus Discovery Limited | Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases |
EP1812439B2 (en) * | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP1945644A2 (en) * | 2005-11-10 | 2008-07-23 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
US20070105864A1 (en) * | 2005-11-10 | 2007-05-10 | Schering Corporation | Methods for inhibiting protein kinases |
-
2007
- 2007-11-06 PE PE2007001524A patent/PE20080931A1/es not_active Application Discontinuation
- 2007-11-06 JP JP2009536269A patent/JP2010509328A/ja not_active Withdrawn
- 2007-11-06 CA CA002669465A patent/CA2669465A1/en not_active Abandoned
- 2007-11-06 CN CNA2007800456864A patent/CN101589045A/zh active Pending
- 2007-11-06 AR ARP070104937A patent/AR063581A1/es not_active Application Discontinuation
- 2007-11-06 MX MX2009005011A patent/MX2009005011A/es unknown
- 2007-11-06 EP EP07861732A patent/EP2079746A2/en not_active Withdrawn
- 2007-11-06 WO PCT/US2007/023329 patent/WO2008057512A2/en active Application Filing
- 2007-11-07 CL CL200703212A patent/CL2007003212A1/es unknown
- 2007-11-07 TW TW096142084A patent/TW200829588A/zh unknown
- 2007-11-07 US US11/936,380 patent/US7511040B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN101589045A (zh) | 2009-11-25 |
JP2010509328A (ja) | 2010-03-25 |
CL2007003212A1 (es) | 2008-06-27 |
CA2669465A1 (en) | 2008-05-15 |
TW200829588A (en) | 2008-07-16 |
AR063581A1 (es) | 2009-02-04 |
US7511040B2 (en) | 2009-03-31 |
US20080139571A1 (en) | 2008-06-12 |
PE20080931A1 (es) | 2008-07-19 |
WO2008057512A3 (en) | 2008-06-26 |
EP2079746A2 (en) | 2009-07-22 |
WO2008057512A2 (en) | 2008-05-15 |
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Legal Events
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HH | Correction or change in general |