MX2009013729A - Imidazopirazinas como inhibidores de proteina quinasa. - Google Patents
Imidazopirazinas como inhibidores de proteina quinasa.Info
- Publication number
- MX2009013729A MX2009013729A MX2009013729A MX2009013729A MX2009013729A MX 2009013729 A MX2009013729 A MX 2009013729A MX 2009013729 A MX2009013729 A MX 2009013729A MX 2009013729 A MX2009013729 A MX 2009013729A MX 2009013729 A MX2009013729 A MX 2009013729A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- imidazopyrazines
- protein kinase
- kinase inhibitors
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En sus muchas modalidades, la presente invención proporciona una nueva clase de compuestos de imidazopirazina como inhibidores de proteínas y/o Aurora quinasas, métodos de preparación de dichos compuestos, composiciones farmacéuticas que incluyen uno o más de dichos compuestos, métodos de preparación de formulaciones farmacéuticas que incluyen uno o más de dichos compuestos, y métodos de tratamiento, prevención, inhibición, o mejoramiento de una o más enfermedades asociadas con las proteínas o Aurora quinasas que utilizan dichos compuestos composiciones farmacéuticas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94399907P | 2007-06-14 | 2007-06-14 | |
US98793207P | 2007-11-14 | 2007-11-14 | |
PCT/US2008/007295 WO2008156614A2 (en) | 2007-06-14 | 2008-06-11 | Imidazopyrazines as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009013729A true MX2009013729A (es) | 2010-01-25 |
Family
ID=40002934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009013729A MX2009013729A (es) | 2007-06-14 | 2008-06-11 | Imidazopirazinas como inhibidores de proteina quinasa. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP2170892A2 (es) |
JP (1) | JP2010529195A (es) |
CN (1) | CN101772500A (es) |
AR (1) | AR066958A1 (es) |
CA (1) | CA2690557A1 (es) |
CL (1) | CL2008001745A1 (es) |
MX (1) | MX2009013729A (es) |
PE (1) | PE20090365A1 (es) |
TW (1) | TW200911811A (es) |
WO (1) | WO2008156614A2 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2756759C (en) | 2009-04-16 | 2017-11-07 | Joaquin Pastor Fernandez | Imidazopyrazines for use as kinase inhibitors |
TW201107329A (en) * | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
WO2011028638A1 (en) | 2009-09-04 | 2011-03-10 | Schering Corporation | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
ES2651296T3 (es) | 2009-10-30 | 2018-01-25 | Janssen Pharmaceutica, N.V. | Derivados de imidazo[1,2-b]piridacina y su uso como inhibidores de PDE10 |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
CA2801031A1 (en) * | 2010-06-01 | 2011-12-08 | Bayer Intellectual Property Gmbh | Substituted imidazopyrazines |
ES2541054T3 (es) * | 2010-10-20 | 2015-07-15 | Université De Bordeaux | Firmas del resultado clínico en tumores estromales gastrointestinales y método de tratamiento de tumores estromales gastrointestinales |
EP2444084A1 (en) | 2010-10-21 | 2012-04-25 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Use of PI3K inibitors for the treatment of obesity |
WO2012052745A1 (en) | 2010-10-21 | 2012-04-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Combinations of pi3k inhibitors with a second anti -tumor agent |
CA2821834A1 (en) * | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
US8673905B2 (en) * | 2011-03-17 | 2014-03-18 | Hoffmann-La Roche Inc. | Imidazo pyrazines |
US9346795B2 (en) | 2011-05-25 | 2016-05-24 | Bristol-Myers Squibb Company | Substituted sulfonamides useful as antiapoptotic Bcl inhibitors |
MX344600B (es) | 2011-06-27 | 2016-12-20 | Janssen Pharmaceutica Nv | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina. |
EP2863909B1 (en) | 2012-06-26 | 2020-11-04 | Janssen Pharmaceutica N.V. | Combinations comprising 4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline compounds as pde 2 inhibitors and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
AU2013289284B2 (en) | 2012-07-09 | 2017-03-30 | Janssen Pharmaceutica Nv | Inhibitors of phosphodiesterase 10 enzyme |
IL294895B2 (en) | 2014-01-13 | 2023-10-01 | Aurigene Oncology Ltd | History of bicyclic heterocyclyls as IRAK4 inhibitors |
US9493442B2 (en) | 2014-02-13 | 2016-11-15 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
CR20200362A (es) | 2014-02-13 | 2020-10-26 | Incyte Corp | CICLOPROPILAMINA COMO INHIBIDORES DE LA LSD1 (Divisional 2016-0395) |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
HUE046273T2 (hu) | 2014-02-13 | 2020-02-28 | Incyte Corp | Ciklopropilaminok mint LSD1 inhibitorok |
US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
US9944647B2 (en) | 2015-04-03 | 2018-04-17 | Incyte Corporation | Heterocyclic compounds as LSD1 inhibitors |
JP7427363B2 (ja) | 2015-08-12 | 2024-02-05 | インサイト・ホールディングス・コーポレイション | Lsd1阻害剤の塩 |
ES2963148T3 (es) | 2016-04-22 | 2024-03-25 | Incyte Corp | Formulaciones de un inhibidor de LSD1 |
US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
AU2018215678A1 (en) | 2017-02-06 | 2019-08-22 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
EP3600270B1 (en) * | 2017-03-31 | 2023-06-14 | Aurigene Oncology Limited | Compounds and compositions for treating hematological disorders |
CN107954977A (zh) * | 2017-12-15 | 2018-04-24 | 上海鼎雅药物化学科技有限公司 | 雷替曲塞中间体的合成方法 |
WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
CN115702156A (zh) * | 2021-04-23 | 2023-02-14 | 南京明德新药研发有限公司 | 吡啶酰胺类化合物 |
WO2023169438A1 (zh) * | 2022-03-07 | 2023-09-14 | 上海凌达生物医药有限公司 | 一类含氮杂环类细胞周期抑制剂化合物、制备方法和用途 |
WO2024088192A1 (en) * | 2022-10-26 | 2024-05-02 | Js Innopharm (Suzhou) Ltd. | An aurora a inhibitor for use in treatments of cancers |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7576085B2 (en) * | 2002-09-23 | 2009-08-18 | Schering Corporation | Imidazopyrazines as cyclin dependent kinase inhibitors |
KR20050057520A (ko) * | 2002-09-23 | 2005-06-16 | 쉐링 코포레이션 | 사이클린 의존성 키나제 억제제로서의 이미다조피라진 |
CA2587192A1 (en) * | 2004-11-10 | 2006-05-18 | Cgi Pharmaceuticals, Inc. | Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity |
CN101370811A (zh) * | 2005-11-10 | 2009-02-18 | 先灵公司 | 作为蛋白激酶抑制剂的咪唑并吡嗪化合物 |
-
2008
- 2008-06-11 WO PCT/US2008/007295 patent/WO2008156614A2/en active Application Filing
- 2008-06-11 PE PE2008001001A patent/PE20090365A1/es not_active Application Discontinuation
- 2008-06-11 CA CA2690557A patent/CA2690557A1/en not_active Abandoned
- 2008-06-11 AR ARP080102481A patent/AR066958A1/es not_active Application Discontinuation
- 2008-06-11 JP JP2010512177A patent/JP2010529195A/ja not_active Withdrawn
- 2008-06-11 CN CN200880101960A patent/CN101772500A/zh active Pending
- 2008-06-11 EP EP08768351A patent/EP2170892A2/en not_active Withdrawn
- 2008-06-11 MX MX2009013729A patent/MX2009013729A/es not_active Application Discontinuation
- 2008-06-12 TW TW097121942A patent/TW200911811A/zh unknown
- 2008-06-12 CL CL2008001745A patent/CL2008001745A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2010529195A (ja) | 2010-08-26 |
CL2008001745A1 (es) | 2008-12-05 |
TW200911811A (en) | 2009-03-16 |
PE20090365A1 (es) | 2009-04-04 |
WO2008156614A3 (en) | 2009-02-12 |
EP2170892A2 (en) | 2010-04-07 |
CA2690557A1 (en) | 2008-12-24 |
WO2008156614A2 (en) | 2008-12-24 |
CN101772500A (zh) | 2010-07-07 |
AR066958A1 (es) | 2009-09-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |