WO2008156614A3 - Imidazopyrazines as protein kinase inhibitors - Google Patents

Imidazopyrazines as protein kinase inhibitors Download PDF

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Publication number
WO2008156614A3
WO2008156614A3 PCT/US2008/007295 US2008007295W WO2008156614A3 WO 2008156614 A3 WO2008156614 A3 WO 2008156614A3 US 2008007295 W US2008007295 W US 2008007295W WO 2008156614 A3 WO2008156614 A3 WO 2008156614A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
imidazopyrazines
protein kinase
kinase inhibitors
methods
Prior art date
Application number
PCT/US2008/007295
Other languages
French (fr)
Other versions
WO2008156614A2 (en
Inventor
Tao Yu
David B Belanger
Angela D Kerekes
Zhaoyang Meng
Jayaram R Tagat
Sara J Esposite
Amit K Mandal
Yushi Xiao
Bheemashankar A Kulkarni
Yonglian Zhang
Patrick J Curran
Ronald Doll
M Arshad Siddiqui
Original Assignee
Schering Corp
Tao Yu
David B Belanger
Angela D Kerekes
Zhaoyang Meng
Jayaram R Tagat
Sara J Esposite
Amit K Mandal
Yushi Xiao
Bheemashankar A Kulkarni
Yonglian Zhang
Patrick J Curran
Ronald Doll
M Arshad Siddiqui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40002934&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008156614(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp, Tao Yu, David B Belanger, Angela D Kerekes, Zhaoyang Meng, Jayaram R Tagat, Sara J Esposite, Amit K Mandal, Yushi Xiao, Bheemashankar A Kulkarni, Yonglian Zhang, Patrick J Curran, Ronald Doll, M Arshad Siddiqui filed Critical Schering Corp
Priority to EP08768351A priority Critical patent/EP2170892A2/en
Priority to CA2690557A priority patent/CA2690557A1/en
Priority to MX2009013729A priority patent/MX2009013729A/en
Priority to CN200880101960A priority patent/CN101772500A/en
Priority to JP2010512177A priority patent/JP2010529195A/en
Publication of WO2008156614A2 publication Critical patent/WO2008156614A2/en
Publication of WO2008156614A3 publication Critical patent/WO2008156614A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions.
PCT/US2008/007295 2007-06-14 2008-06-11 Imidazopyrazines as protein kinase inhibitors WO2008156614A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08768351A EP2170892A2 (en) 2007-06-14 2008-06-11 Imidazopyrazines as protein kinase inhibitors
CA2690557A CA2690557A1 (en) 2007-06-14 2008-06-11 Imidazopyrazines as protein kinase inhibitors
MX2009013729A MX2009013729A (en) 2007-06-14 2008-06-11 Imidazopyrazines as protein kinase inhibitors.
CN200880101960A CN101772500A (en) 2007-06-14 2008-06-11 Imidazopyrazines as protein kinase inhibitors
JP2010512177A JP2010529195A (en) 2007-06-14 2008-06-11 Imidazopyrazine as an inhibitor of protein kinase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94399907P 2007-06-14 2007-06-14
US60/943,999 2007-06-14
US98793207P 2007-11-14 2007-11-14
US60/987,932 2007-11-14

Publications (2)

Publication Number Publication Date
WO2008156614A2 WO2008156614A2 (en) 2008-12-24
WO2008156614A3 true WO2008156614A3 (en) 2009-02-12

Family

ID=40002934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/007295 WO2008156614A2 (en) 2007-06-14 2008-06-11 Imidazopyrazines as protein kinase inhibitors

Country Status (10)

Country Link
EP (1) EP2170892A2 (en)
JP (1) JP2010529195A (en)
CN (1) CN101772500A (en)
AR (1) AR066958A1 (en)
CA (1) CA2690557A1 (en)
CL (1) CL2008001745A1 (en)
MX (1) MX2009013729A (en)
PE (1) PE20090365A1 (en)
TW (1) TW200911811A (en)
WO (1) WO2008156614A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2756759C (en) 2009-04-16 2017-11-07 Joaquin Pastor Fernandez Imidazopyrazines for use as kinase inhibitors
TW201107329A (en) * 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
US8993535B2 (en) 2009-09-04 2015-03-31 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
NZ599597A (en) 2009-10-30 2013-05-31 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
AR080754A1 (en) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv IMIDAZO DERIVATIVES (1,2-A) PIRAZINA AND ITS USE AS PDE10 INHIBITORS
EP2576560B1 (en) * 2010-06-01 2015-09-30 Bayer Intellectual Property GmbH Substituted imidazopyrazines
DK2630259T3 (en) * 2010-10-20 2015-07-06 Univ Bordeaux SIGNATURES OF CLINICAL OUTCOME In gastrointestinal stromal tumors AND METHOD FOR THE TREATMENT OF gastrointestinal stromal tumors
EP2444084A1 (en) 2010-10-21 2012-04-25 Centro Nacional de Investigaciones Oncológicas (CNIO) Use of PI3K inibitors for the treatment of obesity
WO2012052745A1 (en) 2010-10-21 2012-04-26 Centro Nacional De Investigaciones Oncológicas (Cnio) Combinations of pi3k inhibitors with a second anti -tumor agent
US20140187548A1 (en) * 2010-12-17 2014-07-03 Bayer Intellectual Property Gmbh 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US8673905B2 (en) * 2011-03-17 2014-03-18 Hoffmann-La Roche Inc. Imidazo pyrazines
CN103732589B (en) 2011-05-25 2016-03-30 百时美施贵宝公司 Can be used as the sulphonamide of the replacement of anti-apoptotic BCL inhibitor
MX344600B (en) 2011-06-27 2016-12-20 Janssen Pharmaceutica Nv 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES.
RU2657540C2 (en) 2012-06-26 2018-06-14 Янссен Фармацевтика Нв Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4]triazolo[4,3-a]quinoxaline compounds and pde 10 inhibitors for use in treatment of neurological or metabolic disorders
RU2667058C2 (en) 2012-07-09 2018-09-14 Янссен Фармацевтика Нв Inhibitors of phosphodiesterase 10 enzyme
CU24389B1 (en) 2014-01-13 2019-04-04 Aurigene Discovery Tech Ltd BICYCLIC HETEROCICLYL COMPOUNDS AS IRAK4 INHIBITORS
US9493442B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
PL3105218T3 (en) 2014-02-13 2020-03-31 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
LT3105226T (en) 2014-02-13 2019-11-11 Incyte Corp Cyclopropylamines as lsd1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
SG10202001219UA (en) 2015-08-12 2020-03-30 Incyte Corp Salts of an lsd1 inhibitor
PE20190377A1 (en) 2016-04-22 2019-03-08 Incyte Corp FORMULATIONS OF AN LSD INHIBITOR 1
EP3548035A4 (en) 2016-11-30 2020-07-22 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
WO2018145080A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
KR102633530B1 (en) * 2017-03-31 2024-02-02 오리진 온콜로지 리미티드 Compounds and compositions for treating blood disorders
CN107954977A (en) * 2017-12-15 2018-04-24 上海鼎雅药物化学科技有限公司 The synthetic method of Raltitrexed intermediate
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
TW202304911A (en) * 2021-04-23 2023-02-01 大陸商南京明德新藥研發有限公司 Pyridinamide compound
WO2023169438A1 (en) * 2022-03-07 2023-09-14 上海凌达生物医药有限公司 Nitrogen-containing heterocyclic cell cycle inhibitor compounds as well as preparation method therefor and use thereof
WO2024088192A1 (en) * 2022-10-26 2024-05-02 Js Innopharm (Suzhou) Ltd. An aurora a inhibitor for use in treatments of cancers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026877A1 (en) * 2002-09-23 2004-04-01 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
WO2006053121A2 (en) * 2004-11-10 2006-05-18 Cgi Pharmaceuticals, Inc. Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity
WO2007058873A2 (en) * 2005-11-10 2007-05-24 Schering Corporation Imidazopyrazines as cyclin depentend kinase inhibitors
WO2007058942A2 (en) * 2005-11-10 2007-05-24 Schering Corporation Imidazopyrazines as protein kinase inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026877A1 (en) * 2002-09-23 2004-04-01 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
WO2006053121A2 (en) * 2004-11-10 2006-05-18 Cgi Pharmaceuticals, Inc. Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity
WO2007058873A2 (en) * 2005-11-10 2007-05-24 Schering Corporation Imidazopyrazines as cyclin depentend kinase inhibitors
WO2007058942A2 (en) * 2005-11-10 2007-05-24 Schering Corporation Imidazopyrazines as protein kinase inhibitors

Also Published As

Publication number Publication date
EP2170892A2 (en) 2010-04-07
CA2690557A1 (en) 2008-12-24
AR066958A1 (en) 2009-09-23
WO2008156614A2 (en) 2008-12-24
MX2009013729A (en) 2010-01-25
CN101772500A (en) 2010-07-07
JP2010529195A (en) 2010-08-26
PE20090365A1 (en) 2009-04-04
CL2008001745A1 (en) 2008-12-05
TW200911811A (en) 2009-03-16

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