UA95940C2 - Азаіндоли як інгібітори кіназ януса - Google Patents

Азаіндоли як інгібітори кіназ януса

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Publication number
UA95940C2
UA95940C2 UAA200810409A UAA200810409A UA95940C2 UA 95940 C2 UA95940 C2 UA 95940C2 UA A200810409 A UAA200810409 A UA A200810409A UA A200810409 A UAA200810409 A UA A200810409A UA 95940 C2 UA95940 C2 UA 95940C2
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UA
Ukraine
Prior art keywords
inhibitors
janus kinases
useful
azaindoles useful
azaindoles
Prior art date
Application number
UAA200810409A
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English (en)
Russian (ru)
Inventor
Люк Фармер
Габріел Мартінез-Ботелла
Алберт Пайрс
Франческо Салітуро
Жан Ванг
Маріон Ваннамейкер
Тяншенг Ванг
Original Assignee
Вертекс Фармасьютикалс Інкорпорейтед
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38197739&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA95940(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Вертекс Фармасьютикалс Інкорпорейтед filed Critical Вертекс Фармасьютикалс Інкорпорейтед
Publication of UA95940C2 publication Critical patent/UA95940C2/uk

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
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Abstract

Даний винахід стосується сполук формули І-А - інгібіторів протеїнкіназ, зокрема кіназ родини JAK-кіназ, EMBED ISISServer , І-А де: R3 - це Н; R2 - це Н, F, R', OH, OR', COR', COOH, COOR', CONH2, CONHR', CON(R')2 чи CN; R4 - це H, F, R', OH, OR', COR', COOH, COOR', CONH2, CONHR', CON(R')2 чи CN; чи R2 і R4, узяті разом, утворюють 5-7-членне арильне чи гетероарильне кільце, факультативно заміщене 1-4 варіантами R10. Винахід також пропонує фармацевтично прийнятні композиції, що містять вказані сполуки, і способи використання вказаних композицій у лікуванні різних хвороб, станів і розладів.
UAA200810409A 2006-01-17 2007-01-17 Азаіндоли як інгібітори кіназ януса UA95940C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US84247106P 2006-09-06 2006-09-06
PCT/US2007/001225 WO2007084557A2 (en) 2006-01-17 2007-01-17 Azaindoles useful as inhibitors of janus kinases

Publications (1)

Publication Number Publication Date
UA95940C2 true UA95940C2 (uk) 2011-09-26

Family

ID=38197739

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200810409A UA95940C2 (uk) 2006-01-17 2007-01-17 Азаіндоли як інгібітори кіназ януса

Country Status (19)

Country Link
US (6) US7767816B2 (uk)
EP (3) EP2559694A3 (uk)
JP (4) JP5591471B2 (uk)
KR (3) KR20130041313A (uk)
CN (3) CN102532133A (uk)
AR (1) AR060316A1 (uk)
AU (1) AU2007207533B8 (uk)
BR (2) BRPI0722364A2 (uk)
CA (1) CA2636189A1 (uk)
CL (1) CL2008002140A1 (uk)
HK (1) HK1210780A1 (uk)
IL (1) IL191902A0 (uk)
NO (1) NO20083501L (uk)
NZ (3) NZ592968A (uk)
RU (2) RU2453548C2 (uk)
TW (4) TW201412738A (uk)
UA (1) UA95940C2 (uk)
WO (1) WO2007084557A2 (uk)
ZA (2) ZA200805053B (uk)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ584499A (en) * 2004-03-30 2011-08-26 Vertex Pharma Azaindoles Useful as Inhibitors of Jak and Other Protein Kinases
NZ564065A (en) * 2005-05-20 2011-03-31 Vertex Pharma Pyrrolopyridines useful as inhibitors of protein kinase
JP5119154B2 (ja) 2005-09-22 2013-01-16 インサイト・コーポレイション Ｊａｎｕｓキナーゼの四環系阻害剤
TWI630207B (zh) 2005-12-13 2018-07-21 英塞特控股公司 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶
AR060316A1 (es) 2006-01-17 2008-06-11 Vertex Pharma Azaindoles de utilidad como inhibidores de janus quinasas
CN101460499A (zh) * 2006-04-05 2009-06-17 沃泰克斯药物股份有限公司 可用作janus激酶抑制剂的去氮杂嘌呤
US7754838B2 (en) * 2006-08-08 2010-07-13 E.I. Du Pont De Nemours And Company Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide
US8247421B2 (en) 2006-12-21 2012-08-21 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
EP2121692B1 (en) 2006-12-22 2013-04-10 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
CN101778825A (zh) * 2007-03-22 2010-07-14 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的n-杂环类化合物
EP3070090B1 (en) 2007-06-13 2018-12-12 Incyte Holdings Corporation Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
EP2262498A2 (en) * 2008-03-10 2010-12-22 Vertex Pharmceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
PL2288610T3 (pl) 2008-03-11 2017-12-29 Incyte Holdings Corporation Azetydynowe i cyklobutanowe pochodne jako inhibitory jak
EP2318407B1 (en) * 2008-07-23 2013-01-02 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
EP3643312A1 (en) 2009-05-22 2020-04-29 Incyte Holdings Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
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