PE20131164A1 - IMIDAZOPIRIDAZINAS SUSTITUIDAS COMO INHIBIDORES DE LA QUINASA Mps-1 - Google Patents

IMIDAZOPIRIDAZINAS SUSTITUIDAS COMO INHIBIDORES DE LA QUINASA Mps-1

Info

Publication number
PE20131164A1
PE20131164A1 PE2013000392A PE2013000392A PE20131164A1 PE 20131164 A1 PE20131164 A1 PE 20131164A1 PE 2013000392 A PE2013000392 A PE 2013000392A PE 2013000392 A PE2013000392 A PE 2013000392A PE 20131164 A1 PE20131164 A1 PE 20131164A1
Authority
PE
Peru
Prior art keywords
alkyl
integer
response
cellular
methylbenzamide
Prior art date
Application number
PE2013000392A
Other languages
English (en)
Inventor
Ulrich Klar
Marcus Koppitz
Rolf Jautelat
Dirk Kosemund
Rolf Bohlmann
Philip Lienau
Gerhard Siemeister
Antje Margret Wengner
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of PE20131164A1 publication Critical patent/PE20131164A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Paper (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A DERIVADOS IMIDAZOPIRIDAZINAS DE FORMULA (I), DONDE A ES UN GRUPO (a), (b), (c) O (d); Z ES C(=O)N(H)R2, C(=S)N(H)R2, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, HALO-ALQUILO C1-C6, ENTRE OTROS; R3 ES ARIL-X O HETEROARIL-X; X ES O, NR6, S(=O)p, ENTRE OTROS; p ES UN ENTERO DE 0 A 2; n ES UN ENTERO DE 0 A 5; m ES UN ENTERO DE 0 A 6; R4a Y R4d SON H; R4b Y R4c SON H, HALO, CN, OH, ENTRE OTROS; R5 ES H, ALQUILO C1-C6, (CH2)n-ALQUENILO C2-C6, ENTRE OTROS; R6, R6 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-CICLOPROPIL-4-{6-[(2-METOXIFENIL)SULFANIL)]-8-[(3,3,3-TRIFLUOROPROPIL)AMINO]IMIDAZO[1,2-b]PIRIDAZIN-3-IL}-2-METILBENZAMIDA, N-CICLOPROPIL-4-{8-[(2-HIDROXI-2-METILPROPIL)AMINO]-6-[(4-HIDROXIFENIL)SULFANIL]-IMIDAZO[1,2-b]PIRIDAZIN-3-IL}-2-METILBENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN METODO DE PREPARACION. DICHOS COMPUESTOS INHIBEN LA QUINASA Mps-1 (DEL HUSO MONOPOLAR 1) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON LA PROLIFERACION CELULAR DESCONTROLADA, CON UNA RESPUESTA INMUNE CELULAR INAPROPIADA, RESPUESTA INFLAMATORIA CELULAR INAPROPIADA, ENTRE OTRAS
PE2013000392A 2010-09-10 2011-09-06 IMIDAZOPIRIDAZINAS SUSTITUIDAS COMO INHIBIDORES DE LA QUINASA Mps-1 PE20131164A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP10176134 2010-09-10
EP11075022 2011-02-04
EP11170775 2011-06-21
EP11170771 2011-06-21

Publications (1)

Publication Number Publication Date
PE20131164A1 true PE20131164A1 (es) 2013-10-30

Family

ID=44545741

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013000392A PE20131164A1 (es) 2010-09-10 2011-09-06 IMIDAZOPIRIDAZINAS SUSTITUIDAS COMO INHIBIDORES DE LA QUINASA Mps-1

Country Status (38)

Country Link
US (1) US9255100B2 (es)
EP (1) EP2614063B1 (es)
JP (1) JP5824050B2 (es)
KR (1) KR20140032337A (es)
CN (1) CN103370318B (es)
AP (1) AP3607A (es)
AR (1) AR082946A1 (es)
AU (1) AU2011298844B2 (es)
BR (1) BR112013005679A2 (es)
CA (1) CA2810755A1 (es)
CO (1) CO6720961A2 (es)
CR (1) CR20130102A (es)
CU (1) CU24187B1 (es)
CY (1) CY1117352T1 (es)
DK (1) DK2614063T3 (es)
DO (1) DOP2013000054A (es)
EA (1) EA023420B1 (es)
EC (1) ECSP13012752A (es)
ES (1) ES2568220T3 (es)
HK (1) HK1187623A1 (es)
HR (1) HRP20160360T1 (es)
HU (1) HUE028771T2 (es)
IL (1) IL225058A (es)
MA (1) MA34516B1 (es)
ME (1) ME02389B (es)
MX (1) MX2013002713A (es)
MY (1) MY185139A (es)
NZ (1) NZ607904A (es)
PE (1) PE20131164A1 (es)
PL (1) PL2614063T3 (es)
RS (1) RS54661B1 (es)
SA (1) SA111320735B1 (es)
SG (1) SG188417A1 (es)
SI (1) SI2614063T1 (es)
TW (1) TWI541243B (es)
UY (1) UY33598A (es)
WO (1) WO2012032031A1 (es)
ZA (1) ZA201301756B (es)

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Publication number Publication date
AP3607A (en) 2016-02-26
SA111320735B1 (ar) 2015-10-21
WO2012032031A1 (en) 2012-03-15
SI2614063T1 (sl) 2016-05-31
AP2013006790A0 (en) 2013-04-30
ECSP13012752A (es) 2014-01-31
HRP20160360T1 (hr) 2016-05-06
CR20130102A (es) 2013-04-17
PL2614063T3 (pl) 2016-06-30
IL225058A (en) 2017-03-30
CU20130033A7 (es) 2013-08-29
TWI541243B (zh) 2016-07-11
ZA201301756B (en) 2016-06-29
CA2810755A1 (en) 2012-03-15
TW201211049A (en) 2012-03-16
AU2011298844A1 (en) 2013-03-28
UY33598A (es) 2012-04-30
JP5824050B2 (ja) 2015-11-25
US20130338133A1 (en) 2013-12-19
MA34516B1 (fr) 2013-09-02
ME02389B (me) 2016-09-20
SG188417A1 (en) 2013-04-30
RS54661B1 (en) 2016-08-31
US9255100B2 (en) 2016-02-09
CN103370318A (zh) 2013-10-23
BR112013005679A2 (pt) 2016-05-03
ES2568220T3 (es) 2016-04-28
EP2614063A1 (en) 2013-07-17
CO6720961A2 (es) 2013-07-31
DK2614063T3 (en) 2016-04-18
MX2013002713A (es) 2013-05-22
DOP2013000054A (es) 2013-07-31
NZ607904A (en) 2015-02-27
EA201390339A1 (ru) 2013-09-30
AR082946A1 (es) 2013-01-23
HUE028771T2 (en) 2016-12-28
MY185139A (en) 2021-04-30
JP2013537174A (ja) 2013-09-30
CY1117352T1 (el) 2017-04-26
EA023420B1 (ru) 2016-06-30
KR20140032337A (ko) 2014-03-14
EP2614063B1 (en) 2016-01-13
CU24187B1 (es) 2016-07-29
CN103370318B (zh) 2016-04-20
AU2011298844B2 (en) 2015-02-19
HK1187623A1 (zh) 2014-04-11

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