MA34516B1 - Imidizopyridazines substituees - Google Patents

Imidizopyridazines substituees

Info

Publication number
MA34516B1
MA34516B1 MA35720A MA35720A MA34516B1 MA 34516 B1 MA34516 B1 MA 34516B1 MA 35720 A MA35720 A MA 35720A MA 35720 A MA35720 A MA 35720A MA 34516 B1 MA34516 B1 MA 34516B1
Authority
MA
Morocco
Prior art keywords
compounds
imidizopyridazines
substituted
formula
ttk
Prior art date
Application number
MA35720A
Other languages
English (en)
Inventor
Ulrich Klar
Marcus Koppitz
Rolf Jautelat
Dirk Kosemund
Rolf Bohlmann
Philip Lienau
Gerhard Siemeister
Antje Margret Wengner
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MA34516B1 publication Critical patent/MA34516B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Paper (AREA)

Abstract

)CETTE INVENTION CONCERNE DES COMPOSÉS D'IMIDAZOPYRIDAZINES SUBSTITUÉES DE FORMULE GÉNÉRALE (1), QUI SONT DES INHIBITEURS DE MPS-1 (FUSEAU MONOPOLAIRE 1) (ÉGALEMENT CONNU SOUS LE NOM DE TYROSINE THRÉONINE KINASE, TTK), R3, R5, ET A DANS LA FORMULE (1) ÉTANT TELS QUE DÉFINIS DANS LES REVENDICATIONS, AINSI QUE DES PROCÉDÉS DE PRÉPARATION DESDITS COMPOSÉS, DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET L'UTILISATION DESDITS COMPOSÉS POUR FABRIQUER UNE COMPOSITION PHARMACEUTIQUE DESTINÉE À TRAITER OU À PRÉVENIR UNE MALADIE, EN PARTICULIER, UN TROUBLE HYPER-PROLIFÉRATIF ET/OU DE TYPE ANGIOGENÈSE, À TITRE D'AGENT UTILISÉ SEUL OU EN ASSOCIATION AVEC D'AUTRES PRINCIPES ACTIFS.
MA35720A 2010-09-10 2011-09-06 Imidizopyridazines substituees MA34516B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10176134 2010-09-10
EP11075022 2011-02-04
EP11170771 2011-06-21
EP11170775 2011-06-21
PCT/EP2011/065368 WO2012032031A1 (fr) 2010-09-10 2011-09-06 Imidazopyridazines substituées

Publications (1)

Publication Number Publication Date
MA34516B1 true MA34516B1 (fr) 2013-09-02

Family

ID=44545741

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35720A MA34516B1 (fr) 2010-09-10 2011-09-06 Imidizopyridazines substituees

Country Status (38)

Country Link
US (1) US9255100B2 (fr)
EP (1) EP2614063B1 (fr)
JP (1) JP5824050B2 (fr)
KR (1) KR20140032337A (fr)
CN (1) CN103370318B (fr)
AP (1) AP3607A (fr)
AR (1) AR082946A1 (fr)
AU (1) AU2011298844B2 (fr)
BR (1) BR112013005679A2 (fr)
CA (1) CA2810755A1 (fr)
CO (1) CO6720961A2 (fr)
CR (1) CR20130102A (fr)
CU (1) CU24187B1 (fr)
CY (1) CY1117352T1 (fr)
DK (1) DK2614063T3 (fr)
DO (1) DOP2013000054A (fr)
EA (1) EA023420B1 (fr)
EC (1) ECSP13012752A (fr)
ES (1) ES2568220T3 (fr)
HK (1) HK1187623A1 (fr)
HR (1) HRP20160360T1 (fr)
HU (1) HUE028771T2 (fr)
IL (1) IL225058A (fr)
MA (1) MA34516B1 (fr)
ME (1) ME02389B (fr)
MX (1) MX2013002713A (fr)
MY (1) MY185139A (fr)
NZ (1) NZ607904A (fr)
PE (1) PE20131164A1 (fr)
PL (1) PL2614063T3 (fr)
RS (1) RS54661B1 (fr)
SA (1) SA111320735B1 (fr)
SG (1) SG188417A1 (fr)
SI (1) SI2614063T1 (fr)
TW (1) TWI541243B (fr)
UY (1) UY33598A (fr)
WO (1) WO2012032031A1 (fr)
ZA (1) ZA201301756B (fr)

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EP2651945A1 (fr) 2010-12-17 2013-10-23 Bayer Intellectual Property GmbH Imidazopyrazines 6-substituées pour utilisation en tant qu'inhibiteurs de mps-1 et tkk dans le traitement de troubles hyperprolifératifs
CN103443100B (zh) 2010-12-17 2016-03-23 拜耳知识产权有限责任公司 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的取代的6-咪唑并吡嗪

Also Published As

Publication number Publication date
PL2614063T3 (pl) 2016-06-30
ZA201301756B (en) 2016-06-29
EP2614063B1 (fr) 2016-01-13
EP2614063A1 (fr) 2013-07-17
AP2013006790A0 (en) 2013-04-30
MX2013002713A (es) 2013-05-22
EA201390339A1 (ru) 2013-09-30
PE20131164A1 (es) 2013-10-30
CO6720961A2 (es) 2013-07-31
SA111320735B1 (ar) 2015-10-21
US9255100B2 (en) 2016-02-09
KR20140032337A (ko) 2014-03-14
TWI541243B (zh) 2016-07-11
US20130338133A1 (en) 2013-12-19
HRP20160360T1 (hr) 2016-05-06
ME02389B (fr) 2016-09-20
BR112013005679A2 (pt) 2016-05-03
SI2614063T1 (sl) 2016-05-31
WO2012032031A1 (fr) 2012-03-15
TW201211049A (en) 2012-03-16
SG188417A1 (en) 2013-04-30
CR20130102A (es) 2013-04-17
JP2013537174A (ja) 2013-09-30
ES2568220T3 (es) 2016-04-28
JP5824050B2 (ja) 2015-11-25
CU20130033A7 (es) 2013-08-29
ECSP13012752A (es) 2014-01-31
UY33598A (es) 2012-04-30
AP3607A (en) 2016-02-26
CY1117352T1 (el) 2017-04-26
EA023420B1 (ru) 2016-06-30
HUE028771T2 (en) 2016-12-28
CN103370318A (zh) 2013-10-23
RS54661B1 (en) 2016-08-31
HK1187623A1 (zh) 2014-04-11
NZ607904A (en) 2015-02-27
AR082946A1 (es) 2013-01-23
CA2810755A1 (fr) 2012-03-15
CN103370318B (zh) 2016-04-20
AU2011298844A1 (en) 2013-03-28
AU2011298844B2 (en) 2015-02-19
DK2614063T3 (en) 2016-04-18
DOP2013000054A (es) 2013-07-31
CU24187B1 (es) 2016-07-29
IL225058A (en) 2017-03-30
MY185139A (en) 2021-04-30

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