MA34516B1 - Imidizopyridazines substituees - Google Patents
Imidizopyridazines substitueesInfo
- Publication number
- MA34516B1 MA34516B1 MA35720A MA35720A MA34516B1 MA 34516 B1 MA34516 B1 MA 34516B1 MA 35720 A MA35720 A MA 35720A MA 35720 A MA35720 A MA 35720A MA 34516 B1 MA34516 B1 MA 34516B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- imidizopyridazines
- substituted
- formula
- ttk
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Paper (AREA)
- Cosmetics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
)CETTE INVENTION CONCERNE DES COMPOSÉS D'IMIDAZOPYRIDAZINES SUBSTITUÉES DE FORMULE GÉNÉRALE (1), QUI SONT DES INHIBITEURS DE MPS-1 (FUSEAU MONOPOLAIRE 1) (ÉGALEMENT CONNU SOUS LE NOM DE TYROSINE THRÉONINE KINASE, TTK), R3, R5, ET A DANS LA FORMULE (1) ÉTANT TELS QUE DÉFINIS DANS LES REVENDICATIONS, AINSI QUE DES PROCÉDÉS DE PRÉPARATION DESDITS COMPOSÉS, DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET L'UTILISATION DESDITS COMPOSÉS POUR FABRIQUER UNE COMPOSITION PHARMACEUTIQUE DESTINÉE À TRAITER OU À PRÉVENIR UNE MALADIE, EN PARTICULIER, UN TROUBLE HYPER-PROLIFÉRATIF ET/OU DE TYPE ANGIOGENÈSE, À TITRE D'AGENT UTILISÉ SEUL OU EN ASSOCIATION AVEC D'AUTRES PRINCIPES ACTIFS.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10176134 | 2010-09-10 | ||
EP11075022 | 2011-02-04 | ||
EP11170771 | 2011-06-21 | ||
EP11170775 | 2011-06-21 | ||
PCT/EP2011/065368 WO2012032031A1 (fr) | 2010-09-10 | 2011-09-06 | Imidazopyridazines substituées |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34516B1 true MA34516B1 (fr) | 2013-09-02 |
Family
ID=44545741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35720A MA34516B1 (fr) | 2010-09-10 | 2011-09-06 | Imidizopyridazines substituees |
Country Status (38)
Country | Link |
---|---|
US (1) | US9255100B2 (fr) |
EP (1) | EP2614063B1 (fr) |
JP (1) | JP5824050B2 (fr) |
KR (1) | KR20140032337A (fr) |
CN (1) | CN103370318B (fr) |
AP (1) | AP3607A (fr) |
AR (1) | AR082946A1 (fr) |
AU (1) | AU2011298844B2 (fr) |
BR (1) | BR112013005679A2 (fr) |
CA (1) | CA2810755A1 (fr) |
CO (1) | CO6720961A2 (fr) |
CR (1) | CR20130102A (fr) |
CU (1) | CU24187B1 (fr) |
CY (1) | CY1117352T1 (fr) |
DK (1) | DK2614063T3 (fr) |
DO (1) | DOP2013000054A (fr) |
EA (1) | EA023420B1 (fr) |
EC (1) | ECSP13012752A (fr) |
ES (1) | ES2568220T3 (fr) |
HK (1) | HK1187623A1 (fr) |
HR (1) | HRP20160360T1 (fr) |
HU (1) | HUE028771T2 (fr) |
IL (1) | IL225058A (fr) |
MA (1) | MA34516B1 (fr) |
ME (1) | ME02389B (fr) |
MX (1) | MX2013002713A (fr) |
MY (1) | MY185139A (fr) |
NZ (1) | NZ607904A (fr) |
PE (1) | PE20131164A1 (fr) |
PL (1) | PL2614063T3 (fr) |
RS (1) | RS54661B1 (fr) |
SA (1) | SA111320735B1 (fr) |
SG (1) | SG188417A1 (fr) |
SI (1) | SI2614063T1 (fr) |
TW (1) | TWI541243B (fr) |
UY (1) | UY33598A (fr) |
WO (1) | WO2012032031A1 (fr) |
ZA (1) | ZA201301756B (fr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
WO2012088266A2 (fr) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3 |
ES2671748T3 (es) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
CN104284896B (zh) * | 2012-03-14 | 2016-06-01 | 拜耳知识产权有限责任公司 | 取代的咪唑并哒嗪 |
SG11201408238WA (en) | 2012-06-13 | 2015-01-29 | Incyte Corp | Substituted tricyclic compounds as fgfr inhibitors |
WO2014020041A1 (fr) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinaisons pour le traitement du cancer |
WO2014020043A1 (fr) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinaisons pour le traitement du cancer |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
WO2014075168A1 (fr) * | 2012-11-16 | 2014-05-22 | University Health Network | Composés de pyrazolopyrimidine |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
TW201437211A (zh) * | 2013-03-01 | 2014-10-01 | Bayer Pharma AG | 經取代咪唑并嗒□ |
EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
AP2015008898A0 (en) | 2013-06-11 | 2015-12-31 | Bayer Pharma AG | Prodrug derivatives of substituted triazolopyridines |
CN105392484A (zh) * | 2013-06-13 | 2016-03-09 | 拜耳制药股份公司 | 咪唑并哒嗪衍生物与有丝分裂试剂的联用药用于治疗癌症 |
CN103360399B (zh) * | 2013-08-02 | 2016-03-02 | 北京大学 | 6-芳基取代-咪唑-[1,2-b]哒嗪类衍生物,其制备方法及用途 |
GB201321734D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
EP3107909B1 (fr) * | 2014-02-21 | 2021-07-14 | Frost Biologic, Inc. | Amides antimitotiques destinés au traitement du cancer et de troubles prolifératifs |
WO2015157955A1 (fr) * | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Inhibiteurs de tyrosine kinase de bruton (btk) hétérocyclique |
TW201613927A (en) * | 2014-09-01 | 2016-04-16 | Bayer Pharma AG | Method for preparation of substituted imidazopyridazines |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
CR20170390A (es) | 2015-02-20 | 2017-10-23 | Incyte Holdings Corp | Heterociclos biciclicos como inhibidores de fgfr |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
PL3283642T3 (pl) | 2015-04-17 | 2024-04-22 | Crossfire Oncology Holding B.V. | Biomarkery prognostyczne dla chemioterapii inhibitorem TTK |
WO2016187028A1 (fr) * | 2015-05-15 | 2016-11-24 | Celgene Avilomics Research, Inc. | Composés hétéroaryles, leur synthèse, et intermédiaires de ceux-ci |
CN108290749B (zh) * | 2015-12-04 | 2022-06-24 | 埃克森美孚科技工程公司 | Emm-28新型合成结晶材料、其制备和用途 |
US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
JP6961675B2 (ja) * | 2016-07-18 | 2021-11-05 | ユニバーシティー ヘルス ネットワーク | Ttk阻害剤の固体形態 |
US20200078142A1 (en) * | 2017-04-11 | 2020-03-12 | Straumann Holding Ag | Dental implant |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
SG11202010636VA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Solid forms of an fgfr inhibitor and processes for preparing the same |
WO2019213506A1 (fr) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Sels d'un inhibiteur de fgfr |
CA3127502A1 (fr) | 2019-02-12 | 2020-08-20 | Sumitomo Dainippon Pharma Oncology, Inc. | Formulations comprenant des inhibiteurs de proteine kinase heterocycliques |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
CN111978325B (zh) * | 2019-05-22 | 2023-11-17 | 中国药科大学 | 咪唑并哒嗪类mnk1/mnk2激酶抑制剂及其制备方法和应用 |
WO2021007269A1 (fr) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
WO2021076728A1 (fr) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
CA3162010A1 (fr) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derives d'un inhibiteur de fgfr |
US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
CA3220274A1 (fr) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Heterocycles tricycliques en tant qu'inhibiteurs de fgfr |
CA3241213A1 (fr) * | 2021-12-15 | 2023-06-22 | Heidi Lane | Combinaisons pharmaceutiques destinees a etre utilisees dans le traitement du cancer |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9903965A3 (en) | 1996-08-28 | 2002-02-28 | Pfizer | Substituted 6,5-hetero-bicyclic derivatives |
CN1173975C (zh) | 2000-04-27 | 2004-11-03 | 山之内制药株式会社 | 咪唑并吡啶衍生物 |
TWI335328B (en) | 2003-07-14 | 2011-01-01 | Arena Pharm Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related hereto |
EP1713784A1 (fr) | 2004-02-12 | 2006-10-25 | Neurogen Corporation | Imidazo-pyridazines, triazolo-pyridazines et ligands associes des recepteurs de benzodiazepine |
US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
WO2007025090A2 (fr) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibiteurs de kinase mapk/erk |
US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
AR056785A1 (es) * | 2005-11-10 | 2007-10-24 | Schering Corp | COMPUESTOS DE IMIDAZO[1,2-A]PIRAZINAS, uTILES COMO INHIBIDORES, REGULADORES O MODULADORES DE PROTEINQUINASAS |
TW200840584A (en) * | 2006-12-26 | 2008-10-16 | Gilead Sciences Inc | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
JP2010524953A (ja) * | 2007-04-17 | 2010-07-22 | ブリストル−マイヤーズ スクイブ カンパニー | 縮合ヘテロ環11−β−ヒドロキシステロイドデヒドロゲナーゼI型阻害剤 |
EP2217601A1 (fr) | 2007-11-08 | 2010-08-18 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Imidazopyridazines utilisées comme qu'inhibiteurs de protéine kinases |
US8389527B2 (en) | 2008-02-06 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
TWI491610B (zh) | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
WO2010088518A2 (fr) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Modulateurs hétérocycliques du gpr119 pour le traitement de maladies |
CN102413831B (zh) * | 2009-04-29 | 2014-06-04 | 拜耳知识产权有限责任公司 | 取代的咪唑并喹喔啉 |
TW201107329A (en) * | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
CA2772790C (fr) | 2009-09-04 | 2017-06-27 | Benjamin Bader | Aminoquinoxalines substituees servant d'inhibiteurs de tyrosine-threonine kinases |
EP2343294A1 (fr) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines substituées |
EP2343297A1 (fr) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
EP2343295A1 (fr) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Dérivés de triazolopyridine |
US9468642B2 (en) | 2010-03-18 | 2016-10-18 | Bayer Intellectual Property Gmbh | Imidazopyrazines |
CN103038235B (zh) | 2010-06-01 | 2015-07-29 | 拜耳知识产权有限责任公司 | 取代的咪唑并吡嗪 |
TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
CN103403006B (zh) | 2010-12-17 | 2015-11-25 | 拜耳知识产权有限责任公司 | 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的6-硫代-取代的咪唑并吡嗪 |
EP2651950A1 (fr) | 2010-12-17 | 2013-10-23 | Bayer Intellectual Property GmbH | Imidazopyrazines 6-substituées pour l'utilisation en tant qu'inhibiteurs de mps-1 et de tkk dans le traitement de troubles d'hyperprolifération |
CA2821837A1 (fr) | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | Imidazopyrazines 2-substituees pour l'utilisation en tant qu'inhibiteurs de mps-1 et de tkk dans le traitement de troubles d'hyperproliferation |
ES2556458T3 (es) | 2010-12-17 | 2016-01-18 | Bayer Intellectual Property Gmbh | 6-Imidazopirazinas sustituidas para uso como inhibidores de Mps-1 y TKK en el tratamiento de trastornos hiperproliferativos |
EP2651945A1 (fr) | 2010-12-17 | 2013-10-23 | Bayer Intellectual Property GmbH | Imidazopyrazines 6-substituées pour utilisation en tant qu'inhibiteurs de mps-1 et tkk dans le traitement de troubles hyperprolifératifs |
CA2821829A1 (fr) | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | Imidazopyrazines pour l'utilisation en tant qu'inhibiteurs de mps-1 et de tkk dans le traitement de troubles d'hyperproliferation |
-
2011
- 2011-08-25 TW TW100130542A patent/TWI541243B/zh not_active IP Right Cessation
- 2011-09-06 MY MYPI2013700375A patent/MY185139A/en unknown
- 2011-09-06 SG SG2013016480A patent/SG188417A1/en unknown
- 2011-09-06 WO PCT/EP2011/065368 patent/WO2012032031A1/fr active Application Filing
- 2011-09-06 BR BR112013005679A patent/BR112013005679A2/pt not_active IP Right Cessation
- 2011-09-06 KR KR1020137009011A patent/KR20140032337A/ko not_active Application Discontinuation
- 2011-09-06 US US13/822,175 patent/US9255100B2/en not_active Expired - Fee Related
- 2011-09-06 HU HUE11751910A patent/HUE028771T2/en unknown
- 2011-09-06 AU AU2011298844A patent/AU2011298844B2/en not_active Ceased
- 2011-09-06 JP JP2013527575A patent/JP5824050B2/ja not_active Expired - Fee Related
- 2011-09-06 ES ES11751910.8T patent/ES2568220T3/es active Active
- 2011-09-06 CA CA2810755A patent/CA2810755A1/fr not_active Abandoned
- 2011-09-06 AP AP2013006790A patent/AP3607A/xx active
- 2011-09-06 RS RS20160221A patent/RS54661B1/en unknown
- 2011-09-06 ME MEP-2016-63A patent/ME02389B/fr unknown
- 2011-09-06 MA MA35720A patent/MA34516B1/fr unknown
- 2011-09-06 MX MX2013002713A patent/MX2013002713A/es active IP Right Grant
- 2011-09-06 EA EA201390339A patent/EA023420B1/ru not_active IP Right Cessation
- 2011-09-06 DK DK11751910.8T patent/DK2614063T3/en active
- 2011-09-06 SI SI201130761A patent/SI2614063T1/sl unknown
- 2011-09-06 PL PL11751910T patent/PL2614063T3/pl unknown
- 2011-09-06 CU CUP2013000033A patent/CU24187B1/es active IP Right Grant
- 2011-09-06 NZ NZ607904A patent/NZ607904A/en not_active IP Right Cessation
- 2011-09-06 EP EP11751910.8A patent/EP2614063B1/fr active Active
- 2011-09-06 PE PE2013000392A patent/PE20131164A1/es not_active Application Discontinuation
- 2011-09-06 CN CN201180054217.5A patent/CN103370318B/zh not_active Expired - Fee Related
- 2011-09-07 SA SA111320735A patent/SA111320735B1/ar unknown
- 2011-09-08 UY UY0001033598A patent/UY33598A/es unknown
- 2011-09-09 AR ARP110103294A patent/AR082946A1/es unknown
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2013
- 2013-03-05 IL IL225058A patent/IL225058A/en active IP Right Grant
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- 2013-03-08 CO CO13047157A patent/CO6720961A2/es active IP Right Grant
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2014
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2016
- 2016-04-08 HR HRP20160360TT patent/HRP20160360T1/hr unknown
- 2016-04-12 CY CY20161100294T patent/CY1117352T1/el unknown
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