MA33566B1 - Thiohydantoïnes (hétéroarylméthyl) substituées utilisées comme médicaments anticancéreux - Google Patents

Thiohydantoïnes (hétéroarylméthyl) substituées utilisées comme médicaments anticancéreux

Info

Publication number
MA33566B1
MA33566B1 MA34666A MA34666A MA33566B1 MA 33566 B1 MA33566 B1 MA 33566B1 MA 34666 A MA34666 A MA 34666A MA 34666 A MA34666 A MA 34666A MA 33566 B1 MA33566 B1 MA 33566B1
Authority
MA
Morocco
Prior art keywords
thiohydantoids
heteroarylmethyl
substituted
anticancer drugs
prophylaxis
Prior art date
Application number
MA34666A
Other languages
Arabic (ar)
English (en)
Inventor
Ulrich Lücking
Arwed Cleve
Bernard Haendler
Gimenez Hortensia Faus
Silk Köhr
Horst Irlbacher
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MA33566B1 publication Critical patent/MA33566B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

CETTE INVENTION CONCERNE DES THIOHYDANTOÏNES (HÉTÉROARYLMÉTHYL) SUBSTITUÉES DE FORMULE GÉNÉRALE (I) ET LEURS PROCÉDÉS DE PRÉPARATION, LEUR UTILISATION DANS LE TRAITEMENT ET/OU LA PROPHYLAXIE DE CERTAINES AFFECTIONS, ET LEUR UTILISATION DANS LA PRÉPARATION DE MÉDICAMENTS POUR LE TRAITEMENT ET/OU LA PROPHYLAXIE DE CERTAINES AFFECTIONS, EN PARTICULIER LE CANCER DE LA PROSTATE.
MA34666A 2009-09-11 2012-03-08 Thiohydantoïnes (hétéroarylméthyl) substituées utilisées comme médicaments anticancéreux MA33566B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09075421 2009-09-11
EP10075069 2010-02-17
PCT/EP2010/005297 WO2011029537A1 (fr) 2009-09-11 2010-08-28 Thiohydantoïnes (hétéroarylméthyl) substituées utilisées comme médicaments anticancéreux

Publications (1)

Publication Number Publication Date
MA33566B1 true MA33566B1 (fr) 2012-09-01

Family

ID=42782041

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34666A MA33566B1 (fr) 2009-09-11 2012-03-08 Thiohydantoïnes (hétéroarylméthyl) substituées utilisées comme médicaments anticancéreux

Country Status (27)

Country Link
US (1) US20120251551A1 (fr)
EP (1) EP2475653A1 (fr)
JP (1) JP2013504523A (fr)
KR (1) KR20120065396A (fr)
CN (1) CN102639523A (fr)
AR (1) AR078166A1 (fr)
AU (1) AU2010294588A1 (fr)
BR (1) BR112012005526A2 (fr)
CA (1) CA2773591A1 (fr)
CL (1) CL2012000623A1 (fr)
CO (1) CO6511228A2 (fr)
CR (1) CR20120113A (fr)
CU (1) CU20120042A7 (fr)
DO (1) DOP2012000063A (fr)
EA (1) EA201200473A1 (fr)
EC (1) ECSP12011716A (fr)
IL (1) IL218390A0 (fr)
IN (1) IN2012DN02081A (fr)
MA (1) MA33566B1 (fr)
MX (1) MX2012002977A (fr)
NZ (1) NZ598643A (fr)
PE (1) PE20121180A1 (fr)
SG (1) SG178919A1 (fr)
TN (1) TN2012000108A1 (fr)
TW (1) TW201111378A (fr)
UY (1) UY32882A (fr)
WO (1) WO2011029537A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2540728B1 (fr) 2010-02-17 2019-04-10 Takeda Pharmaceutical Company Limited Composé hétérocyclique
EP2576536B1 (fr) * 2010-06-01 2016-09-14 The University of Queensland Inhibiteurs de la prostaglandine d2 synthase hématopoïétique
AP2014007796A0 (en) 2011-12-22 2014-07-31 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AR091156A1 (es) 2012-05-25 2015-01-14 Jansen R & D Ireland Nucleosidos de espirooxetano de uracilo
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之ｎ－（吡啶－２－基）嘧啶－４－胺衍生物
PT2935303T (pt) 2012-12-21 2021-04-30 Alios Biopharma Inc 4'-fluoro-nucleósidos, 4'-fluoro-nucleótidos e seus análogos para o tratamento de hcv
WO2014153280A1 (fr) * 2013-03-22 2014-09-25 Merck Sharp & Dohme Corp. Inhibiteurs de tyrosine kinase de la rate (syk) contenant du 2-pyridyl carboxamide
CN104341351B (zh) * 2013-07-30 2018-02-06 北京海美源医药科技有限公司 一种二芳基硫代乙内酰脲衍生物及其应用
FI3080100T3 (fi) * 2013-12-11 2023-03-15 Celgene Quanticel Res Inc Lysiinispesifisen demetylaasi-1:n estäjät
CN105829296A (zh) 2013-12-18 2016-08-03 巴斯夫欧洲公司 带有亚胺衍生的取代基的唑类化合物
US9682960B2 (en) * 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103896847B (zh) * 2014-04-09 2016-01-20 沈江 一种非甾体类抗雄激素化合物及其制备方法和应用
EP3140300B1 (fr) 2014-05-07 2019-08-14 Evotec International GmbH Quinazolines substituées par une sulfoximine destinées à des compositions pharmaceutiques
TWI656121B (zh) 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
CN106187905B (zh) * 2015-05-05 2020-02-21 北京海步医药科技股份有限公司 丁鲁他胺的结晶形式及其制备方法
JP6888000B2 (ja) 2015-10-08 2021-06-16 バイエル ファーマ アクチエンゲゼルシャフト 新規な修飾された大環状化合物
WO2017060322A2 (fr) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Conjugué anticorps-médicament (adc) inhibiteur de ptefb
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
PL3601253T3 (pl) 2017-03-28 2022-01-17 Bayer Aktiengesellschaft Nowe hamujące ptefb związki makrocykliczne
CA3057891A1 (fr) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Nouveaux composes macrocycliques inhibiteurs de ptefb
JP2020520373A (ja) 2017-05-18 2020-07-09 ピーアイ インダストリーズ リミテッドＰｉ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ 植物病原性微生物に対して有用なホルムイミドアミジン化合物
JP7280286B2 (ja) 2018-02-13 2023-05-23 バイエル アクチェンゲゼルシャフト びまん性大細胞型ｂ細胞リンパ腫を治療するための５－フルオロ－４－（４－フルオロ－２－メトキシフェニル）－ｎ－｛４－［（ｓ－メチルスルホンイミドイル）メチル］ピリジン－２－イル｝ピリジン－２－アミンの使用
EP3953342A4 (fr) * 2019-04-11 2023-01-11 University of Miami Inhibiteurs améliorés du complexe d'activation transcriptionnelle notch et leurs méthodes d'utilisation
CA3165120A1 (fr) * 2020-01-21 2021-07-29 Berkley E. GRYDER Heterocycles d'arylhydantoine et leurs procedes d'utilisation
WO2022206742A1 (fr) * 2021-03-30 2022-10-06 苏州开拓药业股份有限公司 Procédé de synthèse d'un dérivé de thiohydantoïne au moyen d'un procédé en une étape

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2671348B1 (fr) 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
US5411981A (en) 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
USRE35956E (en) 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (fr) 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2716110B1 (fr) 1994-02-16 1996-04-05 Roussel Uclaf Compositions cosmétiques ou pharmaceutiques comprenant des liposomes.
US5656651A (en) 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
CN1129581C (zh) 1998-09-22 2003-12-03 山之内制药株式会社 氰基苯基衍生物
US6472415B1 (en) 1998-12-18 2002-10-29 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
US6861432B2 (en) 2001-11-23 2005-03-01 Schering Aktiengesellschaft Piperazine derivatives that destabilize androgen receptors
AU2003216581A1 (en) 2002-04-12 2003-10-27 Pfizer Inc. Pyrazole compounds as anti-inflammatory and analgesic agents
WO2005005399A1 (fr) 2003-07-02 2005-01-20 Merck & Co., Inc. Antibiotiques a base d'oxazolidinone et derives
RU2006110561A (ru) 2003-09-30 2007-10-10 Янссен Фармацевтика Н.В. (Be) Соединения бензоимидазола
KR101164258B1 (ko) 2003-12-23 2012-07-11 아스텍스 테라퓨틱스 리미티드 단백질 키나아제 조절제로서의 피라졸 유도체
JP4912148B2 (ja) 2004-08-03 2012-04-11 中外製薬株式会社 新規イミダゾリジン誘導体
EP1790640A4 (fr) * 2004-09-09 2009-07-29 Chugai Pharmaceutical Co Ltd Nouveau dérivé d' imidazolidine et utilisation dudit dérivé
EP1824829B1 (fr) 2004-12-03 2010-05-05 F. Hoffmann-Roche AG Derives 3-substitues de pyridine en tant qu'antagonistes de h3
EP3970721A1 (fr) 2005-05-13 2022-03-23 The Regents Of The University Of California Composés diarylhydantoines en tant qu'antagonistes du récepteur d'androgène pour le traitement du cancer
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
US8110594B2 (en) 2006-03-29 2012-02-07 The Regents Of The University Of California Diarylthiohydantoin compounds
CA2966280A1 (fr) 2007-10-26 2009-04-30 The Regents Of The University Of California Composes de diaryl-hydantoine
EP2242745A1 (fr) * 2008-02-07 2010-10-27 Sanofi-Aventis Nouvelles imidazolidines substituées par un phényle, procédé de production, médicaments contenant ces composés et leur utilisation

Also Published As

Publication number Publication date
DOP2012000063A (es) 2012-05-15
CN102639523A (zh) 2012-08-15
PE20121180A1 (es) 2012-08-24
AU2010294588A1 (en) 2012-04-05
BR112012005526A2 (pt) 2016-04-26
IN2012DN02081A (fr) 2015-08-21
ECSP12011716A (es) 2012-04-30
CR20120113A (es) 2012-05-02
US20120251551A1 (en) 2012-10-04
WO2011029537A1 (fr) 2011-03-17
IL218390A0 (en) 2012-04-30
CL2012000623A1 (es) 2012-09-14
CU20120042A7 (es) 2012-06-21
KR20120065396A (ko) 2012-06-20
JP2013504523A (ja) 2013-02-07
UY32882A (es) 2011-04-29
TN2012000108A1 (en) 2013-09-19
SG178919A1 (en) 2012-04-27
EA201200473A1 (ru) 2012-10-30
NZ598643A (en) 2013-10-25
AR078166A1 (es) 2011-10-19
TW201111378A (en) 2011-04-01
EP2475653A1 (fr) 2012-07-18
CA2773591A1 (fr) 2011-03-17
MX2012002977A (es) 2012-04-30
CO6511228A2 (es) 2012-08-31

Similar Documents

Publication Publication Date Title
MA33566B1 (fr) Thiohydantoïnes (hétéroarylméthyl) substituées utilisées comme médicaments anticancéreux
CA2883210C (fr) Composes aza bicycliques utilises comme agonistes du recepteur muscarinique m1
PH12015500940A1 (en) Bruton`s tyrosine kinase inhibitors
MX356205B (es) Benzopirazinas anticancerigenas via la inhibicion de cinasas del receptor del factor de crecimiento de fibroblasto (fgfr).
JO3419B1 (ar) مركبات بيريدوبيرازين مضادة للسرطان من خلال تثبيط إنزيمات كيناز fgfr
TN2015000174A1 (en) Pyrrolopyrimidine compounds as kinase inhibitors
IN2014KN02601A (fr)
MX353806B (es) Quinolinas como moduladores de cinasas del receptor del factor de crecimiento de fibroblasto (fgfr).
PH12014502772A1 (en) Substituted tricyclic compounds as fgfr inhibitors
EA024842B9 (ru) Соединения в качестве модуляторов протеинкиназы pi3k
MX2011010673A (es) Formulaciones de nanoparticulas y usos de las mismas.
MY157124A (en) Substituted imidazopyridinyl-aminopyridine compounds
WO2008086462A3 (fr) Dérivés de quinalozine substitués par amino en tant qu'inhibiteurs de la voie b-caténine/tcf-4 et agents de traitement du cancer
MA37742B1 (fr) Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments
WO2013112950A3 (fr) Entités chimiques particulières, compositions et procédés
FR2921927B1 (fr) Imidazo°1,2-a!quinoxalines et derives pour le traitement des cancers
MA38349A1 (fr) Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)
MA38190A2 (fr) Inhibiteurs d'autotaxine
WO2009151495A3 (fr) Composés oxazoles, compositions et procédés d'utilisation
Xu et al. Novel targeted therapy for advanced gastric cancer
FR2985256B1 (fr) Derives piperazinyles pour le traitement de cancers
UA110910C2 (uk) Карбоксамідні похідні піразолу як інгібітори тирозинкінази брутона, фармацевтична композиція на їх основі та спосіб лікування захворювань (варіанти)
EP2575766A4 (fr) Nouveaux composés pharmaceutiques
MX2012007471A (es) Compuestos substituidos de pirrolo-aminopirimidina.