MA38349A1 - Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3) - Google Patents
Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)Info
- Publication number
- MA38349A1 MA38349A1 MA38349A MA38349A MA38349A1 MA 38349 A1 MA38349 A1 MA 38349A1 MA 38349 A MA38349 A MA 38349A MA 38349 A MA38349 A MA 38349A MA 38349 A1 MA38349 A1 MA 38349A1
- Authority
- MA
- Morocco
- Prior art keywords
- akr1c3
- tetraeno
- estra
- carboxamide
- beta
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
Abstract
L'invention concerne des inhibiteurs de l'akr1c3 suivant la formule (i) et des procédés pour les préparer, leur utilisation dans le traitement et/ou la prévention de maladies ainsi que leur utilisation pour fabriquer des médicaments destinés au traitement et/ou à la prévention de maladies, en particulier des troubles hémorragiques et de l'endométriose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13156125 | 2013-02-21 | ||
PCT/EP2014/053094 WO2014128108A1 (fr) | 2013-02-21 | 2014-02-18 | Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3) |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38349A1 true MA38349A1 (fr) | 2017-02-28 |
Family
ID=47748503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38349A MA38349A1 (fr) | 2013-02-21 | 2014-02-18 | Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3) |
Country Status (28)
Country | Link |
---|---|
US (1) | US9714266B2 (fr) |
EP (1) | EP2958928B1 (fr) |
JP (1) | JP6254195B2 (fr) |
KR (1) | KR20150118153A (fr) |
CN (1) | CN105008382B (fr) |
AP (1) | AP3826A (fr) |
AR (1) | AR094852A1 (fr) |
AU (1) | AU2014220800A1 (fr) |
BR (1) | BR112015018071A2 (fr) |
CA (1) | CA2901632C (fr) |
CL (1) | CL2015002346A1 (fr) |
CR (1) | CR20150432A (fr) |
CU (1) | CU20150091A7 (fr) |
EA (1) | EA201500851A1 (fr) |
ES (1) | ES2678993T3 (fr) |
GT (1) | GT201500235A (fr) |
HK (1) | HK1211592A1 (fr) |
IL (1) | IL240191A0 (fr) |
MA (1) | MA38349A1 (fr) |
MX (1) | MX2015010876A (fr) |
NI (1) | NI201500115A (fr) |
PE (1) | PE20151754A1 (fr) |
PH (1) | PH12015501819A1 (fr) |
SG (1) | SG11201505875WA (fr) |
TN (1) | TN2015000362A1 (fr) |
TW (1) | TWI523862B (fr) |
UY (1) | UY35344A (fr) |
WO (1) | WO2014128108A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170260226A1 (en) * | 2014-09-11 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | 3-nitrogen or sulphur substituted oestra-1,3,5(10),16-tetraene akr1c3 inhibitors |
US20200264187A1 (en) * | 2016-01-05 | 2020-08-20 | Hamamatsu Photonics K.K. | Living body observation method and living body observation device |
US10167293B2 (en) | 2016-05-26 | 2019-01-01 | Bayer Pharma Aktiengesellschaft | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones |
CZ307437B6 (cs) | 2016-06-07 | 2018-08-22 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz |
EP3269373A1 (fr) | 2016-07-11 | 2018-01-17 | Bayer Pharma Aktiengesellschaft | Formes posologiques orales à faible dosage d'un inhibiteur de akr1c3 pour le traitement des maladies |
WO2018114672A1 (fr) | 2016-12-19 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | [4-(phénylsulfonyl)pipérazin-1-yl](1h-1,2,3-triazol-4-yl)méthanones |
TW201825478A (zh) | 2016-12-19 | 2018-07-16 | 德商拜耳製藥公司 | [4-(苯基磺醯基)哌嗪-1--基](1h-1,2,3-三唑-4-基)甲酮 |
US20200085791A1 (en) | 2016-12-19 | 2020-03-19 | Bayer Pharma Aktiengesellschaft | [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones |
EP3421483A1 (fr) | 2017-06-29 | 2019-01-02 | Bayer Pharma Aktiengesellschaft | Nouveaux dérivés 17-beta-hétéroaryle des stéroïdes comme inhibiteurs de akr1c3 |
CN108159056A (zh) * | 2018-02-09 | 2018-06-15 | 上海礼璞生物医药科技有限公司 | 孕激素在制备组蛋白去乙酰化酶抑制剂和气道周围胶原沉积抑制剂药物中的应用及抑制剂 |
CN110693892A (zh) * | 2018-07-09 | 2020-01-17 | 深圳艾欣达伟医药科技有限公司 | 化合物用于制备预防、治疗或改善疼痛的药物的用途 |
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EP1094798A2 (fr) * | 1998-03-11 | 2001-05-02 | Endorecherche Inc. | INHIBITEURS DE LA 17beta-HYDROXYSTEROIDE DESHYDROGENASE DU TYPE 5 ET DU TYPE 3 ET METHODES D'UTILISATION ASSOCIEES |
EP1102582A2 (fr) * | 1998-08-07 | 2001-05-30 | Endorecherche Inc. | INHIBITION DE LA 3$G(a)-HYDROXYSTEROID-DESHYDROGENASE DE TYPE 3 |
CA2558014A1 (fr) | 2004-03-12 | 2005-09-29 | Entremed, Inc. | Agents anti-angiogeniques |
KR20080114711A (ko) | 2006-03-02 | 2008-12-31 | 아스텔라스세이야쿠 가부시키가이샤 | 17β HSD 타입 5 저해제 |
WO2008065100A1 (fr) | 2006-11-30 | 2008-06-05 | Solvay Pharmaceuticals Gmbh | Dérivés oestatriènes substitués en tant qu'inhibiteurs de la 17beta hsd |
JP2010513384A (ja) | 2006-12-22 | 2010-04-30 | エフ.ホフマン−ラ ロシュ アーゲー | スピロ−ピペリジン誘導体 |
US20100190826A1 (en) | 2007-07-24 | 2010-07-29 | Akio Kakefuda | Benzimidazole derivative |
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AU2010295646B2 (en) | 2009-09-15 | 2016-02-11 | Ellipses Pharma Limited | Treatment of cancer |
CN104302958B (zh) | 2011-07-08 | 2017-04-05 | Fmc技术股份有限公司 | 具有多个铰接臂组件的管汇拖车 |
DE102011083725A1 (de) | 2011-09-29 | 2013-04-04 | Bayer Pharma AG | Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
AP2014008179A0 (en) * | 2012-07-10 | 2014-12-31 | Bayer Pharma AG | 3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments |
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2014
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- 2014-02-18 WO PCT/EP2014/053094 patent/WO2014128108A1/fr active Application Filing
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