GT201500235A - Estra -1,3,5 (10) , 16- tetraeno -3-carboxamidas para la inhibicion de la 17b-hidroxiesteroide deshidrogenasa (akr1c3) - Google Patents
Estra -1,3,5 (10) , 16- tetraeno -3-carboxamidas para la inhibicion de la 17b-hidroxiesteroide deshidrogenasa (akr1c3)Info
- Publication number
- GT201500235A GT201500235A GT201500235A GT201500235A GT201500235A GT 201500235 A GT201500235 A GT 201500235A GT 201500235 A GT201500235 A GT 201500235A GT 201500235 A GT201500235 A GT 201500235A GT 201500235 A GT201500235 A GT 201500235A
- Authority
- GT
- Guatemala
- Prior art keywords
- akr1c3
- carboxamids
- estra
- tetraene
- inhibition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
Abstract
LA INVENCIÓN SE REFIERE A AKR1C3 INHIBIDORES DE LA FÓRMULA (I) Y A PROCEDIMIENTOS PARA SU PREPARACIÓN, A SU USO PARA EL TRATAMIENTO Y / O PROFILAXIS DE ENFERMEDADES Y PARA EL USO DE LOS MISMOS PARA LA PRODUCCIÓN DE MEDICAMENTOS PARA EL TRATAMIENTO Y / O PROFILAXIS DE ENFERMEDADES, ESPECIALMENTE DE LAS QUEJAS MENSTRUALES Y ENDOMETRIOSIS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13156125 | 2013-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT201500235A true GT201500235A (es) | 2016-03-08 |
Family
ID=47748503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT201500235A GT201500235A (es) | 2013-02-21 | 2015-08-21 | Estra -1,3,5 (10) , 16- tetraeno -3-carboxamidas para la inhibicion de la 17b-hidroxiesteroide deshidrogenasa (akr1c3) |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9714266B2 (es) |
| EP (1) | EP2958928B1 (es) |
| JP (1) | JP6254195B2 (es) |
| KR (1) | KR20150118153A (es) |
| CN (1) | CN105008382B (es) |
| AP (1) | AP3826A (es) |
| AR (1) | AR094852A1 (es) |
| AU (1) | AU2014220800A1 (es) |
| BR (1) | BR112015018071A2 (es) |
| CA (1) | CA2901632C (es) |
| CL (1) | CL2015002346A1 (es) |
| CR (1) | CR20150432A (es) |
| CU (1) | CU20150091A7 (es) |
| EA (1) | EA201500851A1 (es) |
| ES (1) | ES2678993T3 (es) |
| GT (1) | GT201500235A (es) |
| HK (1) | HK1211592A1 (es) |
| IL (1) | IL240191A0 (es) |
| MA (1) | MA38349A1 (es) |
| MX (1) | MX2015010876A (es) |
| NI (1) | NI201500115A (es) |
| PE (1) | PE20151754A1 (es) |
| PH (1) | PH12015501819A1 (es) |
| SG (1) | SG11201505875WA (es) |
| TN (1) | TN2015000362A1 (es) |
| TW (1) | TWI523862B (es) |
| UY (1) | UY35344A (es) |
| WO (1) | WO2014128108A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016037956A1 (en) * | 2014-09-11 | 2016-03-17 | Bayer Pharma Aktiengesellschaft | 3-nitrogen or sulphur substituted oestra-1,3,5(10),16-tetraene akr1c3 inhibitors |
| CN108474780A (zh) * | 2016-01-05 | 2018-08-31 | 浜松光子学株式会社 | 生物体观察方法和生物体观察装置 |
| US10167293B2 (en) | 2016-05-26 | 2019-01-01 | Bayer Pharma Aktiengesellschaft | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones |
| CZ307437B6 (cs) | 2016-06-07 | 2018-08-22 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz |
| EP3269373A1 (en) | 2016-07-11 | 2018-01-17 | Bayer Pharma Aktiengesellschaft | Low-dosed oral dosage form of an akr1c3 inhibitor for treatment of diseases |
| CA3047196A1 (en) | 2016-12-19 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones |
| US20200087284A1 (en) | 2016-12-19 | 2020-03-19 | Bayer Pharma Aktiengesellschaft | [4-(phenylsulfonyl)piperazin-1-yl](1h-1, 2, 3-triazol-4-yl)methanones |
| TW201825478A (zh) | 2016-12-19 | 2018-07-16 | 德商拜耳製藥公司 | ［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮 |
| EP3421483A1 (en) | 2017-06-29 | 2019-01-02 | Bayer Pharma Aktiengesellschaft | Novel steroidal 17-beta heteroaryl compounds as inhibitors of akr1c3 |
| CN108159056A (zh) * | 2018-02-09 | 2018-06-15 | 上海礼璞生物医药科技有限公司 | 孕激素在制备组蛋白去乙酰化酶抑制剂和气道周围胶原沉积抑制剂药物中的应用及抑制剂 |
| CN110693892A (zh) * | 2018-07-09 | 2020-01-17 | 深圳艾欣达伟医药科技有限公司 | 化合物用于制备预防、治疗或改善疼痛的药物的用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604213A (en) | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| IL122740A (en) | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| JP2001518896A (ja) | 1997-04-07 | 2001-10-16 | アメリカン・ホーム・プロダクツ・コーポレイション | エストロゲン活性を有するエストラ−５（１０），７−ジエン |
| BR9908592A (pt) * | 1998-03-11 | 2001-04-24 | Endorech Inc | Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit |
| AR021757A1 (es) * | 1998-08-07 | 2002-08-07 | Endorech Inc | Metodo para inhibir la conversion de 4-androstan-3,17-diona en testosterona o de 3alfa-androstan-3,17-diona en dihidrotestosterona, inhibir la actividadde la 3alfa-hidroxiesteroide deshidrogenasa de tipo 3 humana, para determinar la eficacia de un inhibidor putativo de la conversion de 4-androsten-3 |
| JP2007529426A (ja) | 2004-03-12 | 2007-10-25 | エントレメッド インコーポレイテッド | 抗血管新生薬 |
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| GB2470700B (en) | 2008-03-25 | 2012-08-08 | Univ Maryland | C-17 heteroaryl steroidal CYP17 inhibitors |
| US20110312916A1 (en) | 2009-02-05 | 2011-12-22 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| CA2774015A1 (en) | 2009-09-15 | 2011-03-24 | Cerulean Pharma Inc. | A cdp-camptothecin conjugate, particle or composition and uses thereof |
| AU2011372831B2 (en) | 2011-07-08 | 2015-08-20 | Fmc Technologies, Inc. | Manifold trailer with multiple articulating arm assemblies |
| DE102011083725A1 (de) * | 2011-09-29 | 2013-04-04 | Bayer Pharma AG | Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| CA2878485A1 (en) | 2012-07-10 | 2014-01-16 | Bayer Pharma Aktiengesellschaft | 3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments |
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2014
- 2014-02-18 CN CN201480009874.1A patent/CN105008382B/zh not_active Expired - Fee Related
- 2014-02-18 AU AU2014220800A patent/AU2014220800A1/en not_active Abandoned
- 2014-02-18 JP JP2015558418A patent/JP6254195B2/ja not_active Expired - Fee Related
- 2014-02-18 KR KR1020157022300A patent/KR20150118153A/ko not_active Application Discontinuation
- 2014-02-18 AP AP2015008658A patent/AP3826A/en active
- 2014-02-18 EP EP14704817.7A patent/EP2958928B1/de active Active
- 2014-02-18 PE PE2015001794A patent/PE20151754A1/es not_active Application Discontinuation
- 2014-02-18 EA EA201500851A patent/EA201500851A1/ru unknown
- 2014-02-18 WO PCT/EP2014/053094 patent/WO2014128108A1/de active Application Filing
- 2014-02-18 MA MA38349A patent/MA38349A1/fr unknown
- 2014-02-18 ES ES14704817.7T patent/ES2678993T3/es active Active
- 2014-02-18 BR BR112015018071A patent/BR112015018071A2/pt not_active IP Right Cessation
- 2014-02-18 SG SG11201505875WA patent/SG11201505875WA/en unknown
- 2014-02-18 US US14/770,444 patent/US9714266B2/en not_active Expired - Fee Related
- 2014-02-18 CA CA2901632A patent/CA2901632C/en not_active Expired - Fee Related
- 2014-02-18 MX MX2015010876A patent/MX2015010876A/es unknown
- 2014-02-21 TW TW103105963A patent/TWI523862B/zh not_active IP Right Cessation
- 2014-02-21 UY UY0001035344A patent/UY35344A/es not_active Application Discontinuation
- 2014-02-21 AR ARP140100555A patent/AR094852A1/es unknown
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2015
- 2015-07-28 IL IL240191A patent/IL240191A0/en unknown
- 2015-08-18 PH PH12015501819A patent/PH12015501819A1/en unknown
- 2015-08-20 CU CUP2015000091A patent/CU20150091A7/es unknown
- 2015-08-21 TN TN2015000362A patent/TN2015000362A1/en unknown
- 2015-08-21 CL CL2015002346A patent/CL2015002346A1/es unknown
- 2015-08-21 CR CR20150432A patent/CR20150432A/es unknown
- 2015-08-21 GT GT201500235A patent/GT201500235A/es unknown
- 2015-08-21 NI NI201500115A patent/NI201500115A/es unknown
- 2015-12-11 HK HK15112236.2A patent/HK1211592A1/xx unknown
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