HK1211592A1 - Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (akr1 c3) 17-(akr1 c3)-135(10)16--3- - Google Patents
Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (akr1 c3) 17-(akr1 c3)-135(10)16--3-Info
- Publication number
- HK1211592A1 HK1211592A1 HK15112236.2A HK15112236A HK1211592A1 HK 1211592 A1 HK1211592 A1 HK 1211592A1 HK 15112236 A HK15112236 A HK 15112236A HK 1211592 A1 HK1211592 A1 HK 1211592A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- akr1
- estra
- tetraene
- carboxamides
- inhibition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13156125 | 2013-02-21 | ||
| PCT/EP2014/053094 WO2014128108A1 (de) | 2013-02-21 | 2014-02-18 | Estra-1,3,5(10),16-tetraen-3-carboxamide zur inhibierung von 17.beta.-hydroxysteroid dehdrogenase (akr1 c3) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1211592A1 true HK1211592A1 (en) | 2016-05-27 |
Family
ID=47748503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15112236.2A HK1211592A1 (en) | 2013-02-21 | 2015-12-11 | Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (akr1 c3) 17-(akr1 c3)-135(10)16--3- |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9714266B2 (es) |
| EP (1) | EP2958928B1 (es) |
| JP (1) | JP6254195B2 (es) |
| KR (1) | KR20150118153A (es) |
| CN (1) | CN105008382B (es) |
| AP (1) | AP3826A (es) |
| AR (1) | AR094852A1 (es) |
| AU (1) | AU2014220800A1 (es) |
| BR (1) | BR112015018071A2 (es) |
| CA (1) | CA2901632C (es) |
| CL (1) | CL2015002346A1 (es) |
| CR (1) | CR20150432A (es) |
| CU (1) | CU20150091A7 (es) |
| EA (1) | EA201500851A1 (es) |
| ES (1) | ES2678993T3 (es) |
| GT (1) | GT201500235A (es) |
| HK (1) | HK1211592A1 (es) |
| IL (1) | IL240191A0 (es) |
| MA (1) | MA38349A1 (es) |
| MX (1) | MX2015010876A (es) |
| NI (1) | NI201500115A (es) |
| PE (1) | PE20151754A1 (es) |
| PH (1) | PH12015501819A1 (es) |
| SG (1) | SG11201505875WA (es) |
| TN (1) | TN2015000362A1 (es) |
| TW (1) | TWI523862B (es) |
| UY (1) | UY35344A (es) |
| WO (1) | WO2014128108A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2960630A1 (en) * | 2014-09-11 | 2016-03-17 | Bayer Pharma Aktiengesellschaft | 3-nitrogen or sulphur substituted oestra-1,3,5(10),16-tetraene akr1c3 inhibitors |
| JPWO2017119340A1 (ja) * | 2016-01-05 | 2018-10-25 | 浜松ホトニクス株式会社 | 生体観察方法及び生体観察装置 |
| US10167293B2 (en) | 2016-05-26 | 2019-01-01 | Bayer Pharma Aktiengesellschaft | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones |
| CZ307437B6 (cs) | 2016-06-07 | 2018-08-22 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz |
| EP3269373A1 (en) | 2016-07-11 | 2018-01-17 | Bayer Pharma Aktiengesellschaft | Low-dosed oral dosage form of an akr1c3 inhibitor for treatment of diseases |
| WO2018114677A2 (en) | 2016-12-19 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones |
| EP3555067A1 (en) | 2016-12-19 | 2019-10-23 | Bayer Pharma Aktiengesellschaft | [4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones |
| TW201825478A (zh) | 2016-12-19 | 2018-07-16 | 德商拜耳製藥公司 | ［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮 |
| EP3421483A1 (en) | 2017-06-29 | 2019-01-02 | Bayer Pharma Aktiengesellschaft | Novel steroidal 17-beta heteroaryl compounds as inhibitors of akr1c3 |
| CN108159056A (zh) * | 2018-02-09 | 2018-06-15 | 上海礼璞生物医药科技有限公司 | 孕激素在制备组蛋白去乙酰化酶抑制剂和气道周围胶原沉积抑制剂药物中的应用及抑制剂 |
| CN110693892A (zh) * | 2018-07-09 | 2020-01-17 | 深圳艾欣达伟医药科技有限公司 | 化合物用于制备预防、治疗或改善疼痛的药物的用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604213A (en) | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| IL122740A (en) | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| CN1259137A (zh) | 1997-04-07 | 2000-07-05 | 美国家用产品公司 | 具有雌激素活性的雌－5(10),7－二烯 |
| CN1429104A (zh) * | 1998-03-11 | 2003-07-09 | 内部研究股份有限公司 | 5型和3型17β－羟基类固醇脱氢酶的抑制剂及其用法 |
| EP1102582A2 (en) * | 1998-08-07 | 2001-05-30 | Endorecherche Inc. | Inhibitors of type 3 3alpha-hydroxysteroid dehydrogenase |
| EP1756139A4 (en) | 2004-03-12 | 2009-07-29 | Entremed Inc | ANTI-ANGIOGENIC AGENTS |
| EP1990335A4 (en) | 2006-03-02 | 2009-11-11 | Astellas Pharma Inc | 17-BETA-HSD-type-5 INHIBITOR |
| CN101568547B (zh) | 2006-11-30 | 2014-06-25 | 索尔瓦药物有限公司 | 作为17βHSD抑制剂的被取代的雌三烯衍生物 |
| WO2008077810A2 (en) | 2006-12-22 | 2008-07-03 | F. Hoffmann-La Roche Ag | Spiro-piperidine derivatives |
| US20100190826A1 (en) | 2007-07-24 | 2010-07-29 | Akio Kakefuda | Benzimidazole derivative |
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2014
- 2014-02-18 US US14/770,444 patent/US9714266B2/en not_active Expired - Fee Related
- 2014-02-18 MX MX2015010876A patent/MX2015010876A/es unknown
- 2014-02-18 AU AU2014220800A patent/AU2014220800A1/en not_active Abandoned
- 2014-02-18 KR KR1020157022300A patent/KR20150118153A/ko not_active Application Discontinuation
- 2014-02-18 BR BR112015018071A patent/BR112015018071A2/pt not_active IP Right Cessation
- 2014-02-18 EP EP14704817.7A patent/EP2958928B1/de active Active
- 2014-02-18 CA CA2901632A patent/CA2901632C/en not_active Expired - Fee Related
- 2014-02-18 SG SG11201505875WA patent/SG11201505875WA/en unknown
- 2014-02-18 EA EA201500851A patent/EA201500851A1/ru unknown
- 2014-02-18 ES ES14704817.7T patent/ES2678993T3/es active Active
- 2014-02-18 CN CN201480009874.1A patent/CN105008382B/zh not_active Expired - Fee Related
- 2014-02-18 WO PCT/EP2014/053094 patent/WO2014128108A1/de active Application Filing
- 2014-02-18 PE PE2015001794A patent/PE20151754A1/es not_active Application Discontinuation
- 2014-02-18 MA MA38349A patent/MA38349A1/fr unknown
- 2014-02-18 JP JP2015558418A patent/JP6254195B2/ja not_active Expired - Fee Related
- 2014-02-18 AP AP2015008658A patent/AP3826A/en active
- 2014-02-21 AR ARP140100555A patent/AR094852A1/es unknown
- 2014-02-21 UY UY0001035344A patent/UY35344A/es not_active Application Discontinuation
- 2014-02-21 TW TW103105963A patent/TWI523862B/zh not_active IP Right Cessation
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2015
- 2015-07-28 IL IL240191A patent/IL240191A0/en unknown
- 2015-08-18 PH PH12015501819A patent/PH12015501819A1/en unknown
- 2015-08-20 CU CUP2015000091A patent/CU20150091A7/es unknown
- 2015-08-21 NI NI201500115A patent/NI201500115A/es unknown
- 2015-08-21 GT GT201500235A patent/GT201500235A/es unknown
- 2015-08-21 CL CL2015002346A patent/CL2015002346A1/es unknown
- 2015-08-21 CR CR20150432A patent/CR20150432A/es unknown
- 2015-08-21 TN TN2015000362A patent/TN2015000362A1/en unknown
- 2015-12-11 HK HK15112236.2A patent/HK1211592A1/xx unknown
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