CU20150091A7 - Estra-1, 3,5(10), 16tetraeno-3-carboxamidas para la inhibición de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3) - Google Patents

Estra-1, 3,5(10), 16tetraeno-3-carboxamidas para la inhibición de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3)

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Publication number
CU20150091A7
CU20150091A7 CUP2015000091A CU20150091A CU20150091A7 CU 20150091 A7 CU20150091 A7 CU 20150091A7 CU P2015000091 A CUP2015000091 A CU P2015000091A CU 20150091 A CU20150091 A CU 20150091A CU 20150091 A7 CU20150091 A7 CU 20150091A7
Authority
CU
Cuba
Prior art keywords
carboxamids
akr1
estra
tetraene
inhibition
Prior art date
Application number
CUP2015000091A
Other languages
English (en)
Inventor
Ulrich Bothe
Matthias Busemann
Naomi Barak
Andrea Rotgeri
Oliver Martin Fischer
Tobias Marquardt
Original Assignee
Bayer Fharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Fharma Ag filed Critical Bayer Fharma Ag
Publication of CU20150091A7 publication Critical patent/CU20150091A7/es

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    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Inhibidores de AKR1C3 de fórmula (I) útiles en el tratamiento y/o profilaxis de enfermedades, en especial de trastornos de sangrado y endometriosis
CUP2015000091A 2013-02-21 2015-08-20 Estra-1, 3,5(10), 16tetraeno-3-carboxamidas para la inhibición de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3) CU20150091A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13156125 2013-02-21
PCT/EP2014/053094 WO2014128108A1 (de) 2013-02-21 2014-02-18 Estra-1,3,5(10),16-tetraen-3-carboxamide zur inhibierung von 17.beta.-hydroxysteroid dehdrogenase (akr1 c3)

Publications (1)

Publication Number Publication Date
CU20150091A7 true CU20150091A7 (es) 2016-02-29

Family

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Application Number Title Priority Date Filing Date
CUP2015000091A CU20150091A7 (es) 2013-02-21 2015-08-20 Estra-1, 3,5(10), 16tetraeno-3-carboxamidas para la inhibición de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3)

Country Status (28)

Country Link
US (1) US9714266B2 (es)
EP (1) EP2958928B1 (es)
JP (1) JP6254195B2 (es)
KR (1) KR20150118153A (es)
CN (1) CN105008382B (es)
AP (1) AP3826A (es)
AR (1) AR094852A1 (es)
AU (1) AU2014220800A1 (es)
BR (1) BR112015018071A2 (es)
CA (1) CA2901632C (es)
CL (1) CL2015002346A1 (es)
CR (1) CR20150432A (es)
CU (1) CU20150091A7 (es)
EA (1) EA201500851A1 (es)
ES (1) ES2678993T3 (es)
GT (1) GT201500235A (es)
HK (1) HK1211592A1 (es)
IL (1) IL240191A0 (es)
MA (1) MA38349A1 (es)
MX (1) MX2015010876A (es)
NI (1) NI201500115A (es)
PE (1) PE20151754A1 (es)
PH (1) PH12015501819A1 (es)
SG (1) SG11201505875WA (es)
TN (1) TN2015000362A1 (es)
TW (1) TWI523862B (es)
UY (1) UY35344A (es)
WO (1) WO2014128108A1 (es)

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EP3269373A1 (en) 2016-07-11 2018-01-17 Bayer Pharma Aktiengesellschaft Low-dosed oral dosage form of an akr1c3 inhibitor for treatment of diseases
CA3047191A1 (en) 2016-12-19 2018-06-28 Bayer Pharma Aktiengesellschaft [4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones
TW201825478A (zh) 2016-12-19 2018-07-16 德商拜耳製藥公司 ［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮
WO2018114677A2 (en) 2016-12-19 2018-06-28 Bayer Pharma Aktiengesellschaft [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
EP3421483A1 (en) 2017-06-29 2019-01-02 Bayer Pharma Aktiengesellschaft Novel steroidal 17-beta heteroaryl compounds as inhibitors of akr1c3
CN108159056A (zh) * 2018-02-09 2018-06-15 上海礼璞生物医药科技有限公司 孕激素在制备组蛋白去乙酰化酶抑制剂和气道周围胶原沉积抑制剂药物中的应用及抑制剂
CN110693892A (zh) * 2018-07-09 2020-01-17 深圳艾欣达伟医药科技有限公司 化合物用于制备预防、治疗或改善疼痛的药物的用途

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EA201500851A1 (ru) 2016-02-29
TN2015000362A1 (en) 2017-01-03
CN105008382A (zh) 2015-10-28
KR20150118153A (ko) 2015-10-21
CR20150432A (es) 2015-10-19
TW201444861A (zh) 2014-12-01
EP2958928A1 (de) 2015-12-30
JP6254195B2 (ja) 2017-12-27
AR094852A1 (es) 2015-09-02
HK1211592A1 (en) 2016-05-27
PE20151754A1 (es) 2015-12-20
SG11201505875WA (en) 2015-09-29
CA2901632C (en) 2017-11-07
MA38349A1 (fr) 2017-02-28
EP2958928B1 (de) 2018-03-28
CL2015002346A1 (es) 2015-12-28
UY35344A (es) 2014-09-30
ES2678993T3 (es) 2018-08-21
JP2016509038A (ja) 2016-03-24
US20160024142A1 (en) 2016-01-28
TWI523862B (zh) 2016-03-01
IL240191A0 (en) 2015-09-24
BR112015018071A2 (pt) 2017-07-18
CN105008382B (zh) 2018-01-30
US9714266B2 (en) 2017-07-25
CA2901632A1 (en) 2014-08-28
NI201500115A (es) 2015-10-20
GT201500235A (es) 2016-03-08
AP3826A (en) 2016-09-30
MX2015010876A (es) 2015-12-03
AU2014220800A1 (en) 2015-08-27
WO2014128108A1 (de) 2014-08-28
AP2015008658A0 (en) 2015-08-31
PH12015501819A1 (en) 2015-12-07

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