MX364486B - Derivados de piridazinona-amidas. - Google Patents

Derivados de piridazinona-amidas.

Info

Publication number
MX364486B
MX364486B MX2015010125A MX2015010125A MX364486B MX 364486 B MX364486 B MX 364486B MX 2015010125 A MX2015010125 A MX 2015010125A MX 2015010125 A MX2015010125 A MX 2015010125A MX 364486 B MX364486 B MX 364486B
Authority
MX
Mexico
Prior art keywords
pyridazinone
amides derivatives
amides
derivatives
prophylaxis
Prior art date
Application number
MX2015010125A
Other languages
English (en)
Other versions
MX2015010125A (es
Inventor
Jorand-Lebrun Catherine
Crosignani Stefano
Kulkarni Santosh
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2015010125A publication Critical patent/MX2015010125A/es
Publication of MX364486B publication Critical patent/MX364486B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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Abstract

La presente invención se relaciona con compuestos de la fórmula (I), en donde R1, Ra, Rb, y Z tienen el significado dado en la reivindicación 1, y su uso en la profilaxis y tratamiento de enfermedades.
MX2015010125A 2013-02-07 2014-02-06 Derivados de piridazinona-amidas. MX364486B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13154390 2013-02-07
PCT/EP2014/000316 WO2014121931A1 (en) 2013-02-07 2014-02-06 Pyridazinone-amides derivatives

Publications (2)

Publication Number Publication Date
MX2015010125A MX2015010125A (es) 2016-04-25
MX364486B true MX364486B (es) 2019-04-29

Family

ID=47681772

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015010125A MX364486B (es) 2013-02-07 2014-02-06 Derivados de piridazinona-amidas.

Country Status (22)

Country Link
US (2) US9567320B2 (es)
EP (1) EP2953944B1 (es)
JP (1) JP6483624B2 (es)
KR (1) KR102293952B1 (es)
CN (1) CN104968658B (es)
AU (1) AU2014214321B2 (es)
BR (1) BR112015018663A2 (es)
CA (1) CA2900431C (es)
DK (1) DK2953944T3 (es)
ES (1) ES2634627T3 (es)
HR (1) HRP20171076T1 (es)
HU (1) HUE032863T2 (es)
IL (1) IL240290B (es)
LT (1) LT2953944T (es)
MX (1) MX364486B (es)
PL (1) PL2953944T3 (es)
PT (1) PT2953944T (es)
RS (1) RS56331B1 (es)
RU (1) RU2666899C2 (es)
SG (1) SG11201506100XA (es)
SI (1) SI2953944T1 (es)
WO (1) WO2014121931A1 (es)

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ES2861351T3 (es) 2015-04-22 2021-10-06 Rigel Pharmaceuticals Inc Compuestos de pirazol y método para fabricar y usar los compuestos
MX383707B (es) * 2015-09-18 2025-03-14 Merck Patent Gmbh Compuestos de heteroarilo como inhibidores de cinasas asociadas a receptor de interleucina-1 (irak) y usos de los mismos.
CA3002560A1 (en) 2015-10-23 2017-04-27 Array Biopharma, Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
CA3076613A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
EP3737675A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
JP2021527636A (ja) * 2018-06-04 2021-10-14 オハイオ・ステイト・イノベーション・ファウンデーション Ｅａａｔ２活性化因子およびその使用方法
WO2020010227A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
TWI842978B (zh) 2018-07-13 2024-05-21 美商基利科學股份有限公司 衍生物
KR20210100094A (ko) 2018-11-06 2021-08-13 엣지와이즈 테라퓨틱스, 인크. 피리다지논 화합물 및 이의 용도
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