PL2953944T3 - Pochodne pirydazynonowe-amidowe - Google Patents

Pochodne pirydazynonowe-amidowe

Info

Publication number
PL2953944T3
PL2953944T3 PL14703537T PL14703537T PL2953944T3 PL 2953944 T3 PL2953944 T3 PL 2953944T3 PL 14703537 T PL14703537 T PL 14703537T PL 14703537 T PL14703537 T PL 14703537T PL 2953944 T3 PL2953944 T3 PL 2953944T3
Authority
PL
Poland
Prior art keywords
pyridazinone
amides derivatives
amides
derivatives
Prior art date
Application number
PL14703537T
Other languages
English (en)
Inventor
Catherine Jorand-Lebrun
Santosh Kulkarni
Stefano Crosignani
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL2953944T3 publication Critical patent/PL2953944T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
PL14703537T 2013-02-07 2014-02-06 Pochodne pirydazynonowe-amidowe PL2953944T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13154390 2013-02-07

Publications (1)

Publication Number Publication Date
PL2953944T3 true PL2953944T3 (pl) 2017-09-29

Family

ID=47681772

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14703537T PL2953944T3 (pl) 2013-02-07 2014-02-06 Pochodne pirydazynonowe-amidowe

Country Status (23)

Country Link
US (2) US9567320B2 (pl)
EP (1) EP2953944B1 (pl)
JP (1) JP6483624B2 (pl)
KR (1) KR102293952B1 (pl)
CN (1) CN104968658B (pl)
AU (1) AU2014214321B2 (pl)
BR (1) BR112015018663A2 (pl)
CA (1) CA2900431C (pl)
DK (1) DK2953944T3 (pl)
ES (1) ES2634627T3 (pl)
HK (1) HK1215708A1 (pl)
HR (1) HRP20171076T1 (pl)
HU (1) HUE032863T2 (pl)
IL (1) IL240290B (pl)
LT (1) LT2953944T (pl)
MX (1) MX364486B (pl)
PL (1) PL2953944T3 (pl)
PT (1) PT2953944T (pl)
RS (1) RS56331B1 (pl)
RU (1) RU2666899C2 (pl)
SG (1) SG11201506100XA (pl)
SI (1) SI2953944T1 (pl)
WO (1) WO2014121931A1 (pl)

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EA039043B1 (ru) 2015-04-22 2021-11-25 Райджел Фармасьютикалз, Инк. Пиразольные соединения и способ получения и применения данных соединений
AU2016323612B2 (en) * 2015-09-18 2021-04-08 Merck Patent Gmbh Heteroaryl compounds as IRAK inhibitors and uses thereof
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IL307995A (en) 2017-09-22 2023-12-01 Kymera Therapeutics Inc Protein compounds and their uses
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WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
MX2020006812A (es) 2017-12-26 2020-11-06 Kymera Therapeutics Inc Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. PROTEIN DEGRADANTS AND USES THEREOF
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
CN113272291A (zh) 2018-11-06 2021-08-17 艾知怀斯治疗学公司 哒嗪酮化合物及其用途
WO2020097258A1 (en) * 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
EA202191082A1 (ru) 2018-11-06 2021-09-10 Эджвайз Терапьютикс, Инк. Соединения пиридазинонов и их применения
US11352350B2 (en) 2018-11-30 2022-06-07 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
EP4003990A1 (en) 2019-08-30 2022-06-01 Rigel Pharmaceuticals, Inc. Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations
IL293917A (en) 2019-12-17 2022-08-01 Kymera Therapeutics Inc Iraq joints and their uses
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
WO2021231630A1 (en) * 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
CN114957132A (zh) * 2021-02-20 2022-08-30 中国科学院上海药物研究所 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用
WO2022222890A1 (en) * 2021-04-19 2022-10-27 Shanghai Yao Yuan Biotechnology Co., Ltd. Benzothiazole and quinoline derivatives for use in treating kawasaki disease

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CN104968658B (zh) 2017-08-01
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KR20150118981A (ko) 2015-10-23
MX364486B (es) 2019-04-29
WO2014121931A1 (en) 2014-08-14
PT2953944T (pt) 2017-08-01
JP2016508505A (ja) 2016-03-22
SI2953944T1 (sl) 2017-08-31
SG11201506100XA (en) 2015-09-29
RU2666899C2 (ru) 2018-09-13
CA2900431C (en) 2021-05-04
BR112015018663A2 (pt) 2017-07-18
MX2015010125A (es) 2016-04-25
AU2014214321A1 (en) 2015-09-17
EP2953944B1 (en) 2017-04-26
KR102293952B1 (ko) 2021-08-26
HUE032863T2 (en) 2017-11-28
DK2953944T3 (en) 2017-07-10
AU2014214321B2 (en) 2018-04-19
US20170071936A1 (en) 2017-03-16
EP2953944A1 (en) 2015-12-16
HK1215708A1 (zh) 2016-09-09
US20150376167A1 (en) 2015-12-31
CN104968658A (zh) 2015-10-07
CA2900431A1 (en) 2014-08-14
RU2015137757A (ru) 2017-03-13
RS56331B1 (sr) 2017-12-29
IL240290A0 (en) 2015-09-24
ES2634627T3 (es) 2017-09-28
HRP20171076T1 (hr) 2017-10-06
IL240290B (en) 2019-06-30
LT2953944T (lt) 2017-07-10
US9567320B2 (en) 2017-02-14

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