RU2015137757A - Производные пиридазинон-амидов - Google Patents
Производные пиридазинон-амидов Download PDFInfo
- Publication number
- RU2015137757A RU2015137757A RU2015137757A RU2015137757A RU2015137757A RU 2015137757 A RU2015137757 A RU 2015137757A RU 2015137757 A RU2015137757 A RU 2015137757A RU 2015137757 A RU2015137757 A RU 2015137757A RU 2015137757 A RU2015137757 A RU 2015137757A
- Authority
- RU
- Russia
- Prior art keywords
- disease
- compound
- formula
- syndrome
- alkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (37)
1. Соединение формулы (I)
в которой
Z означает группу
в которой
X означает СН или N,
Y означает СН или N,
Ra, Rc, R1 каждый независимо означают Н, Hal или Al,
Rb означает Н или алкил
Al означает разветвленный или линейный алкил, имеющий от 1 до 12 атомов углерода, в котором один или больше, например, от 1 до 7, атомов Н могут быть заменены посредством Hal, ORb, COORb, CN или N(Rb)2 и причем одна или больше, предпочтительно от 1 до 5 СН2-группы могут быть заменены посредством О, СО, NRb или S, SO, SO2, 1,2-, 1,3- или 1,4-фенилен, -СН=СН- или -С≡С-,
и
Hal означает F, Cl, Br, I
и его фармацевтически приемлемые производные, сольваты, соли и стереоизомеры, включая их смеси во всех соотношениях.
2. Соединение формулы (I) по п. 1, причем Ra означает Hal ORd или алкил, причем Rd означает Н, алкил или СОН или СОалкил.
3. Соединение формулы (I) по п. 1 или 2, причем R1 означает Н, алкил, Hal, Оалкил, ORd, или (CH2)nCONHRb или (CH2)nCOORb, причем n означает 0, 1, 2, 3, 4, 5, или 6 и Rb является таким, как определено выше и причем Rd означает Н, алкил или CORb.
4. Соединение формулы (I) по п. 1 или 2, причем Z означает пиридинил или пиримидинил.
5. Соединение формулы (I), выбранное из следующей группы:
и его фармацевтически приемлемые производные, сольваты, соли и стереоизомеры, включая их смеси во всех соотношениях.
6. Применение соединения формулы (I) по предыдущим пунктам и его фармацевтически приемлемые производные, сольваты, таутомеры, соли, гидраты и стереоизомеры, включая их смеси во всех соотношениях, для применения в качестве лекарственного средства.
7. Применение соединения по п. 6 для применения в лечении или предупреждения воспалительного заболевания, аутоиммунного заболевания, рака или множественного склероза и связанных заболеваний.
8. Применение соединения по п. 7, причем аутоиммунное заболевание выбирают из группы, состоящей из астмы, ревматоидного артрита, острого множественного энцефаломиелита (ОМЭМ), болезни Аддисона, очаговой алопеции, анкилозирующего спондилита, синдрома антифосфолипидных антител (АФС), аутоиммунной гемолитической анемии, аутоиммунного гепатита, аутоиммунного заболевания внутреннего уха, буллезного пемфигоида, болезни Бехчета, целиакии, антитрансглутаминазы, болезни Чагаса, хронического обструктивного заболевания легких, болезни Крона, дерматомиозита, сахарного диабета 1 типа, эндометриоза, синдрома Гудпасчера, болезни Грейвса, синдрома Гийена-Барре (СГБ), тиреоидита Хашимото, гнойного гидраденита, синдрома Кавасаки, нефропатии IgA, идиопатической тромбоцитопенической пурпуры, интерстициального цистита, эритематозной волчанки, смешанной болезни соединительной ткани, кольцевидной склеродермии, множественного склероза (МС), тяжелой миастении, нарколепсии, нейромиотомии, обыкновенной пузырчатки, злокачественной анемии, псориаза, псориатического артрита, полимиозита, билиарного первичного цирроза печени, ревматоидного артрита, шизофрении, склеродермии, синдрома Шегрена, синдрома скованного человека, системного склероза, височного артериита, язвенного колита, васкулита, витилиго, гранулематоза Вегенера.
9. Применение соединения по п. 7, причем заболевание выбирают из ревматоидного артрита, псориатического артрита, остеоартрита, системной красной волчанки, волчаночного нефрита, анкилозирующего спондилоартрита, остеопороза, системного склероза, множественного склероза, псориаза, сахарного диабета I типа, сахарного диабета II типа, воспалительного заболевания кишечника (болезнь Крона и язвенный колит), гипериммуноглобулинемии D и синдрома периодической лихорадки, криопирин-связанных периодических синдромов, синдрома Шницлера, системного ювенильного идиопатического артрита, приобретенной болезни Стилла, подагры, псевдоподагры, синдрома САПГО, болезни Кастлемана, сепсиса, инсульта, атеросклероза, целиакии, DIRA (дефицит антагониста рецептора IL-1), болезни Альцгеймера, болезни Паркинсона, рака.
10. Соединение по п. 6, причем заболевание выбирают из ревматоидного артрита, волчаночного нефрита, системной красной волчанки.
11. Соединение формулы (I) по п. 1 для предупреждения и/или лечения заболеваний, связанных с повышенной экспрессией IRAK.
12. Набор, состоящий из отдельных упаковок:
(а) эффективного количества соединения формулы (I) и/или его фармацевтически приемлемых производных, сольватов, солей, гидратов и стереоизомеров, включая их смеси во всех соотношениях, и
(б) эффективного количества дополнительного действующего вещества лекарственного средства.
13. Фармацевтическая композиция, содержащая по меньшей мере одно из соединений формулы (I) по любому из пп. от 1 до 5 и/или любое его фармацевтически приемлемое производное, сольват, соль и стереоизомер, включая их смеси во всех соотношениях.
14. Фармацевтическая композиция по п. 13, дополнительно содержащая по меньшей мере одно другое лекарственное средство, применяемое в лечении воспалительных заболеваний или иммунных заболеваний.
15. Фармацевтическая композиция по п. 14, дополнительно содержащая по меньшей мере одно другое иммуномодулирующее средство.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13154390.2 | 2013-02-07 | ||
EP13154390 | 2013-02-07 | ||
PCT/EP2014/000316 WO2014121931A1 (en) | 2013-02-07 | 2014-02-06 | Pyridazinone-amides derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2015137757A true RU2015137757A (ru) | 2017-03-13 |
RU2666899C2 RU2666899C2 (ru) | 2018-09-13 |
Family
ID=47681772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2015137757A RU2666899C2 (ru) | 2013-02-07 | 2014-02-06 | Производные пиридазинон-амидов |
Country Status (23)
Country | Link |
---|---|
US (2) | US9567320B2 (ru) |
EP (1) | EP2953944B1 (ru) |
JP (1) | JP6483624B2 (ru) |
KR (1) | KR102293952B1 (ru) |
CN (1) | CN104968658B (ru) |
AU (1) | AU2014214321B2 (ru) |
BR (1) | BR112015018663A2 (ru) |
CA (1) | CA2900431C (ru) |
DK (1) | DK2953944T3 (ru) |
ES (1) | ES2634627T3 (ru) |
HK (1) | HK1215708A1 (ru) |
HR (1) | HRP20171076T1 (ru) |
HU (1) | HUE032863T2 (ru) |
IL (1) | IL240290B (ru) |
LT (1) | LT2953944T (ru) |
MX (1) | MX364486B (ru) |
PL (1) | PL2953944T3 (ru) |
PT (1) | PT2953944T (ru) |
RS (1) | RS56331B1 (ru) |
RU (1) | RU2666899C2 (ru) |
SG (1) | SG11201506100XA (ru) |
SI (1) | SI2953944T1 (ru) |
WO (1) | WO2014121931A1 (ru) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6920202B2 (ja) * | 2015-02-06 | 2021-08-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Irak阻害剤としてのピリダジノン大環状化合物及びその使用 |
BR112017022349B1 (pt) | 2015-04-22 | 2023-11-07 | Rigel Pharmaceuticals, Inc | Composto, composição o compreendendo, seus usos, e, método |
AU2016323612B2 (en) * | 2015-09-18 | 2021-04-08 | Merck Patent Gmbh | Heteroaryl compounds as IRAK inhibitors and uses thereof |
US10208024B2 (en) | 2015-10-23 | 2019-02-19 | Array Biopharma Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases |
JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
AU2018338314A1 (en) | 2017-09-22 | 2020-04-09 | Kymera Therapeutics, Inc | Protein degraders and uses thereof |
EP3684366A4 (en) | 2017-09-22 | 2021-09-08 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES OF THE LATEST |
WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
US10874743B2 (en) | 2017-12-26 | 2020-12-29 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND THEIR USES |
EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
TW202136268A (zh) | 2018-07-13 | 2021-10-01 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
MX2021005350A (es) | 2018-11-06 | 2021-08-11 | Edgewise Therapeutics Inc | Compuestos de piridazinona y usos de los mismos. |
AU2019374812A1 (en) * | 2018-11-06 | 2021-06-10 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
ES2957383T3 (es) | 2018-11-06 | 2024-01-18 | Edgewise Therapeutics Inc | Compuestos de piridazinona y usos de estos |
BR112021010484A2 (pt) | 2018-11-30 | 2021-08-24 | Kymera Therapeutics, Inc. | Degradadores de irak e usos dos mesmos |
JOP20220050A1 (ar) | 2019-08-30 | 2023-01-30 | Rigel Pharmaceuticals Inc | مركبات بيرازول، صياغات منها وطريقة لاستخدام المركبات و/ أو صياغات |
BR112022011651A2 (pt) | 2019-12-17 | 2022-08-23 | Kymera Therapeutics Inc | Degradadores de irak e usos dos mesmos |
EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
EP4149466A1 (en) * | 2020-05-13 | 2023-03-22 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
CN114957132A (zh) * | 2021-02-20 | 2022-08-30 | 中国科学院上海药物研究所 | 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用 |
WO2022222890A1 (en) * | 2021-04-19 | 2022-10-27 | Shanghai Yao Yuan Biotechnology Co., Ltd. | Benzothiazole and quinoline derivatives for use in treating kawasaki disease |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3734083A1 (de) * | 1987-10-08 | 1989-04-20 | Heumann Pharma Gmbh & Co | Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
AU5310096A (en) * | 1995-03-17 | 1996-10-08 | Du Pont Merck Pharmaceutical Company, The | Cyclic urea hiv protease inhibitors |
JP2000247959A (ja) * | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−3−オン誘導体及びこれを含有する医薬 |
WO2003030902A1 (en) * | 2001-10-09 | 2003-04-17 | Tularik Inc. | Imidazole derivates as anti-inflammatory agents |
KR20050113627A (ko) | 2003-03-18 | 2005-12-02 | 코와 가부시키가이샤 | 수용성 페닐피리다진 유도체 및 이를 함유하는 의약 |
DE102006037478A1 (de) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
JP2008063265A (ja) * | 2006-09-06 | 2008-03-21 | Kyorin Pharmaceut Co Ltd | ピリダジノン誘導体及びそれらを有効成分とするpde阻害剤 |
CA2663100A1 (en) * | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | Indazole derivatives as modulators of interleukin-1 receptor-associated kinase |
DE102007025717A1 (de) * | 2007-06-01 | 2008-12-11 | Merck Patent Gmbh | Arylether-pyridazinonderivate |
DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008062826A1 (de) * | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinonderivate |
RS55165B1 (sr) * | 2010-12-20 | 2017-01-31 | Merck Serono Sa | Indazolil triazol derivati kao irak inhibitori |
US9169260B2 (en) | 2011-03-22 | 2015-10-27 | Merck Sharp & Dohme Corp. | Amidopyrazole inhibitors of interleukin receptor-associated kinases |
CA2900442C (en) * | 2013-02-07 | 2021-09-21 | Merck Patent Gmbh | Macrocyclic pyridazinone derivatives |
-
2014
- 2014-02-06 JP JP2015556421A patent/JP6483624B2/ja not_active Expired - Fee Related
- 2014-02-06 RS RS20170743A patent/RS56331B1/sr unknown
- 2014-02-06 KR KR1020157024342A patent/KR102293952B1/ko active IP Right Grant
- 2014-02-06 RU RU2015137757A patent/RU2666899C2/ru active
- 2014-02-06 MX MX2015010125A patent/MX364486B/es active IP Right Grant
- 2014-02-06 US US14/766,671 patent/US9567320B2/en active Active
- 2014-02-06 SI SI201430307T patent/SI2953944T1/sl unknown
- 2014-02-06 HU HUE14703537A patent/HUE032863T2/en unknown
- 2014-02-06 EP EP14703537.2A patent/EP2953944B1/en active Active
- 2014-02-06 PL PL14703537T patent/PL2953944T3/pl unknown
- 2014-02-06 WO PCT/EP2014/000316 patent/WO2014121931A1/en active Application Filing
- 2014-02-06 AU AU2014214321A patent/AU2014214321B2/en not_active Ceased
- 2014-02-06 CA CA2900431A patent/CA2900431C/en not_active Expired - Fee Related
- 2014-02-06 PT PT147035372T patent/PT2953944T/pt unknown
- 2014-02-06 LT LTEP14703537.2T patent/LT2953944T/lt unknown
- 2014-02-06 ES ES14703537.2T patent/ES2634627T3/es active Active
- 2014-02-06 DK DK14703537.2T patent/DK2953944T3/en active
- 2014-02-06 CN CN201480007676.1A patent/CN104968658B/zh not_active Expired - Fee Related
- 2014-02-06 SG SG11201506100XA patent/SG11201506100XA/en unknown
- 2014-02-06 BR BR112015018663A patent/BR112015018663A2/pt not_active Application Discontinuation
-
2015
- 2015-08-02 IL IL240290A patent/IL240290B/en active IP Right Grant
-
2016
- 2016-03-31 HK HK16103688.3A patent/HK1215708A1/zh not_active IP Right Cessation
- 2016-11-23 US US15/360,288 patent/US20170071936A1/en not_active Abandoned
-
2017
- 2017-07-13 HR HRP20171076TT patent/HRP20171076T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
JP2016508505A (ja) | 2016-03-22 |
US9567320B2 (en) | 2017-02-14 |
KR20150118981A (ko) | 2015-10-23 |
ES2634627T3 (es) | 2017-09-28 |
WO2014121931A1 (en) | 2014-08-14 |
CA2900431A1 (en) | 2014-08-14 |
PT2953944T (pt) | 2017-08-01 |
IL240290B (en) | 2019-06-30 |
SI2953944T1 (sl) | 2017-08-31 |
HUE032863T2 (en) | 2017-11-28 |
HRP20171076T1 (hr) | 2017-10-06 |
AU2014214321A1 (en) | 2015-09-17 |
EP2953944B1 (en) | 2017-04-26 |
US20150376167A1 (en) | 2015-12-31 |
RU2666899C2 (ru) | 2018-09-13 |
JP6483624B2 (ja) | 2019-03-13 |
KR102293952B1 (ko) | 2021-08-26 |
SG11201506100XA (en) | 2015-09-29 |
MX364486B (es) | 2019-04-29 |
IL240290A0 (en) | 2015-09-24 |
CN104968658B (zh) | 2017-08-01 |
BR112015018663A2 (pt) | 2017-07-18 |
RS56331B1 (sr) | 2017-12-29 |
US20170071936A1 (en) | 2017-03-16 |
HK1215708A1 (zh) | 2016-09-09 |
CN104968658A (zh) | 2015-10-07 |
EP2953944A1 (en) | 2015-12-16 |
LT2953944T (lt) | 2017-07-10 |
DK2953944T3 (en) | 2017-07-10 |
AU2014214321B2 (en) | 2018-04-19 |
MX2015010125A (es) | 2016-04-25 |
CA2900431C (en) | 2021-05-04 |
PL2953944T3 (pl) | 2017-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2015137757A (ru) | Производные пиридазинон-амидов | |
RU2015137756A (ru) | Макроциклические производные пиридазинона | |
JP2016508505A5 (ru) | ||
HRP20161127T1 (hr) | Derivati indazolil triazola kao inhibitori irak | |
RU2015104123A (ru) | Производные пиримидинпиразолила | |
HRP20191430T1 (hr) | Spojevi heteroarila kao inhibitori btk i njihove uporabe | |
JP2013510825A5 (ru) | ||
HRP20210745T1 (hr) | Supstituirani spojevi tetrahidrokinolinona kao ror gama modulatori | |
HRP20200819T1 (hr) | Spojevi indol karboksamida korisni kao inhibitori kinaze | |
HRP20231381T1 (hr) | Spojevi inhibitori rip1 i postupci za njihovo dobivanje i upotrebu | |
JP2020537657A5 (ru) | ||
RU2017134551A (ru) | Новые дигидропиридоизохинолиноны и их фармацевтические композиции для лечения воспалительных расстройств | |
RU2014149149A (ru) | БИЦИКЛИЧЕСКИЕ СУЛЬФОНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORгамма АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ | |
RU2015107552A (ru) | Бивалентные ингибиторы ингибиторов белков апоптоза и терапевтические способы их применения | |
RU2013144579A (ru) | Ингибиторы киназы mst1 и способы их применения | |
CN108601952B (zh) | 雷公藤内酯的葡萄糖缀合物、类似物及其用途 | |
HRP20211583T1 (hr) | Tienopiridini i benzotiofeni korisni kao irak4 inhibitori | |
JP2013525433A5 (ru) | ||
HRP20120490T1 (hr) | Spojevi za inhibiciju napredovanja mitoze | |
JP2016505019A5 (ru) | ||
JP2017527578A5 (ru) | ||
CA2797663A1 (en) | Compounds that modulate intracellular calcium | |
JP2015529235A5 (ru) | ||
JP2015501847A5 (ru) | ||
JP2015515961A5 (ru) |