MX366955B - Crlx101 para usarse en el tratamiento de cáncer. - Google Patents
Crlx101 para usarse en el tratamiento de cáncer.Info
- Publication number
- MX366955B MX366955B MX2016013249A MX2016013249A MX366955B MX 366955 B MX366955 B MX 366955B MX 2016013249 A MX2016013249 A MX 2016013249A MX 2016013249 A MX2016013249 A MX 2016013249A MX 366955 B MX366955 B MX 366955B
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- treatment
- cdp
- camptothecin
- crlx101
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 229960005529 CRLX101 Drugs 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a un conjugado de polímero que contiene ciclodextrina (CDP)-inhibidor de topoisomerasa para usarse en un método de tratamiento de cáncer en un individuo, en donde el método comprende: proveer una administración inicial de dicho conjugado de CDP-inhibidor de topoisomerasa a dicho individuo a una dosificación de 12 mg/m2, 13 mg/m2, 14 mg/m2 o 15 mg/m2, en donde dicho dosificación se expresa en mg de inhibidor de topoisomerasa, en oposición a mg de conjugado; y proveer más de una administración subsecuente de dicho conjugado de CDP-inhibidor de topoisomerasa a una dosificación de 12 mg/m2, 13 mg/m2, 14 mg/m2 o 15 mg/m2, en donde cada administración subsecuente se proporciona, independientemente, entre 12, 13, 14, 15 o 16 días después de la administración preveía: en donde el método comprende administrar dicho conjugado de CDP-inhibidor de topoisomerasa en combinación con uno o más agentes terapéuticos adicionales: en donde el conjugado de CDP-inhibidor de topoisomerasa es un conjugado de CDP-camptotecina ; y en donde le conjugado de CDP-camptotecina es CRLX101.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24275209P | 2009-09-15 | 2009-09-15 | |
US31703910P | 2010-03-24 | 2010-03-24 | |
US33215010P | 2010-05-06 | 2010-05-06 | |
US38185110P | 2010-09-10 | 2010-09-10 | |
PCT/US2010/048973 WO2011034954A1 (en) | 2009-09-15 | 2010-09-15 | Treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX366955B true MX366955B (es) | 2019-07-31 |
Family
ID=43758997
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012003046A MX342709B (es) | 2009-09-15 | 2010-09-15 | Tratamiento contra el cancer. |
MX2016013249A MX366955B (es) | 2009-09-15 | 2010-09-15 | Crlx101 para usarse en el tratamiento de cáncer. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012003046A MX342709B (es) | 2009-09-15 | 2010-09-15 | Tratamiento contra el cancer. |
Country Status (11)
Country | Link |
---|---|
US (5) | US20110160159A1 (es) |
EP (1) | EP2477985B1 (es) |
JP (6) | JP5855568B2 (es) |
CN (1) | CN102666533A (es) |
AU (1) | AU2010295646B2 (es) |
BR (1) | BR112012005594A2 (es) |
CA (2) | CA2939165A1 (es) |
EA (1) | EA201200486A1 (es) |
IL (1) | IL218575A0 (es) |
MX (2) | MX342709B (es) |
WO (1) | WO2011034954A1 (es) |
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TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
EA201171195A8 (ru) * | 2009-03-30 | 2014-08-29 | Серулин Фарма Инк. | Конъюгаты, частицы, композиции "полимер-агент" и способы их применения |
US20120114658A1 (en) * | 2009-09-15 | 2012-05-10 | John Ryan | Treatment of cancer |
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2010
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- 2010-09-15 JP JP2012529881A patent/JP5855568B2/ja active Active
- 2010-09-15 CA CA2939165A patent/CA2939165A1/en not_active Abandoned
- 2010-09-15 MX MX2012003046A patent/MX342709B/es active IP Right Grant
- 2010-09-15 AU AU2010295646A patent/AU2010295646B2/en active Active
- 2010-09-15 CN CN2010800410580A patent/CN102666533A/zh active Pending
- 2010-09-15 CA CA2774015A patent/CA2774015A1/en not_active Abandoned
- 2010-09-15 MX MX2016013249A patent/MX366955B/es unknown
- 2010-09-15 BR BR112012005594A patent/BR112012005594A2/pt not_active Application Discontinuation
- 2010-09-15 EA EA201200486A patent/EA201200486A1/ru unknown
- 2010-09-15 WO PCT/US2010/048973 patent/WO2011034954A1/en active Application Filing
- 2010-09-15 US US12/883,084 patent/US20110160159A1/en not_active Abandoned
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- 2012-03-11 IL IL218575A patent/IL218575A0/en unknown
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2013
- 2013-01-10 US US13/738,630 patent/US20130338103A1/en not_active Abandoned
- 2013-02-15 US US13/769,046 patent/US20130164282A1/en not_active Abandoned
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2014
- 2014-11-04 JP JP2014223985A patent/JP2015025020A/ja not_active Withdrawn
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2015
- 2015-04-01 US US14/675,815 patent/US20160058875A1/en not_active Abandoned
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2016
- 2016-03-09 JP JP2016045695A patent/JP2016106143A/ja active Pending
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2017
- 2017-04-26 US US15/498,056 patent/US20180071404A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
JP5855568B2 (ja) | 2016-02-09 |
AU2010295646B2 (en) | 2016-02-11 |
EP2477985B1 (en) | 2018-11-07 |
BR112012005594A2 (pt) | 2015-09-08 |
US20160058875A1 (en) | 2016-03-03 |
EA201200486A1 (ru) | 2012-08-30 |
WO2011034954A1 (en) | 2011-03-24 |
JP2020164547A (ja) | 2020-10-08 |
US20130338103A1 (en) | 2013-12-19 |
EP2477985A4 (en) | 2013-05-15 |
JP2022166327A (ja) | 2022-11-01 |
EP2477985A1 (en) | 2012-07-25 |
JP2013504630A (ja) | 2013-02-07 |
JP2015025020A (ja) | 2015-02-05 |
MX2012003046A (es) | 2012-09-07 |
IL218575A0 (en) | 2012-05-31 |
JP2016106143A (ja) | 2016-06-16 |
CA2939165A1 (en) | 2011-03-24 |
AU2010295646A1 (en) | 2012-04-05 |
CA2774015A1 (en) | 2011-03-24 |
JP2017226708A (ja) | 2017-12-28 |
CN102666533A (zh) | 2012-09-12 |
US20110160159A1 (en) | 2011-06-30 |
MX342709B (es) | 2016-10-10 |
US20130164282A1 (en) | 2013-06-27 |
US20180071404A1 (en) | 2018-03-15 |
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