MX2011003738A - Conjugados hpma-docetaxel o gemcitabine y sus usos asociados. - Google Patents

Conjugados hpma-docetaxel o gemcitabine y sus usos asociados.

Info

Publication number
MX2011003738A
MX2011003738A MX2011003738A MX2011003738A MX2011003738A MX 2011003738 A MX2011003738 A MX 2011003738A MX 2011003738 A MX2011003738 A MX 2011003738A MX 2011003738 A MX2011003738 A MX 2011003738A MX 2011003738 A MX2011003738 A MX 2011003738A
Authority
MX
Mexico
Prior art keywords
docetaxel
hpma
gemcitabine
gemcitabine conjugates
conjugates
Prior art date
Application number
MX2011003738A
Other languages
English (en)
Inventor
Abhijit Ray
Young Bok Lee
Chang Ho Ahn
Deog Joong Kim
Hamidreza Ghandehari
Anjan Nan
Original Assignee
Rexahn Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rexahn Pharmaceuticals Inc filed Critical Rexahn Pharmaceuticals Inc
Publication of MX2011003738A publication Critical patent/MX2011003738A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

La presente invención se refiere a composiciones solubles en agua de gemcitabine y de docetaxel formadas por la conjugación de gemcitabine o de docetaxel con un polímero soluble en agua tal como N-2-hidroxipropil metacrilamida (HPMA). La presente invención se refiere igualmente a los procesos de utilización de las composiciones de la invención destinadas al tratamiento del cáncer.
MX2011003738A 2008-10-07 2009-10-07 Conjugados hpma-docetaxel o gemcitabine y sus usos asociados. MX2011003738A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10339008P 2008-10-07 2008-10-07
PCT/US2009/059869 WO2010042638A2 (en) 2008-10-07 2009-10-07 Hpma - docetaxel or gemcitabine conjugates and uses therefore

Publications (1)

Publication Number Publication Date
MX2011003738A true MX2011003738A (es) 2011-09-30

Family

ID=41683287

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011003738A MX2011003738A (es) 2008-10-07 2009-10-07 Conjugados hpma-docetaxel o gemcitabine y sus usos asociados.

Country Status (11)

Country Link
US (1) US9434610B2 (es)
EP (1) EP2349347A2 (es)
JP (2) JP2012505228A (es)
KR (1) KR101705077B1 (es)
CN (2) CN105879044A (es)
AU (1) AU2009302387B2 (es)
BR (1) BRPI0920655A2 (es)
CA (1) CA2739757C (es)
IL (1) IL212199A0 (es)
MX (1) MX2011003738A (es)
WO (1) WO2010042638A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
KR101045422B1 (ko) 2002-09-11 2011-06-30 프레제니우스 카비 도이치란트 게엠베하 하이드록시알킬 전분 유도체의 제조 방법
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
WO2005092928A1 (en) 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
EP2210616A1 (en) * 2009-01-21 2010-07-28 Centre National de la Recherche Scientifique Multifunctional stealth nanoparticles for biomedical use
EP3239139B1 (en) 2010-05-27 2020-10-28 Ningbo Combireg Pharmaceutical Technology Co. Ltd Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
WO2012004009A1 (en) * 2010-07-09 2012-01-12 Fresenius Kabi Deutschland Gmbh Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
BR112015010941A2 (pt) 2012-11-13 2017-07-11 Boyen Therapeutics Inc pró-fármacos de gemcitabina e suas utilizações
JP6497683B2 (ja) * 2014-09-29 2019-04-10 国立大学法人東北大学 プロテアーゼの基質ペプチド及びプロテアーゼの活性測定方法
WO2016134066A1 (en) * 2015-02-17 2016-08-25 Mallinckrodt Llc Modified docetaxel liposome formulations and uses thereof
CN106083960B (zh) 2016-06-15 2019-06-25 常州方圆制药有限公司 新型紫杉类化合物及其制备方法和应用
GB2551979A (en) * 2016-06-30 2018-01-10 Rs Arastirma Egitim Danismanlik Llac Sanayi Ticaret Ltd Cleavable polymer drug conjugates
JPWO2018003739A1 (ja) * 2016-06-30 2019-04-18 レナセラピューティクス株式会社 機能的リガンドを含む核酸複合体
CN106581690B (zh) * 2016-12-23 2019-05-28 四川大学 肿瘤微环境刺激可降解的两亲性嵌段hpma聚合物给药系统及其制备方法
CN106880848B (zh) * 2017-02-14 2019-09-06 四川大学 可生物降解的多聚HPMA-Gd磁共振成像探针及其制备方法
CN107550864B (zh) * 2017-08-23 2020-12-18 科笛生物医药(上海)有限公司 Eppt多肽-聚乙二醇-磷脂复合膜材料、其制备方法及主动靶向脂质体递药系统和应用
CN108359052B (zh) * 2018-04-24 2020-11-17 辽宁大学 一种藤黄酸-叶酸-hpma高分子聚合物及其制备方法和应用
CN116262132B (zh) * 2021-12-13 2024-06-25 中科帅天医药(深圳)有限公司 抗胰腺癌多肽药物偶联物及其无载体自组装纳米药物和制备方法及应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4074039A (en) * 1970-03-26 1978-02-14 Ceskoslovenska Akademie Ved Hydrophilic N,N-diethyl acrylamide copolymers
CS159937B1 (es) * 1972-02-29 1975-02-28
US3997660A (en) * 1972-02-29 1976-12-14 Ceskoslovenska Akademie Ved Soluble hydrophilic polymers and process for producing the same
CS158458B1 (es) * 1972-05-02 1974-11-25
CS173846B1 (es) * 1974-04-23 1977-03-31
CS173849B1 (es) * 1974-04-25 1977-03-31
GB8500209D0 (en) * 1985-01-04 1985-02-13 Ceskoslovenska Akademie Ved Synthetic polymeric drugs
US5258453A (en) * 1992-01-21 1993-11-02 University Of Utah Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
EP0954283B1 (en) * 1996-12-30 2007-03-21 Battelle Memorial Institute Use of a non-encapsulated anticancer drug for the preparation of a formulation for treating neoplasms by inhalation
US5965118A (en) * 1997-04-18 1999-10-12 Access Pharmaceuticals, Inc. Polymer-platinum compounds
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6346349B1 (en) * 1999-02-11 2002-02-12 Alcatel Anode invention for lithium/transition metal fluoride molten salt cells and batteries
US20010041189A1 (en) * 1999-04-13 2001-11-15 Jingya Xu Poly(dipeptide) as a drug carrier
KR100816572B1 (ko) * 1999-04-28 2008-03-24 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 항-ｖｅｇｆ 항체 및 이를 포함하는 약제학적 조성물
AUPQ014799A0 (en) 1999-05-04 1999-05-27 Access Pharmaceuticals Australia Pty Limited Amplification of folate-mediated targeting to tumor cells using polymers
WO2001026693A2 (en) * 1999-10-12 2001-04-19 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
AU2762101A (en) * 2000-01-04 2001-07-16 Access Pharmaceuticals, Inc. N,o-amidomalonate platinum complexes
US7166733B2 (en) * 2000-01-04 2007-01-23 Access Pharmaceuticals, Inc. O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
GB0018240D0 (en) * 2000-07-25 2000-09-13 Pharmacia & Upjohn Spa Polymeric conjugates of antitumor agents
EP1401875A4 (en) * 2001-05-04 2005-01-26 Univ Utah Res Found HYALURONIC ACID-CONTAINING BIOKON JUGATES: TARGETED DELIVERY OF ANTIBODIES TO CANCER CELLS
WO2003043568A2 (en) * 2001-11-15 2003-05-30 The Regents Of The University Of California Compositions and methods for the suppression of mammary epithelial cell proliferation
WO2003066068A1 (en) * 2002-02-01 2003-08-14 Intradigm Corporation Hpma-polyamine conjugates and uses therefore
US20050129769A1 (en) * 2002-06-03 2005-06-16 Barry Stephen E. Polymeric articles for carrying therapeutic agents
WO2003101425A2 (en) 2002-06-03 2003-12-11 Alnis Biosciences, Inc. Therapeutic agent-containing polymeric nanoarticles
CN101524549A (zh) 2002-07-22 2009-09-09 匹斯美药物公开公司 新抗癌化合物
WO2004062588A2 (en) * 2003-01-06 2004-07-29 University Of Utah Water-soluble polymeric bone-targeting drug delivery system
FR2858936A1 (fr) * 2003-08-22 2005-02-25 Diatos Potentialisation de l'activation de prodrogues de haut poids moleculaire
US20050196343A1 (en) 2004-02-27 2005-09-08 Molecular Therapeutics, Inc. Degradable nanoparticles
US20070287680A1 (en) * 2004-05-10 2007-12-13 University Of Utah Research Foundation Combined Active and Passive Targeting of Biologically Active Agents
EP1768706A2 (en) * 2004-06-28 2007-04-04 University of Maryland, Baltimore Radiolabeled nanohybrids targeting solid tumor neovasculature and method of using same
EP1812864A2 (en) 2004-10-07 2007-08-01 Emory University Multifunctional nanoparticles conjugates and their use
WO2006113666A2 (en) 2005-04-19 2006-10-26 Massachusetts Institute Of Technology Amphiphilic polymers and methods of use thereof
US7647312B2 (en) * 2005-05-12 2010-01-12 Microsoft Corporation System and method for automatic generation of suggested inline search terms
KR20080074207A (ko) 2005-12-05 2008-08-12 닛토덴코 가부시키가이샤 폴리글루타메이트-아미노산 콘쥬게이트 및 이의 제조 방법
CZ298945B6 (cs) * 2006-09-18 2008-03-19 Zentiva, A. S. Polymerní lécivo a zpusob jeho výroby
US8017141B2 (en) * 2006-12-15 2011-09-13 Advanced Cardiovascular Systems, Inc. Coatings of acrylamide-based copolymers
EP2488207A4 (en) * 2009-10-13 2015-06-10 Rexahn Pharmaceuticals Inc POLYMERIC SYSTEMS FOR ADMINISTERING ANTICANCER AGENTS

Also Published As

Publication number Publication date
JP2015034170A (ja) 2015-02-19
WO2010042638A3 (en) 2010-05-27
AU2009302387A1 (en) 2010-04-15
CN102264396A (zh) 2011-11-30
CN105879044A (zh) 2016-08-24
JP2012505228A (ja) 2012-03-01
JP6013424B2 (ja) 2016-10-25
KR101705077B1 (ko) 2017-02-09
EP2349347A2 (en) 2011-08-03
US20100099644A1 (en) 2010-04-22
AU2009302387B2 (en) 2014-12-04
IL212199A0 (en) 2011-06-30
CA2739757C (en) 2016-07-05
WO2010042638A2 (en) 2010-04-15
KR20110076986A (ko) 2011-07-06
BRPI0920655A2 (pt) 2019-07-09
US9434610B2 (en) 2016-09-06
CA2739757A1 (en) 2010-04-15

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