ES2058081T3 - Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. - Google Patents

Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.

Info

Publication number
ES2058081T3
ES2058081T3 ES87112279T ES87112279T ES2058081T3 ES 2058081 T3 ES2058081 T3 ES 2058081T3 ES 87112279 T ES87112279 T ES 87112279T ES 87112279 T ES87112279 T ES 87112279T ES 2058081 T3 ES2058081 T3 ES 2058081T3
Authority
ES
Spain
Prior art keywords
alkylene oxide
medicines
administration
systems
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87112279T
Other languages
English (en)
Inventor
Donald James Casey
Louis Rosati
Peter Kendrick Jarrett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/903,801 external-priority patent/US4882168A/en
Priority claimed from US06/903,797 external-priority patent/US4716203A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2058081T3 publication Critical patent/ES2058081T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

LA INVENCION ES UN BLOQUE COPLIMERO ABA O AB ASI COMO UN SISTEMA DE LIBERACION DE FARMACOS DE LENTA LIBERACION QUE COMPRENDE UN FARMACO Y EL BLOQUE COPOLIMERO ABA O AB EN DONDE UN BLOQUE (B) EN UN POLI(ALQUILENE OXIDO) Y LOS OTROS BLOQUES (A) CONSTAN DE COPOLIMEROS DEGRADABLES AL AZAR DEL (1) ESTER CICLICO DE UN ACIDO ALFA-HIDROXI Y (2) UN SEGUNDO MONOMERO DE ESTER CICLICO CON LA CONDICION DE QUE EL SEGUNDO MONOMERO DE ESTER CICLICO NO SEA EL MISMO QUE EN EL PRIMER ESTER CICLICO.
ES87112279T 1986-09-05 1987-08-25 Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. Expired - Lifetime ES2058081T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/903,801 US4882168A (en) 1986-09-05 1986-09-05 Polyesters containing alkylene oxide blocks as drug delivery systems
US06/903,797 US4716203A (en) 1986-09-05 1986-09-05 Diblock and triblock copolymers

Publications (1)

Publication Number Publication Date
ES2058081T3 true ES2058081T3 (es) 1994-11-01

Family

ID=27129378

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87112279T Expired - Lifetime ES2058081T3 (es) 1986-09-05 1987-08-25 Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.

Country Status (13)

Country Link
EP (1) EP0258780B1 (es)
KR (1) KR880003985A (es)
AU (1) AU605172B2 (es)
BR (1) BR8704648A (es)
CA (1) CA1283988C (es)
DE (1) DE3786309T2 (es)
DK (1) DK462287A (es)
ES (1) ES2058081T3 (es)
FI (1) FI873840A (es)
GR (1) GR3008526T3 (es)
HU (1) HU205711B (es)
IL (1) IL83764A (es)
NZ (1) NZ221647A (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9401703A (nl) * 1994-10-14 1996-05-01 Rijksuniversiteit Kauwgom.
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
DE19726412A1 (de) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
KR20010030891A (ko) * 1997-10-03 2001-04-16 마크로메드 인코퍼레이션 가역적 열 겔화 성질을 갖는 생분해성 저분자량 트리블럭폴리(락티드-코-글리콜리드) 폴리에틸렌 글리콜 공중합체
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US7018645B1 (en) 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
WO2002076228A1 (en) * 2001-03-23 2002-10-03 Gumlink A/S Degradable resin substitute for chewing gum
JP4354700B2 (ja) 2001-03-23 2009-10-28 ガムリンク エー／エス 改良された保存寿命を有する被覆された分解性チューインガムおよびその調製方法
JP2004535431A (ja) 2001-06-22 2004-11-25 サザン バイオシステムズ， インコーポレイテッド ゼロ次長期放出同軸インプラント
ES2304501T3 (es) 2002-02-15 2008-10-16 Nektar Therapeutics Al, Corporation Polimeros a base de oxido de alquileno degradables hidroliticamente.
WO2003092468A2 (en) 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
CN1290893C (zh) * 2002-05-03 2006-12-20 詹森药业有限公司 聚合物微乳状液
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
ES2377318T3 (es) 2002-09-06 2012-03-26 Cerulean Pharma Inc. Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos
CA2500022C (en) 2002-09-24 2011-02-22 Gumlink A/S Biodegradable chewing gum comprising at least one high molecular weight biodegradable polymer
JP2006500041A (ja) 2002-09-24 2006-01-05 ガムリンク エー／エス 少なくとも２種類の異なる生分解性ポリマーを含有するチューインガム
ES2312741T3 (es) 2003-05-06 2009-03-01 Gumlink A/S Procedimiento para producir granulos de goma de mascar y granulos de goma comprimidos, y un equipo para granular goma de mascar.
EP1474995B1 (en) 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
US8465537B2 (en) 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
WO2005034852A2 (en) 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
US8529939B2 (en) 2003-12-08 2013-09-10 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
WO2009086483A2 (en) 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein particles, particle devices and methods thereof
US10016534B2 (en) 2008-11-17 2018-07-10 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
BR112012005594A2 (pt) 2009-09-15 2015-09-08 Cerulean Pharma Inc tratamento de câncer
CN105797168A (zh) 2010-05-18 2016-07-27 天蓝制药公司 用于治疗自身免疫性疾病或其它疾病的组合物和方法
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US20230285576A1 (en) 2020-08-05 2023-09-14 Ellipses Pharma Ltd Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3736646A (en) * 1971-10-18 1973-06-05 American Cyanamid Co Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures
US4047533A (en) * 1976-09-20 1977-09-13 American Cyanamid Company Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4429080A (en) * 1982-07-01 1984-01-31 American Cyanamid Company Synthetic copolymer surgical articles and method of manufacturing the same
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
US4438253A (en) * 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same

Also Published As

Publication number Publication date
NZ221647A (en) 1990-09-26
BR8704648A (pt) 1988-04-26
AU7797087A (en) 1988-03-10
HU205711B (en) 1992-06-29
IL83764A (en) 1991-05-12
DE3786309T2 (de) 1994-02-10
AU605172B2 (en) 1991-01-10
GR3008526T3 (es) 1993-10-29
FI873840A0 (fi) 1987-09-04
CA1283988C (en) 1991-05-07
EP0258780B1 (en) 1993-06-23
KR880003985A (ko) 1988-05-31
EP0258780A3 (en) 1988-05-18
FI873840A (fi) 1988-03-06
DE3786309D1 (de) 1993-07-29
HUT52945A (en) 1990-09-28
EP0258780A2 (en) 1988-03-09
DK462287D0 (da) 1987-09-04
IL83764A0 (en) 1988-02-29
DK462287A (da) 1988-03-06

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