ES2058081T3 - Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. - Google Patents
Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.Info
- Publication number
- ES2058081T3 ES2058081T3 ES87112279T ES87112279T ES2058081T3 ES 2058081 T3 ES2058081 T3 ES 2058081T3 ES 87112279 T ES87112279 T ES 87112279T ES 87112279 T ES87112279 T ES 87112279T ES 2058081 T3 ES2058081 T3 ES 2058081T3
- Authority
- ES
- Spain
- Prior art keywords
- alkylene oxide
- medicines
- administration
- systems
- cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
LA INVENCION ES UN BLOQUE COPLIMERO ABA O AB ASI COMO UN SISTEMA DE LIBERACION DE FARMACOS DE LENTA LIBERACION QUE COMPRENDE UN FARMACO Y EL BLOQUE COPOLIMERO ABA O AB EN DONDE UN BLOQUE (B) EN UN POLI(ALQUILENE OXIDO) Y LOS OTROS BLOQUES (A) CONSTAN DE COPOLIMEROS DEGRADABLES AL AZAR DEL (1) ESTER CICLICO DE UN ACIDO ALFA-HIDROXI Y (2) UN SEGUNDO MONOMERO DE ESTER CICLICO CON LA CONDICION DE QUE EL SEGUNDO MONOMERO DE ESTER CICLICO NO SEA EL MISMO QUE EN EL PRIMER ESTER CICLICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/903,801 US4882168A (en) | 1986-09-05 | 1986-09-05 | Polyesters containing alkylene oxide blocks as drug delivery systems |
US06/903,797 US4716203A (en) | 1986-09-05 | 1986-09-05 | Diblock and triblock copolymers |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058081T3 true ES2058081T3 (es) | 1994-11-01 |
Family
ID=27129378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87112279T Expired - Lifetime ES2058081T3 (es) | 1986-09-05 | 1987-08-25 | Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0258780B1 (es) |
KR (1) | KR880003985A (es) |
AU (1) | AU605172B2 (es) |
BR (1) | BR8704648A (es) |
CA (1) | CA1283988C (es) |
DE (1) | DE3786309T2 (es) |
DK (1) | DK462287A (es) |
ES (1) | ES2058081T3 (es) |
FI (1) | FI873840A (es) |
GR (1) | GR3008526T3 (es) |
HU (1) | HU205711B (es) |
IL (1) | IL83764A (es) |
NZ (1) | NZ221647A (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL9401703A (nl) * | 1994-10-14 | 1996-05-01 | Rijksuniversiteit | Kauwgom. |
US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
US5702717A (en) * | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
DE19726412A1 (de) * | 1997-06-21 | 1998-12-24 | Merck Patent Gmbh | Implantatmaterial mit einer Träger-Wirkstoff-Kombination |
US6004573A (en) * | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
KR20010030891A (ko) * | 1997-10-03 | 2001-04-16 | 마크로메드 인코퍼레이션 | 가역적 열 겔화 성질을 갖는 생분해성 저분자량 트리블럭폴리(락티드-코-글리콜리드) 폴리에틸렌 글리콜 공중합체 |
US6117949A (en) * | 1998-10-01 | 2000-09-12 | Macromed, Inc. | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6201072B1 (en) | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
US7018645B1 (en) | 2000-04-27 | 2006-03-28 | Macromed, Inc. | Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties |
WO2002076228A1 (en) * | 2001-03-23 | 2002-10-03 | Gumlink A/S | Degradable resin substitute for chewing gum |
JP4354700B2 (ja) | 2001-03-23 | 2009-10-28 | ガムリンク エー/エス | 改良された保存寿命を有する被覆された分解性チューインガムおよびその調製方法 |
JP2004535431A (ja) | 2001-06-22 | 2004-11-25 | サザン バイオシステムズ, インコーポレイテッド | ゼロ次長期放出同軸インプラント |
ES2304501T3 (es) | 2002-02-15 | 2008-10-16 | Nektar Therapeutics Al, Corporation | Polimeros a base de oxido de alquileno degradables hidroliticamente. |
WO2003092468A2 (en) | 2002-04-29 | 2003-11-13 | Gel-Del Technologies, Inc. | Biomatrix structural containment and fixation systems and methods of use thereof |
CN1290893C (zh) * | 2002-05-03 | 2006-12-20 | 詹森药业有限公司 | 聚合物微乳状液 |
US7649023B2 (en) | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
ES2377318T3 (es) | 2002-09-06 | 2012-03-26 | Cerulean Pharma Inc. | Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos |
CA2500022C (en) | 2002-09-24 | 2011-02-22 | Gumlink A/S | Biodegradable chewing gum comprising at least one high molecular weight biodegradable polymer |
JP2006500041A (ja) | 2002-09-24 | 2006-01-05 | ガムリンク エー/エス | 少なくとも2種類の異なる生分解性ポリマーを含有するチューインガム |
ES2312741T3 (es) | 2003-05-06 | 2009-03-01 | Gumlink A/S | Procedimiento para producir granulos de goma de mascar y granulos de goma comprimidos, y un equipo para granular goma de mascar. |
EP1474995B1 (en) | 2003-05-06 | 2012-11-14 | Gumlink A/S | A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product |
US8465537B2 (en) | 2003-06-17 | 2013-06-18 | Gel-Del Technologies, Inc. | Encapsulated or coated stent systems |
WO2005034852A2 (en) | 2003-08-26 | 2005-04-21 | Gel-Del Technologies, Inc. | Protein biomaterials and biocoacervates and methods of making and using thereof |
US8529939B2 (en) | 2003-12-08 | 2013-09-10 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
WO2009086483A2 (en) | 2007-12-26 | 2009-07-09 | Gel-Del Technologies, Inc. | Biocompatible protein particles, particle devices and methods thereof |
US10016534B2 (en) | 2008-11-17 | 2018-07-10 | Gel-Del Technologies, Inc. | Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof |
BR112012005594A2 (pt) | 2009-09-15 | 2015-09-08 | Cerulean Pharma Inc | tratamento de câncer |
CN105797168A (zh) | 2010-05-18 | 2016-07-27 | 天蓝制药公司 | 用于治疗自身免疫性疾病或其它疾病的组合物和方法 |
US20140094432A1 (en) | 2012-10-02 | 2014-04-03 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
US20230285576A1 (en) | 2020-08-05 | 2023-09-14 | Ellipses Pharma Ltd | Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3736646A (en) * | 1971-10-18 | 1973-06-05 | American Cyanamid Co | Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures |
US4047533A (en) * | 1976-09-20 | 1977-09-13 | American Cyanamid Company | Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant |
US4429080A (en) * | 1982-07-01 | 1984-01-31 | American Cyanamid Company | Synthetic copolymer surgical articles and method of manufacturing the same |
US4452973A (en) * | 1982-11-12 | 1984-06-05 | American Cyanamid Company | Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same |
US4438253A (en) * | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
-
1987
- 1987-08-25 EP EP87112279A patent/EP0258780B1/en not_active Expired - Lifetime
- 1987-08-25 DE DE87112279T patent/DE3786309T2/de not_active Expired - Fee Related
- 1987-08-25 ES ES87112279T patent/ES2058081T3/es not_active Expired - Lifetime
- 1987-09-02 NZ NZ221647A patent/NZ221647A/xx unknown
- 1987-09-03 IL IL83764A patent/IL83764A/xx not_active IP Right Cessation
- 1987-09-03 CA CA000546072A patent/CA1283988C/en not_active Expired - Fee Related
- 1987-09-04 FI FI873840A patent/FI873840A/fi not_active Application Discontinuation
- 1987-09-04 DK DK462287A patent/DK462287A/da not_active Application Discontinuation
- 1987-09-04 AU AU77970/87A patent/AU605172B2/en not_active Ceased
- 1987-09-04 KR KR870009842A patent/KR880003985A/ko not_active Application Discontinuation
- 1987-09-04 HU HU873970A patent/HU205711B/hu not_active IP Right Cessation
- 1987-09-04 BR BR8704648A patent/BR8704648A/pt not_active Application Discontinuation
-
1993
- 1993-07-16 GR GR920403165T patent/GR3008526T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ221647A (en) | 1990-09-26 |
BR8704648A (pt) | 1988-04-26 |
AU7797087A (en) | 1988-03-10 |
HU205711B (en) | 1992-06-29 |
IL83764A (en) | 1991-05-12 |
DE3786309T2 (de) | 1994-02-10 |
AU605172B2 (en) | 1991-01-10 |
GR3008526T3 (es) | 1993-10-29 |
FI873840A0 (fi) | 1987-09-04 |
CA1283988C (en) | 1991-05-07 |
EP0258780B1 (en) | 1993-06-23 |
KR880003985A (ko) | 1988-05-31 |
EP0258780A3 (en) | 1988-05-18 |
FI873840A (fi) | 1988-03-06 |
DE3786309D1 (de) | 1993-07-29 |
HUT52945A (en) | 1990-09-28 |
EP0258780A2 (en) | 1988-03-09 |
DK462287D0 (da) | 1987-09-04 |
IL83764A0 (en) | 1988-02-29 |
DK462287A (da) | 1988-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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