ATE391742T1 - Hydrolytisch abbaubare polyalkylenoxid-polymere - Google Patents
Hydrolytisch abbaubare polyalkylenoxid-polymereInfo
- Publication number
- ATE391742T1 ATE391742T1 AT03709198T AT03709198T ATE391742T1 AT E391742 T1 ATE391742 T1 AT E391742T1 AT 03709198 T AT03709198 T AT 03709198T AT 03709198 T AT03709198 T AT 03709198T AT E391742 T1 ATE391742 T1 AT E391742T1
- Authority
- AT
- Austria
- Prior art keywords
- polymer
- hydrolytically degradable
- hydrolytically
- polyalkylene oxide
- oxide polymers
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 5
- 229920000233 poly(alkylene oxides) Polymers 0.000 title 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 abstract 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000000017 hydrogel Substances 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- 229920000428 triblock copolymer Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
- C08G64/183—Block or graft polymers containing polyether sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
- C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33344—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carbamate group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Polyethers (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35735002P | 2002-02-15 | 2002-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE391742T1 true ATE391742T1 (de) | 2008-04-15 |
Family
ID=27757601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03709198T ATE391742T1 (de) | 2002-02-15 | 2003-02-14 | Hydrolytisch abbaubare polyalkylenoxid-polymere |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20060239961A1 (de) |
| EP (1) | EP1476489B8 (de) |
| AT (1) | ATE391742T1 (de) |
| AU (1) | AU2003213152A1 (de) |
| DE (1) | DE60320224T2 (de) |
| ES (1) | ES2304501T3 (de) |
| WO (1) | WO2003070805A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE391742T1 (de) * | 2002-02-15 | 2008-04-15 | Nektar Therapeutics Al Corp | Hydrolytisch abbaubare polyalkylenoxid-polymere |
| WO2004022120A1 (en) * | 2002-09-04 | 2004-03-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions comprising bone marrow cells, demineralized bone matrix and rtg polymers for use in the induction of bone and cartilage formation |
| WO2006019904A1 (en) | 2004-07-14 | 2006-02-23 | University Of Utha Research Foundation | Netrin-related compositions and uses |
| EP1841808B1 (de) * | 2004-12-22 | 2009-01-21 | California Institute Of Technology | Abbaubare polymere und herstellungsverfahren dafür |
| WO2006078163A2 (en) * | 2005-01-18 | 2006-07-27 | Dolphys Technologies B.V. | High molecular weight non-ionic surfactants comprising nitrogen or phosphorus containing groups |
| EP1861125A2 (de) * | 2005-03-23 | 2007-12-05 | Nektar Therapeutics Al, Corporation | Konjugate eines hgh-teils und peg-derivate |
| US7517914B2 (en) | 2005-04-04 | 2009-04-14 | Boston Scientificscimed, Inc. | Controlled degradation materials for therapeutic agent delivery |
| US8263109B2 (en) | 2005-05-09 | 2012-09-11 | Boston Scientific Scimed, Inc. | Injectable bulking compositions |
| JP5096363B2 (ja) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | Ｇｌｐ−１のポリマ複合体 |
| EP1986695B1 (de) | 2006-02-21 | 2015-06-03 | Nektar Therapeutics | Segmentierte abbaubare polymere und daraus hergestellte konjugate |
| SI2054074T1 (sl) * | 2006-08-04 | 2014-12-31 | Prolong Pharmaceuticals Llc | Modificiran eritropoetin |
| WO2008033497A1 (en) * | 2006-09-14 | 2008-03-20 | The Research Foundation Of State University Of New York | Nanostructured smart gel for time release drug delivery |
| KR100838809B1 (ko) | 2007-05-03 | 2008-06-17 | 성균관대학교산학협력단 | 겔강도가 우수한 온도 및 피에치 민감성 블록 공중합체 및이의 제조방법과 이를 이용한 약물전달체 |
| JP5739668B2 (ja) * | 2008-02-13 | 2015-06-24 | ハイパーブランチ メディカル テクノロジー， インコーポレイテッド | 調節可能な分解速度を有する架橋ポリアルキレンイミンヒドロゲル |
| WO2009108891A2 (en) * | 2008-02-29 | 2009-09-03 | Egen, Inc. | Modified poloxamers for gene expression and associated methods |
| AU2009292643B2 (en) | 2008-09-19 | 2016-02-18 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
| US9399044B2 (en) | 2014-05-28 | 2016-07-26 | International Business Machines Corporation | Antimicrobial cationic polyamines |
| WO2024153784A1 (en) * | 2023-01-20 | 2024-07-25 | Basf Se | Use of butronics as small molecule solubilizers |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3227740A (en) * | 1963-02-25 | 1966-01-04 | Union Oil Co | Preparation of alkyl carbonates |
| US4189609A (en) * | 1974-08-19 | 1980-02-19 | Basf Wyandotte Corporation | Multi-block coupled polyoxyalkylene copolymer surfactants |
| DE2536121A1 (de) * | 1974-08-19 | 1976-03-04 | Basf Wyandotte Corp | Oberflaechenaktive block-polyoxyalkylencopolymere |
| DE3786309T2 (de) * | 1986-09-05 | 1994-02-10 | American Cyanamid Co | Alkylenoxydblöcke enthaltende Polyester und deren Verwendung als Arzneimittelabgabesysteme. |
| US4866143A (en) * | 1988-04-21 | 1989-09-12 | Basf Corporation | Novel surfactants based on poly(alkylene carbonate)s |
| US5330768A (en) * | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
| US5650234A (en) * | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
| WO1997005185A2 (en) * | 1995-07-28 | 1997-02-13 | Focal, Inc. | Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents |
| US5861174A (en) * | 1996-07-12 | 1999-01-19 | University Technology Corporation | Temperature sensitive gel for sustained delivery of protein drugs |
| ZA978537B (en) * | 1996-09-23 | 1998-05-12 | Focal Inc | Polymerizable biodegradable polymers including carbonate or dioxanone linkages. |
| US6258351B1 (en) * | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
| US7074878B1 (en) * | 1999-12-10 | 2006-07-11 | Harris J Milton | Hydrolytically degradable polymers and hydrogels made therefrom |
| US6348558B1 (en) * | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
| ATE391742T1 (de) * | 2002-02-15 | 2008-04-15 | Nektar Therapeutics Al Corp | Hydrolytisch abbaubare polyalkylenoxid-polymere |
| JP4723244B2 (ja) * | 2002-07-19 | 2011-07-13 | オメロス コーポレイション | 生分解性トリブロックコポリマー、その合成方法、ならびにそれから作製されるヒドロゲルおよび生体材料 |
-
2003
- 2003-02-14 AT AT03709198T patent/ATE391742T1/de not_active IP Right Cessation
- 2003-02-14 AU AU2003213152A patent/AU2003213152A1/en not_active Abandoned
- 2003-02-14 DE DE60320224T patent/DE60320224T2/de not_active Expired - Lifetime
- 2003-02-14 ES ES03709198T patent/ES2304501T3/es not_active Expired - Lifetime
- 2003-02-14 EP EP03709198A patent/EP1476489B8/de not_active Expired - Lifetime
- 2003-02-14 US US10/371,996 patent/US20060239961A1/en not_active Abandoned
- 2003-02-14 WO PCT/US2003/005113 patent/WO2003070805A1/en not_active Ceased
-
2011
- 2011-05-16 US US13/108,616 patent/US9040060B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003213152A1 (en) | 2003-09-09 |
| DE60320224T2 (de) | 2009-05-14 |
| WO2003070805A1 (en) | 2003-08-28 |
| US9040060B2 (en) | 2015-05-26 |
| ES2304501T3 (es) | 2008-10-16 |
| DE60320224D1 (de) | 2008-05-21 |
| EP1476489A1 (de) | 2004-11-17 |
| US20060239961A1 (en) | 2006-10-26 |
| EP1476489B1 (de) | 2008-04-09 |
| EP1476489B8 (de) | 2008-10-08 |
| US20110217343A1 (en) | 2011-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |