DK1638539T3 - Farmaceutiske sammensætninger omfattende pH-sensitive blokcopolymerer og et hydrofobisk medikament - Google Patents
Farmaceutiske sammensætninger omfattende pH-sensitive blokcopolymerer og et hydrofobisk medikamentInfo
- Publication number
- DK1638539T3 DK1638539T3 DK04727195T DK04727195T DK1638539T3 DK 1638539 T3 DK1638539 T3 DK 1638539T3 DK 04727195 T DK04727195 T DK 04727195T DK 04727195 T DK04727195 T DK 04727195T DK 1638539 T3 DK1638539 T3 DK 1638539T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical compositions
- block copolymers
- poly
- alkyl
- hydrophobic drug
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229920001400 block copolymer Polymers 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 230000002209 hydrophobic effect Effects 0.000 title abstract 2
- 230000000712 assembly Effects 0.000 abstract 2
- 238000000429 assembly Methods 0.000 abstract 2
- 239000000693 micelle Substances 0.000 abstract 2
- -1 poly(ethylene oxide) Polymers 0.000 abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/607,446 US7094810B2 (en) | 2001-06-08 | 2003-06-25 | pH-sensitive block copolymers for pharmaceutical compositions |
| PCT/CA2004/000561 WO2004112757A1 (en) | 2003-06-25 | 2004-04-14 | Pharmaceutical compositions comprising ph-sensitive block copolymers and a hydrophobic drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1638539T3 true DK1638539T3 (da) | 2009-05-04 |
Family
ID=33540273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04727195T DK1638539T3 (da) | 2003-06-25 | 2004-04-14 | Farmaceutiske sammensætninger omfattende pH-sensitive blokcopolymerer og et hydrofobisk medikament |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7094810B2 (da) |
| EP (1) | EP1638539B1 (da) |
| JP (1) | JP4619357B2 (da) |
| AT (1) | ATE418970T1 (da) |
| AU (1) | AU2004248863B2 (da) |
| BR (1) | BRPI0411872A (da) |
| CA (1) | CA2530736C (da) |
| CY (1) | CY1110264T1 (da) |
| DE (1) | DE602004018772D1 (da) |
| DK (1) | DK1638539T3 (da) |
| ES (1) | ES2323701T3 (da) |
| MX (1) | MXPA05014017A (da) |
| PL (1) | PL1638539T3 (da) |
| PT (1) | PT1638539E (da) |
| SI (1) | SI1638539T1 (da) |
| WO (1) | WO2004112757A1 (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523544A (ja) * | 2000-02-17 | 2003-08-05 | レックスマーク・インターナショナル・インコーポレーテツド | 導電性駆動ハブを備えたトナーカートリッジ |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| WO2005079856A1 (en) * | 2004-02-23 | 2005-09-01 | The University Of British Columbia | Drug delivery compositions comprising hydrophobic polymers and amphipathic molecules |
| US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| US20090074872A1 (en) * | 2006-06-26 | 2009-03-19 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
| RU2009102262A (ru) * | 2006-06-26 | 2010-08-10 | Мьючуал Фармасьютикал Компани, Инк. (Us) | Композиции активного агента, способы их получения и способы применения |
| BRPI0716890A2 (pt) * | 2006-09-22 | 2013-10-22 | Labopharm Inc | Composição, e, método de produção de uma composição, de administração de um agente farmaceuticamente ativo insolúvel em água a um mamífero, e de tratamento de câncer em um mamífero |
| JP5340956B2 (ja) * | 2006-12-20 | 2013-11-13 | アーケマ・インコーポレイテッド | ポリマーの封入および／または結合 |
| WO2008128292A1 (en) * | 2007-04-20 | 2008-10-30 | University Of South Australia | Nanoparticle-coated capsule formulation for dermal drug delivery |
| JP2010539245A (ja) * | 2007-09-14 | 2010-12-16 | 日東電工株式会社 | 薬物担体 |
| FR2922452B1 (fr) * | 2007-10-19 | 2010-01-22 | Coatex Sas | Formulations de composes organoplatiniques en presence de polymeres associatifs, produits obtenus et leurs utilisations |
| TWI388591B (zh) * | 2008-03-28 | 2013-03-11 | Ind Tech Res Inst | 溫度敏感性材料 |
| US8778400B2 (en) * | 2008-04-21 | 2014-07-15 | University Of South Australia | Nanoparticle-stabilized capsule formulation for treatment of inflammation |
| AU2009246321A1 (en) * | 2008-05-13 | 2009-11-19 | Phaserx, Inc. | Polymeric carrier |
| CN102066444A (zh) | 2008-05-13 | 2011-05-18 | 华盛顿大学 | 胶束装配体 |
| WO2009140427A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Diblock copolymers and polynucleotide complexes thereof for delivery into cells |
| WO2009140423A2 (en) * | 2008-05-13 | 2009-11-19 | University Of Washington | Targeted polymer bioconjugates |
| WO2009140432A2 (en) * | 2008-05-13 | 2009-11-19 | University Of Washington | Micelles for intracellular delivery of therapeutic agents |
| CA2724004C (en) * | 2008-05-16 | 2016-08-23 | The University Of Sydney | Administrable compositions comprising particulate material dispersed throughout a liquid carrier |
| CA2635187A1 (en) | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
| CN102076345B (zh) | 2008-06-24 | 2013-05-08 | 那野伽利阿株式会社 | 顺铂配位化合物的液体组合物 |
| CA2734917A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| CA2742955A1 (en) | 2008-11-06 | 2010-05-14 | University Of Washington | Bispecific intracellular delivery vehicles |
| KR20110095292A (ko) | 2008-11-06 | 2011-08-24 | 유니버시티 오브 워싱톤 | 다중블록 공중합체 |
| JP2012511053A (ja) | 2008-12-08 | 2012-05-17 | ユニヴァーシティ オブ ワシントン | オメガ機能性化ポリマー、ジャンクション機能性化ブロック共重合体、およびラジカル連鎖延長重合 |
| US20100159010A1 (en) * | 2008-12-24 | 2010-06-24 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
| TWI374903B (en) * | 2008-12-31 | 2012-10-21 | Ind Tech Res Inst | Biodegradable copolymer hydrogel materials |
| WO2011062965A2 (en) | 2009-11-18 | 2011-05-26 | University Of Washington Through Its Center For Commercialization | Targeting monomers and polymers having targeting blocks |
| CA2919828C (en) | 2013-07-30 | 2022-07-19 | Phaserx, Inc. | Block copolymers and their conjugates or complexes with oligonucleotides |
| CA2974503A1 (en) | 2015-01-21 | 2016-07-28 | Phaserx, Inc. | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
| JP2019513151A (ja) | 2016-03-08 | 2019-05-23 | ロス ガトス ファーマスーティカルズ， インク．Ｌｏｓ Ｇａｔｏｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | カンプトテシン誘導体及びその使用 |
| WO2017156191A1 (en) | 2016-03-08 | 2017-09-14 | Los Gatos Pharmaceuticals, Inc. | Composite nanoparticles and uses thereof |
| CN106432647B (zh) * | 2016-09-26 | 2018-10-30 | 华南理工大学 | 基于叔氨基的pH响应嵌段聚合物及其混合胶束与应用 |
| WO2018126084A1 (en) | 2016-12-30 | 2018-07-05 | Phaserx, Inc. | Branched peg molecules and related compositions and methods |
| WO2019032975A1 (en) * | 2017-08-10 | 2019-02-14 | Mec Device Pharma International Llc | ANTI-ABUSE MEDICINAL FORMULATIONS |
| CN114377144A (zh) * | 2022-01-28 | 2022-04-22 | 南通大学 | pH/活性氧双重响应性超分子聚肽前药纳米粒子 |
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| GB1411843A (en) * | 1973-02-28 | 1975-10-29 | Univ Strathclyde | Method of modifying the properties of a polymer |
| JPS5767860A (en) * | 1980-10-15 | 1982-04-24 | Fuji Photo Film Co Ltd | Material for multilayer analysis |
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| KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
| US5840319A (en) | 1992-10-08 | 1998-11-24 | Alakhov; Valery Yu | Biological agent compositions |
| EP0639592A1 (en) * | 1993-08-18 | 1995-02-22 | Nippon Shokubai Co., Ltd. | Water-soluble graft polymers and production process thereof |
| US5786387A (en) | 1994-03-23 | 1998-07-28 | Meiji Seika Kabushiki Kaisha | Lipid double-chain derivative containing polyoxyethylene |
| US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
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| US6221959B1 (en) | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
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| WO1996021036A2 (en) | 1994-12-30 | 1996-07-11 | Chiron Viagene, Inc. | Nucleic acid condensing agents with reduced immunogenicity |
| US5492996A (en) * | 1995-02-21 | 1996-02-20 | The United States Of America As Represented By The Secretary Of The Air Force | Alcohol soluble benzazole polymers |
| CN1085987C (zh) | 1995-04-19 | 2002-06-05 | 片冈一则 | 杂远螯嵌段共聚物及其制备方法 |
| US5908777A (en) | 1995-06-23 | 1999-06-01 | University Of Pittsburgh | Lipidic vector for nucleic acid delivery |
| NZ313769A (en) | 1995-08-10 | 2000-02-28 | Kazunori Kataoka | block polymer having a functional group presented on each end |
| US5770627A (en) | 1995-08-16 | 1998-06-23 | University Of Washington | Hydrophobically-modified bioadhesive polyelectrolytes and methods relating thereto |
| US5702717A (en) | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
| DE69707853T2 (de) | 1996-03-15 | 2002-06-27 | President And Fellows Of Harvard College, Cambridge | Verfahren zum formen von gegenständen und zum mikrostrukturieren von oberflächen durch giessformen mit kapillarwirkung |
| US5955509A (en) | 1996-05-01 | 1999-09-21 | Board Of Regents, The University Of Texas System | pH dependent polymer micelles |
| EP0910351A1 (en) * | 1996-06-27 | 1999-04-28 | G.D. Searle & Co. | Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications |
| GB9623051D0 (en) | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
| AU733692B2 (en) | 1997-02-28 | 2001-05-24 | Regents Of The University Of California, The | Inhibition of cell-cell binding by lipid assemblies |
| EP0963758A3 (en) | 1998-05-07 | 2000-03-22 | Universiteit Gent | Synthetic polyaminoacid complexes for delivery of nucleic acids to target cells |
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| CN1313873A (zh) | 1998-07-13 | 2001-09-19 | 表达遗传学公司 | 作为可溶性,生物可降解基因送递载体的聚－l－赖氨酸的聚酯类似物 |
| DE19919785A1 (de) | 1999-04-30 | 2000-12-07 | Wella Ag | Haarbehandlungsmittel mit Polymeren aus ungesättigten Sacchariden, ungesättigten Saccharidsäuren oder deren Derivaten |
| DE10008895A1 (de) | 2000-02-25 | 2001-08-30 | Beiersdorf Ag | Stabilisierung oxidations- und/oder UV-empfindlicher Wirkstoffe |
| EP1286643A2 (en) | 2000-05-17 | 2003-03-05 | Labopharm Inc. | Drug containing polymeric micelles |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US6780428B2 (en) | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
| GB0131112D0 (en) * | 2001-12-31 | 2002-02-13 | Univ London Pharmacy | Block copolymers |
| WO2004035013A2 (en) | 2002-10-21 | 2004-04-29 | L'oreal | Process for dissolving lipophilic compounds, and cosmetic composition |
-
2003
- 2003-06-25 US US10/607,446 patent/US7094810B2/en not_active Expired - Lifetime
-
2004
- 2004-04-14 WO PCT/CA2004/000561 patent/WO2004112757A1/en active Application Filing
- 2004-04-14 CA CA2530736A patent/CA2530736C/en not_active Expired - Lifetime
- 2004-04-14 AU AU2004248863A patent/AU2004248863B2/en not_active Ceased
- 2004-04-14 ES ES04727195T patent/ES2323701T3/es not_active Expired - Lifetime
- 2004-04-14 MX MXPA05014017A patent/MXPA05014017A/es active IP Right Grant
- 2004-04-14 DK DK04727195T patent/DK1638539T3/da active
- 2004-04-14 JP JP2006515571A patent/JP4619357B2/ja not_active Expired - Lifetime
- 2004-04-14 SI SI200431088T patent/SI1638539T1/sl unknown
- 2004-04-14 PT PT04727195T patent/PT1638539E/pt unknown
- 2004-04-14 EP EP04727195A patent/EP1638539B1/en not_active Expired - Lifetime
- 2004-04-14 AT AT04727195T patent/ATE418970T1/de active
- 2004-04-14 PL PL04727195T patent/PL1638539T3/pl unknown
- 2004-04-14 DE DE602004018772T patent/DE602004018772D1/de not_active Expired - Lifetime
- 2004-04-14 BR BRPI0411872-3A patent/BRPI0411872A/pt not_active IP Right Cessation
-
2009
- 2009-03-31 CY CY20091100371T patent/CY1110264T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1638539A1 (en) | 2006-03-29 |
| MXPA05014017A (es) | 2007-01-31 |
| CY1110264T1 (el) | 2015-01-14 |
| DE602004018772D1 (de) | 2009-02-12 |
| CA2530736A1 (en) | 2004-12-29 |
| ATE418970T1 (de) | 2009-01-15 |
| SI1638539T1 (sl) | 2009-10-31 |
| AU2004248863B2 (en) | 2009-03-12 |
| JP2007505029A (ja) | 2007-03-08 |
| US7094810B2 (en) | 2006-08-22 |
| WO2004112757A1 (en) | 2004-12-29 |
| BRPI0411872A (pt) | 2006-08-08 |
| US20040072784A1 (en) | 2004-04-15 |
| ES2323701T3 (es) | 2009-07-23 |
| AU2004248863A1 (en) | 2004-12-29 |
| JP4619357B2 (ja) | 2011-01-26 |
| PL1638539T3 (pl) | 2009-10-30 |
| EP1638539B1 (en) | 2008-12-31 |
| PT1638539E (pt) | 2009-04-09 |
| CA2530736C (en) | 2013-07-02 |
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