WO2004078111A3 - Extended release minocycline compositions and processes for their preparation - Google Patents

Extended release minocycline compositions and processes for their preparation Download PDF

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Publication number
WO2004078111A3
WO2004078111A3 PCT/IB2004/000631 IB2004000631W WO2004078111A3 WO 2004078111 A3 WO2004078111 A3 WO 2004078111A3 IB 2004000631 W IB2004000631 W IB 2004000631W WO 2004078111 A3 WO2004078111 A3 WO 2004078111A3
Authority
WO
WIPO (PCT)
Prior art keywords
minocycline
extended release
processes
preparation
demethyltetracycline
Prior art date
Application number
PCT/IB2004/000631
Other languages
French (fr)
Other versions
WO2004078111A2 (en
Inventor
Prashant Manohar Mandaogade
Rajeev Singh Raghuvanshi
Ashok Rampal
Original Assignee
Ranbaxy Lab Ltd
Prashant Manohar Mandaogade
Rajeev Singh Raghuvanshi
Ashok Rampal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Prashant Manohar Mandaogade, Rajeev Singh Raghuvanshi, Ashok Rampal filed Critical Ranbaxy Lab Ltd
Publication of WO2004078111A2 publication Critical patent/WO2004078111A2/en
Publication of WO2004078111A3 publication Critical patent/WO2004078111A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to extended or controlled release pharmaceutical compositions of 7-dimethylamino-6-deoxy-6-demethyltetracycline (minocycline) or non-toxic acid addition salts thereof. More particularly, it relates to a once-a-day delivery system for minocycline that maintains its therapeutic plasma concentrations in a patient for twenty-four hours. The extended release pharmaceutical composition includes a mixture of 7-dimethylamino-6-deoxy-6-demethyltetracycline (minocycline), or a non-toxic acid addition salt thereof, and two or more hydrophilic matrix forming polymers configured to form a matrix upon administration. Each hydrophilic matrix forming polymer differs at least in viscosity.
PCT/IB2004/000631 2003-03-06 2004-03-08 Extended release minocycline compositions and processes for their preparation WO2004078111A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN235/DEL/2003 2003-03-06
IN235DE2003 2003-03-06

Publications (2)

Publication Number Publication Date
WO2004078111A2 WO2004078111A2 (en) 2004-09-16
WO2004078111A3 true WO2004078111A3 (en) 2004-10-28

Family

ID=32948048

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/000631 WO2004078111A2 (en) 2003-03-06 2004-03-08 Extended release minocycline compositions and processes for their preparation

Country Status (1)

Country Link
WO (1) WO2004078111A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006099258A1 (en) 2005-03-14 2006-09-21 Wyeth Tigecycline compositions and methods of preparation
US7541347B2 (en) 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7544373B2 (en) 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7919483B2 (en) 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
GB0703909D0 (en) * 2007-02-28 2007-04-11 Neuropharm Ltd Treatment of anxiety disorders
PT2271348T (en) * 2008-03-28 2018-04-16 Paratek Pharm Innc Oral tablet formulation of tetracycline compound
WO2010017310A1 (en) 2008-08-06 2010-02-11 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
CN104606171A (en) * 2015-02-04 2015-05-13 上海华源安徽仁济制药有限公司 Minocycline hydrochloride capsule and preparation method thereof
US11103517B2 (en) 2015-04-07 2021-08-31 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions for minocycline

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5277916A (en) * 1988-02-01 1994-01-11 F. H. Faulding & Co., Ltd. Tetracycline dosage form
WO2000038650A1 (en) * 1998-12-23 2000-07-06 Alza Corporation Gastric retention dosage form having multiple layers
US20030017189A1 (en) * 1998-12-23 2003-01-23 Patrick S.-L. Wong Gastric retaining oral liquid dosage form

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5277916A (en) * 1988-02-01 1994-01-11 F. H. Faulding & Co., Ltd. Tetracycline dosage form
WO2000038650A1 (en) * 1998-12-23 2000-07-06 Alza Corporation Gastric retention dosage form having multiple layers
US20030017189A1 (en) * 1998-12-23 2003-01-23 Patrick S.-L. Wong Gastric retaining oral liquid dosage form

Also Published As

Publication number Publication date
WO2004078111A2 (en) 2004-09-16

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