DE60044459D1 - IN ORGANISCHEN LÖSEMITTELN LÖSLICHE BIOLOGISCH ABBAUBARE POLY (ALKYLENOXID)- POLY (p-DIOXANON) BLOCKCOPOLYMERE SOWIE DIESE ENTHALTENDE ZUSAMMENSETZUNG ZUR ARZNEISTOFFVERABREICHUNG - Google Patents
IN ORGANISCHEN LÖSEMITTELN LÖSLICHE BIOLOGISCH ABBAUBARE POLY (ALKYLENOXID)- POLY (p-DIOXANON) BLOCKCOPOLYMERE SOWIE DIESE ENTHALTENDE ZUSAMMENSETZUNG ZUR ARZNEISTOFFVERABREICHUNGInfo
- Publication number
- DE60044459D1 DE60044459D1 DE60044459T DE60044459T DE60044459D1 DE 60044459 D1 DE60044459 D1 DE 60044459D1 DE 60044459 T DE60044459 T DE 60044459T DE 60044459 T DE60044459 T DE 60044459T DE 60044459 D1 DE60044459 D1 DE 60044459D1
- Authority
- DE
- Germany
- Prior art keywords
- poly
- dioxanone
- organic solvents
- alkylene oxide
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019990029269A KR20010010393A (ko) | 1999-07-20 | 1999-07-20 | 소수성 고분자와 친수성 고분자의 생분해성 블록 공중합체 및이를 포함하는 약물 전달체 조성물 |
PCT/KR2000/000779 WO2001005379A1 (en) | 1999-07-20 | 2000-07-18 | BIODEGRADABLE POLY(ALKYLENE OXIDE)-POLY(p-DIOXANONE) BLOCK COPOLYMER SOLUBLE IN ORGANIC SOLVENTS, AND DRUG DELIVERY COMPOSITION COMPRISING SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60044459D1 true DE60044459D1 (de) | 2010-07-08 |
Family
ID=19602907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60044459T Expired - Lifetime DE60044459D1 (de) | 1999-07-20 | 2000-07-18 | IN ORGANISCHEN LÖSEMITTELN LÖSLICHE BIOLOGISCH ABBAUBARE POLY (ALKYLENOXID)- POLY (p-DIOXANON) BLOCKCOPOLYMERE SOWIE DIESE ENTHALTENDE ZUSAMMENSETZUNG ZUR ARZNEISTOFFVERABREICHUNG |
Country Status (14)
Country | Link |
---|---|
US (1) | US6599519B1 (de) |
EP (1) | EP1196149B1 (de) |
JP (1) | JP3955759B2 (de) |
KR (2) | KR20010010393A (de) |
CN (1) | CN1205248C (de) |
AT (1) | ATE468848T1 (de) |
AU (1) | AU758838B2 (de) |
BR (1) | BRPI0012588B8 (de) |
CA (1) | CA2379672C (de) |
DE (1) | DE60044459D1 (de) |
MX (1) | MXPA02000600A (de) |
NZ (1) | NZ517035A (de) |
WO (1) | WO2001005379A1 (de) |
ZA (1) | ZA200200462B (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6201072B1 (en) * | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US7217770B2 (en) * | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
US6362308B1 (en) * | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
US7374782B2 (en) * | 2000-10-27 | 2008-05-20 | Baxter International Inc. | Production of microspheres |
GB0029750D0 (en) * | 2000-12-06 | 2001-01-17 | Laporte Performance Chemicals | Alkylene oxide-lactone copolymers |
EP1343372A2 (de) | 2000-12-21 | 2003-09-17 | Nektar Therapeutics | Pulmonale verabreichung von polyene-antipilzmitteln |
DK1392254T3 (da) | 2001-04-20 | 2007-07-02 | Univ British Columbia | Micelle-lægemiddelindgivelsessystem for hydrofobe lægemidler |
KR100773078B1 (ko) * | 2001-06-21 | 2007-11-02 | 주식회사 삼양사 | 결정성이 높은 난용성 약물을 함유하는 고분자 미셀형약물 조성물 |
US7049285B2 (en) * | 2001-10-31 | 2006-05-23 | Myung-Ok Park | Biocompatible polymers including peptide spacer |
JP4290381B2 (ja) * | 2002-04-11 | 2009-07-01 | 学校法人 聖マリアンナ医科大学 | ピリドンカルボン酸化合物含有エマルション |
EP1532985B1 (de) * | 2002-06-25 | 2016-10-12 | Takeda Pharmaceutical Company Limited | Verfahren zur herstellung einer zusammensetzung mit verzögerter freisetzung |
KR100502840B1 (ko) * | 2002-09-04 | 2005-07-21 | 학교법인 포항공과대학교 | 약물 담지능력이 우수한 블록 공중합체 미셀 조성물 |
EP2181704B1 (de) * | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Wirkstofffreisetzung von schnell gelierender Polymerzusammensetzung |
JPWO2005018607A1 (ja) * | 2003-08-20 | 2007-11-01 | 味の素株式会社 | 溶解性を改善した医薬品製剤 |
KR100597845B1 (ko) | 2004-12-29 | 2006-07-10 | 호남석유화학 주식회사 | 폴리파라다이옥산온의 제조방법 |
CA2628580C (en) * | 2005-12-06 | 2014-07-08 | Tyco Healthcare Group Lp | Bioabsorbable compounds and compositions containing them |
US20100008998A1 (en) * | 2006-09-26 | 2010-01-14 | Samyang Corporation | Submicron nanoparticle of poorly water soluble camptothecin derivatives and process for preparation thereof |
EP1920765A1 (de) * | 2006-11-07 | 2008-05-14 | Medigene AG | Single-Pass Verfahren zur Liposomherstellung |
JP5613679B2 (ja) | 2009-10-21 | 2014-10-29 | 日本化薬株式会社 | 腹腔内投与用の抗がん剤含有ブロック共重合体、ミセル調製物及びそれを有効成分とする癌治療薬 |
US20110237686A1 (en) | 2010-03-26 | 2011-09-29 | Cerulean Pharma Inc | Formulations and methods of use |
WO2012108606A1 (ko) * | 2011-02-08 | 2012-08-16 | 이화여자대학교 산학협력단 | 졸-겔 전이 키토산-폴리머 복합체 및 그의 용도 |
PL2782584T3 (pl) | 2011-11-23 | 2021-12-13 | Therapeuticsmd, Inc. | Naturalne skojarzone hormonalne formulacje i terapie zastępcze |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9822257B2 (en) | 2012-07-23 | 2017-11-21 | Crayola Llc | Dissolvable films and methods of using the same |
US20150202313A1 (en) * | 2012-08-31 | 2015-07-23 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Macromolecular Prodrugs for Hard Tissue and Methods of Use Thereof |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9949928B2 (en) * | 2013-05-01 | 2018-04-24 | The Regents Of The University Of Colorado, A Body Corporate | Biodegradable copolymers, systems including the copolymers, and methods of forming and using same |
US10206932B2 (en) | 2014-05-22 | 2019-02-19 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
KR101501217B1 (ko) * | 2014-07-17 | 2015-03-10 | 최명 | 필러용 폴리디옥사논 입자의 제조방법 |
HRP20221024T1 (hr) | 2014-12-09 | 2022-11-11 | Sweetwater Energy, Inc. | Brza prethodna obrada |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
AU2017239645A1 (en) | 2016-04-01 | 2018-10-18 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
CN110087637A (zh) * | 2016-12-14 | 2019-08-02 | 株式会社三养生物制药 | 胶束稳定性提升的两亲性嵌段共聚物组合物及包含其的药学组合物 |
BR112019017106A2 (pt) | 2017-02-16 | 2020-04-28 | Sweetwater Energy Inc | formação de zona de alta pressão para pré-tratamento |
KR102013041B1 (ko) | 2017-12-21 | 2019-08-21 | 포항공과대학교 산학협력단 | 항암제가 담지된 나노구조체를 유효성분으로 포함하는 간암 치료용 약학조성물 |
KR102093660B1 (ko) * | 2019-07-08 | 2020-03-26 | (주)리젠바이오참 | 온도감응형 조직유착 방지용 하이드로겔 조성물 및 그 제조방법 |
BR112022012348A2 (pt) | 2019-12-22 | 2022-09-13 | Sweetwater Energy Inc | Métodos de fazer lignina especializada e produtos de lignina da biomassa |
KR102365597B1 (ko) * | 2019-12-24 | 2022-02-18 | 성균관대학교산학협력단 | 에멀젼 조성물, 그리고 이를 포함하는 약물 조성물 및 화장품용 조성물 |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4052988A (en) | 1976-01-12 | 1977-10-11 | Ethicon, Inc. | Synthetic absorbable surgical devices of poly-dioxanone |
US4643191A (en) | 1985-11-29 | 1987-02-17 | Ethicon, Inc. | Crystalline copolymers of p-dioxanone and lactide and surgical devices made therefrom |
US5019094A (en) * | 1990-05-09 | 1991-05-28 | Ethicon, Inc. | Crystalline copolymers of p-dioxanone and poly(alkylene oxides) |
US5080665A (en) | 1990-07-06 | 1992-01-14 | American Cyanamid Company | Deformable, absorbable surgical device |
US5352515A (en) * | 1992-03-02 | 1994-10-04 | American Cyanamid Company | Coating for tissue drag reduction |
US5522841A (en) * | 1993-05-27 | 1996-06-04 | United States Surgical Corporation | Absorbable block copolymers and surgical articles fabricated therefrom |
-
1999
- 1999-07-20 KR KR1019990029269A patent/KR20010010393A/ko active Search and Examination
-
2000
- 2000-07-18 MX MXPA02000600A patent/MXPA02000600A/es active IP Right Grant
- 2000-07-18 AU AU60247/00A patent/AU758838B2/en not_active Expired
- 2000-07-18 AT AT00946497T patent/ATE468848T1/de not_active IP Right Cessation
- 2000-07-18 CN CNB008105375A patent/CN1205248C/zh not_active Expired - Lifetime
- 2000-07-18 WO PCT/KR2000/000779 patent/WO2001005379A1/en active IP Right Grant
- 2000-07-18 NZ NZ517035A patent/NZ517035A/en not_active IP Right Cessation
- 2000-07-18 CA CA002379672A patent/CA2379672C/en not_active Expired - Lifetime
- 2000-07-18 BR BRPI0012588A patent/BRPI0012588B8/pt not_active IP Right Cessation
- 2000-07-18 KR KR10-2001-7001936A patent/KR100431491B1/ko active IP Right Grant
- 2000-07-18 JP JP2001510436A patent/JP3955759B2/ja not_active Expired - Fee Related
- 2000-07-18 EP EP00946497A patent/EP1196149B1/de not_active Expired - Lifetime
- 2000-07-18 DE DE60044459T patent/DE60044459D1/de not_active Expired - Lifetime
- 2000-07-18 US US09/763,921 patent/US6599519B1/en not_active Expired - Lifetime
-
2002
- 2002-01-18 ZA ZA200200462A patent/ZA200200462B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATE468848T1 (de) | 2010-06-15 |
EP1196149A4 (de) | 2004-04-21 |
WO2001005379A1 (en) | 2001-01-25 |
BR0012588B1 (pt) | 2013-02-19 |
BRPI0012588B8 (pt) | 2021-05-25 |
EP1196149B1 (de) | 2010-05-26 |
EP1196149A1 (de) | 2002-04-17 |
BR0012588A (pt) | 2002-04-09 |
CA2379672A1 (en) | 2001-01-25 |
MXPA02000600A (es) | 2002-07-02 |
US6599519B1 (en) | 2003-07-29 |
CN1361684A (zh) | 2002-07-31 |
ZA200200462B (en) | 2003-03-26 |
KR20010010393A (ko) | 2001-02-05 |
KR100431491B1 (ko) | 2004-05-14 |
CN1205248C (zh) | 2005-06-08 |
CA2379672C (en) | 2005-03-22 |
NZ517035A (en) | 2003-07-25 |
AU758838B2 (en) | 2003-04-03 |
JP2003504393A (ja) | 2003-02-04 |
JP3955759B2 (ja) | 2007-08-08 |
KR20020008815A (ko) | 2002-01-31 |
AU6024700A (en) | 2001-02-05 |
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