ATE491475T1 - Konjugate enthaltend gm-csf und ein polymer - Google Patents
Konjugate enthaltend gm-csf und ein polymerInfo
- Publication number
- ATE491475T1 ATE491475T1 AT05771041T AT05771041T ATE491475T1 AT E491475 T1 ATE491475 T1 AT E491475T1 AT 05771041 T AT05771041 T AT 05771041T AT 05771041 T AT05771041 T AT 05771041T AT E491475 T1 ATE491475 T1 AT E491475T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- csf
- polymer
- conjugates containing
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58860104P | 2004-07-16 | 2004-07-16 | |
PCT/US2005/025052 WO2006019950A2 (en) | 2004-07-16 | 2005-07-14 | Conjugates of a gm-csf moiety and a polymer |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE491475T1 true ATE491475T1 (de) | 2011-01-15 |
Family
ID=35565892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05771041T ATE491475T1 (de) | 2004-07-16 | 2005-07-14 | Konjugate enthaltend gm-csf und ein polymer |
Country Status (12)
Country | Link |
---|---|
US (2) | US20060036080A1 (de) |
EP (1) | EP1768700B1 (de) |
JP (1) | JP2008506704A (de) |
KR (1) | KR101330338B1 (de) |
CN (1) | CN101031323A (de) |
AT (1) | ATE491475T1 (de) |
AU (1) | AU2005275108B2 (de) |
CA (1) | CA2573262C (de) |
DE (1) | DE602005025355D1 (de) |
ES (1) | ES2355642T3 (de) |
MX (1) | MX2007000568A (de) |
WO (1) | WO2006019950A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007009208A1 (en) * | 2005-06-02 | 2007-01-25 | Cangene Corporation | Poly(ethylene glocol) modified human gm-csf with increased biological activity |
CU23556A1 (es) * | 2005-11-30 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico |
US8309680B2 (en) * | 2006-02-21 | 2012-11-13 | Nektar Therapeutics | Segmented degradable polymers and conjugates made therefrom |
EP1834963A1 (de) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Di-Polymer-Konjugate von Proteinen und Verfahren zur deren Erstellung |
WO2008019214A1 (en) | 2006-08-04 | 2008-02-14 | Prolong Pharmaceuticals, Inc. | Modified erythropoietin |
ITMI20061624A1 (it) | 2006-08-11 | 2008-02-12 | Bioker Srl | Mono-coniugati sito-specifici di g-csf |
JP2008069073A (ja) * | 2006-09-12 | 2008-03-27 | Yokohama Tlo Co Ltd | ラクトフェリン複合体及びその製造方法 |
CA2723821C (en) * | 2008-05-16 | 2017-05-02 | Nektar Therapeutics | Conjugates of a cholinesterase moiety and a polymer |
CA2737040C (en) | 2008-09-19 | 2017-05-02 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
WO2010033221A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of protegrin peptides |
US20110165113A1 (en) * | 2008-09-19 | 2011-07-07 | Nektar Therapeutics | Polymer conjugates of v681-like peptides |
TW201808987A (zh) * | 2016-06-08 | 2018-03-16 | 健生生物科技公司 | Gm-csf變體及使用方法 |
KR101947342B1 (ko) * | 2017-05-05 | 2019-02-12 | 주식회사 유비프로틴 | Gm-csf 반감기를 증가시키는 방법 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5908763A (en) * | 1984-07-06 | 1999-06-01 | Novartis Corporation | DNA encoding GM-CSF and a method of producing GM-CSF protein |
US5391485A (en) * | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US5214131A (en) * | 1988-05-06 | 1993-05-25 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, modified peptides and production thereof |
JP2958019B2 (ja) * | 1988-05-06 | 1999-10-06 | 住友製薬株式会社 | ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法 |
US5349052A (en) * | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
GB8824591D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
DE69026306T2 (de) * | 1989-05-27 | 1996-10-17 | Sumitomo Pharma | Verfahren für die Herstellung von Polyethylenglykolderivate und modifizierte Proteine. |
US5109119A (en) * | 1989-06-06 | 1992-04-28 | Schering Corporation | Crystalline r-h-gm-csf and method |
AU1462392A (en) * | 1991-02-22 | 1992-09-15 | Amgen, Inc. | Use of gm-csf and g-csf to promote accelerated wound healing |
GB9317618D0 (en) * | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
WO1995026746A1 (en) * | 1994-03-31 | 1995-10-12 | Amgen Inc. | Compositions and methods for stimulating megakaryocyte growth and differentiation |
US5629384A (en) * | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
ATE200030T1 (de) * | 1997-01-29 | 2001-04-15 | Polymasc Pharmaceuticals Plc | Pegylationsverfahren |
US6548644B1 (en) * | 1997-03-10 | 2003-04-15 | Immunex Corporation | Site protected protein modification |
BR9812267B1 (pt) * | 1997-07-14 | 2013-11-26 | Hormônio de crescimento recombinante. | |
US7153943B2 (en) * | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
US6221378B1 (en) * | 1998-02-10 | 2001-04-24 | Generex Pharmaceuticals Incorporated | Mixed micellar delivery system and method of preparation |
ATE367398T1 (de) * | 2000-05-16 | 2007-08-15 | Bolder Biotechnology Inc | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
AR032757A1 (es) * | 2000-06-30 | 2003-11-26 | Smithkline Beecham Corp | Composiciones biologicamente activas de conjugados de quimioquina, uso de dichas composiciones en la fabricacion de composiciones farmaceuticas, metodo para preparar dichas composiciones, y metodos para mejorar la farmacocinetica de una quimioquina |
ATE537845T1 (de) * | 2000-10-31 | 2012-01-15 | Pr Pharmaceuticals Inc | Verfahren zur herstellung von formulierungen zur verbesserten abgabe von bioaktiven molekülen |
US20020142964A1 (en) * | 2000-11-02 | 2002-10-03 | Nissen Torben Lauesgaard | Single-chain polypeptides |
JP4758608B2 (ja) * | 2001-11-07 | 2011-08-31 | ネクター セラピューティックス | 分枝ポリマーおよびそれらの結合体 |
WO2004012773A1 (en) * | 2002-07-24 | 2004-02-12 | F. Hoffmann-La Roche Ag | Polyalkylene glycol acid additives |
AU2003265523A1 (en) * | 2002-08-20 | 2004-03-11 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
RS20050202A (en) * | 2002-09-09 | 2007-08-03 | Nektar Therapeuticals Al.Corporation, | Water-soluble polymer alkanals |
EA013535B1 (ru) * | 2002-12-26 | 2010-06-30 | Маунтин Вью Фамэсьютикэлс, Инк. | Полимерный конъюгат биоактивного компонента (варианты), способ его получения и использования, фармацевтические продукты на его основе |
US7208145B2 (en) * | 2002-12-31 | 2007-04-24 | Nektar Therapeutics Al, Corporation | Polymeric reagents comprising a ketone or a related functional group |
NZ541374A (en) * | 2003-05-23 | 2008-09-26 | Nektar Therapeutics Al Corp | PEG derivatives having an amidocarbonate linkage |
-
2005
- 2005-07-14 JP JP2007521649A patent/JP2008506704A/ja not_active Withdrawn
- 2005-07-14 EP EP05771041A patent/EP1768700B1/de active Active
- 2005-07-14 WO PCT/US2005/025052 patent/WO2006019950A2/en active Application Filing
- 2005-07-14 KR KR1020077003912A patent/KR101330338B1/ko active IP Right Grant
- 2005-07-14 MX MX2007000568A patent/MX2007000568A/es active IP Right Grant
- 2005-07-14 AT AT05771041T patent/ATE491475T1/de not_active IP Right Cessation
- 2005-07-14 CA CA2573262A patent/CA2573262C/en active Active
- 2005-07-14 DE DE602005025355T patent/DE602005025355D1/de active Active
- 2005-07-14 CN CNA2005800311705A patent/CN101031323A/zh active Pending
- 2005-07-14 US US11/181,692 patent/US20060036080A1/en not_active Abandoned
- 2005-07-14 ES ES05771041T patent/ES2355642T3/es active Active
- 2005-07-14 AU AU2005275108A patent/AU2005275108B2/en active Active
-
2013
- 2013-03-01 US US13/782,842 patent/US20140044672A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE602005025355D1 (de) | 2011-01-27 |
EP1768700A2 (de) | 2007-04-04 |
CA2573262C (en) | 2015-02-10 |
MX2007000568A (es) | 2007-03-30 |
WO2006019950A3 (en) | 2006-08-03 |
ES2355642T3 (es) | 2011-03-29 |
US20060036080A1 (en) | 2006-02-16 |
AU2005275108B2 (en) | 2011-05-12 |
AU2005275108A1 (en) | 2006-02-23 |
CN101031323A (zh) | 2007-09-05 |
EP1768700B1 (de) | 2010-12-15 |
US20140044672A1 (en) | 2014-02-13 |
KR101330338B1 (ko) | 2013-11-15 |
WO2006019950A2 (en) | 2006-02-23 |
KR20070043852A (ko) | 2007-04-25 |
JP2008506704A (ja) | 2008-03-06 |
CA2573262A1 (en) | 2006-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |