WO2006102659A3 - CONJUGATES OF AN hGH MOIETY AND A POLYMER - Google Patents

CONJUGATES OF AN hGH MOIETY AND A POLYMER Download PDF

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Publication number
WO2006102659A3
WO2006102659A3 PCT/US2006/011126 US2006011126W WO2006102659A3 WO 2006102659 A3 WO2006102659 A3 WO 2006102659A3 US 2006011126 W US2006011126 W US 2006011126W WO 2006102659 A3 WO2006102659 A3 WO 2006102659A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugates
polymer
hgh moiety
methods
water soluble
Prior art date
Application number
PCT/US2006/011126
Other languages
French (fr)
Other versions
WO2006102659A2 (en
Inventor
Mary J Bossard
Ping Zhang
Original Assignee
Nektar Therapeutics Al Corp
Mary J Bossard
Ping Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics Al Corp, Mary J Bossard, Ping Zhang filed Critical Nektar Therapeutics Al Corp
Priority to EP06739738A priority Critical patent/EP1861125A2/en
Publication of WO2006102659A2 publication Critical patent/WO2006102659A2/en
Publication of WO2006102659A3 publication Critical patent/WO2006102659A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Abstract

Conjugates of an hGH moiety and one or more non-peptidic water soluble polymers are provided. Typically, the non-peptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making the conjugates, and methods of administering compositions comprising such conjugates to a mammalian subject.
PCT/US2006/011126 2005-03-23 2006-03-23 CONJUGATES OF AN hGH MOIETY AND A POLYMER WO2006102659A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06739738A EP1861125A2 (en) 2005-03-23 2006-03-23 Conjugates of an hgh moiety and peg derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66440105P 2005-03-23 2005-03-23
US60/664,401 2005-03-23

Publications (2)

Publication Number Publication Date
WO2006102659A2 WO2006102659A2 (en) 2006-09-28
WO2006102659A3 true WO2006102659A3 (en) 2007-06-14

Family

ID=37024717

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/011126 WO2006102659A2 (en) 2005-03-23 2006-03-23 CONJUGATES OF AN hGH MOIETY AND A POLYMER

Country Status (3)

Country Link
US (1) US20060233740A1 (en)
EP (1) EP1861125A2 (en)
WO (1) WO2006102659A2 (en)

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CN101219219B (en) * 2007-01-10 2013-02-13 北京普罗吉生物科技发展有限公司 Complex containing vascellum chalone or fragment, preparation method and application thereof
AU2008353850B2 (en) * 2008-04-03 2014-08-21 Biosteed Gene Expression Tech. Co., Ltd. Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof
ES2875426T3 (en) 2008-04-29 2021-11-10 Ascendis Pharma Endocrinology Div A/S Pegylated Recombinant Human Growth Hormone Compounds
EP2113256A1 (en) 2008-04-29 2009-11-04 Ascendis Pharma AS PEGylated rhGH compounds
WO2010033205A1 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of v681-like peptides
LT2512450T (en) 2009-12-15 2018-04-25 Ascendis Pharma Endocrinology Division A/S Dry growth hormone composition transiently linked to a polymer carrier
DK3653227T5 (en) * 2014-11-18 2023-08-21 Ascendis Pharma Endocrinology Div A/S Hitherto UNKNOWN POLYMERS HGH PRODUCTS
WO2020014307A1 (en) * 2018-07-11 2020-01-16 Ohio University Peptide-based inhibitors of growth hormone action and methods of the thereof

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US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
WO2004022630A2 (en) * 2002-09-09 2004-03-18 Nektar Therapeutics Al, Corporation Water-soluble polymer alkanals
US20040127417A1 (en) * 2002-11-20 2004-07-01 Finn Rory F. N-terminally monopegylated human growth hormone conjugates and process for their preparation
WO2004060406A2 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Polymeric reagents comprising a ketone or a related functional group
WO2004075923A2 (en) * 2003-02-26 2004-09-10 Nektar Therapeutics Al, Corporation Polymer-factor viii moiety conjugates
WO2005000360A2 (en) * 2003-05-23 2005-01-06 Nektar Therapeutics Al, Corporation Peg derivatives having an amidocarbonate linkage

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AU7266898A (en) * 1997-04-30 1998-11-24 Enzon, Inc. Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
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MXPA02006216A (en) * 1999-12-22 2004-02-26 Nektar Therapeutics Al Corp Sterically hindered derivatives of water soluble polymers.
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US20040142870A1 (en) * 2002-11-20 2004-07-22 Finn Rory F. N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof
US7432330B2 (en) * 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
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Publication number Priority date Publication date Assignee Title
WO2003031581A2 (en) * 2001-10-09 2003-04-17 Nektar Therapeutics Al, Corporation Thioester-terminated water soluble polymers and method of modifying the n-terminus of a polypeptide therewith
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
WO2004022630A2 (en) * 2002-09-09 2004-03-18 Nektar Therapeutics Al, Corporation Water-soluble polymer alkanals
US20040127417A1 (en) * 2002-11-20 2004-07-01 Finn Rory F. N-terminally monopegylated human growth hormone conjugates and process for their preparation
WO2004060406A2 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Polymeric reagents comprising a ketone or a related functional group
WO2004075923A2 (en) * 2003-02-26 2004-09-10 Nektar Therapeutics Al, Corporation Polymer-factor viii moiety conjugates
WO2005000360A2 (en) * 2003-05-23 2005-01-06 Nektar Therapeutics Al, Corporation Peg derivatives having an amidocarbonate linkage

Also Published As

Publication number Publication date
EP1861125A2 (en) 2007-12-05
US20060233740A1 (en) 2006-10-19
WO2006102659A2 (en) 2006-09-28

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