ATE407963T1 - Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus - Google Patents

Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus

Info

Publication number
ATE407963T1
ATE407963T1 AT02789694T AT02789694T ATE407963T1 AT E407963 T1 ATE407963 T1 AT E407963T1 AT 02789694 T AT02789694 T AT 02789694T AT 02789694 T AT02789694 T AT 02789694T AT E407963 T1 ATE407963 T1 AT E407963T1
Authority
AT
Austria
Prior art keywords
block copolymers
polyorthoesters
biodegradable amine
hydrophobic
biodegradable
Prior art date
Application number
AT02789694T
Other languages
English (en)
Inventor
Steven Ng
Jorge Heller
Original Assignee
Ap Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ap Pharma Inc filed Critical Ap Pharma Inc
Application granted granted Critical
Publication of ATE407963T1 publication Critical patent/ATE407963T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/40—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds, other than from esters thereof
    • C08G63/42—Cyclic ethers; Cyclic carbonates; Cyclic sulfites; Cyclic orthoesters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyethers (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
AT02789694T 2001-11-16 2002-11-15 Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus ATE407963T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/991,537 US6524606B1 (en) 2001-11-16 2001-11-16 Bioerodible polyorthoesters containing amine groups

Publications (1)

Publication Number Publication Date
ATE407963T1 true ATE407963T1 (de) 2008-09-15

Family

ID=25537313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02789694T ATE407963T1 (de) 2001-11-16 2002-11-15 Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus

Country Status (10)

Country Link
US (3) US6524606B1 (de)
EP (1) EP1448666B1 (de)
JP (1) JP2005509709A (de)
KR (1) KR20040066818A (de)
AT (1) ATE407963T1 (de)
AU (1) AU2002352743B2 (de)
CA (1) CA2463179A1 (de)
DE (1) DE60228875D1 (de)
ES (1) ES2314118T3 (de)
WO (1) WO2003044076A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311684A (zh) * 1998-07-10 2001-09-05 悉尼大学 黄斑变性中新生血管形成的预防治疗
AUPQ496500A0 (en) * 2000-01-06 2000-02-03 University Of Sydney, The Kit
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6613355B2 (en) * 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
ATE377048T1 (de) * 2000-09-06 2007-11-15 Ap Pharma Inc Abbaubare polyacetal-polymere
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US8403954B2 (en) 2001-05-22 2013-03-26 Sanostec Corp. Nasal congestion, obstruction relief, and drug delivery
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7354574B2 (en) * 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US7083802B2 (en) * 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US7083803B2 (en) * 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7329413B1 (en) 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
WO2005070333A1 (en) * 2004-01-13 2005-08-04 Orthobiologica, Inc. Drug delivery to a joint
WO2005074942A1 (en) * 2004-02-04 2005-08-18 Retmed Pty Ltd Slow release steroid composition
US20050192257A1 (en) * 2004-02-26 2005-09-01 Peyman Gholam A. Predictors for patients at risk for glaucoma from steroid therapy
CA2557216A1 (en) * 2004-02-26 2005-09-09 Advanced Ocular Systems Limited Heparin for the treatment of ocular pathologies
SI1755616T1 (sl) 2004-04-08 2014-04-30 Eye Co Pty Ltd. Zdravljenje eksudativne retinopatije z mineralkortikoidi
EP1740168A2 (de) * 2004-04-21 2007-01-10 Advanced Ocular Systems Limited Antiprostaglandine zur behandlung von augenpathologien
US20080255492A1 (en) * 2004-08-19 2008-10-16 Jens Hoeg Truelsen Absorbent Fiber Material and Use Thereof in Wound Dressings
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
US20060122152A1 (en) * 2004-12-03 2006-06-08 Peyman Gholam A Heparin for the treatment of ocular pathologies
KR100732013B1 (ko) * 2005-03-18 2007-06-25 성균관대학교산학협력단 ｐＨ 민감성 블록 공중합체 및 이를 이용한 고분자 마이셀
JP2008537969A (ja) * 2005-03-31 2008-10-02 エーピー ファーマ， インコーポレイテッド Ｐｅｇ−ポリアセタールジブロックコポリマーおよびｐｅｇ−ポリアセタールトリブロックコポリマーならびに医薬組成物
US20070014760A1 (en) 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
PL1904056T3 (pl) * 2005-07-18 2009-09-30 Minu Llc Zastosowanie makrolidu do przywracania czucia rogówkowego
US7713916B2 (en) * 2005-09-22 2010-05-11 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
WO2007061896A1 (en) 2005-11-17 2007-05-31 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
EP2374472B9 (de) 2006-03-16 2019-06-12 Dyax Corp. Zusammensetzungen und Verfahren zur Behandlung von Augenerkrankungen
US20070265329A1 (en) * 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US7458953B2 (en) * 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
WO2008005371A2 (en) * 2006-06-29 2008-01-10 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
AU2007272224B2 (en) 2006-07-10 2013-05-02 Novartis Ag scFv antibodies which pass epithelial and/or endothelial layers
WO2009091790A1 (en) 2008-01-15 2009-07-23 Invista Technologies S.A.R.L. Hydrocyanation of pentenenitriles
US8722079B2 (en) * 2008-04-18 2014-05-13 Warsaw Orthopedic, Inc. Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
JP2011518881A (ja) 2008-04-28 2011-06-30 ゾゲニクス インコーポレーティッド 片頭痛の治療のための製剤
WO2009135246A1 (en) * 2008-05-07 2009-11-12 Obj Limited Method and apparatus for enhanced transdermal diffusion
US9095404B2 (en) * 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
MX2011000629A (es) 2008-07-17 2011-04-26 Merial Ltd Formulaciones analgesicas inyectables de larga duracion para animales.
AU2008359989A1 (en) * 2008-07-30 2010-02-04 Nitto Denko Corporation Drug carriers
AU2009324545A1 (en) * 2008-12-11 2011-06-30 A.P. Pharma, Inc. Methods for enhancing stability of polyorthoesters and their formulations
WO2011046515A1 (en) 2009-10-14 2011-04-21 Nanyang Technological University Antiproliferative agent
WO2011146978A1 (en) 2010-05-25 2011-12-01 International Scientific Pty Ltd Delivery of oral care products
WO2011156869A1 (en) 2010-06-17 2011-12-22 International Scientific Pty Ltd Delivery of skin care products
WO2013142152A1 (en) * 2012-03-23 2013-09-26 Regents Of The University Of Minnesota Semi-solid delivery systems
US8945827B2 (en) 2013-03-13 2015-02-03 Awareness Technology, Inc. Serological methods and diagnostic tests for syphilis antibodies
WO2014143635A1 (en) * 2013-03-15 2014-09-18 Heron Therapeutics, Inc. Compositions of a polyorthoester and an aprotic solvent
JP6232280B2 (ja) * 2013-12-25 2017-11-15 株式会社ダイセル 含酸素飽和ヘテロ環を有する重合体及びその製造方法
WO2015103319A1 (en) * 2013-12-31 2015-07-09 Heron Therapeutics, Inc. Polymer-based compositions for extended release of proteins
WO2015188223A1 (en) 2014-06-11 2015-12-17 International Scientific Pty Ltd Device and method to treat or prevent joint degeneration
BR112019022307A2 (pt) 2017-04-24 2020-05-26 Cocrystal Pharma, Inc. Derivados da pirrolopirimidina úteis como inibidores de replicação de vírus da influenza.
MX2019015321A (es) 2017-06-16 2020-07-20 Avery Therapeutics Inc Composiciones tridimensionales de tejido y métodos de uso.
AU2019311117A1 (en) 2018-07-27 2021-02-04 Cocrystal Pharma, Inc. Pyrrolo(2,3-b)pyridin derivatives as inhibitors of influenza virus replication
WO2020055858A1 (en) 2018-09-10 2020-03-19 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication
AU2019361038A1 (en) 2018-10-17 2021-05-13 Cocrystal Pharma, Inc. Combinations of inhibitors of influenza virus replication
US20220048897A1 (en) 2018-11-26 2022-02-17 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
WO2021188620A1 (en) 2020-03-17 2021-09-23 Cocrystal Pharma Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
MX2022012714A (es) 2020-04-10 2022-12-15 Cocrystal Pharma Inc Inhibidores de la replicacion de norovirus y coronavirus.
IL310394A (en) 2021-08-03 2024-03-01 Cocrystal Pharma Inc Corona virus inhibitors

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US90398A (en) * 1869-05-25 Improvement in tree-boxes
US82362A (en) * 1868-09-22 Samuel swes
US176844A (en) * 1876-05-02 Improvement in beer-taps
US130472A (en) * 1872-08-13 Improvement in hinges for sewing-machine tables
US37300A (en) * 1863-01-06 Improvement in window-blind fastenings
US152630A (en) * 1874-06-30 Improvement in cars for transporting coal
US138474A (en) * 1873-05-06 Improvement in wave-powers
US3268550A (en) * 1963-08-26 1966-08-23 Ibm Nu-butenyl carbazoles
US4180064A (en) 1972-12-27 1979-12-25 Alza Corporation System for delivering agent to environment of use over prolonged time
US4014987A (en) * 1974-06-04 1977-03-29 Alza Corporation Device for delivery of useful agent
US4180646A (en) 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4131648A (en) 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US4079038A (en) 1976-03-05 1978-03-14 Alza Corporation Poly(carbonates)
US4261969A (en) * 1979-05-03 1981-04-14 World Health Organization Controlled drug release composition
US4249531A (en) * 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4304767A (en) 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4502976A (en) * 1982-10-25 1985-03-05 Bend Research, Inc. Water soluble polyesters
US4513143A (en) * 1982-12-01 1985-04-23 Sri International Preparation of ketene acetals
US4532335A (en) 1983-03-07 1985-07-30 Sri International Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals
US4690682A (en) * 1983-04-15 1987-09-01 Damon Biotech, Inc. Sustained release
US4710497A (en) 1983-05-20 1987-12-01 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents
US5449670A (en) 1983-05-20 1995-09-12 Skinner; Wilfred A. Composition and method for the transdermal delivery of bioactive peptides
US5128376A (en) * 1983-07-01 1992-07-07 Nitto Denko Corporation Method for percutaneously administering physiologically active agents using an adjuvant a solvent and a diol moderator
US4752612A (en) * 1983-07-01 1988-06-21 Nitto Electrical Industrial Co., Ltd. Method and percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent
US4590190A (en) * 1983-07-01 1986-05-20 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent
US4548990A (en) 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4605670A (en) * 1984-02-01 1986-08-12 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering metoclopramide
US4639366A (en) * 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4765973A (en) * 1984-06-06 1988-08-23 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4549010A (en) 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4690825A (en) * 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen
US4738932A (en) * 1985-12-03 1988-04-19 Advanced Polymer Systems, Inc. Reaginic test for syphilis
US5145675A (en) 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
US5879716A (en) * 1985-12-18 1999-03-09 Advanced Polymer Systems, Inc. Methods and compositions for topical delivery of benzoyl peroxide
US4855132A (en) 1986-02-25 1989-08-08 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4764364A (en) 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4713441A (en) 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4801457A (en) * 1986-08-01 1989-01-31 Sandoz Pharm. Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4849426A (en) * 1987-05-15 1989-07-18 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
US5013553A (en) * 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
US4806360A (en) * 1987-10-23 1989-02-21 Advanced Polymer Systems Synthetic melanin aggregates
US4855144A (en) * 1987-10-23 1989-08-08 Advanced Polymer Systems Synthetic melanin aggregates
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US4898928A (en) * 1988-03-07 1990-02-06 Sandoz Pharmaceuticals Corp. Polyacetal and polyketal hydrogels formed from acetals or ketals and polyols
ZA892859B (en) * 1988-04-22 1989-12-27 Advanced Polymer Systems Inc Porous particles in preparations involving immiscible phases
US4957998A (en) 1988-08-22 1990-09-18 Pharmaceutical Delivery Systems, Inc. Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages
US5632727A (en) * 1988-10-03 1997-05-27 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5725491A (en) * 1988-10-03 1998-03-10 Atrix Laboratories, Inc. Method of forming a biodegradable film dressing on tissue
US5840293A (en) 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
US4963369A (en) 1989-01-19 1990-10-16 Wm. Wrigley Jr. Co. Gum composition containing dispersed porous beads containing active chewing gum ingredients and method
US5287588A (en) * 1989-01-31 1994-02-22 U.S. Products, Inc. Upholstery and carpet cleaning equipment including external heat exchanger
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
ATE133087T1 (de) * 1989-05-04 1996-02-15 Southern Res Inst Einkapselungsverfahren
US5028435A (en) * 1989-05-22 1991-07-02 Advanced Polymer Systems, Inc. System and method for transdermal drug delivery
US4946931A (en) 1989-06-14 1990-08-07 Pharmaceutical Delivery Systems, Inc. Polymers containing carboxy-ortho ester and ortho ester linkages
US5013821A (en) * 1989-06-15 1991-05-07 Pharmaceutical Delivery Systems, Inc. Ortho and thio-ortho ester polymer
US5077049A (en) 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5487897A (en) * 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5030457A (en) * 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
KR920702383A (ko) 1989-08-28 1992-09-03 원본미기재 치료제의 방출을 조절하는데 유용한 생부식성 중합체
US5217712A (en) * 1989-09-20 1993-06-08 Merck & Co., Inc. Bioerodible thermoset elastomers
US5047464A (en) 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
WO1991007101A1 (en) 1989-11-09 1991-05-30 Advanced Polymer Systems, Inc. Methods and compositions for flavoring orally-delivered products
IL98087A (en) * 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
US5240715A (en) * 1990-05-14 1993-08-31 Advanced Polymer Systems Color modified melanins and methods for their preparation and use
US5188844A (en) * 1990-05-14 1993-02-23 Advanced Polymer Systems, Inc. Color modified melanins and methods for their preparation and use
EP0533799B1 (de) * 1990-06-20 1995-10-18 Advanced Polymer Systems, Inc. Zusammensetzungen und verfahren für die kontrollierte freisetzung von löslichen wirkstoffen
SE9002339L (sv) * 1990-07-04 1992-01-05 Kabi Pharmacia Ab Terapeutisk komposition och foerfarande foer dess framstaellning
NZ239370A (en) 1990-08-22 1994-04-27 Merck & Co Inc Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone
AU8935591A (en) * 1990-10-30 1992-05-26 Alza Corporation Drug delivery system and method
US5422121A (en) * 1990-11-14 1995-06-06 Rohm Gmbh Oral dosage unit form
US5261169A (en) 1991-10-11 1993-11-16 Advanced Polymer Systems, Inc. System and method for deodorant delivery in footwear
AU2605592A (en) * 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5256400A (en) 1991-12-04 1993-10-26 Advanced Polymer Systems, Inc. Pressurized product delivery systems
EP0560014A1 (de) * 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biologisch abbaubarer Wundverband in Form eines Sprühfilms und Verfahren zu seiner Herstellung
AU3941493A (en) * 1992-03-30 1993-11-08 Alza Corporation Viscous suspensions of controlled-release drug particles
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
MY113268A (en) * 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
GB2273874A (en) 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix
IL110787A0 (en) * 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
US5681873A (en) 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
WO1995016659A1 (en) * 1993-12-15 1995-06-22 Avon Products, Inc. Novel retinoid conjugate compounds and methods for treating skin aging
ATE209907T1 (de) * 1994-04-08 2001-12-15 Atrix Lab Inc Flüssige mittel zur wirkstoffabgabe
US5849327A (en) 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
US5607686A (en) * 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
US6281015B1 (en) * 1994-12-16 2001-08-28 Children's Medical Center Corp. Localized delivery of factors enhancing survival of transplanted cells
US5627187A (en) * 1995-04-12 1997-05-06 Katz; Bruce E. 5-FU for treating actinic kerotoses
US6096344A (en) * 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
WO1997007788A2 (en) * 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
US5851538A (en) 1995-12-29 1998-12-22 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
US5968543A (en) 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
DE69703430T2 (de) 1996-01-05 2001-05-03 Advanced Polymer Systems Inc Polymere mit kontrolliertem physikalischen zustand und bioerodierbarkeit
IL118235A0 (en) * 1996-05-13 1996-09-12 Univ Ben Gurion Composition and method for forming biodegradable implants in situ and uses of these implants
US6193991B1 (en) * 1997-10-29 2001-02-27 Atul J. Shukla Biodegradable delivery systems of biologically active substances
US5891470A (en) * 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6245345B1 (en) * 1998-07-07 2001-06-12 Atrix Laboratories, Inc. Filamentous porous films and methods for producing the same
US6261583B1 (en) * 1998-07-28 2001-07-17 Atrix Laboratories, Inc. Moldable solid delivery system
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6613355B2 (en) 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups

Also Published As

Publication number Publication date
ES2314118T3 (es) 2009-03-16
AU2002352743B2 (en) 2008-10-23
WO2003044076A8 (en) 2004-07-29
CA2463179A1 (en) 2003-05-30
JP2005509709A (ja) 2005-04-14
US20040146550A1 (en) 2004-07-29
US6667371B2 (en) 2003-12-23
WO2003044076A1 (en) 2003-05-30
EP1448666B1 (de) 2008-09-10
AU2002352743A1 (en) 2003-06-10
US20030138474A1 (en) 2003-07-24
DE60228875D1 (de) 2008-10-23
US6946145B2 (en) 2005-09-20
KR20040066818A (ko) 2004-07-27
EP1448666A1 (de) 2004-08-25
US6524606B1 (en) 2003-02-25

Similar Documents

Publication Publication Date Title
ATE407963T1 (de) Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus
CA2355657A1 (en) Biodegradable ph/thermosensitive hydrogels for sustained delivery of biologically active agents
ITTO20020100A0 (it) Sistema per la gestione delle identita' di stazioni mobili in roamingfra reti radiomobili.
EP1569664A4 (de) Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere
BR9916857A (pt) 4 heteroaril diarilaminas
BR0111016A (pt) Composições farmacêuticas de liberação sustentada para a administração parenteral de compostos hidrófilos biologicamente ativos
PT1401501E (pt) Composicoes farmaceuticas orais com libertacao modificada do ingrediente activo
ATE461961T1 (de) Mehrarmige polypeptid-poly(ethylenglykol)- blockcopolymere als arzneistoffzufuhrvehikel
BR0210335A (pt) Copolìmero de blocos, e, composição
DK1487416T3 (da) Lægemiddelmikropartikler
BR0212475A (pt) Composições farmacêuticas
HK1087031A1 (en) Subcutaneous implants having limited initial release of the active principle and subsequent linearlyvarying extended release thereof
WO2004104021A3 (en) Controlled release of active agents utilizing repeat sequence protein polymers
EP1539109A4 (de) Blockcopolymer-mizellenzusammensetzung mit verbesserter arzneimittelbeladungskapazität und verzögerter freisetzung
ATE344826T1 (de) Alkylmethylsiloxan- dimethylsiloxan- polyalkylenoxid- copolymere
PT1195160E (pt) Composições farmacêuticas de trimetazidina de libertação sustentada e método para a sua preparação
DE60139195D1 (de) Aktivierbare polymerzusammensetzung, und gegenstände, die diese nutzen
BR9917195A (pt) Nucleadores para polìmeros termoplásticoscristalizáveis
BR0210632A (pt) Tratamento de doença parasìtica
IT1318962B1 (it) Procedimento per l'invio di messaggi pubblicitari direttamente adutenti.
ATE362512T1 (de) Stickstoffhaltige polymere umfassende reinigungsmittelzusammensetzung
BR0111055A (pt) Formulação farmacêutica, e, processo para a preparação e uso da mesma
TW200624464A (en) Amphiphilic block copolymer and pharmaceutical formulation comprising the same
DK1478659T3 (da) Biologisk aktive peptider
RU2001100069A (ru) Антгельминтное средство

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties