PL310072A1 - Small-diameter microcapsules, method of making them and their applications - Google Patents

Small-diameter microcapsules, method of making them and their applications

Info

Publication number
PL310072A1
PL310072A1 PL31007294A PL31007294A PL310072A1 PL 310072 A1 PL310072 A1 PL 310072A1 PL 31007294 A PL31007294 A PL 31007294A PL 31007294 A PL31007294 A PL 31007294A PL 310072 A1 PL310072 A1 PL 310072A1
Authority
PL
Poland
Prior art keywords
cyanoacrylate
applications
making
small
mch3
Prior art date
Application number
PL31007294A
Inventor
Valery Alexandrovich Dyatlow
Georgy Arkadievich Katz
Original Assignee
Abacol Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abacol Ltd filed Critical Abacol Ltd
Publication of PL310072A1 publication Critical patent/PL310072A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nanocapsules typically having a diameter in the range of 20-150 nm are provided and consist of a polymeric shell formed of a surface active poly(alkyl cyanoacrylate) material arranged in one or more layers. The polymeric shell can be composed of a surface active poly(alkyl 2-cyanoacrylate) having general formula (I), wherein R is -CH2-(-CH2-)-mCH3, -CH2-(-CH2-)-mCOOH, -CH2-(-CH2-)-mCOOR', or -CH2CH2-O-(-CH2CH2-O-)-mR'; R' is -CH3, -CH2-(-CH2-)-mCH3, -C-(-CH3-)-2-CH2-C(CH3)3, or -O-Ar; m has a value of from 0 to 20; and n has a value of from 1 to 20, formed by the interfacial polymerisation of self-arranged micelles of the cyanoacrylate monomers. The nanocapsules can be used to encapsulate a wide range of water soluble and water insoluble active agents in high yield for delivery to a target system or locus, for example, drugs for use in therapy or prophylaxis.
PL31007294A 1993-01-11 1994-01-10 Small-diameter microcapsules, method of making them and their applications PL310072A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU93001196 1993-01-11

Publications (1)

Publication Number Publication Date
PL310072A1 true PL310072A1 (en) 1995-11-27

Family

ID=20135403

Family Applications (1)

Application Number Title Priority Date Filing Date
PL31007294A PL310072A1 (en) 1993-01-11 1994-01-10 Small-diameter microcapsules, method of making them and their applications

Country Status (5)

Country Link
EP (1) EP0682513A1 (en)
AU (1) AU5714194A (en)
CA (1) CA2153343A1 (en)
PL (1) PL310072A1 (en)
WO (1) WO1994015590A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
JP2000514791A (en) * 1996-06-27 2000-11-07 ジー．ディー．サール アンド カンパニー Particles consisting of an amphiphilic copolymer having a crosslinked outer shell region and inner core region, useful for pharmaceutical and other applications
EP0986373B1 (en) * 1997-06-13 2004-03-17 Nanopharm AG Drug targeting system, method of its preparation and its use
US6616946B1 (en) 1999-11-15 2003-09-09 Biocure, Inc. Triblock copolymer hollow particles for agent delivery by permeability change
FR2806005B1 (en) * 2000-03-10 2002-06-14 Univ Claude Bernard Lyon PROCESS FOR THE PREPARATION OF COLLOIDAL PARTICLES IN THE FORM OF NANOCAPSULES
JP2003530156A (en) * 2000-04-06 2003-10-14 ユニバーシティ ライセンス ホールディングス インコーポレイテッド Compositions and methods for promoting wound healing
DE10111508A1 (en) * 2001-03-09 2002-09-26 Henkel Kgaa Modified cyanoacrylate esters, nano- or microcapsules made from them and their use in detergents or cleaning agents
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
FR2839517A1 (en) * 2002-05-07 2003-11-14 Centre Nat Rech Scient NOVEL BIODEGRADABLE SURFACTANTS OF THE AMPHIPHILIC COPOLYMER TYPE COMPRISING HYDROPHOBIC SEGMENTS AND OLIGO AND / OR POLYSACCHARIDES
US20100143485A1 (en) * 2003-03-05 2010-06-10 Hudnut Paul S Oxycontin controlled release formulations and methods of using same
US7659423B1 (en) 2006-04-18 2010-02-09 Loctite (R&D) Limited Method of preparing electron deficient olefins in polar solvents
US7569719B1 (en) 2006-10-25 2009-08-04 Loctite (R&D) Limited Method of preparing electron deficient olefins
US7718821B1 (en) 2006-12-19 2010-05-18 Loctite (R&D) Limited Method of preparing electron deficient olefins
US8053589B1 (en) 2007-10-24 2011-11-08 Henkel Ireland Limited Imines and methods of preparing electron deficient olefins using such novel imines
CA2703603A1 (en) 2007-10-24 2009-04-30 Loctite (R&D) Limited Electron deficient olefins
US7973119B1 (en) 2007-10-24 2011-07-05 Loctite (R&D) Limited Adhesive systems using imines and salts thereof and precursurs to electron deficient olefins
WO2009053482A2 (en) 2007-10-24 2009-04-30 Loctite (R & D) Limited Activated methylene reagents and curable compositions prepared therefrom
US8399698B1 (en) 2008-10-24 2013-03-19 Henkel Ireland Limited Substituted activated methylene reagents and methods of using such reagents to form electron deficient olefins
US10196471B1 (en) 2008-10-24 2019-02-05 Henkel IP & Holding GmbH Curable composition having an electron deficient olefin
TWI664224B (en) 2014-12-12 2019-07-01 日商東亞合成股份有限公司 Two-liquid type hardening composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646775A1 (en) * 1989-05-11 1990-11-16 Centre Nat Rech Scient USE OF CASEINOGLYCOPEPTIDE K, IN PARTICULAR COW MILK, FOR THE MANUFACTURE OF A COMPOSITION, IN PARTICULAR A MEDICINAL PRODUCT, FOR THE PREVENTION AND TREATMENT OF THROMBOSIS
FR2659554B1 (en) * 1990-03-16 1994-09-30 Oreal COMPOSITION FOR THE COSMETIC AND / OR PHARMACEUTICAL TREATMENT OF THE TOP LAYERS OF THE EPIDERMIS BY TOPICAL APPLICATION TO THE SKIN AND PREPARATION METHOD THEREOF.

Also Published As

Publication number Publication date
EP0682513A1 (en) 1995-11-22
AU5714194A (en) 1994-08-15
CA2153343A1 (en) 1994-07-21
WO1994015590A1 (en) 1994-07-21

Similar Documents

Publication Publication Date Title
PL310072A1 (en) Small-diameter microcapsules, method of making them and their applications
EP1518550A3 (en) Bioadhesive drug delivery systems comprising poly(fumaric-co-sebacic acid)
AU7992987A (en) Method and formulation for orally administering bioactive agents to and through the peyer's patch
IL64298A0 (en) Pharmaceutical compositions for the sustained release of hormonally active polypeptides
EP1516615A3 (en) Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
CA2047738A1 (en) Dispensing device
ATE173161T1 (en) BUDESONIDE PELLETS WITH CONTROLLED RELEASE PROFILE AND METHOD FOR THE PRODUCTION THEREOF
ATE61613T1 (en) BIODEGRADABLE AMPHIPHILIC COPOLYMERS.
CA2190882A1 (en) The production of active substance compositions in the form of a solid solution of the active substance in a polymer matrix, and active substance compositions produced by this process
MY109366A (en) Polysuccinimide polymers and process for preparing polysuccinimide polymers
DE69110740D1 (en) Oral formulations disintegrating in the colon containing polypeptides.
AU4693485A (en) Sustained release drug in ter polymer coat (pvc and pvacand pvom)
FR2640547B1 (en) COMPOSITE MATERIAL CAPABLE OF INFLATING IN THE PRESENCE OF WATER, SUPPORTS FOR USE IN THE PRODUCTION THEREOF AND USES THEREOF
CA2000932A1 (en) Oral pharmaceutical controlled release multiple unit dosage form
NO950595L (en) Ophthalmological preparation
WO2003013717A3 (en) Improvements in or relating to encapsulation
FR2454804A1 (en) DIHYDROERGOTOXIN-BASED MEDICINAL PRODUCT AND PROCESS FOR PREPARING THE SAME
CA2209673A1 (en) Solid medicament form with active agent distributed in polymer material
JPS5331579A (en) Production of microcapsule contained isocyanate hardening agent
EP0561595A3 (en) Polymer scale preventive agent
FR2703908B1 (en) Pharmaceutical form for rectal administration of pharmacologically active compounds.
CA2134082A1 (en) Bioadhesive microspheres and their use as drug delivery and imaging systems
CA2073561A1 (en) Polyanhydrides of the oligomerized unsaturated aliphatic acids
Pakter et al. Influence of the Hydrostatic Treatment on Formation of Structural Organization of Narrow-Meshed Epoxy-Polymers