BR112015029462A8 - Inibidores de quinase - Google Patents

Inibidores de quinase

Info

Publication number
BR112015029462A8
BR112015029462A8 BR112015029462A BR112015029462A BR112015029462A8 BR 112015029462 A8 BR112015029462 A8 BR 112015029462A8 BR 112015029462 A BR112015029462 A BR 112015029462A BR 112015029462 A BR112015029462 A BR 112015029462A BR 112015029462 A8 BR112015029462 A8 BR 112015029462A8
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
compositions
compounds
compound
treatment
Prior art date
Application number
BR112015029462A
Other languages
English (en)
Other versions
BR112015029462A2 (pt
Inventor
Woo Chi-Kit
Alcaraz Lilian
Capaldi Carmelida
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of BR112015029462A2 publication Critical patent/BR112015029462A2/pt
Publication of BR112015029462A8 publication Critical patent/BR112015029462A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSTO, MÉTODO E USO DE INIBIDORES DE QUINASE. A presente invenção refere-se a compostos e composições que são inibidores de MAPK p38 úteis como agentes anti inflamatórios no tratamento, inter alia, de doenças do trato respiratório.
BR112015029462A 2013-06-06 2014-06-05 Inibidores de quinase BR112015029462A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13170921 2013-06-06
PCT/EP2014/061677 WO2014195400A1 (en) 2013-06-06 2014-06-05 Kinase inhibitors

Publications (2)

Publication Number Publication Date
BR112015029462A2 BR112015029462A2 (pt) 2017-08-22
BR112015029462A8 true BR112015029462A8 (pt) 2023-03-21

Family

ID=48569995

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015029462A BR112015029462A8 (pt) 2013-06-06 2014-06-05 Inibidores de quinase

Country Status (9)

Country Link
US (1) US9359354B2 (pt)
EP (1) EP3004098B1 (pt)
KR (1) KR20160015221A (pt)
CN (1) CN105308046A (pt)
BR (1) BR112015029462A8 (pt)
CA (1) CA2914449A1 (pt)
HK (1) HK1219104A1 (pt)
RU (1) RU2015151834A (pt)
WO (1) WO2014195400A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2612259T3 (es) 2011-12-09 2017-05-16 Chiesi Farmaceutici S.P.A. Inhibidores de cinasa
RU2015151886A (ru) 2013-06-06 2017-06-08 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Ингибиторы киназ
AR107164A1 (es) 2015-12-23 2018-03-28 Chiesi Farm Spa INHIBIDORES DE QUINASA p38
WO2017108737A1 (en) 2015-12-23 2017-06-29 Chiesi Farmaceutici S.P.A. 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors
US10364245B2 (en) * 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
WO2019071147A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN108424372B (zh) * 2018-05-11 2021-08-10 浙江华贝药业有限责任公司 2，2，2-三氟-n-[(s)-4-羰基四氢萘-1-基]-乙酰胺的纯化工艺
TW202043407A (zh) * 2019-03-04 2020-12-01 日商拓自達電線股份有限公司 導電性接著劑組成物
WO2021007477A1 (en) 2019-07-11 2021-01-14 E-Scape Bio, Inc. Indazoles and azaindazoles as lrrk2 inhibitors
CN114324669B (zh) * 2022-01-04 2023-11-14 宁波第二激素厂 一种鲑鱼促性腺激素释放激素类似物中l-精氨酸残留量的柱前手性衍生测定方法
CN115650824B (zh) * 2022-10-31 2024-01-23 合肥工业大学 手性二醇及其制备方法、制得的催化剂及制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007091152A1 (en) * 2006-02-09 2007-08-16 Pfizer Limited Triazolopyridine compounds
PE20120655A1 (es) * 2009-02-17 2012-06-07 Chiesi Farma Spa Derivados de triazolopiridina como inhibidores de proteinas cinasas activadas por mitogeno p38 (map)
GB201009731D0 (en) * 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
ES2612259T3 (es) * 2011-12-09 2017-05-16 Chiesi Farmaceutici S.P.A. Inhibidores de cinasa
RU2015151886A (ru) * 2013-06-06 2017-06-08 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Ингибиторы киназ

Also Published As

Publication number Publication date
EP3004098B1 (en) 2017-08-09
US9359354B2 (en) 2016-06-07
WO2014195400A1 (en) 2014-12-11
CN105308046A (zh) 2016-02-03
HK1219104A1 (zh) 2017-03-24
EP3004098A1 (en) 2016-04-13
KR20160015221A (ko) 2016-02-12
CA2914449A1 (en) 2014-12-11
BR112015029462A2 (pt) 2017-08-22
US20140364411A1 (en) 2014-12-11
RU2015151834A (ru) 2017-06-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2517 DE 02-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA:

Ipc: A61K 31/475 (2006.01), A61P 11/06 (2006.01), C07D