BR9809748A - Estra-5(10), 7-dienos com atividade estrogênica - Google Patents

Estra-5(10), 7-dienos com atividade estrogênica

Info

Publication number
BR9809748A
BR9809748A BR9809748-2A BR9809748A BR9809748A BR 9809748 A BR9809748 A BR 9809748A BR 9809748 A BR9809748 A BR 9809748A BR 9809748 A BR9809748 A BR 9809748A
Authority
BR
Brazil
Prior art keywords
estra
dien
pharmaceutically acceptable
acceptable salt
estrogenic activity
Prior art date
Application number
BR9809748-2A
Other languages
English (en)
Inventor
Fangmin Kong
Leonard Alexander Mcdonald
Michael Z Kagan
Syed Muzafar Shah
Panolil Chirukan Raveendranath
Mark Andrew Collins
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9809748A publication Critical patent/BR9809748A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"ESTRA-5(10),7-DIENOS COM ATIVIDADE ESTROGêNICA"<D> A presente invenção refere-se à estra-5(10),7-dien-3<225>-ol-17-ona ou um sal farmaceuticamente aceitável de seu éster de 3-sulfato ou 3-glucuronídeo de estra-5(10),7-dien-3<225>-ol-17-ona ou sal farmaceuticamente aceitável do mesmo, estra-5(10),7-dien-3<244>-ol-17-ona ou um sal farmaceuticamente aceitável de seu éster de 3-sulfato ou 3-glucuronídeo de estra-5(10),7-dien-3<244>-ol-17-ona ou um sal farmaceuticamente aceitável do mesmo, sal de metal 3-alcalino de estra-5(10),7dien-3<225>-ol-17-ona e sal de metal 3-alcalino de estra-5(10),7-dien-3<244>-ol-17-ona, os quais são úteis como agentes estrogênicos
BR9809748-2A 1997-04-07 1998-04-02 Estra-5(10), 7-dienos com atividade estrogênica BR9809748A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83533697A 1997-04-07 1997-04-07
US85057097A 1997-05-02 1997-05-02
PCT/US1998/006461 WO1998045315A1 (en) 1997-04-07 1998-04-02 Estra-5(10),7-dienes with estrogenic activity

Publications (1)

Publication Number Publication Date
BR9809748A true BR9809748A (pt) 2000-06-20

Family

ID=27125779

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809748-2A BR9809748A (pt) 1997-04-07 1998-04-02 Estra-5(10), 7-dienos com atividade estrogênica

Country Status (15)

Country Link
EP (1) EP0973790B1 (pt)
JP (1) JP2001518896A (pt)
KR (1) KR20010006118A (pt)
CN (1) CN1259137A (pt)
AR (1) AR012341A1 (pt)
AT (1) ATE242263T1 (pt)
AU (1) AU738486B2 (pt)
BR (1) BR9809748A (pt)
CA (1) CA2286457A1 (pt)
DE (1) DE69815329T2 (pt)
DK (1) DK0973790T3 (pt)
ES (1) ES2200334T3 (pt)
NZ (1) NZ500217A (pt)
PT (1) PT973790E (pt)
WO (1) WO1998045315A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004524354A (ja) * 2001-03-16 2004-08-12 ワイス エストロゲン補充療法
US20110082306A1 (en) * 2008-03-24 2011-04-07 Costanzo Michael J Birch reduction of steroid substrates via alkali metal - silica gel materials
AU2013289344A1 (en) 2012-07-10 2015-02-05 Bayer Pharma Aktiengesellschaft 3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments
US9714266B2 (en) 2013-02-21 2017-07-25 Bayer Pharma Aktiengesellschaft Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930805A (en) * 1959-01-19 1960-03-29 American Home Prod Novel derivatives of estrane
DE1093360B (de) * 1958-02-17 1960-11-24 Ayerst Mckenna & Harrison Verfahren zur Herstellung von stabilen antioestrogen wirksamen Verbindungen der Oestranreihe
US3340278A (en) * 1965-05-03 1967-09-05 American Home Prod 5(10), 7-estradiene-3, 17-dione and the process for the production thereof
ATE141051T1 (de) * 1992-04-07 1996-08-15 Neurim Pharma 1991 Verwendung von melatonin zur herstellung eines arzneimittels zur behandlung der gutartigen prostatahyperplasie

Also Published As

Publication number Publication date
EP0973790B1 (en) 2003-06-04
EP0973790A1 (en) 2000-01-26
NZ500217A (en) 2001-11-30
DE69815329D1 (de) 2003-07-10
DK0973790T3 (da) 2003-09-22
AU738486B2 (en) 2001-09-20
CA2286457A1 (en) 1998-10-15
AU6946298A (en) 1998-10-30
DE69815329T2 (de) 2004-04-29
AR012341A1 (es) 2000-10-18
KR20010006118A (ko) 2001-01-26
ATE242263T1 (de) 2003-06-15
PT973790E (pt) 2003-10-31
WO1998045315A1 (en) 1998-10-15
ES2200334T3 (es) 2004-03-01
CN1259137A (zh) 2000-07-05
JP2001518896A (ja) 2001-10-16

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A,9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1942 DE 25 - 03 - 2008.