ATE242263T1 - Estra-5(10),7-diene mit östrogener aktivität - Google Patents

Estra-5(10),7-diene mit östrogener aktivität

Info

Publication number
ATE242263T1
ATE242263T1 AT98915224T AT98915224T ATE242263T1 AT E242263 T1 ATE242263 T1 AT E242263T1 AT 98915224 T AT98915224 T AT 98915224T AT 98915224 T AT98915224 T AT 98915224T AT E242263 T1 ATE242263 T1 AT E242263T1
Authority
AT
Austria
Prior art keywords
estra
diene
estrogenic activity
estrogenic
activity
Prior art date
Application number
AT98915224T
Other languages
English (en)
Inventor
Fangming Kong
Leonard Alexander Mcdonald
Michael Z Kagan
Syed Muzafar Shah
Panolil Raveendranath
Mark Andrew Collins
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE242263T1 publication Critical patent/ATE242263T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98915224T 1997-04-07 1998-04-02 Estra-5(10),7-diene mit östrogener aktivität ATE242263T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83533697A 1997-04-07 1997-04-07
US85057097A 1997-05-02 1997-05-02
PCT/US1998/006461 WO1998045315A1 (en) 1997-04-07 1998-04-02 Estra-5(10),7-dienes with estrogenic activity

Publications (1)

Publication Number Publication Date
ATE242263T1 true ATE242263T1 (de) 2003-06-15

Family

ID=27125779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98915224T ATE242263T1 (de) 1997-04-07 1998-04-02 Estra-5(10),7-diene mit östrogener aktivität

Country Status (15)

Country Link
EP (1) EP0973790B1 (de)
JP (1) JP2001518896A (de)
KR (1) KR20010006118A (de)
CN (1) CN1259137A (de)
AR (1) AR012341A1 (de)
AT (1) ATE242263T1 (de)
AU (1) AU738486B2 (de)
BR (1) BR9809748A (de)
CA (1) CA2286457A1 (de)
DE (1) DE69815329T2 (de)
DK (1) DK0973790T3 (de)
ES (1) ES2200334T3 (de)
NZ (1) NZ500217A (de)
PT (1) PT973790E (de)
WO (1) WO1998045315A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG154323A1 (en) * 2001-03-16 2009-08-28 Wyeth Corp Estrogen replacement therapy
EP2268655A4 (de) * 2008-03-24 2013-03-13 Signa Chemistry Llc Birch-reduktion von steroidsubstraten über alkalimetall-kieselgel-materialien
BR112015000443A2 (pt) 2012-07-10 2017-06-27 Bayer Pharma AG derivados de estra-1,3,5(10),16-tetraeno 3-substituídos, processo para a sua produção, preparações farmacêuticas que contêm os mesmos, bem como seu uso para a produção de medicamentos
AP3826A (en) 2013-02-21 2016-09-30 Bayer Pharma Aktiengellschaft Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (akr1 c3)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930805A (en) * 1959-01-19 1960-03-29 American Home Prod Novel derivatives of estrane
DE1093360B (de) * 1958-02-17 1960-11-24 Ayerst Mckenna & Harrison Verfahren zur Herstellung von stabilen antioestrogen wirksamen Verbindungen der Oestranreihe
US3340278A (en) * 1965-05-03 1967-09-05 American Home Prod 5(10), 7-estradiene-3, 17-dione and the process for the production thereof
EP0565296B1 (de) * 1992-04-07 1996-08-07 Neurim Pharmaceuticals (1991) Limited Verwendung von Melatonin zur Herstellung eines Arzneimittels zur Behandlung der gutartigen Prostatahyperplasie

Also Published As

Publication number Publication date
JP2001518896A (ja) 2001-10-16
EP0973790B1 (de) 2003-06-04
CN1259137A (zh) 2000-07-05
CA2286457A1 (en) 1998-10-15
ES2200334T3 (es) 2004-03-01
BR9809748A (pt) 2000-06-20
DE69815329T2 (de) 2004-04-29
DE69815329D1 (de) 2003-07-10
NZ500217A (en) 2001-11-30
PT973790E (pt) 2003-10-31
WO1998045315A1 (en) 1998-10-15
AR012341A1 (es) 2000-10-18
AU6946298A (en) 1998-10-30
DK0973790T3 (da) 2003-09-22
EP0973790A1 (de) 2000-01-26
KR20010006118A (ko) 2001-01-26
AU738486B2 (en) 2001-09-20

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