DE69528197D1 - Neue 1,3-dialkylharnstoff-derivate - Google Patents

Neue 1,3-dialkylharnstoff-derivate

Info

Publication number
DE69528197D1
DE69528197D1 DE69528197T DE69528197T DE69528197D1 DE 69528197 D1 DE69528197 D1 DE 69528197D1 DE 69528197 T DE69528197 T DE 69528197T DE 69528197 T DE69528197 T DE 69528197T DE 69528197 D1 DE69528197 D1 DE 69528197D1
Authority
DE
Germany
Prior art keywords
dialkyl
new
urine derivatives
urine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528197T
Other languages
English (en)
Other versions
DE69528197T2 (de
Inventor
Yoichi Kawashima
Ken-Ichi Fujimura
Hiroshi Suhara
Noriyoshi Yamamoto
Hiromi Matsumoto
Nobuaki Miyawaki
Yuko Fujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of DE69528197D1 publication Critical patent/DE69528197D1/de
Application granted granted Critical
Publication of DE69528197T2 publication Critical patent/DE69528197T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
DE69528197T 1994-12-14 1995-12-11 Neue 1,3-dialkylharnstoff-derivate Expired - Fee Related DE69528197T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31049394 1994-12-14
PCT/JP1995/002539 WO1996018606A1 (fr) 1994-12-14 1995-12-11 Nouveaux derives 1,3-dialkyluree

Publications (2)

Publication Number Publication Date
DE69528197D1 true DE69528197D1 (de) 2002-10-17
DE69528197T2 DE69528197T2 (de) 2003-06-05

Family

ID=18005896

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528197T Expired - Fee Related DE69528197T2 (de) 1994-12-14 1995-12-11 Neue 1,3-dialkylharnstoff-derivate

Country Status (4)

Country Link
US (1) US5968980A (de)
EP (1) EP0798291B1 (de)
DE (1) DE69528197T2 (de)
WO (1) WO1996018606A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL128190A0 (en) 1996-07-31 1999-11-30 Shionogi & Co Novel p-terphenyl compounds
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
GB9811159D0 (en) * 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
US20050119237A1 (en) * 1999-06-18 2005-06-02 Ramot University Authority For Applied Research & Industrial Development Ltd. Non-malignant disease treatment with Ras antagonists
AU6909300A (en) * 1999-08-20 2001-03-19 Merck & Co., Inc. Substituted ureas as cell adhesion inhibitors
FR2820136A1 (fr) * 2001-01-26 2002-08-02 Aventis Pharma Sa Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
MY140707A (en) 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
RU2315041C2 (ru) * 2002-04-30 2008-01-20 ЮСиБи, С.А. Производные 2,6-хинолинила и 2,6-нафтила, фармацевтические композиции на их основе, их применение в качестве ингибиторов vla-4 и промежуточные соединения
US7045653B2 (en) 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
AU2004236247B2 (en) * 2003-04-30 2008-11-06 The Institutes For Pharmaceutical Discovery, Llc Substituted amino carboxylic acids as inhibitors of protein tyrosine phosphatase-1 B
WO2005063699A1 (en) * 2003-12-31 2005-07-14 Council Of Scientific & Industrial Research N-aryloxypropanolyl-n’-phenethyl-urea
US6962945B2 (en) 2004-03-26 2005-11-08 Council Of Scientific And Industrial Research N-aryloxypropanolyl-N′-phenethyl-urea
WO2006055725A2 (en) * 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Substituted amino acids as protein tyrosine phosphatase inhibitors
FR2885129B1 (fr) 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
KR20080021085A (ko) 2005-06-09 2008-03-06 유씨비 파마, 에스.에이. 2，6 퀴놀리닐 유도체, 이들을 제조하는 방법 및 이들의약제로서의 용도
DE602006010905D1 (de) * 2005-11-25 2010-01-14 Galapagos Sas Harnstoff-derivate als calcium-rezeptor-modulatoren
GB0613674D0 (en) * 2006-07-10 2006-08-16 Proskelia Sas Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
WO2008033931A1 (en) * 2006-09-13 2008-03-20 The Institutes For Pharmaceutical Discovery, Llc Para-xylylene carboxylic acids and isothiazolones useful as protein tyrosine phosphatases (ptps) in particular ptp-ib
SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
DK2435409T3 (da) * 2009-05-28 2014-10-27 Novartis Ag Substituerede aminopropionsyrederivater som neprilysininhibitorer
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
BR112015019307A8 (pt) 2013-02-14 2018-01-30 Novartis Ag derivados de ácido butanóico substituído com bisfenila, seus usos, e composição farmacêutica
JP6295277B2 (ja) 2013-02-14 2018-03-14 ノバルティス アーゲー Ｎｅｐ（中性エンドペプチダーゼ）阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体
CN105732480B (zh) * 2016-04-13 2019-04-05 中国药科大学 2-氨基-3-(6-羟基萘-2-基)丙酸衍生物、其制法及应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028401A (en) * 1976-07-01 1977-06-07 Morton-Norwich Products, Inc. (Substituted)ureidoacetohydroxamic acids
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
JPS6140252A (ja) * 1984-08-02 1986-02-26 Kureha Chem Ind Co Ltd Ｎ−カルバモイルアミノ酸誘導体
FR2568723B1 (fr) * 1984-08-03 1987-06-05 Commissariat Energie Atomique Circuit integre notamment de type mos et son procede de fabrication
US4728670A (en) * 1986-06-04 1988-03-01 E. R. Squibb & Sons, Inc. Biphenyl hydroxamic acids
US5262178A (en) * 1987-01-12 1993-11-16 Genentech, Inc. Therapeutic use of enkephalinase
US5403585A (en) * 1987-01-12 1995-04-04 Genentech, Inc. Therapeutic use of enkephalinase
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5066658A (en) * 1988-11-10 1991-11-19 Ortho Pharmaceutical Corporation Substituted hydroxyureas
US5175183A (en) * 1989-02-01 1992-12-29 Abbott Laboratories Lipoxygenase inhibiting compounds
JPH04503074A (ja) * 1989-02-01 1992-06-04 アボツト・ラボラトリーズ リポキシゲナーゼ阻止化合物
JP2775690B2 (ja) * 1989-08-22 1998-07-16 昭和シェル石油株式会社 スリップ・レイヤー・シート
JPH0672985A (ja) * 1992-08-28 1994-03-15 Ono Pharmaceut Co Ltd （チオ）ウレア誘導体
JP3118738B2 (ja) * 1992-12-22 2000-12-18 小野薬品工業株式会社 （チオ）ウレア誘導体

Also Published As

Publication number Publication date
EP0798291B1 (de) 2002-09-11
WO1996018606A1 (fr) 1996-06-20
DE69528197T2 (de) 2003-06-05
US5968980A (en) 1999-10-19
EP0798291A4 (de) 1999-06-23
EP0798291A1 (de) 1997-10-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee