DE69714358D1 - 9,10-disubstituierte campothecinderivate mit antitumoraktivität - Google Patents

9,10-disubstituierte campothecinderivate mit antitumoraktivität

Info

Publication number
DE69714358D1
DE69714358D1 DE69714358T DE69714358T DE69714358D1 DE 69714358 D1 DE69714358 D1 DE 69714358D1 DE 69714358 T DE69714358 T DE 69714358T DE 69714358 T DE69714358 T DE 69714358T DE 69714358 D1 DE69714358 D1 DE 69714358D1
Authority
DE
Germany
Prior art keywords
oractivity
antitum
disubstituted
campothecine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69714358T
Other languages
English (en)
Other versions
DE69714358T2 (de
Inventor
Angelo Bedeschi
Walter Cabri
Ilaria Candiani
Franco Zarini
Sergio Penco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of DE69714358D1 publication Critical patent/DE69714358D1/de
Publication of DE69714358T2 publication Critical patent/DE69714358T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69714358T 1996-01-30 1997-01-11 9,10-disubstituierte campothecinderivate mit antitumoraktivität Expired - Fee Related DE69714358T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9601779.3A GB9601779D0 (en) 1996-01-30 1996-01-30 9, 10 Disubstituted camptothecin derivatives
PCT/EP1997/000194 WO1997028164A1 (en) 1996-01-30 1997-01-11 9,10 disubstituted camptothecin derivatives with antitumor activity

Publications (2)

Publication Number Publication Date
DE69714358D1 true DE69714358D1 (de) 2002-09-05
DE69714358T2 DE69714358T2 (de) 2003-03-06

Family

ID=10787751

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69714358T Expired - Fee Related DE69714358T2 (de) 1996-01-30 1997-01-11 9,10-disubstituierte campothecinderivate mit antitumoraktivität

Country Status (6)

Country Link
US (1) US5998426A (de)
EP (1) EP0824534B1 (de)
JP (1) JPH11503464A (de)
DE (1) DE69714358T2 (de)
GB (1) GB9601779D0 (de)
WO (1) WO1997028164A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111689978A (zh) * 2019-03-11 2020-09-22 兰州大学 一种喜树碱20-位修饰的磺酰胺类化合物及其制备方法和用途

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9702807D0 (en) 1997-02-12 1997-04-02 Pharmacia & Upjohn Spa Alkynyl-substituted camptothecins and process for their preparation
US6355448B1 (en) 1998-06-02 2002-03-12 3M Innovative Properties Company Sterilization indicator with chemically stabilized enzyme
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2427467C (en) 2000-11-09 2010-01-12 Neopharm, Inc. Sn-38 lipid complexes and methods of use
WO2003030864A1 (en) 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
AU2005244768B2 (en) 2004-04-27 2011-06-09 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
ATE540698T1 (de) 2005-07-14 2012-01-15 Wellstat Biologics Corp Krebsbehandlung mit viren, fluoropyrimidinen und camptothecinen
CN108135917B (zh) 2015-09-25 2021-07-09 Zy医疗 基于包含多糖-维生素缀合物的颗粒的药物制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
DE69131775T2 (de) * 1990-09-28 2000-04-20 Smithkline Beecham Corp. Verfahren zur Herstellung wasserlöslicher Camptothecinanaloge, sowie die Verbindungen 10-Hydroxy-11-C(1-6)-alkoxycamptothecin
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111689978A (zh) * 2019-03-11 2020-09-22 兰州大学 一种喜树碱20-位修饰的磺酰胺类化合物及其制备方法和用途

Also Published As

Publication number Publication date
WO1997028164A1 (en) 1997-08-07
GB9601779D0 (en) 1996-04-03
JPH11503464A (ja) 1999-03-26
EP0824534A1 (de) 1998-02-25
DE69714358T2 (de) 2003-03-06
EP0824534B1 (de) 2002-07-31
US5998426A (en) 1999-12-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee