CU20120042A7 - (heteroarilmetil)tiohidantoínas sustituidas como drogas anticáncer - Google Patents

(heteroarilmetil)tiohidantoínas sustituidas como drogas anticáncer

Info

Publication number
CU20120042A7
CU20120042A7 CU20120042A CU20120042A CU20120042A7 CU 20120042 A7 CU20120042 A7 CU 20120042A7 CU 20120042 A CU20120042 A CU 20120042A CU 20120042 A CU20120042 A CU 20120042A CU 20120042 A7 CU20120042 A7 CU 20120042A7
Authority
CU
Cuba
Prior art keywords
heteroarilmetil
cancer drugs
thiohydantoins
substituted
substituted thiohydantoins
Prior art date
Application number
CU20120042A
Other languages
English (en)
Inventor
Horst Irlbacher
Gimenez Hortensia Faus
Bernard Haendler
Silke Koehr
Arwed Cleve
Ulrich Luecking
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CU20120042A7 publication Critical patent/CU20120042A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Compuestos de (heteroarilmetil)tiohidantoínas sustituidas de la fórmula general (I) ESPACIO PARA LA FÓRMULA según se define, y métodos para su preparación, su uso para el tratamiento y/o profilaxis de enfermedades, y su uso para la preparación de medicamentos para el tratamiento y/o profilaxis de enfermedades, en particular del cáncer de próstata.
CU20120042A 2009-09-11 2012-03-09 (heteroarilmetil)tiohidantoínas sustituidas como drogas anticáncer CU20120042A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09075421 2009-09-11
EP10075069 2010-02-17

Publications (1)

Publication Number Publication Date
CU20120042A7 true CU20120042A7 (es) 2012-06-21

Family

ID=42782041

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20120042A CU20120042A7 (es) 2009-09-11 2012-03-09 (heteroarilmetil)tiohidantoínas sustituidas como drogas anticáncer

Country Status (27)

Country Link
US (1) US20120251551A1 (es)
EP (1) EP2475653A1 (es)
JP (1) JP2013504523A (es)
KR (1) KR20120065396A (es)
CN (1) CN102639523A (es)
AR (1) AR078166A1 (es)
AU (1) AU2010294588A1 (es)
BR (1) BR112012005526A2 (es)
CA (1) CA2773591A1 (es)
CL (1) CL2012000623A1 (es)
CO (1) CO6511228A2 (es)
CR (1) CR20120113A (es)
CU (1) CU20120042A7 (es)
DO (1) DOP2012000063A (es)
EA (1) EA201200473A1 (es)
EC (1) ECSP12011716A (es)
IL (1) IL218390A0 (es)
IN (1) IN2012DN02081A (es)
MA (1) MA33566B1 (es)
MX (1) MX2012002977A (es)
NZ (1) NZ598643A (es)
PE (1) PE20121180A1 (es)
SG (1) SG178919A1 (es)
TN (1) TN2012000108A1 (es)
TW (1) TW201111378A (es)
UY (1) UY32882A (es)
WO (1) WO2011029537A1 (es)

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SG11201402826YA (en) 2011-12-22 2014-12-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EA027929B1 (ru) 2012-05-25 2017-09-29 Янссен Сайенсиз Айрлэнд Юси Нуклеозиды на основе урацила и спирооксетана
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之ｎ－（吡啶－２－基）嘧啶－４－胺衍生物
SG11201504554UA (en) 2012-12-21 2015-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2014153280A1 (en) * 2013-03-22 2014-09-25 Merck Sharp & Dohme Corp. 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
CN104341351B (zh) * 2013-07-30 2018-02-06 北京海美源医药科技有限公司 一种二芳基硫代乙内酰脲衍生物及其应用
MX2016007585A (es) * 2013-12-11 2016-12-16 Celgene Quanticel Res Inc Inhibidores de desmetilasa-1 especifica de lisina.
CN105829296A (zh) 2013-12-18 2016-08-03 巴斯夫欧洲公司 带有亚胺衍生的取代基的唑类化合物
US9682960B2 (en) * 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103896847B (zh) * 2014-04-09 2016-01-20 沈江 一种非甾体类抗雄激素化合物及其制备方法和应用
US10167296B2 (en) 2014-05-07 2019-01-01 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
TWI700283B (zh) 2014-08-04 2020-08-01 德商拜耳製藥公司 ２-(嗎啉-４-基)-１,７-萘啶
CN106187905B (zh) * 2015-05-05 2020-02-21 北京海步医药科技股份有限公司 丁鲁他胺的结晶形式及其制备方法
WO2017060167A1 (en) 2015-10-08 2017-04-13 Bayer Pharma Aktiengesellschaft Novel modified macrocyclic compounds
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
WO2018177889A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
PL3601253T3 (pl) 2017-03-28 2022-01-17 Bayer Aktiengesellschaft Nowe hamujące ptefb związki makrocykliczne
EP3625215B1 (en) 2017-05-18 2023-09-13 PI Industries Ltd Formimidamidine compounds useful against phytopathogenic microorganisms
JOP20200196A1 (ar) 2018-02-13 2020-08-13 Bayer Ag استخدام 5-فلورو-4-(4-فلورو-2-مثوكسي فنيل)- n-{4-[(s-مثيل كبريتون ايميدويل) مثيل] بيريدين-2-يل} بيريدين -2-امين لمعالجة ليمفومة الخلايا البائية الكبيرة المنتشرة
MX2021012499A (es) * 2019-04-11 2022-01-24 Univ Miami Inhibidores mejorados del complejo de activación transcripcional notch y métodos para el uso de estos.
CA3165120A1 (en) * 2020-01-21 2021-07-29 Berkley E. GRYDER Aryl hydantoin heterocycles and methods of use
WO2022206742A1 (zh) * 2021-03-30 2022-10-06 苏州开拓药业股份有限公司 一种一步法合成乙内酰硫脲衍生物的方法

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Also Published As

Publication number Publication date
TW201111378A (en) 2011-04-01
CN102639523A (zh) 2012-08-15
ECSP12011716A (es) 2012-04-30
IL218390A0 (en) 2012-04-30
DOP2012000063A (es) 2012-05-15
JP2013504523A (ja) 2013-02-07
MA33566B1 (fr) 2012-09-01
AR078166A1 (es) 2011-10-19
AU2010294588A1 (en) 2012-04-05
EA201200473A1 (ru) 2012-10-30
NZ598643A (en) 2013-10-25
TN2012000108A1 (en) 2013-09-19
US20120251551A1 (en) 2012-10-04
KR20120065396A (ko) 2012-06-20
EP2475653A1 (en) 2012-07-18
CL2012000623A1 (es) 2012-09-14
CO6511228A2 (es) 2012-08-31
BR112012005526A2 (pt) 2016-04-26
MX2012002977A (es) 2012-04-30
PE20121180A1 (es) 2012-08-24
CR20120113A (es) 2012-05-02
UY32882A (es) 2011-04-29
IN2012DN02081A (es) 2015-08-21
WO2011029537A1 (en) 2011-03-17
CA2773591A1 (en) 2011-03-17
SG178919A1 (en) 2012-04-27

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