IN2012DN02081A - - Google Patents

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Publication number
IN2012DN02081A
IN2012DN02081A IN2081DEN2012A IN2012DN02081A IN 2012DN02081 A IN2012DN02081 A IN 2012DN02081A IN 2081DEN2012 A IN2081DEN2012 A IN 2081DEN2012A IN 2012DN02081 A IN2012DN02081 A IN 2012DN02081A
Authority
IN
India
Prior art keywords
prophylaxis
disorders
preparation
treatment
heteroarylmethyl
Prior art date
Application number
Inventor
Lucking Ulrich
Cleve Arwed
Haendler Bernard
Faus Gimenez Hortensia
Kohr Silke
Irlbacher Horst
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of IN2012DN02081A publication Critical patent/IN2012DN02081A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to substituted (heteroarylmethyl)thiohydantoin compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, and their use for the preparation of medicaments for the treatment and/or prophylaxis of disorders, in particular of prostate cancer.
IN2081DEN2012 2009-09-11 2010-08-28 IN2012DN02081A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09075421 2009-09-11
EP10075069 2010-02-17
PCT/EP2010/005297 WO2011029537A1 (en) 2009-09-11 2010-08-28 Sustituted ( heteroarylmethyl ) thiohydantoins as anticancer drugs

Publications (1)

Publication Number Publication Date
IN2012DN02081A true IN2012DN02081A (en) 2015-08-21

Family

ID=42782041

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2081DEN2012 IN2012DN02081A (en) 2009-09-11 2010-08-28

Country Status (27)

Country Link
US (1) US20120251551A1 (en)
EP (1) EP2475653A1 (en)
JP (1) JP2013504523A (en)
KR (1) KR20120065396A (en)
CN (1) CN102639523A (en)
AR (1) AR078166A1 (en)
AU (1) AU2010294588A1 (en)
BR (1) BR112012005526A2 (en)
CA (1) CA2773591A1 (en)
CL (1) CL2012000623A1 (en)
CO (1) CO6511228A2 (en)
CR (1) CR20120113A (en)
CU (1) CU20120042A7 (en)
DO (1) DOP2012000063A (en)
EA (1) EA201200473A1 (en)
EC (1) ECSP12011716A (en)
IL (1) IL218390A0 (en)
IN (1) IN2012DN02081A (en)
MA (1) MA33566B1 (en)
MX (1) MX2012002977A (en)
NZ (1) NZ598643A (en)
PE (1) PE20121180A1 (en)
SG (1) SG178919A1 (en)
TN (1) TN2012000108A1 (en)
TW (1) TW201111378A (en)
UY (1) UY32882A (en)
WO (1) WO2011029537A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX353500B (en) 2010-02-17 2018-01-16 Takeda Pharmaceuticals Co Heterocyclic compound.
US9199976B2 (en) * 2010-06-01 2015-12-01 The University Of Queensland Haematopoietic-prostaglandin D2 synthase inhibitors
HUE041509T2 (en) 2011-12-22 2019-05-28 Janssen Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
SG11201407336PA (en) 2012-05-25 2015-03-30 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
TW201418243A (en) 2012-11-15 2014-05-16 Bayer Pharma AG N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group
CA2894542C (en) 2012-12-21 2023-10-31 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2014153280A1 (en) * 2013-03-22 2014-09-25 Merck Sharp & Dohme Corp. 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
CN104341351B (en) * 2013-07-30 2018-02-06 北京海美源医药科技有限公司 A kind of Diarylthiohydantoin derivative and its application
CA2933480C (en) * 2013-12-11 2022-08-23 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
WO2015091645A1 (en) 2013-12-18 2015-06-25 Basf Se Azole compounds carrying an imine-derived substituent
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103896847B (en) * 2014-04-09 2016-01-20 沈江 A kind of nonsteroidal Anti-androgenic compounds and its preparation method and application
JP6479854B2 (en) 2014-05-07 2019-03-06 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＥｖｏｔｅｃ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ Sulfoxyimine substituted quinazolines for pharmaceutical compositions
TWI656121B (en) 2014-08-04 2019-04-11 德商拜耳製藥公司 2-(morpholin-4-yl)-1,7-naphthyridine
CN106187905B (en) * 2015-05-05 2020-02-21 北京海步医药科技股份有限公司 Crystalline forms of bufutamide and methods of making the same
JP6888000B2 (en) 2015-10-08 2021-06-16 バイエル ファーマ アクチエンゲゼルシャフト New modified macrocycle
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
TWI726969B (en) 2016-01-11 2021-05-11 比利時商健生藥品公司 Substituted thiohydantoin derivatives as androgen receptor antagonists
PL3601253T3 (en) 2017-03-28 2022-01-17 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
CA3057891A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
EP3625215B1 (en) 2017-05-18 2023-09-13 PI Industries Ltd Formimidamidine compounds useful against phytopathogenic microorganisms
KR20200119800A (en) 2018-02-13 2020-10-20 바이엘 악티엔게젤샤프트 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2- for treatment of diffuse large B-cell lymphoma Uses of [yl]pyridin-2-amine
AU2020271767A1 (en) * 2019-04-11 2021-11-11 Stem Synergy Therapeutics, Inc Improved inhibitors of the notch transcriptional activation complex and methods for use of the same
US20230135524A1 (en) * 2020-01-21 2023-05-04 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Aryl hydantoin heterocycles and methods of use
CN117120436A (en) * 2021-03-30 2023-11-24 苏州开拓药业股份有限公司 Method for synthesizing thiohydantoin derivative by one-step method

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411981A (en) 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (en) * 1992-07-08 1994-09-02 Roussel Uclaf New substituted phenylimidazolidines, process for their preparation, their use as medicaments and the pharmaceutical compositions containing them.
FR2671348B1 (en) 1991-01-09 1993-03-26 Roussel Uclaf NOVEL PHENYLIMIDAZOLIDINES, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
USRE35956E (en) 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2694290B1 (en) 1992-07-08 1994-09-02 Roussel Uclaf New phenylimidazolidines which may be substituted, their preparation process, their use as medicaments and the pharmaceutical compositions containing them.
TW521073B (en) 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2716110B1 (en) 1994-02-16 1996-04-05 Roussel Uclaf Cosmetic or pharmaceutical compositions comprising liposomes.
US5656651A (en) 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
EP1122242B1 (en) 1998-09-22 2008-01-16 Astellas Pharma Inc. Cyanophenyl derivatives
US6472415B1 (en) 1998-12-18 2002-10-29 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
US6861432B2 (en) 2001-11-23 2005-03-01 Schering Aktiengesellschaft Piperazine derivatives that destabilize androgen receptors
BR0309188A (en) 2002-04-12 2005-02-09 Pfizer Pyrazole compounds as antiinflammatory and analgesic agents
EP1656357A1 (en) 2003-07-02 2006-05-17 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
EP1673348B1 (en) 2003-09-30 2009-04-01 Janssen Pharmaceutica N.V. Benzoimidazole compounds
CA2548374C (en) 2003-12-23 2014-05-27 Astex Therapeutics Limited Pyrazole derivatives as protein kinase modulators
TW200612920A (en) 2004-08-03 2006-05-01 Chugai Pharmaceutical Co Ltd Novel imidazolidine derivatives
CN101048381A (en) * 2004-09-09 2007-10-03 中外制药株式会社 Novel imidazolidine derivative and use thereof
KR100903248B1 (en) 2004-12-03 2009-06-17 에프. 호프만-라 로슈 아게 3-substituted pyridine derivatives as h3 antagonists
RS52274B2 (en) 2005-05-13 2018-05-31 Univ California Diarzlhzdantoin compound
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
SG10201408699TA (en) 2006-03-29 2015-02-27 Univ California Diarylthiohydantoin compounds
UY31432A1 (en) 2007-10-26 2009-05-29 DIARILHIDANTOINE COMPOUNDS
WO2009097995A1 (en) * 2008-02-07 2009-08-13 Sanofi-Aventis Novel phenyl-substituted imidazolidines, method for the production thereof, medicaments containing said compounds and use thereof

Also Published As

Publication number Publication date
SG178919A1 (en) 2012-04-27
IL218390A0 (en) 2012-04-30
NZ598643A (en) 2013-10-25
MA33566B1 (en) 2012-09-01
CA2773591A1 (en) 2011-03-17
CL2012000623A1 (en) 2012-09-14
WO2011029537A1 (en) 2011-03-17
ECSP12011716A (en) 2012-04-30
CR20120113A (en) 2012-05-02
TN2012000108A1 (en) 2013-09-19
JP2013504523A (en) 2013-02-07
DOP2012000063A (en) 2012-05-15
CN102639523A (en) 2012-08-15
MX2012002977A (en) 2012-04-30
AU2010294588A1 (en) 2012-04-05
US20120251551A1 (en) 2012-10-04
TW201111378A (en) 2011-04-01
EP2475653A1 (en) 2012-07-18
KR20120065396A (en) 2012-06-20
CU20120042A7 (en) 2012-06-21
CO6511228A2 (en) 2012-08-31
AR078166A1 (en) 2011-10-19
UY32882A (en) 2011-04-29
PE20121180A1 (en) 2012-08-24
BR112012005526A2 (en) 2016-04-26
EA201200473A1 (en) 2012-10-30

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