CN102596932A - 作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉 - Google Patents
作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉 Download PDFInfo
- Publication number
- CN102596932A CN102596932A CN2010800490392A CN201080049039A CN102596932A CN 102596932 A CN102596932 A CN 102596932A CN 2010800490392 A CN2010800490392 A CN 2010800490392A CN 201080049039 A CN201080049039 A CN 201080049039A CN 102596932 A CN102596932 A CN 102596932A
- Authority
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- China
- Prior art keywords
- phenyl
- quinoxalin
- alkyl
- piperazine
- pyridin
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- 0 CC(Cc(cc(*)cc1)c1/*=C1)C(C)C1=O Chemical compound CC(Cc(cc(*)cc1)c1/*=C1)C(C)C1=O 0.000 description 1
- ZIUUDTYYEITUSJ-UHFFFAOYSA-N CNS(Nc(cc1)ccc1-c1cc2nc(N3CCOCC3)cnc2cc1)(=O)=O Chemical compound CNS(Nc(cc1)ccc1-c1cc2nc(N3CCOCC3)cnc2cc1)(=O)=O ZIUUDTYYEITUSJ-UHFFFAOYSA-N 0.000 description 1
- ARPOBOFFMOLBKB-UHFFFAOYSA-N Cc1cc(-c(cc2)cc3c2ncc(N2CCN(C)CC2)n3)cc(C)c1O Chemical compound Cc1cc(-c(cc2)cc3c2ncc(N2CCN(C)CC2)n3)cc(C)c1O ARPOBOFFMOLBKB-UHFFFAOYSA-N 0.000 description 1
- PZGRGIHLECCNLD-UHFFFAOYSA-N Nc(ccc(-c1cc2nc(N3CCOCC3)cnc2cc1)c1)c1N Chemical compound Nc(ccc(-c1cc2nc(N3CCOCC3)cnc2cc1)c1)c1N PZGRGIHLECCNLD-UHFFFAOYSA-N 0.000 description 1
- RELDELLUOBLSTB-UHFFFAOYSA-N O=C(Cc1ccccc1)Nc(cc1)ccc1-c(cc1)cc2c1ncc(N(CC1)CCN1c1nccnc1)n2 Chemical compound O=C(Cc1ccccc1)Nc(cc1)ccc1-c(cc1)cc2c1ncc(N(CC1)CCN1c1nccnc1)n2 RELDELLUOBLSTB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09075415.1 | 2009-09-04 | ||
EP09075415 | 2009-09-04 | ||
PCT/EP2010/005183 WO2011026579A1 (en) | 2009-09-04 | 2010-08-24 | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102596932A true CN102596932A (zh) | 2012-07-18 |
Family
ID=43037638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010800490392A Pending CN102596932A (zh) | 2009-09-04 | 2010-08-24 | 作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9340528B2 (zh) |
EP (1) | EP2473498A1 (zh) |
JP (1) | JP5728683B2 (zh) |
CN (1) | CN102596932A (zh) |
CA (1) | CA2772790C (zh) |
WO (1) | WO2011026579A1 (zh) |
Cited By (5)
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---|---|---|---|---|
CN104140395A (zh) * | 2013-05-08 | 2014-11-12 | 中国医学科学院药物研究所 | 丁炔酰胺衍生物及其制法和药物组合物与用途 |
CN107935944A (zh) * | 2017-10-31 | 2018-04-20 | 广西师范大学 | 具有抗肿瘤活性双芳基脲喹喔啉衍生物及其合成方法 |
CN110981819A (zh) * | 2019-12-24 | 2020-04-10 | 广西师范大学 | 一种喹喔啉类信号通路抑制剂及其制备方法和应用 |
CN111557899A (zh) * | 2020-04-30 | 2020-08-21 | 北华大学 | 一种治疗角膜炎的药物及其制备方法 |
CN111689951A (zh) * | 2020-06-11 | 2020-09-22 | 西北师范大学 | 一种1-苄基-3-烷基喹喔啉-2(1h)-酮的合成方法 |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
ES2555261T3 (es) | 2010-06-01 | 2015-12-30 | Bayer Intellectual Property Gmbh | Imidazopirazinas sustituidas |
UY33452A (es) | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
JP2013545779A (ja) | 2010-12-17 | 2013-12-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン |
CA2821817A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | Substituted 6-imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
ES2530802T3 (es) | 2010-12-17 | 2015-03-06 | Bayer Ip Gmbh | Imidazopirazinas 6-tiosustituidas para uso como inhibidores de MPS-1 y TKK en el tratamiento de trastornos hiperproliferativos |
CA2821837A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | 2-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
JP2013545776A (ja) | 2010-12-17 | 2013-12-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン |
JP2014503521A (ja) | 2010-12-17 | 2014-02-13 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過増殖性障害の処置におけるmps−1およびtkk阻害剤としての使用のための、イミダゾピラジン類 |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
EP2691375B1 (en) | 2011-03-31 | 2016-03-16 | Bayer Intellectual Property GmbH | Substituted benzimidazoles as mps-1 kinase inhibitors |
US20140255392A1 (en) | 2011-04-06 | 2014-09-11 | Bayer Intellectual Property Gmbh | Substituted imidazopyridines and intermediates thereof |
EP2699575B1 (en) | 2011-04-21 | 2015-03-25 | Bayer Intellectual Property GmbH | Triazolopyridines |
WO2012160029A1 (en) | 2011-05-23 | 2012-11-29 | Bayer Intellectual Property Gmbh | Substituted triazolopyridines |
CN102250022B (zh) * | 2011-05-26 | 2013-10-16 | 浙江大学 | 取代喹喔啉胺类化合物及其制备方法和用途 |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
UA112096C2 (uk) | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
ES2605946T3 (es) | 2012-03-14 | 2017-03-17 | Bayer Intellectual Property Gmbh | Imidazopiridazinas sustituidas |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
LT3495367T (lt) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai |
PE20150354A1 (es) | 2012-07-10 | 2015-03-21 | Bayer Pharma AG | Metodos para preparar triazolopiridinas sustituidas |
WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
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US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
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KR20180030913A (ko) * | 2015-07-30 | 2018-03-26 | 브리스톨-마이어스 스큅 컴퍼니 | 아릴 치환된 비시클릭 헤테로아릴 화합물 |
LT3353177T (lt) | 2015-09-23 | 2020-08-25 | Janssen Pharmaceutica Nv | Tricikliniai heterociklai, skirti vėžio gydymui |
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JP6727660B2 (ja) * | 2015-09-30 | 2020-07-22 | 国立大学法人東北大学 | 糖尿病性腎症の判定マーカー |
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AU2017342928B2 (en) * | 2016-10-10 | 2021-09-09 | Development Center For Biotechnology | Quinoxaline compounds as type III receptor tyrosine kinase inhibitors |
KR102599339B1 (ko) * | 2016-12-20 | 2023-11-08 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조정제로서 유용한 화합물 |
US9975886B1 (en) | 2017-01-23 | 2018-05-22 | Cadent Therapeutics, Inc. | Potassium channel modulators |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
EP3788046A1 (en) | 2018-05-04 | 2021-03-10 | Incyte Corporation | Salts of an fgfr inhibitor |
MA52494A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation |
AU2019344897B2 (en) | 2018-09-18 | 2024-01-18 | Nikang Therapeutics, Inc. | Tri-substituted heteroaryl derivatives AS SRC homology-2 phosphatase inhibitors |
CA3125353A1 (en) | 2018-12-31 | 2020-07-09 | Biomea Fusion, Llc | Inhibitors of menin-mll interaction |
CA3125350A1 (en) | 2018-12-31 | 2020-07-09 | Biomea Fusion, Llc | Irreversible inhibitors of menin-mll interaction |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
EP4045151A1 (en) | 2019-10-14 | 2022-08-24 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
CA3162010A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
CA3208361A1 (en) | 2021-02-19 | 2022-08-25 | Anjali Pandey | Tyk2 inhibitors and uses thereof |
TW202313611A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為fgfr抑制劑之三環雜環 |
Citations (3)
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JP2004346016A (ja) * | 2003-05-22 | 2004-12-09 | Otsuka Chemical Co Ltd | トリフルオロメチルキノキサリン化合物、その製造方法、及び有害生物防除剤 |
WO2008141065A1 (en) * | 2007-05-10 | 2008-11-20 | Smithkline Beecham Corporation | Quinoxaline derivatives as p13 kinase inhibitors |
WO2009021083A1 (en) * | 2007-08-09 | 2009-02-12 | Smithkline Beecham Corporation | Quinoxaline derivatives as pi3 kinase inhibitors |
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-
2010
- 2010-08-24 JP JP2012527219A patent/JP5728683B2/ja not_active Expired - Fee Related
- 2010-08-24 CN CN2010800490392A patent/CN102596932A/zh active Pending
- 2010-08-24 CA CA2772790A patent/CA2772790C/en not_active Expired - Fee Related
- 2010-08-24 WO PCT/EP2010/005183 patent/WO2011026579A1/en active Application Filing
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Cited By (9)
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CN104140395A (zh) * | 2013-05-08 | 2014-11-12 | 中国医学科学院药物研究所 | 丁炔酰胺衍生物及其制法和药物组合物与用途 |
CN104140395B (zh) * | 2013-05-08 | 2018-07-24 | 中国医学科学院药物研究所 | 丁炔酰胺衍生物及其制法和药物组合物与用途 |
CN107935944A (zh) * | 2017-10-31 | 2018-04-20 | 广西师范大学 | 具有抗肿瘤活性双芳基脲喹喔啉衍生物及其合成方法 |
CN107935944B (zh) * | 2017-10-31 | 2021-12-21 | 广西师范大学 | 具有抗肿瘤活性双芳基脲喹喔啉衍生物及其合成方法 |
CN110981819A (zh) * | 2019-12-24 | 2020-04-10 | 广西师范大学 | 一种喹喔啉类信号通路抑制剂及其制备方法和应用 |
CN110981819B (zh) * | 2019-12-24 | 2022-07-01 | 广西师范大学 | 一种喹喔啉类信号通路抑制剂及其制备方法和应用 |
CN111557899A (zh) * | 2020-04-30 | 2020-08-21 | 北华大学 | 一种治疗角膜炎的药物及其制备方法 |
CN111557899B (zh) * | 2020-04-30 | 2023-02-21 | 北华大学 | 一种治疗角膜炎的药物及其制备方法 |
CN111689951A (zh) * | 2020-06-11 | 2020-09-22 | 西北师范大学 | 一种1-苄基-3-烷基喹喔啉-2(1h)-酮的合成方法 |
Also Published As
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JP2013503824A (ja) | 2013-02-04 |
CA2772790C (en) | 2017-06-27 |
US9340528B2 (en) | 2016-05-17 |
WO2011026579A1 (en) | 2011-03-10 |
CA2772790A1 (en) | 2011-03-10 |
JP5728683B2 (ja) | 2015-06-03 |
EP2473498A1 (en) | 2012-07-11 |
US20120263708A1 (en) | 2012-10-18 |
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