DE60228317D1 - N-aryl-n'-arylcycloalkyl-harnstoff als mch antagonisten zur behandlung von fettleibigkeit - Google Patents

N-aryl-n'-arylcycloalkyl-harnstoff als mch antagonisten zur behandlung von fettleibigkeit

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Publication number
DE60228317D1
DE60228317D1 DE60228317T DE60228317T DE60228317D1 DE 60228317 D1 DE60228317 D1 DE 60228317D1 DE 60228317 T DE60228317 T DE 60228317T DE 60228317 T DE60228317 T DE 60228317T DE 60228317 D1 DE60228317 D1 DE 60228317D1
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Germany
Prior art keywords
fatibility
arylcycloalkyl
urea
aryl
treatment
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DE60228317T
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English (en)
Inventor
John W Clader
Anandan Palani
Ruo Xu
Briar Mark D Mc
Jing Su
Haiqun Tang
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Merck Sharp and Dohme LLC
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Schering Corp
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DE60228317T 2001-12-04 2002-12-03 N-aryl-n'-arylcycloalkyl-harnstoff als mch antagonisten zur behandlung von fettleibigkeit Expired - Lifetime DE60228317D1 (de)

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MXPA06003738A (es) * 2003-10-02 2006-06-14 Schering Corp Aminobenzimidazoles como antagonistas selectivos del receptor de la hormona que concentra la melanina para el tratamiento de la obesidad y trastornos relacionados.
DE102004003811A1 (de) * 2004-01-25 2005-08-11 Aventis Pharma Deutschland Gmbh Substituierte N-Cyclohexylimidazolinone, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel
EP1734963A4 (de) 2004-04-02 2008-06-18 Merck & Co Inc Verfahren zur behandlung von menschen mit metabolischen und anthropometrischen störungen
EP1773822B1 (de) * 2004-07-16 2009-06-17 Shering Corporation Heterocyclylverbindungen als selektive antagonisten am rezeptor für das melaninkonzentrierende hormon zur behandlung von obesitas und verwandten erkrankungen
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP1807409A2 (de) * 2004-10-12 2007-07-18 Pharmacopeia Drug Discovery, Inc. Bicyclische verbindungen als selektiveantagonisten am rezeptor für das melaninkonzentrierende hormon zur behandlungvon obesitas und verwandten erkrankungen
AU2005305036B2 (en) * 2004-11-01 2011-03-10 Amylin Pharmaceuticals, Llc Treatment of obesity and related disorders
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
DK1814590T4 (da) * 2004-11-01 2014-02-24 Amylin Pharmaceuticals Llc Behandling af obesitet og beslægtede sygdomme.
WO2006104280A1 (ja) * 2005-03-31 2006-10-05 Takeda Pharmaceutical Company Limited 糖尿病の予防・治療剤
US7799943B2 (en) * 2005-06-24 2010-09-21 Rohm And Haas Company Method for promoting Michael addition reactions
BRPI0613943B1 (pt) 2005-07-27 2021-06-22 Otsuka America Pharmaceutical, Inc Composto, composição farmacêutica o compreendendo, usos de um composto e de uma composição farmacêutica, bem como composição neurobiologicamente ativa
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
WO2008150364A1 (en) * 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
EP2036578A1 (de) * 2007-09-13 2009-03-18 Bayer Schering Pharma Aktiengesellschaft Diagnostische Wirkstoffe für die Positronenemissionstomographie mit radioaktiv markierten F18-Aminoalkoholen
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
CN102875385A (zh) * 2012-10-18 2013-01-16 浙江大学 N,n-二异丙基乙胺的合成方法
WO2018026890A1 (en) 2016-08-03 2018-02-08 Cymabay Therapeutics Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
CN114269719A (zh) * 2019-06-28 2022-04-01 Rti国际 作为cb1变构调节剂的脲衍生物

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TW209868B (de) 1991-04-04 1993-07-21 Yoshitomi Pharmaceutical
US5908830A (en) 1996-10-31 1999-06-01 Merck & Co., Inc. Combination therapy for the treatment of diabetes and obesity
DE69720051T2 (de) 1996-12-03 2003-09-04 Banyu Pharmaceutical Co., Ltd. Harnstoffderivate
PE20000564A1 (es) * 1998-06-08 2000-07-05 Schering Corp Antagonistas receptores y5 de neuropeptidos
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