ATE325808T1 - 5-beta-sapogenin und pseudosapogeninderivate und ihre verwendung zur behandlung von demenz - Google Patents

5-beta-sapogenin und pseudosapogeninderivate und ihre verwendung zur behandlung von demenz

Info

Publication number
ATE325808T1
ATE325808T1 AT00964439T AT00964439T ATE325808T1 AT E325808 T1 ATE325808 T1 AT E325808T1 AT 00964439 T AT00964439 T AT 00964439T AT 00964439 T AT00964439 T AT 00964439T AT E325808 T1 ATE325808 T1 AT E325808T1
Authority
AT
Austria
Prior art keywords
treatment
sapogenin
pseudosapogen
inderivatives
dementia
Prior art date
Application number
AT00964439T
Other languages
English (en)
Inventor
Paul Barraclough
Jim Hanson
Phil Gunning
Daryl Rees
Zongqin Xia
Yaer Hu
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Application granted granted Critical
Publication of ATE325808T1 publication Critical patent/ATE325808T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00964439T 1999-09-29 2000-09-29 5-beta-sapogenin und pseudosapogeninderivate und ihre verwendung zur behandlung von demenz ATE325808T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9923076.5A GB9923076D0 (en) 1999-09-29 1999-09-29 Sapogenin derivatives and their use

Publications (1)

Publication Number Publication Date
ATE325808T1 true ATE325808T1 (de) 2006-06-15

Family

ID=10861837

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00964439T ATE325808T1 (de) 1999-09-29 2000-09-29 5-beta-sapogenin und pseudosapogeninderivate und ihre verwendung zur behandlung von demenz

Country Status (27)

Country Link
US (2) US7138427B2 (de)
EP (2) EP1724279A2 (de)
JP (1) JP2003510332A (de)
KR (1) KR100771491B1 (de)
CN (2) CN100445295C (de)
AT (1) ATE325808T1 (de)
AU (1) AU778294C (de)
BR (1) BR0014381A (de)
CA (2) CA2640998A1 (de)
CY (1) CY1105225T1 (de)
CZ (1) CZ300150B6 (de)
DE (1) DE60027913T2 (de)
DK (1) DK1224205T3 (de)
ES (1) ES2260055T3 (de)
GB (1) GB9923076D0 (de)
HK (1) HK1045525B (de)
HR (2) HRP20020255A2 (de)
IL (2) IL148920A0 (de)
MX (1) MXPA02003305A (de)
NO (1) NO324959B1 (de)
NZ (1) NZ518596A (de)
PT (1) PT1224205E (de)
RU (1) RU2325396C2 (de)
TR (1) TR200200821T2 (de)
UA (1) UA82978C2 (de)
WO (1) WO2001023406A1 (de)
ZA (1) ZA200202382B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
ES2323363T3 (es) * 2002-03-27 2009-07-14 Phytopharm Plc Usos terapeuticos de sapogeninas.
NZ535093A (en) * 2002-03-27 2006-09-29 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
KR20100093621A (ko) * 2002-03-27 2010-08-25 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 용도
CA2503899C (en) * 2002-10-28 2011-12-20 Phytopharm Plc Stereospecific reduction of sapogen-3-ones
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
EP2389182A1 (de) 2009-01-24 2011-11-30 Phytopharm PLC Behandlung von erkrankungen, die durch den neurotrophen faktor vermittelt werden
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AU2011281336B2 (en) 2010-07-20 2015-03-05 Junaxo, Inc. Treatment of L-DOPA, dopamine agonist and/or dopamine enhancer induced disorders
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
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CN102924559B (zh) * 2012-11-16 2015-10-28 沈阳药科大学 菝葜皂苷元衍生物及其制备和应用
GB201305708D0 (en) * 2013-03-28 2013-05-15 Clasado Inc Novel use
CN103232520A (zh) * 2013-05-13 2013-08-07 中国药科大学 一种螺甾类化合物、其制备方法及医药用途
CN106905407B (zh) * 2015-01-27 2019-08-13 华东理工大学 知母皂苷元结构修饰的衍生物、其药物组合物及其应用
JP6791977B2 (ja) * 2015-10-29 2020-11-25 エミオン インコーポレイテッドＥｍｍｙｏｎ， Ｉｎｃ． 骨格筋の肥大剤としてのフロスタン−３オール誘導体
CN106977581B (zh) * 2017-04-17 2021-01-01 华东理工大学 知母皂苷元结构修饰的衍生物的应用以及药物组合物

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Also Published As

Publication number Publication date
CN100445295C (zh) 2008-12-24
HK1045525A1 (en) 2002-11-29
HRP20020255A2 (en) 2003-08-31
CZ300150B6 (cs) 2009-02-25
JP2003510332A (ja) 2003-03-18
US20030004147A1 (en) 2003-01-02
CA2640998A1 (en) 2001-04-05
NO20021541D0 (no) 2002-03-27
BR0014381A (pt) 2002-06-25
US20060276415A1 (en) 2006-12-07
PL357370A1 (en) 2004-07-26
KR100771491B1 (ko) 2007-10-30
HK1045525B (zh) 2006-08-04
ZA200202382B (en) 2003-09-23
CA2385402C (en) 2009-01-13
CN101411712A (zh) 2009-04-22
US20060100184A9 (en) 2006-05-11
NZ518596A (en) 2004-07-30
UA82978C2 (ru) 2008-06-10
RU2325396C2 (ru) 2008-05-27
AU778294B2 (en) 2004-11-25
CN1377368A (zh) 2002-10-30
EP1724279A2 (de) 2006-11-22
EP1224205B1 (de) 2006-05-10
ES2260055T3 (es) 2006-11-01
KR20020092914A (ko) 2002-12-12
DK1224205T3 (da) 2006-06-12
DE60027913D1 (de) 2006-06-14
DE60027913T2 (de) 2007-01-11
NO20021541L (no) 2002-05-28
MXPA02003305A (es) 2002-10-04
GB9923076D0 (en) 1999-12-01
HRP20080467A2 (en) 2008-11-30
AU7537500A (en) 2001-04-30
CA2385402A1 (en) 2001-04-05
US7138427B2 (en) 2006-11-21
IL148920A0 (en) 2002-09-12
US7507720B2 (en) 2009-03-24
CY1105225T1 (el) 2010-03-03
TR200200821T2 (tr) 2002-06-21
IL180972A0 (en) 2007-07-04
WO2001023406A1 (en) 2001-04-05
PT1224205E (pt) 2006-08-31
EP1224205A1 (de) 2002-07-24
AU778294C (en) 2005-08-04
NO324959B1 (no) 2008-01-14

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