NO20021541L - 5-beta-sapogenin- og pseudosapogeninderivater samt deres anvendelse ved behandling av demens - Google Patents
5-beta-sapogenin- og pseudosapogeninderivater samt deres anvendelse ved behandling av demensInfo
- Publication number
- NO20021541L NO20021541L NO20021541A NO20021541A NO20021541L NO 20021541 L NO20021541 L NO 20021541L NO 20021541 A NO20021541 A NO 20021541A NO 20021541 A NO20021541 A NO 20021541A NO 20021541 L NO20021541 L NO 20021541L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- well
- sapogenin
- dementia
- beta
- Prior art date
Links
- 206010012289 Dementia Diseases 0.000 title 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Det er beskrevet anvendelse av sapogeninderivater ved behandling av kognitiv disfunksjon og lignende tilstander. Fremgangsmåter for behandling samt farmasøytiske sammen-setninger er også beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9923076.5A GB9923076D0 (en) | 1999-09-29 | 1999-09-29 | Sapogenin derivatives and their use |
PCT/GB2000/003737 WO2001023406A1 (en) | 1999-09-29 | 2000-09-29 | 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20021541D0 NO20021541D0 (no) | 2002-03-27 |
NO20021541L true NO20021541L (no) | 2002-05-28 |
NO324959B1 NO324959B1 (no) | 2008-01-14 |
Family
ID=10861837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20021541A NO324959B1 (no) | 1999-09-29 | 2002-03-27 | 5-beta-sapogenin- og pseudosapogeninderivater samt deres anvendelse ved behandling av demens |
Country Status (27)
Country | Link |
---|---|
US (2) | US7138427B2 (no) |
EP (2) | EP1224205B1 (no) |
JP (1) | JP2003510332A (no) |
KR (1) | KR100771491B1 (no) |
CN (2) | CN101411712A (no) |
AT (1) | ATE325808T1 (no) |
AU (1) | AU778294C (no) |
BR (1) | BR0014381A (no) |
CA (2) | CA2640998A1 (no) |
CY (1) | CY1105225T1 (no) |
CZ (1) | CZ300150B6 (no) |
DE (1) | DE60027913T2 (no) |
DK (1) | DK1224205T3 (no) |
ES (1) | ES2260055T3 (no) |
GB (1) | GB9923076D0 (no) |
HK (1) | HK1045525B (no) |
HR (2) | HRP20020255A2 (no) |
IL (2) | IL148920A0 (no) |
MX (1) | MXPA02003305A (no) |
NO (1) | NO324959B1 (no) |
NZ (1) | NZ518596A (no) |
PT (1) | PT1224205E (no) |
RU (1) | RU2325396C2 (no) |
TR (1) | TR200200821T2 (no) |
UA (1) | UA82978C2 (no) |
WO (1) | WO2001023406A1 (no) |
ZA (1) | ZA200202382B (no) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
KR20080031062A (ko) * | 2002-03-27 | 2008-04-07 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 용도 |
KR20100093621A (ko) * | 2002-03-27 | 2010-08-25 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 용도 |
CA2477787C (en) * | 2002-03-27 | 2011-12-20 | Phytopharm Plc | Therapeutic methods and uses of sapogenins and their derivatives |
US7718792B2 (en) | 2002-10-28 | 2010-05-18 | Phytopharm Plc | Stereospecific reduction of sapogen-3-ones |
US20080182801A1 (en) * | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
GB0513881D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
GB0409567D0 (en) | 2004-04-28 | 2004-06-02 | Phytopharm Plc | Chemical compounds |
GB0424528D0 (en) | 2004-11-05 | 2004-12-08 | Phytopharm Plc | Chemical compounds |
GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
MX2011007842A (es) | 2009-01-24 | 2012-01-12 | Phytopharm Plc | Tratamiento de trastornos mediados por factores neurotroficos. |
CN101768202B (zh) * | 2009-02-18 | 2013-10-30 | 沈阳药科大学 | 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 |
US20130210786A1 (en) | 2010-07-20 | 2013-08-15 | Patrick Alexander Howson | Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders |
CU20110244A7 (es) * | 2011-12-27 | 2013-08-29 | Ct De Investigación Y Desarrollo De Medicamentos Cidem | Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios |
US11319338B2 (en) | 2012-04-03 | 2022-05-03 | Goldporp Pharma Limited | Timosaponin compounds |
CN102924559B (zh) * | 2012-11-16 | 2015-10-28 | 沈阳药科大学 | 菝葜皂苷元衍生物及其制备和应用 |
GB201305708D0 (en) * | 2013-03-28 | 2013-05-15 | Clasado Inc | Novel use |
CN103232520A (zh) * | 2013-05-13 | 2013-08-07 | 中国药科大学 | 一种螺甾类化合物、其制备方法及医药用途 |
CN106905407B (zh) * | 2015-01-27 | 2019-08-13 | 华东理工大学 | 知母皂苷元结构修饰的衍生物、其药物组合物及其应用 |
US10662219B2 (en) * | 2015-10-29 | 2020-05-26 | Emmyon, Inc. | Furostan-3-ol derivatives as skeletal muscle hypertrophic agents |
CN106977581B (zh) * | 2017-04-17 | 2021-01-01 | 华东理工大学 | 知母皂苷元结构修饰的衍生物的应用以及药物组合物 |
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GB0000228D0 (en) | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
BR0001794A (pt) | 2000-05-15 | 2001-12-26 | Laboratorios Biosintetica Ltda | Aplicação de fitosteróides (e seus isÈmeros), ácidofólico, cianocobalamina e piridoxina em fibrasdietéticas (alimentares) |
US20050130948A1 (en) | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
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1999
- 1999-09-29 GB GBGB9923076.5A patent/GB9923076D0/en not_active Ceased
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2000
- 2000-09-29 DE DE60027913T patent/DE60027913T2/de not_active Expired - Lifetime
- 2000-09-29 CA CA002640998A patent/CA2640998A1/en not_active Abandoned
- 2000-09-29 AT AT00964439T patent/ATE325808T1/de active
- 2000-09-29 PT PT00964439T patent/PT1224205E/pt unknown
- 2000-09-29 TR TR2002/00821T patent/TR200200821T2/xx unknown
- 2000-09-29 WO PCT/GB2000/003737 patent/WO2001023406A1/en active Application Filing
- 2000-09-29 JP JP2001526556A patent/JP2003510332A/ja active Pending
- 2000-09-29 AU AU75375/00A patent/AU778294C/en not_active Ceased
- 2000-09-29 CA CA002385402A patent/CA2385402C/en not_active Expired - Fee Related
- 2000-09-29 CZ CZ20021114A patent/CZ300150B6/cs not_active IP Right Cessation
- 2000-09-29 UA UA2002043435A patent/UA82978C2/ru unknown
- 2000-09-29 EP EP00964439A patent/EP1224205B1/en not_active Expired - Lifetime
- 2000-09-29 DK DK00964439T patent/DK1224205T3/da active
- 2000-09-29 CN CNA2008101760374A patent/CN101411712A/zh active Pending
- 2000-09-29 CN CNB008136068A patent/CN100445295C/zh not_active Expired - Fee Related
- 2000-09-29 IL IL14892000A patent/IL148920A0/xx not_active IP Right Cessation
- 2000-09-29 KR KR1020027003973A patent/KR100771491B1/ko not_active IP Right Cessation
- 2000-09-29 ES ES00964439T patent/ES2260055T3/es not_active Expired - Lifetime
- 2000-09-29 MX MXPA02003305A patent/MXPA02003305A/es active IP Right Grant
- 2000-09-29 EP EP06005887A patent/EP1724279A2/en not_active Withdrawn
- 2000-09-29 BR BR0014381-2A patent/BR0014381A/pt not_active Application Discontinuation
- 2000-09-29 NZ NZ518596A patent/NZ518596A/en unknown
- 2000-09-29 RU RU2002111355/04A patent/RU2325396C2/ru not_active IP Right Cessation
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2002
- 2002-03-25 ZA ZA200202382A patent/ZA200202382B/en unknown
- 2002-03-27 NO NO20021541A patent/NO324959B1/no not_active IP Right Cessation
- 2002-03-27 HR HR20020255A patent/HRP20020255A2/hr not_active Application Discontinuation
- 2002-03-28 US US10/109,095 patent/US7138427B2/en not_active Expired - Fee Related
- 2002-09-11 HK HK02106662.2A patent/HK1045525B/zh not_active IP Right Cessation
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2006
- 2006-07-17 CY CY20061100986T patent/CY1105225T1/el unknown
- 2006-08-11 US US11/502,784 patent/US7507720B2/en not_active Expired - Fee Related
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2007
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2008
- 2008-09-22 HR HR20080467A patent/HRP20080467A2/xx not_active Application Discontinuation
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