BR0014381A - Derivados de 5-beta-sapogenina e pseudossapogenina e seu uso no tratamento de demência - Google Patents

Derivados de 5-beta-sapogenina e pseudossapogenina e seu uso no tratamento de demência

Info

Publication number
BR0014381A
BR0014381A BR0014381-2A BR0014381A BR0014381A BR 0014381 A BR0014381 A BR 0014381A BR 0014381 A BR0014381 A BR 0014381A BR 0014381 A BR0014381 A BR 0014381A
Authority
BR
Brazil
Prior art keywords
sapogenin
derivatives
treatment
beta
dementia
Prior art date
Application number
BR0014381-2A
Other languages
English (en)
Inventor
Paul Barraclough
Jim Hanson
Phil Gunning
Daryl Rees
Zongqin Xia
Yaer Hu
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Publication of BR0014381A publication Critical patent/BR0014381A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE 5-BETA-SAPOGENINA E PSEU-DOSSAPOGENINA E SEU USO NO TRATAMENTO DE DEMêNCIA". A invenção mostra o uso de derivados de sapogenina no tratamento de disfunção cognitiva e condições similares. Métodos de tratamento e composições farmacêuticas são também descritos.
BR0014381-2A 1999-09-29 2000-09-29 Derivados de 5-beta-sapogenina e pseudossapogenina e seu uso no tratamento de demência BR0014381A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9923076.5A GB9923076D0 (en) 1999-09-29 1999-09-29 Sapogenin derivatives and their use
PCT/GB2000/003737 WO2001023406A1 (en) 1999-09-29 2000-09-29 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia

Publications (1)

Publication Number Publication Date
BR0014381A true BR0014381A (pt) 2002-06-25

Family

ID=10861837

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014381-2A BR0014381A (pt) 1999-09-29 2000-09-29 Derivados de 5-beta-sapogenina e pseudossapogenina e seu uso no tratamento de demência

Country Status (27)

Country Link
US (2) US7138427B2 (pt)
EP (2) EP1724279A2 (pt)
JP (1) JP2003510332A (pt)
KR (1) KR100771491B1 (pt)
CN (2) CN100445295C (pt)
AT (1) ATE325808T1 (pt)
AU (1) AU778294C (pt)
BR (1) BR0014381A (pt)
CA (2) CA2640998A1 (pt)
CY (1) CY1105225T1 (pt)
CZ (1) CZ300150B6 (pt)
DE (1) DE60027913T2 (pt)
DK (1) DK1224205T3 (pt)
ES (1) ES2260055T3 (pt)
GB (1) GB9923076D0 (pt)
HK (1) HK1045525B (pt)
HR (2) HRP20020255A2 (pt)
IL (2) IL148920A0 (pt)
MX (1) MXPA02003305A (pt)
NO (1) NO324959B1 (pt)
NZ (1) NZ518596A (pt)
PT (1) PT1224205E (pt)
RU (1) RU2325396C2 (pt)
TR (1) TR200200821T2 (pt)
UA (1) UA82978C2 (pt)
WO (1) WO2001023406A1 (pt)
ZA (1) ZA200202382B (pt)

Families Citing this family (27)

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GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
ATE424211T1 (de) * 2002-03-27 2009-03-15 Phytopharm Plc Therapeutische verwendung von sapogeninen
EP2111864A3 (en) * 2002-03-27 2009-12-30 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
JP4573157B2 (ja) * 2002-03-27 2010-11-04 フィトファーム・パブリック・リミテッド・カンパニー 治療方法ならびにサポゲニンおよびその誘導体の使用
KR101092150B1 (ko) * 2002-10-28 2011-12-12 파이토팜 피엘씨 사포겐-3-온의 입체특이적 환원
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
MX2011007842A (es) 2009-01-24 2012-01-12 Phytopharm Plc Tratamiento de trastornos mediados por factores neurotroficos.
CN101768202B (zh) * 2009-02-18 2013-10-30 沈阳药科大学 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途
KR20130043197A (ko) 2010-07-20 2013-04-29 파이토팜 피엘씨 엘-도파, 도파민 효능제 및/또는 도파민 증강제 유도된 장애의 치료
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
WO2013149580A1 (en) * 2012-04-03 2013-10-10 Chiming Che Timosaponin compounds
CN102924559B (zh) * 2012-11-16 2015-10-28 沈阳药科大学 菝葜皂苷元衍生物及其制备和应用
GB201305708D0 (en) * 2013-03-28 2013-05-15 Clasado Inc Novel use
CN103232520A (zh) * 2013-05-13 2013-08-07 中国药科大学 一种螺甾类化合物、其制备方法及医药用途
CN106905407B (zh) * 2015-01-27 2019-08-13 华东理工大学 知母皂苷元结构修饰的衍生物、其药物组合物及其应用
JP6791977B2 (ja) * 2015-10-29 2020-11-25 エミオン インコーポレイテッドＥｍｍｙｏｎ， Ｉｎｃ． 骨格筋の肥大剤としてのフロスタン−３オール誘導体
CN106977581B (zh) * 2017-04-17 2021-01-01 华东理工大学 知母皂苷元结构修饰的衍生物的应用以及药物组合物

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Also Published As

Publication number Publication date
DE60027913T2 (de) 2007-01-11
NO20021541L (no) 2002-05-28
AU778294B2 (en) 2004-11-25
IL180972A0 (en) 2007-07-04
HRP20020255A2 (en) 2003-08-31
PT1224205E (pt) 2006-08-31
IL148920A0 (en) 2002-09-12
HK1045525A1 (en) 2002-11-29
AU778294C (en) 2005-08-04
RU2325396C2 (ru) 2008-05-27
AU7537500A (en) 2001-04-30
KR100771491B1 (ko) 2007-10-30
NO324959B1 (no) 2008-01-14
ES2260055T3 (es) 2006-11-01
NZ518596A (en) 2004-07-30
HK1045525B (zh) 2006-08-04
NO20021541D0 (no) 2002-03-27
DE60027913D1 (de) 2006-06-14
US20060100184A9 (en) 2006-05-11
CN101411712A (zh) 2009-04-22
CZ300150B6 (cs) 2009-02-25
KR20020092914A (ko) 2002-12-12
EP1224205B1 (en) 2006-05-10
CA2385402A1 (en) 2001-04-05
US7507720B2 (en) 2009-03-24
DK1224205T3 (da) 2006-06-12
UA82978C2 (ru) 2008-06-10
GB9923076D0 (en) 1999-12-01
PL357370A1 (en) 2004-07-26
US20030004147A1 (en) 2003-01-02
CA2385402C (en) 2009-01-13
CN100445295C (zh) 2008-12-24
US7138427B2 (en) 2006-11-21
CA2640998A1 (en) 2001-04-05
CY1105225T1 (el) 2010-03-03
EP1724279A2 (en) 2006-11-22
ATE325808T1 (de) 2006-06-15
CN1377368A (zh) 2002-10-30
JP2003510332A (ja) 2003-03-18
WO2001023406A1 (en) 2001-04-05
MXPA02003305A (es) 2002-10-04
HRP20080467A2 (en) 2008-11-30
EP1224205A1 (en) 2002-07-24
TR200200821T2 (tr) 2002-06-21
US20060276415A1 (en) 2006-12-07
ZA200202382B (en) 2003-09-23

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