BRPI0410049A - composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, uso de um composto, composição farmacêutica, e, kit farmacêutico - Google Patents

composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, uso de um composto, composição farmacêutica, e, kit farmacêutico

Info

Publication number
BRPI0410049A
BRPI0410049A BRPI0410049-2A BRPI0410049A BRPI0410049A BR PI0410049 A BRPI0410049 A BR PI0410049A BR PI0410049 A BRPI0410049 A BR PI0410049A BR PI0410049 A BRPI0410049 A BR PI0410049A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
pharmaceutical
pharmaceutical composition
Prior art date
Application number
BRPI0410049-2A
Other languages
English (en)
Inventor
Francesca Benedini
Ennio Ongini
Piero Del Soldato
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of BRPI0410049A publication Critical patent/BRPI0410049A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSTO OU UM SAL OU ESTEREOISÈMERO FARMACEUTICAMENTE ACEITáVEL DO MESMO, USO DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA, E, KIT FARMACêUTICO". São descritos nitroxiderivados de fluvastatina, cerivastatina, atorvastatina e rosuvastatina tendo atividade farmacológica melhorada e tolerabilidade intensificada. ELes podem ser empregados para o tratamento e/ou prevenção de várias doenças, em particular síndromes coronarianas, distúrbios neurodegenerativos, assim como para a redução dos níveis de colesterol.
BRPI0410049-2A 2003-05-27 2004-05-24 composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, uso de um composto, composição farmacêutica, e, kit farmacêutico BRPI0410049A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03101530 2003-05-27
PCT/EP2004/050897 WO2004105754A1 (en) 2003-05-27 2004-05-24 Nitrooxyderivatives of fluvastatin, pravastatin, cerivastatin, atorvastatin and rosuvastatin as cholesterol-reducing agents with improved anti-inflammatory, antithrombotic and antiplatelet activity

Publications (1)

Publication Number Publication Date
BRPI0410049A true BRPI0410049A (pt) 2006-04-25

Family

ID=33483985

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410049-2A BRPI0410049A (pt) 2003-05-27 2004-05-24 composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, uso de um composto, composição farmacêutica, e, kit farmacêutico

Country Status (23)

Country Link
US (4) US7166638B2 (pt)
EP (1) EP1626716B1 (pt)
KR (1) KR101136434B1 (pt)
CN (1) CN1794987B (pt)
AR (1) AR044561A1 (pt)
AT (1) ATE353214T1 (pt)
AU (1) AU2004243443B2 (pt)
BR (1) BRPI0410049A (pt)
CA (1) CA2527168C (pt)
CY (1) CY1107614T1 (pt)
DE (1) DE602004004652T2 (pt)
DK (1) DK1626716T3 (pt)
ES (1) ES2280978T3 (pt)
HK (1) HK1090295A1 (pt)
MX (1) MXPA05012755A (pt)
NO (1) NO20056152L (pt)
NZ (1) NZ543086A (pt)
PL (1) PL379019A1 (pt)
PT (1) PT1626716E (pt)
RU (1) RU2362770C2 (pt)
SI (1) SI1626716T1 (pt)
WO (1) WO2004105754A1 (pt)
ZA (1) ZA200509460B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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WO2006027711A2 (en) 2004-08-26 2006-03-16 Nicholas Piramal India Limited Prodrugs and codrugs containing bio- cleavable disulfide linkers
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
KR20080097989A (ko) 2006-02-03 2008-11-06 니콕스 에스. 에이. 근위축증 치료를 위한 의약의 니트록시 유도체의 용도
EP1889617A1 (en) * 2006-07-11 2008-02-20 Freie Universität Berlin Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents
WO2008125412A1 (en) * 2007-04-13 2008-10-23 Nicox S.A. Crystalline forms of atorvastatin 4-(nitrooxy) butyl ester
EP2164484A1 (en) * 2007-06-25 2010-03-24 Nicox S.A. Use of nitric oxide-releasing statins in the treatment of pulmonary arterial hypertension
US20090226515A1 (en) * 2008-03-04 2009-09-10 Pharma Pass Ii Llc Statin compositions
EP2307053A2 (en) * 2008-06-06 2011-04-13 Nicox S.A. Compositions comprising atorvastatin 4-(nitrooxy) butyl ester and a hypolipidemic drug
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
CN101613284B (zh) * 2009-06-26 2013-05-08 四川抗菌素工业研究所有限公司 洛伐他汀、辛伐他汀和辛伐他汀-6-氧化物的硝基氧基衍生物及其制备方法
EP2371404A3 (de) 2010-03-30 2014-08-20 Biotronik AG Medizinisches Implantat mit einer Beschichtung bestehend aus oder enthaltend mindestens einen Nitro-Statin-Wirkstoff
WO2011160974A2 (en) 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
EP2983711A4 (en) 2013-04-08 2016-11-23 Cytodyn Inc FELLINED ANTIBODIES AND METHODS OF TREATING RETROVIRAL INFECTIONS IN FELINES
EP2949324A1 (en) 2014-05-27 2015-12-02 Consorci Institut Catala de Ciencies Cardiovasculars Prevention and/or treatment of ischemia/reperfusion injury
CN104327057B (zh) * 2014-10-17 2017-01-18 上海应用技术学院 多取代吲哚类他汀内酯脱水化合物及其用途
WO2017041701A1 (zh) * 2015-09-07 2017-03-16 浙江华海药业股份有限公司 可释放一氧化氮的前药分子
CN108114282B (zh) * 2016-11-28 2021-03-02 北京大学第三医院 他汀类化合物治疗缺血性疾病的用途
CN107043373B (zh) * 2017-03-31 2020-04-28 中国医药集团总公司四川抗菌素工业研究所 一种噁三唑类no供体型他汀衍生物及其制备方法和应用
CN106938979B (zh) * 2017-03-31 2019-08-02 中国医药集团总公司四川抗菌素工业研究所 一种no供体型他汀衍生物、制备方法和应用
MX2019011567A (es) 2017-03-31 2020-01-21 Fundacio Inst De Recerca De L''hospital De La Santa Creu I Sant Pau Estatina para la prevención/reducción de daño relacionado con isquemia.
CN107098843B (zh) * 2017-03-31 2020-04-28 中国医药集团总公司四川抗菌素工业研究所 一种fk409类no供体型他汀降血脂药物衍生物及其制备方法
EP3381452A1 (en) 2017-03-31 2018-10-03 Instituto Catalán de Ciencias Cardiovasculares (ICCC), Hospital de la Santa Creu i Sant Pau, Avda. Statin for prevention/reduction of ischemia-related damage
CN110183329B (zh) * 2019-06-19 2022-09-13 中国医药集团总公司四川抗菌素工业研究所 硝酸酯类no供体型他汀衍生物及其制备方法
CN113929609B (zh) * 2021-10-13 2024-08-23 深圳弘汇生物医药有限公司 一种调血脂的阿托伐他汀衍生物及其组合物、制备方法和医药用途

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HU9203780D0 (en) * 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
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IT1276071B1 (it) 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
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US6573385B1 (en) * 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
US20030100493A1 (en) 2001-07-19 2003-05-29 Sol Weiss Sublingual use of inhibitors in the biosynthesis of cholesterol

Also Published As

Publication number Publication date
US7563909B2 (en) 2009-07-21
US7462716B2 (en) 2008-12-09
ZA200509460B (en) 2007-04-25
PL379019A1 (pl) 2006-06-26
RU2362770C2 (ru) 2009-07-27
ES2280978T3 (es) 2007-09-16
DE602004004652T2 (de) 2007-11-08
AU2004243443A1 (en) 2004-12-09
WO2004105754A1 (en) 2004-12-09
RU2005138139A (ru) 2006-05-10
SI1626716T1 (sl) 2007-06-30
NZ543086A (en) 2009-11-27
CN1794987B (zh) 2010-09-29
US20070072942A1 (en) 2007-03-29
ATE353214T1 (de) 2007-02-15
CY1107614T1 (el) 2013-03-13
DK1626716T3 (da) 2007-05-14
US7166638B2 (en) 2007-01-23
PT1626716E (pt) 2007-04-30
DE602004004652D1 (de) 2007-03-22
MXPA05012755A (es) 2006-02-13
CA2527168A1 (en) 2004-12-09
US7297808B2 (en) 2007-11-20
CA2527168C (en) 2014-08-12
EP1626716A1 (en) 2006-02-22
HK1090295A1 (en) 2006-12-22
US20050165084A1 (en) 2005-07-28
CN1794987A (zh) 2006-06-28
KR101136434B1 (ko) 2012-04-19
AR044561A1 (es) 2005-09-21
EP1626716B1 (en) 2007-02-07
NO20056152L (no) 2005-12-23
KR20060013551A (ko) 2006-02-10
US20080096908A1 (en) 2008-04-24
US20080090857A1 (en) 2008-04-17
AU2004243443B2 (en) 2009-09-10

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B25G Requested change of headquarter approved

Owner name: NICOX S.A. (FR)

B25G Requested change of headquarter approved

Owner name: NICOX S.A. (FR)

B25A Requested transfer of rights approved

Owner name: NICOX SCIENCE IRELAND (IE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2412 DE 28-03-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.