PE20120877A1 - ANTICUERPOS ANTI-FcRH5 E INMUNOCONJUGADOS - Google Patents
ANTICUERPOS ANTI-FcRH5 E INMUNOCONJUGADOSInfo
- Publication number
- PE20120877A1 PE20120877A1 PE2011001751A PE2011001751A PE20120877A1 PE 20120877 A1 PE20120877 A1 PE 20120877A1 PE 2011001751 A PE2011001751 A PE 2011001751A PE 2011001751 A PE2011001751 A PE 2011001751A PE 20120877 A1 PE20120877 A1 PE 20120877A1
- Authority
- PE
- Peru
- Prior art keywords
- hvr
- sequence
- seq
- immunoconjugates
- variant
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
REFERIDA A UN ANTICUERPO ANTI-FcRH5 QUE COMPRENDE: a) UNA SECUENCIA DE HVR SELECCIONADA DEL GRUPO: i) HVR-L1 DE SECUENCIA KASQNVGSNVA (SEQ ID NO:28), ii) HVR-L2 DE SECUENCIA SASYRYS (SEQ ID NO:29), iii) HVR-L3 DE SECUENCIA QQYKTWT (SEQ ID NO:30), iv) HVR-H1 DE SECUENCIA GYTFTNYGMN (SEQ ID NO:37), v) HVR-H2 DE SECUENCIA NTYTGEPTYTDDFKG (SEQ ID NO:38), vi) HVR-H3 DE SECUENCIA ARRSIPYYYAMDY (SEQ ID NO:39) Y b) UNA VARIANTE DE HVR, DONDE LA VARIANTE DE HVR COMPRENDE LA MODIFICACION DE UN RESIDUO DE LA SECUENCIA SEQ ID NO:28, 29, 30, 37, 38 O 39. TAMBIEN ESTA REFERIDA A UNA FORMULACION FARMACEUTICA Y A UN COMPUESTO CONJUGADO
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21175409P | 2009-04-01 | 2009-04-01 | |
US16621409P | 2009-04-02 | 2009-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120877A1 true PE20120877A1 (es) | 2012-08-06 |
Family
ID=42236394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001751A PE20120877A1 (es) | 2009-04-01 | 2010-03-31 | ANTICUERPOS ANTI-FcRH5 E INMUNOCONJUGADOS |
Country Status (19)
Country | Link |
---|---|
US (2) | US8362213B2 (es) |
EP (1) | EP2414395A1 (es) |
JP (2) | JP6099976B2 (es) |
KR (1) | KR20120003478A (es) |
CN (1) | CN102369218B (es) |
AR (1) | AR076030A1 (es) |
AU (1) | AU2010232682A1 (es) |
BR (1) | BRPI1012560A2 (es) |
CA (1) | CA2756988A1 (es) |
CL (1) | CL2011002418A1 (es) |
HK (1) | HK1166805A1 (es) |
IL (1) | IL215404A0 (es) |
MX (1) | MX2011010265A (es) |
PE (1) | PE20120877A1 (es) |
RU (2) | RU2016110891A (es) |
SG (1) | SG174930A1 (es) |
TW (1) | TW201039846A (es) |
WO (1) | WO2010114940A1 (es) |
ZA (1) | ZA201107128B (es) |
Families Citing this family (60)
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US8466260B2 (en) | 2009-04-01 | 2013-06-18 | Genentech, Inc. | Anti-FcRH5 antibodies and immunoconjugates and methods of use |
US8962804B2 (en) | 2010-10-08 | 2015-02-24 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
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BR112013031819B1 (pt) | 2011-06-10 | 2022-05-03 | Mersana Therapeutics, Inc | Suporte polimérico, composição farmacêutica, composto, e, uso do suporte |
US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
US9428553B2 (en) | 2012-02-10 | 2016-08-30 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
KR20150115000A (ko) * | 2013-02-08 | 2015-10-13 | 아이알엠 엘엘씨 | 면역접합체의 제조를 위한 항체의 변형에 사용되는 특정 부위 |
JP6671956B2 (ja) * | 2013-03-29 | 2020-03-25 | 大日本住友製薬株式会社 | Erap1によるトリミング機能をきっかけとしたコンジュゲートワクチン |
RU2668560C2 (ru) | 2013-03-29 | 2018-10-02 | Сумитомо Дайниппон Фарма Ко., Лтд. | Конъюгированная вакцина на основе пептида антигена wt1 |
AU2014299561B2 (en) * | 2013-06-24 | 2017-06-08 | Ablbio | Antibody-drug conjugate having improved stability and use thereof |
TWI725931B (zh) * | 2013-06-24 | 2021-05-01 | 美商建南德克公司 | 抗fcrh5抗體 |
EP3054991B1 (en) | 2013-10-11 | 2019-04-03 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
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PE20210107A1 (es) | 2013-12-17 | 2021-01-19 | Genentech Inc | Anticuerpos anti-cd3 y metodos de uso |
MA40579A (fr) | 2014-09-12 | 2016-03-17 | Genentech Inc | Anticorps anti-cll-1 et immunoconjugués |
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JP7174522B2 (ja) | 2014-12-05 | 2022-11-17 | メモリアル スローン ケタリング キャンサー センター | Fc受容体様5を標的とするキメラ抗原受容体およびその使用 |
AR104987A1 (es) * | 2015-06-15 | 2017-08-30 | Genentech Inc | Inmunoconjugados anticuerpo-fármaco unidos por enlazadores no peptídicos |
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MY189840A (en) * | 2015-06-16 | 2022-03-11 | Genentech Inc | Humanized and affinity matured antibodies to fcrh5 and methods of use |
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-
2010
- 2010-03-31 BR BRPI1012560A patent/BRPI1012560A2/pt not_active IP Right Cessation
- 2010-03-31 PE PE2011001751A patent/PE20120877A1/es not_active Application Discontinuation
- 2010-03-31 RU RU2016110891A patent/RU2016110891A/ru not_active Application Discontinuation
- 2010-03-31 SG SG2011069895A patent/SG174930A1/en unknown
- 2010-03-31 EP EP10711526A patent/EP2414395A1/en not_active Ceased
- 2010-03-31 AR ARP100101080A patent/AR076030A1/es not_active Application Discontinuation
- 2010-03-31 CN CN201080014347.1A patent/CN102369218B/zh not_active Expired - Fee Related
- 2010-03-31 KR KR1020117025849A patent/KR20120003478A/ko active IP Right Grant
- 2010-03-31 WO PCT/US2010/029521 patent/WO2010114940A1/en active Application Filing
- 2010-03-31 RU RU2011144119/10A patent/RU2583270C2/ru not_active IP Right Cessation
- 2010-03-31 TW TW099109950A patent/TW201039846A/zh unknown
- 2010-03-31 CA CA2756988A patent/CA2756988A1/en not_active Abandoned
- 2010-03-31 JP JP2012503682A patent/JP6099976B2/ja not_active Expired - Fee Related
- 2010-03-31 AU AU2010232682A patent/AU2010232682A1/en not_active Abandoned
- 2010-03-31 MX MX2011010265A patent/MX2011010265A/es active IP Right Grant
- 2010-03-31 US US12/751,791 patent/US8362213B2/en not_active Expired - Fee Related
-
2011
- 2011-09-27 IL IL215404A patent/IL215404A0/en unknown
- 2011-09-29 ZA ZA2011/07128A patent/ZA201107128B/en unknown
- 2011-09-30 CL CL2011002418A patent/CL2011002418A1/es unknown
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2012
- 2012-07-26 HK HK12107358.7A patent/HK1166805A1/xx not_active IP Right Cessation
- 2012-11-09 US US13/673,565 patent/US9017951B2/en not_active Expired - Fee Related
-
2015
- 2015-08-27 JP JP2015168182A patent/JP2016028052A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2414395A1 (en) | 2012-02-08 |
AU2010232682A1 (en) | 2011-11-10 |
RU2583270C2 (ru) | 2016-05-10 |
JP2016028052A (ja) | 2016-02-25 |
US8362213B2 (en) | 2013-01-29 |
US20130089497A1 (en) | 2013-04-11 |
RU2016110891A (ru) | 2018-11-27 |
TW201039846A (en) | 2010-11-16 |
CN102369218B (zh) | 2014-07-16 |
WO2010114940A1 (en) | 2010-10-07 |
SG174930A1 (en) | 2011-11-28 |
CA2756988A1 (en) | 2010-10-07 |
CN102369218A (zh) | 2012-03-07 |
CL2011002418A1 (es) | 2012-03-16 |
AR076030A1 (es) | 2011-05-11 |
KR20120003478A (ko) | 2012-01-10 |
US9017951B2 (en) | 2015-04-28 |
JP2012522513A (ja) | 2012-09-27 |
HK1166805A1 (en) | 2012-11-09 |
MX2011010265A (es) | 2011-10-11 |
BRPI1012560A2 (pt) | 2016-07-26 |
IL215404A0 (en) | 2011-12-29 |
US20110171125A1 (en) | 2011-07-14 |
JP6099976B2 (ja) | 2017-03-29 |
ZA201107128B (en) | 2012-12-27 |
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